Product Name

  • Name

    4-CHLOROPHTHALIC ACID MONOSODIUM SALT

  • EINECS 259-963-2
  • CAS No. 56047-23-5
  • Article Data1
  • CAS DataBase
  • Density g/cm3
  • Solubility Soluble in water
  • Melting Point
  • Formula C8H5 Cl O4 . Na
  • Boiling Point 399.5 °C at 760 mmHg
  • Molecular Weight 222.56
  • Flash Point 195.4 °C
  • Transport Information UN 2811 6
  • Appearance white to light tan powder.
  • Safety 26-36
  • Risk Codes 20/21/22-36
  • Molecular Structure Molecular Structure of 56047-23-5 (4-CHLOROPHTHALIC ACID MONOSODIUM SALT)
  • Hazard Symbols HarmfulXn
  • Synonyms 1,2-Benzenedicarboxylicacid, 4-chloro-, monosodium salt (9CI); Phthalic acid, 4-chloro-, sodium salt(6CI); 4-Chloro-o-phthalic acid sodium salt; 4-Chlorophthalic acid monosodiumsalt; Monosodium 4-chlorophthalate
  • PSA 77.43000
  • LogP 0.40170

Synthetic route

phthalic anhydride
85-44-9

phthalic anhydride

monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

Conditions
ConditionsYield
Stage #1: phthalic anhydride With sodium chlorate; sodium hydroxide In water at 28 - 30℃; for 17h;
Stage #2: With hydrogenchloride In water at 30℃; pH=Ca. 5.5;
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4-chlorophthalic anhydride
118-45-6

4-chlorophthalic anhydride

Conditions
ConditionsYield
With thionyl chloride for 2h; Heating;70%
With sulfuric acid In acetic anhydride for 3h; Heating;
With thionyl chloride for 2h; Reflux;
ethanol
64-17-5

ethanol

monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4-chlorodiethylphthalate
38717-95-2

4-chlorodiethylphthalate

Conditions
ConditionsYield
With hydrogenchloride at 80℃; for 48h; Esterification;62%
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4-chloro-2-hydroxy-1(H)-isoindole-1,3-dione
173962-58-8

4-chloro-2-hydroxy-1(H)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 62 percent / HCl(g) / 48 h / 80 °C
2: hydroxylamine; KOH / methanol / 8 h / -70 °C / RT, 72 h
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4-chloro-2-methylsulfonyloxy-1(H)-isoindole-1,3-dione

4-chloro-2-methylsulfonyloxy-1(H)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 62 percent / HCl(g) / 48 h / 80 °C
2: hydroxylamine; KOH / methanol / 8 h / -70 °C / RT, 72 h
3: 48 percent / NaHCO3 / H2O / 3 h / 0 °C
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4-chloro-2-isopropylsulfonyloxy-1(H)-isoindole-1,3-dione

4-chloro-2-isopropylsulfonyloxy-1(H)-isoindole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 62 percent / HCl(g) / 48 h / 80 °C
2: hydroxylamine; KOH / methanol / 8 h / -70 °C / RT, 72 h
3: 56 percent / NaHCO3 / H2O / 3 h / 0 °C
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4-chlorophthalimide
7147-90-2

4-chlorophthalimide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / thionylchloride / 2 h / Heating
2: 98 percent / urea / 0.67 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride / 2 h / Reflux
2: formamide / 1 h / 150 °C
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

6-chlorophthalide
19641-29-3

6-chlorophthalide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 83 percent / NaBH4 / methanol
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

5-chloro-1H-indene-1,3(2H)-dione
22018-96-8

5-chloro-1H-indene-1,3(2H)-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 2 h / Heating
3: 1.) SOCl2 / 1.) reflux; 2.) benzene, reflux, 1.5 h
4: Na / reflux 2 h, then r.t., 15 h
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

chloro-4 phtalate acide d'ethyle

chloro-4 phtalate acide d'ethyle

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 2 h / Heating
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4-chlorodiethylphthalate
38717-95-2

