4-Chlorophthalic anhydride supplier

Name
4-Chlorophthalic anhydride
EINECS 204-251-9
CAS No. 118-45-6
Article Data39
CAS DataBase
Density 1.594 g/cm³
Solubility
Melting Point 96 °C
Formula C₈H₃ClO₃
Boiling Point 299.8 °C at 760 mmHg
Molecular Weight 182.563
Flash Point 142.4 °C
Transport Information
Appearance white crystal powder
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms 5-chloroisobenzofuran-1,3-dione;4-Chlorophthalic Acid Anhydride;
PSA 43.37000
LogP 1.65060

Synthetic route

: 1204-28-0
trimellitic anhydride acid chloride

A: 85-44-9
phthalic anhydride

B: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
palladium dichloride In melt at 290℃; for 2h; Product distribution; other temperatures and other catalysts (Pd/C, Pd(PPh3)4);	A 1% B 99%
tetrakis(triphenylphosphine) palladium(0) In melt at 265℃; for 16h;	A 10% B 79%

: 89-20-3
4-chlorophthalic acid

: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
With acetic anhydride for 3h; Heating;	98%
With acetic anhydride for 1h; Heating;	90%
With acetic anhydride for 2h; Reflux;	88%

: 1204-28-0
trimellitic anhydride acid chloride

: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
With bis(tri-ortho-tolylphosphine)palladium(0); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine In toluene at 130℃; for 20h; Inert atmosphere; Glovebox;	84%

: 56047-23-5
monosodique de l'acide chloro-4 phtalique

: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
With thionyl chloride for 2h; Heating;	70%
With sulfuric acid In acetic anhydride for 3h; Heating;
With thionyl chloride for 2h; Reflux;

: 85-44-9
phthalic anhydride

: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
With sulfuric acid; chlorine at 50℃; in Gegenwart von Jod;
With chlorine In water at 70℃; for 12h;

: 56-23-5
tetrachloromethane

: 5466-84-2
4-nitrophthalic anhydride

: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
at 280℃;

: 5466-84-2
4-nitrophthalic anhydride

: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
With chlorine at 230 - 250℃;

: 89-20-3
4-chlorophthalic acid

: 75-36-5
acetyl chloride

: 118-45-6
4-chlorophthalic anhydride

: 85-44-9
phthalic anhydride

A: 118-45-6
4-chlorophthalic anhydride

B: 117-21-5
3-chlorophthalic anhydride

C: 942-06-3
4,5-dichlorophthalic anhydride

D: 51971-64-3
4,6-dichloroisobenzofuran-1,3-diketone

Conditions

Conditions	Yield
With chlorine at 390℃; Product distribution; var. temp, var. conc. of Cl2;
With chlorine at 420℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With chlorine at 390℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 91-58-7
2-chloronaphthalene

air: air

titanium yl vanadate: titanium yl vanadate

titanium oxide: titanium oxide

pumice stone: pumice stone

A: 85-44-9
phthalic anhydride

B: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
at 340℃;

...Expand

: 2065-70-5
2,6-dichloronaphthalene

: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: nitric acid / 190 - 200 °C / im geschlossenen Rohr 2: durch Sublimation View Scheme

: 40604-49-7
6-chloronaphthalen-2-ol

: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: bei der Oxydation 2: durch Sublimation View Scheme

: 88-99-3
benzene-1,2-dicarboxylic acid

: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diluted NaOH-solution; chlorine View Scheme

: 2C6H15N*C8H9ClO4

: 2C6H15N*C8H5ClO4

A: 118-45-6
4-chlorophthalic anhydride

B: 14737-08-7
4-chloro-1,2,3,6-tetrahydrophthalic anhydride

Conditions

Conditions	Yield
In water

...Expand

: 89-20-3
4-chlorophthalic acid

: 27563-65-1
3-chlorobenzene-1,2-dicarboxylic acid

A: 118-45-6
4-chlorophthalic anhydride

B: 117-21-5
3-chlorophthalic anhydride

Conditions

Conditions	Yield
With acetic anhydride at 122 - 136℃; for 2h; Product distribution / selectivity;
at 175℃; under 60.006 Torr; for 3h; Product distribution / selectivity;

