4-Chloro-2-fluoronitrobenzene supplier

Name
4-Chloro-2-fluoronitrobenzene
EINECS 211-842-5
CAS No. 700-37-8
Density 1.494 g/cm³
Solubility
Melting Point 48°C
Formula C₆H₃ClFNO₂
Boiling Point 241.8 °C at 760 mmHg
Molecular Weight 175.547
Flash Point 100 °C
Transport Information
Appearance light brown solid
Safety S26-36/37/39
Risk Codes R20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms 2-Fluoro-4-chloronitrobenzene
PSA 45.82000
LogP 2.91050

Synthetic route

: 611-06-3
2,4-dichloronitrobenzene

A: 2106-50-5
2-chloro-4-fluoro-1-nitrobenzene

B: 446-35-5
2,4-Difluoronitrobenzene

C: 700-37-8
4-chloro-2-fluoro-nitrobenzene

Conditions

Conditions	Yield
With potassium fluoride; water; tetramethlyammonium chloride In acetic acid at 120℃; for 3.5h;	A n/a B 70% C n/a

...Expand

: 610-40-2
3,4-dinitro-chlorobenzene

A: 345-18-6
2-fluoro-5-chloronitrobenzene

B: 700-37-8
4-chloro-2-fluoro-nitrobenzene

Conditions

Conditions	Yield
With N-methylhexamethylenetetrammonium fluoride In dimethyl sulfoxide at 65℃; for 0.1h; Title compound not separated from byproducts;

: 611-06-3
2,4-dichloronitrobenzene

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

Conditions

Conditions	Yield
With potassium fluoride; tetramethlyammonium chloride In malononitrile at 170℃; for 4h; Product distribution / selectivity;	7 %Chromat.

: 611-06-3
2,4-dichloronitrobenzene

A: 446-35-5
2,4-Difluoronitrobenzene

B: 700-37-8
4-chloro-2-fluoro-nitrobenzene

Conditions

Conditions	Yield
With potassium fluoride; tetramethlyammonium chloride In sulfolane at 170℃; for 4h; Product distribution / selectivity;	A 57 %Chromat. B 13 %Chromat.
With cesium fluoride In hexanedinitrile at 180 - 220℃; for 0.166667h; Microwave irradiation;	A 8 - 54 %Chromat. B 32 - 50 %Chromat.
With potassium fluoride; tetramethlyammonium chloride In pimelonitrile at 170℃; for 4h; Product distribution / selectivity;	A 48 %Chromat. B 20 %Chromat.

: 625-98-9
3-chlorofluorobenzene

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

Conditions

Conditions	Yield
With sulfuric acid; potassium nitrate at 0 - 20℃;

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 5188-07-8
sodium thiomethoxide

: 70019-41-9
4-chloro-2-(methylthio)-1-nitrobenzene

Conditions

Conditions	Yield
In methanol at 15 - 25℃;	100%

: 1126-09-6
4-carbethoxypiperidine

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 847408-05-3
1-(5-chloro-2-nitrophenyl)-piperidine-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With cesium fluoride In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 5h;	100%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 3850-30-4, 22526-47-2, 59367-75-8, 66228-31-7
(R)-1,2,2-trimethylpropylamine

: 863605-26-9
(5-chloro-2-nitrophenyl)-(1-(R)-methyl-2,2-dimethylpropyl)amine

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran; water at 75℃; for 3h;	100%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 932700-82-8
tert-butyl 4-((5-chloro-2-nitrophenyl)amino)piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	100%
With sodium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	100%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; for 18h;	93.2%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20 - 80℃; for 1h;
With potassium carbonate In dimethyl sulfoxide at 20℃; Inert atmosphere;

: 4-fluoropiperidine hydrochloride

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 885705-11-3
1-(5-chloro-2-nitro-phenyl)-4-fluoro-piperidine

Conditions

Conditions	Yield
With sodium carbonate In toluene at 40℃; for 6h;	99%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 75336-86-6
(2R)-methylpiperazine