4-chlorodiethylphthalate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 2 h / Heating
3: 1.) SOCl2 / 1.) reflux; 2.) benzene, reflux, 1.5 h
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

chloro-5 (dihydro-1,4 pyridinylidene-4)-2 indanedione-1,3
111983-50-7

chloro-5 (dihydro-1,4 pyridinylidene-4)-2 indanedione-1,3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 57.1 percent / molecular sieves 3 Angstroem / diphenyl ether / 24 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 83 percent / NaBH4 / methanol
3: 62.3 percent / NaOMe, ethyl propionate / methanol / 5 h / Heating
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

chloro-5 (dimethyl-2,6 4 H-pyrannylidene-4)-2 indanedione-1,3

chloro-5 (dimethyl-2,6 4 H-pyrannylidene-4)-2 indanedione-1,3

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 2 h / Heating
3: 1.) SOCl2 / 1.) reflux; 2.) benzene, reflux, 1.5 h
4: Na / reflux 2 h, then r.t., 15 h
5: 38.1 percent / acetic anhydride / 24 h / Heating
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

5-Chloro-2-(1-ethyl-1H-pyridin-4-ylidene)-indan-1,3-dione
111983-51-8

5-Chloro-2-(1-ethyl-1H-pyridin-4-ylidene)-indan-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 57.1 percent / molecular sieves 3 Angstroem / diphenyl ether / 24 h / Heating
3: 89.2 percent / 50percent NaH / dimethylsulfoxide / 8 h / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 83 percent / NaBH4 / methanol
3: 62.3 percent / NaOMe, ethyl propionate / methanol / 5 h / Heating
4: 89.2 percent / 50percent NaH / dimethylsulfoxide / 8 h / Ambient temperature
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

(chloro-5 isopropyl-1 dihydro-1,4 pyridinylidene-4)-2 indanedione-1,3
111983-53-0

(chloro-5 isopropyl-1 dihydro-1,4 pyridinylidene-4)-2 indanedione-1,3

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 2 h / Heating
3: 1.) SOCl2 / 1.) reflux; 2.) benzene, reflux, 1.5 h
4: Na / reflux 2 h, then r.t., 15 h
5: 1.) 10N NaOH; 2.) O2, air / 1.) MeOH, r.t., 8 d
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

chloro-5 (isopropyl-1 dimethyl-2,6 dihydro-1,4 pyridinylidene-4)-2 indanedione-1,3

chloro-5 (isopropyl-1 dimethyl-2,6 dihydro-1,4 pyridinylidene-4)-2 indanedione-1,3

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 2 h / Heating
3: 1.) SOCl2 / 1.) reflux; 2.) benzene, reflux, 1.5 h
4: Na / reflux 2 h, then r.t., 15 h
5: 38.1 percent / acetic anhydride / 24 h / Heating
6: 36 percent / acetonitrile / 0.5 h / Heating
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

5-Chloro-2-[1-(2-methoxy-ethyl)-1H-pyridin-4-ylidene]-indan-1,3-dione
111983-52-9

5-Chloro-2-[1-(2-methoxy-ethyl)-1H-pyridin-4-ylidene]-indan-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 57.1 percent / molecular sieves 3 Angstroem / diphenyl ether / 24 h / Heating
3: 92 percent / 50percent NaH / dimethylsulfoxide / 8 h / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 83 percent / NaBH4 / methanol
3: 62.3 percent / NaOMe, ethyl propionate / methanol / 5 h / Heating
4: 92 percent / 50percent NaH / dimethylsulfoxide / 8 h / Ambient temperature
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

5-Chloro-2-[1-(2-piperidin-1-yl-ethyl)-1H-pyridin-4-ylidene]-indan-1,3-dione
111983-54-1

5-Chloro-2-[1-(2-piperidin-1-yl-ethyl)-1H-pyridin-4-ylidene]-indan-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 57.1 percent / molecular sieves 3 Angstroem / diphenyl ether / 24 h / Heating
3: 59.9 percent / 50percent NaH / dimethylsulfoxide / 8 h / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: H2SO4 / acetic anhydride / 3 h / Heating
2: 83 percent / NaBH4 / methanol
3: 62.3 percent / NaOMe, ethyl propionate / methanol / 5 h / Heating
4: 59.9 percent / 50percent NaH / dimethylsulfoxide / 8 h / Ambient temperature
View Scheme
pyrographite
7440-44-0

pyrographite

monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4-chlorophthalic acid
89-20-3