...Expand

: 96-02-6
2-chloromaleic anhydride

: 1122-17-4
dichloromaleic acid anhydride

: 92-84-2
10H-phenothiazine

: 126-99-8
chloroprene

: 118-45-6
4-chlorophthalic anhydride

...Expand

: 4-chlorotetrahydrophthalic anhydride

: 7440-44-0
pyrographite

: 118-45-6
4-chlorophthalic anhydride

: 4-chlorotetrahydrophthalic anhydride

: 120-82-1
1,2,4-Trichlorobenzene

: 118-45-6
4-chlorophthalic anhydride

: 615-60-1
4-chloro-1,2-dimethylbenzene

A: 118-45-6
4-chlorophthalic anhydride

B: 89-20-3
4-chlorophthalic acid

Conditions

Conditions	Yield
With hydrogenchloride; potassium permanganate In water; acetic anhydride
With hydrogenchloride; potassium permanganate In water; acetic anhydride

: monosodium salt of 4-chlorophthalic acid

: 118-45-6
4-chlorophthalic anhydride

Conditions

Conditions	Yield
With thionyl chloride for 2h; Reflux;

: 118-45-6
4-chlorophthalic anhydride

: 108-45-2
m-phenylenediamine

: 148935-94-8
1,3-bis[N-(4-chlorophthalimidio)]benzene

Conditions

Conditions	Yield
Sodium phenylphosphinate In methoxybenzene at 200℃; under 760.051 - 1824.12 Torr; for 2 - 7h; Conversion of starting material;	99.44%
In glycerol at 150℃; for 15h;	55.3%
In 1,2-dichloro-benzene at 20 - 180℃; for 32h;

: 118-45-6
4-chlorophthalic anhydride

: 25884-43-9
3,3′,4,4′-diphenylsulfidetetracarboxylic dianhydride

Conditions

Conditions	Yield
With carbon disulfide; sulfur; sodium t-butanolate In dimethyl sulfoxide at 150℃; Temperature; Reagent/catalyst; Solvent;	99.08%
With sodium sulfide; 18-crown-6 ether at 200℃; for 24h;	70%

: 118-45-6
4-chlorophthalic anhydride

: 7147-90-2
4-chlorophthalimide

Conditions

Conditions	Yield
With choline chloride; urea at 140℃; for 1h; Green chemistry;	99%
With urea for 0.666667h; Heating;	98%
With formamide for 0.0333333h; microwave irradiation;	93%

: 118-45-6
4-chlorophthalic anhydride

: C8H3O4(1-)*Na(1+)

: 1823-59-2
4,4'-oxydiphthalic dianhydride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide; toluene at 110℃; for 6h;	98.1%

: 118-45-6
4-chlorophthalic anhydride

: 126916-57-2, 127000-91-3, 132563-71-4
(2R*,3R*)-3-Amino-2-(2,4-difluoropropyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 126917-83-7
(2R*,3R*)-3-(4-Chlorophthalimido)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Conditions

Conditions	Yield
With triethylamine In toluene for 4h; Heating;	98%

: 118-45-6
4-chlorophthalic anhydride

: 3682-29-9
6-chloro-2,3-dihydrophthalazine-1,4-dione

Conditions

Conditions	Yield
Stage #1: 4-chlorophthalic anhydride With hydrazine hydrate Inert atmosphere; Stage #2: With hydrogenchloride In water for 24h; Reflux; Inert atmosphere;	97%
With hydrazine In acetic acid for 2h; Heating / reflux;	95%
With hydrazine hydrate In acetic acid for 0.5h; Heating;
With hydrazine hydrate In ethanol for 5h; Ambient temperature;
With hydrogenchloride; hydrazine hydrate In quinoline for 24h; Reflux;

: 118-45-6
4-chlorophthalic anhydride

: 579472-20-1
1-(3-aminophenyl)-1,1-bis(4-hydroxyphenyl)ethane

: 579472-24-5
N-{3-[1,1-bis(4-hydroxyphenyl)]ethylphenyl}-4-chlorophthalimide

Conditions

Conditions	Yield
Stage #1: 4-chlorophthalic anhydride; 1-(3-aminophenyl)-1,1-bis(4-hydroxyphenyl)ethane In N,N-dimethyl acetamide at 20℃; Stage #2: In N,N-dimethyl acetamide; xylene Heating;	97%

: 118-45-6
4-chlorophthalic anhydride

: 579472-19-8
4-amino-4',4''-dihydroxytriphenylmethane

: 579472-21-2
N-[4-bis(4-hydroxyphenyl)toluoyl]-4-chlorophthalimide

Conditions

Conditions	Yield
Stage #1: 4-chlorophthalic anhydride; 4-amino-4',4''-dihydroxytriphenylmethane In N,N-dimethyl acetamide at 20℃; for 24h; Stage #2: In N,N-dimethyl acetamide; xylene for 10h; Heating;	95%