: 907991-13-3
(R)-1-(5-chloro-2-nitrophenyl)-3-methylpiperazine

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 80℃; for 3h;	98%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80℃; for 16h;

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 109-55-7
1-amino-3-(dimethylamino)propane

: 92547-10-9
N1-(5-chloro-2-nitrophenyl)-N3,N3-dimethylpropane-1,3-diamine

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;	98%
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 60℃; for 18h;

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 104223-69-0, 116574-75-5
3-fluoropiperidine

: 885705-14-6
1-(5-chloro-2-nitro-phenyl)-3-fluoro-piperidine

Conditions

Conditions	Yield
With sodium carbonate In toluene at 40℃; for 6h;	98%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 150-76-5
4-methoxy-phenol

: 1299465-90-9
4-chloro-2-(4-methoxy-phenoxy)nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 75℃; for 3h;	98%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 62-53-3
aniline

: 25781-92-4
5-chloro-2-nitro-N-phenylaniline

Conditions

Conditions	Yield
In dimethyl sulfoxide at 110℃; for 4h;	98%
With triethylamine In dimethyl sulfoxide at 20℃; for 43h;
With potassium carbonate In dimethyl sulfoxide at 50℃;
With potassium carbonate In dimethyl sulfoxide at 50℃;

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 169447-70-5
(S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

: (S)-tert-butyl 4-(5-chloro-2-nitrophenyl)-2-methylpiperazine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane Reflux;	98%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 216064-48-1
2-tert-butyloxycarbonyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

: 2-tert-butoxycarbonyl-5-(5-chloro-2-nitrophenoxy)-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	97.7%

: 110-89-4
piperidine

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 53013-43-7
1-(5-chloro-2-nitrophenyl)piperidine

Conditions

Conditions	Yield
In ethanol at 0 - 23℃; for 0.75h;	97%
In ethanol at 0 - 23℃; for 0.666667h;	96%
In ethanol	2.33 g (97%)

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 129150-68-1
N-(t-butoxycarbonyl)-2-(3-hydroxyphenyl)-ethylamine

: tert-butyl 2-[3-(5-chloro-2-nitrophenoxy)phenyl]ethylcarbamate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	96.6%

: 626-58-4
4-methylpiperidin

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 885704-47-2
1-(5-chloro-2-nitrophenyl)-4-methylpiperidine

Conditions

Conditions	Yield
In ethanol at 0 - 23℃; for 0.666667h;	96%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 111010-08-3
1-bromo-2-chloro-4-fluoro-5-nitrobenzene

Conditions

Conditions	Yield
With sulfuric acid; bromine; silver sulfate	95%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 100-46-9
benzylamine

: 10066-19-0
N-benzyl-N-(2-nitro-5-chlorophenyl)-amine

Conditions

Conditions	Yield
In water at 100℃; for 1h;	95%
With potassium carbonate In ethanol at 20℃;

: 110-91-8
morpholine

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 65976-63-8
4-(5-chloro-2-nitrophenyl)morpholine

Conditions

Conditions	Yield
With potassium carbonate at 30℃; for 16h;	94%
With potassium carbonate In toluene at 0 - 20℃;	67%

: 29559-82-8
N'-ethyl-N,N-dimethyl-hydrazine

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 5010-24-2
N-(5-Chloro-2-nitrophenyl)-N',N'-dimethylethylenediamine

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide	94%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 74-89-5
methylamine

: 35966-84-8
4-chloro-2-methylaminonitrobenzene

Conditions

Conditions	Yield
In ethanol at 0℃; for 2.25h;	92.7%
In ethanol; water for 1h;	33%
In tetrahydrofuran; dimethyl sulfoxide at 20℃; for 24h; Product distribution / selectivity;
In tetrahydrofuran at 20℃;
In tetrahydrofuran at 20℃; for 1h; Microwave irradiation; Sealed tube;

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 4892-02-8
Methyl thiosalicylate