4-chlorophthalic acid

Conditions
ConditionsYield
With sulfuric acid In water
With sulfuric acid In water
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4-(5-chloro-1,3-dioxo-2-isoindolinyl)-3-(4-chlorophenyl)butanoic acid
1221962-70-4

4-(5-chloro-1,3-dioxo-2-isoindolinyl)-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / 2 h / Reflux
2: sodium acetate / acetic acid / 20 h / Reflux
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

N-[(5-chloro-1,3-dioxo-2-isoindolinyl)methyl]-N-(4-chlorophenyl)glycine
1221962-71-5

N-[(5-chloro-1,3-dioxo-2-isoindolinyl)methyl]-N-(4-chlorophenyl)glycine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / 2 h / Reflux
2.1: formamide / 1 h / 150 °C
3.1: ethanol
3.2: 3 h / Reflux
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4-chloro-phthaloyl dichloride
62366-66-9

4-chloro-phthaloyl dichloride

Conditions
ConditionsYield
With phosphorus pentachloride at 180℃; for 3h;
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

(R)-3-(5-chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester
849106-72-5

(R)-3-(5-chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: phosphorus pentachloride / 3 h / 180 °C
2: pyridine / 2.5 h / 80 °C
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

(R)-3-(5-chloro-1,3-dihydro-isoindol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester
849106-73-6

(R)-3-(5-chloro-1,3-dihydro-isoindol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / 3 h / 180 °C
2: pyridine / 2.5 h / 80 °C
3: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 1.5 h / 0 °C
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

3,3',4,4'-biphenyltetracarboxylic anhydride
2420-87-3

3,3',4,4'-biphenyltetracarboxylic anhydride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide; palladium on activated charcoal / water / 6 h / Reflux
1.2: 6 h / Reflux
2.1: hydrogenchloride / water / 7 h / Reflux
3.1: 24 h / 120 - 250 °C / Heating
View Scheme
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

sodium [1,1'-biphenyl]-3,3',4,4'-tetracarboxylate

sodium [1,1'-biphenyl]-3,3',4,4'-tetracarboxylate

Conditions
ConditionsYield
Stage #1: monosodique de l'acide chloro-4 phtalique With palladium on activated charcoal; sodium hydroxide In water for 6h; Reflux;
Stage #2: With hydroxyammonium sulfate In water for 6h; Reflux;
monosodique de l'acide chloro-4 phtalique
56047-23-5

monosodique de l'acide chloro-4 phtalique

4,4'-biphthalic acid
22803-05-0

4,4'-biphthalic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide; palladium on activated charcoal / water / 6 h / Reflux
1.2: 6 h / Reflux
2.1: hydrogenchloride / water / 7 h / Reflux
View Scheme

4-Chlorophthalic acid monosodium salt Chemical Properties


IUPAC Name: Sodium 2-carboxy-5-chlorobenzoate 
Empirical Formula: C8H3ClNaO4
Molecular Weight: 221.5503 
Nominal Mass: 221 
Average Mass: 221.5503 
Monoisotopic Mass: 220.962305
Canonical SMILES: C1=CC(=C(C=C1Cl)C(=O)[O-])C(=O)O.[Na+]
InChI: InChI=1S/C8H5ClO4.Na/c9-4-1-2-5(7(10)11)6(3-4)8(12)13;/h1-3H,(H,10,11)(H,12,13);/q;+1/p-1
InChIKey: MWZMHSGEQHVWED-UHFFFAOYSA-M
EINECS: 259-963-2 
H-Bond Donor: 1
H-Bond Acceptor: 4 
Freely Rotating Bonds of 4-Chlorophthalic acid monosodium salt (CAS NO.56047-23-5): 2

4-Chlorophthalic acid monosodium salt Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 20/21/22-36 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36:Irritating to eyes.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup of 4-Chlorophthalic acid monosodium salt (CAS NO.56047-23-5): III

4-Chlorophthalic acid monosodium salt Specification

  4-Chlorophthalic acid monosodium salt (CAS NO.56047-23-5), its Synonyms are 1,2-Benzenedicarboxylic acid, 4-chloro-, monosodium salt ; 1,2-Benzenedicarboxylic acid, 4-chloro-, sodium salt (1:1) ; Monosodium hydrogen 4-chlorophthalate ; Sodium 4-chlorophthalate . It is white to tan to beige crystalline powder.

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View