: 118-45-6
4-chlorophthalic anhydride

: 100-46-9
benzylamine

: 136860-33-8
2-benzyl-5-chloroisoindolin-1,3-dione

Conditions

Conditions	Yield
In xylene Heating;	93%

: 118-45-6
4-chlorophthalic anhydride

: 107-15-3
ethylenediamine

: C18H10Cl2N2O4

Conditions

Conditions	Yield
at 150℃; for 16h;	92.4%

: 118-45-6
4-chlorophthalic anhydride

: 106-50-3
1,4-phenylenediamine

: C22H10Cl2N2O4

Conditions

Conditions	Yield
In paraffin oil at 170℃; for 10h;	92.1%

: 118-45-6
4-chlorophthalic anhydride

: 341-58-2
2,2'-bis(trifluoromethyl)benzidine

: C30H12Cl2F6N2O4

Conditions

Conditions	Yield
With 4-hydroxymethyl-1,3-dioxolan-2-one at 180℃; for 14h;	91.8%

: 118-45-6
4-chlorophthalic anhydride

: 80-08-0
dapsone

: C28H14Cl2N2O6S

Conditions

Conditions	Yield
at 180℃; for 12h;	91.5%

: 118-45-6
4-chlorophthalic anhydride

: 101-80-4
4,4'-oxydiphenylene diamine

: 4,4'-bis(4-chlorophthalimido)diphenyl ether

Conditions

Conditions	Yield
With ethylene glycol carbonate at 190℃; for 10h;	91.4%
With acetic acid for 24h; Heating;	88%

: 875-79-6
1,2-dimethylindole

: 118-45-6
4-chlorophthalic anhydride

: C18H14ClNO3

Conditions

Conditions	Yield
at 110℃;	90.6%

: 118-45-6
4-chlorophthalic anhydride

: 109811-59-8
3-amino-4',4''-dihydroxytriphenylmethane

: 579472-23-4
N-[3-bis(4-hydroxyphenyl)toluoyl]-4-chlorophthalimide

Conditions

Conditions	Yield
Stage #1: 4-chlorophthalic anhydride; 3-amino-4',4''-dihydroxytriphenylmethane In N,N-dimethyl acetamide at 20℃; Stage #2: In N,N-dimethyl acetamide; xylene Heating;	90%

: 118-45-6
4-chlorophthalic anhydride

: 266001-57-4
1-(4-aminophenyl)-1,1-bis(4-hydroxyphenyl)ethane

: 579472-22-3
N-{4-[1,1-bis(4-hydroxyphenyl)]ethylphenyl}-4-chlorophthalimide

Conditions

Conditions	Yield
Stage #1: 4-chlorophthalic anhydride; 1-(4-aminophenyl)-1,1-bis(4-hydroxyphenyl)ethane In N,N-dimethyl acetamide at 20℃; Stage #2: In N,N-dimethyl acetamide; xylene Heating;	90%

: 118-45-6
4-chlorophthalic anhydride

: 95-53-4
o-toluidine

: N-(2-methylphenyl)-4-chlorophthalimide

Conditions

Conditions	Yield
	90%

: 118-45-6
4-chlorophthalic anhydride

: 117-21-5
3-chlorophthalic anhydride

: 36978-41-3
2,3',3,4'-biphenyltetracarboxylic acid dianhydride

Conditions

Conditions	Yield
With N-phenylpicolinamide; sodium bromide; nickel dichloride; zinc at 30℃; for 8h; Catalytic behavior; Reagent/catalyst; Temperature; Time; Inert atmosphere;	87.7%

: 118-45-6
4-chlorophthalic anhydride

: C28H6F36O2

: C44H10F36O8

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide; toluene for 15h; Reflux;	87.7%

: 118-45-6
4-chlorophthalic anhydride

: C8H3ClO2S

Conditions

Conditions	Yield
With sodium sulfide In tetrahydrofuran at 20℃; for 4h;	87.6%

: 118-45-6
4-chlorophthalic anhydride

: 56-12-2
4-amino-n-butyric acid

: C12H10ClNO4

Conditions

Conditions	Yield
With acetic acid at 100℃; for 3h;	86.4%

: 118-45-6
4-chlorophthalic anhydride

: 6442-08-6
1,1'-bis(3-methyl-4-aminophenyl)cyclohexane

: 582303-39-7
4,4'-bis(4-chlorophthalimido)-3,3'-dimethyldiphenyl-1,1'-cyclohexane