: 92161-65-4
methyl 2-((4-chloro-2-nitrophenyl)thio)benzoate

Conditions

Conditions	Yield
With caesium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 2h;	92%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;	92%

: trans-4-(tert-butoxycarbonylamino)cyclohexylamine

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: tert-butyl ((1r,4r)-4-((5-chloro-2-nitrophenyl)amino)cyclohexyl)carbamate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 80℃; for 5h;	90%

: 123-75-1
pyrrolidine

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 133387-30-1
4-chloro-2-(1-pyrrolidinyl)nitrobenzene

Conditions

Conditions	Yield
In dimethyl sulfoxide at 80℃; for 1h;	89%
With potassium carbonate In dimethyl sulfoxide at 120℃;

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 158985-25-2
tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate

: tert-butyl 4-[4-(5-chloro-2-nitrophenoxy)phenyl]piperazine-1-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	89%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 109-07-9
(RS)-2-methylpiperazine

: 709023-21-2
1-(5-chloro-2-nitro-phenyl)-3-methyl-piperazine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80℃; for 16h;	88%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: cis-4-(5-chloro-2-nitrophenylamino)-N-isopropylcyclohexanecarboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 80℃; for 16h;	87%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 169447-70-5
(S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

: (S)-1-(5-chloro-2-nitrophenyl)-3-methylpiperazine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 12h; Reflux;	86.3%

: 5118-06-9
methyl 3-hydroxy-2-thiophenecarboxylate

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: methyl 3-(5-chloro-2-nitrophenoxy)thiophene-2-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	85%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 765-30-0
Cyclopropylamine

: 147245-29-2
5-chloro-N-cyclopropyl-2-nitroaniline

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 80℃; for 16h; Inert atmosphere;	83%
With triethylamine In tetrahydrofuran at 80℃; for 16h; Inert atmosphere;	83%

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 119-36-8
methyl salicylate

: 858670-83-4
methyl 2-(4-chloro-2-nitrophenoxy)benzoate

Conditions

Conditions	Yield
With caesium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 2h;	82%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;	82%

4-Chloro-2-fluoronitrobenzene Chemical Properties

The Molecular formula of 4-Chloro-2-fluoronitrobenzene(700-37-8): C₆H₃ClFNO₂
The Molecular Weight of 4-Chloro-2-fluoronitrobenzene(700-37-8): 175.54
Molecular Structure:
EINECS: 211-842-5
Melting point: 48^°C
Boiling Point: 241.8 °C at 760 mmHg
Flash Point: 100 °C
Index of Refraction: 1.554
Molar Refractivity: 37.68 cm³
Molar Volume: 117.4 cm³
Polarizability: 14.94 10^-24 cm³
Surface Tension: 45.9 dyne/cm
Density: 1.494 g/cm³
Enthalpy of Vaporization: 45.93 kJ/mol
Vapour Pressure: 0.0547 mmHg at 25°C
IUPAC Name: 4-chloro-2-fluoro-1-nitrobenzene
Synonyms: 2-FLUORO-4-CHLORONITROBENZENE;1-CHLORO-3-FLUORO-4-NITROBENZENE;4-CHLORO-2-FLUORONITROBENZENE;4-CHLORO-2-FLUORO-1-NITROBENZENE;2-fluoro-4-chloroitrobenzene;4-Chloro-5-fluoronitrobenzene;Chlorofluoronitrobenzene;4-Chlor-2-fluor-1-nitrobenzol;

4-Chloro-2-fluoronitrobenzene Safety Profile

The Hazard Codes of 4-Chloro-2-fluoronitrobenzene(700-37-8): Xi
Hazard Note: Irritant
The Risk Statements information of 4-Chloro-2-fluoronitrobenzene(700-37-8):
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
SaThe Risk Statements information of 4-Chloro-2-fluoronitrobenzene(700-37-8):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection

Product Name

4-Chloro-2-fluoronitrobenzene

Synthetic route

4-Chloro-2-fluoronitrobenzene Chemical Properties

4-Chloro-2-fluoronitrobenzene Safety Profile

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