Conditions

Conditions	Yield
With acetic acid for 24h; Heating;	85%

: 118-45-6
4-chlorophthalic anhydride

: 1823-59-2
4,4'-oxydiphthalic dianhydride

Conditions

Conditions	Yield
With potassium carbonate; hexaethylguanidinium chloride In water; 1,2-dichloro-benzene for 3.5h; Heating / reflux;	85%
With potassium carbonate; sodium nitrite In N,N-dimethyl acetamide; toluene at 162 - 170℃; for 5h;	85%
Stage #1: 4-chlorophthalic anhydride With monopotassium carbonate; tetraphenylphosphonium bromide; potassium hydrogencarbonate In 2,4-dichlorotoluene for 7.5h; Heating / reflux; Nitrogen atmosphere; Stage #2: Conversion of starting material; Heating / reflux;	82%

: 118-45-6
4-chlorophthalic anhydride

: 57-13-6
urea

: copper(l) chloride

: 16040-69-0
C32H12Cl4CuN8, β

Conditions

Conditions	Yield
In further solvent(s) stirring of a mixt. of CuCl, urea and C8H3ClO3 in trichlorobenzene at ambient temp. for 30 minutes; heating at 175-180°C for 4 h; evapn.; heating with 5% HCl; heating with 2% aq. Na2CO3;; washing with H2O and ethanol; drying at 95-100°C;;	85%

...Expand

: 80-05-7
BPA

: 118-45-6
4-chlorophthalic anhydride

: 38103-06-9
4,4'-bis(4,4'-isopropylidene diphenoxy)-bis(phthalic anhydride)

Conditions

Conditions	Yield
Stage #1: BPA With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 85 - 172℃; for 15h; Stage #2: 4-chlorophthalic anhydride In water; 1,3,5-trimethyl-benzene at 130 - 145℃; for 5h; Time;	85%

: 118-45-6
4-chlorophthalic anhydride

: 501-65-5
diphenyl acetylene

: 3-chloro-5,6,7,8-tetraphenyl-1-naphthoic acid

Conditions

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; tetrabutylammomium bromide In N,N-dimethyl-formamide at 100℃; for 12h; Sealed tube;	85%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; tetrabutylammomium bromide; 5-methyl-dihydro-furan-2-one In N,N-dimethyl-formamide at 100℃; for 12h;	83%

4-Chlorophthalic anhydride Chemical Properties

Structure of 4-Chlorophthalic anhydride (CAS NO.118-45-6):

IUPAC Name: 5-chloro-2-benzofuran-1,3-dione
Empirical Formula: C₈H₃ClO₃
Molecular Weight: 182.5606
EINECS: 204-251-9
Index of Refraction: 1.626 Molar
Refractivity: 40.57 cm³
Molar Volume: 114.5 cm³
Polarizability: 16.08 10^-24cm³
Surface Tension: 61.1 dyne/cm
Density: 1.594 g/cm³
Flash Point: 142.4 °C
Enthalpy of Vaporization: 53.99 kJ/mol
Melting Point: 96°C
Boiling Point: 299.8 °C at 760 mmHg
Vapour Pressure: 0.00116 mmHg at 25°C
Product Categories: Acids and Derivatives;Phthalic Acids, Esters and Derivatives
Canonical SMILES: C1=CC2=C(C=C1Cl)C(=O)OC2=O
InChI: InChI=1S/C8H3ClO3/c9-4-1-2-5-6(3-4)8(11)12-7(5)10/h1-3H
InChIKey: BTTRMCQEPDPCPA-UHFFFAOYSA-N

4-Chlorophthalic anhydride Production

4-Chlorophthalic anhydride (CAS NO.118-45-6) can be produced by chlorination of phthalic anhydride.

4-Chlorophthalic anhydride Safety Profile

Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36/37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection

4-Chlorophthalic anhydride Specification

4-Chlorophthalic anhydride , its cas register number is 118-45-6. It also can be called 1,3-isobenzofurandione, 5-chloro- ;
5-Chloro-2-benzofuran-1,3-dione ; 4-Chlorophthalic anhydride ; phthalic anhydride, 4-chloro- .

Product Name

4-Chlorophthalic anhydride

Synthetic route

4-Chlorophthalic anhydride Chemical Properties

4-Chlorophthalic anhydride Production

4-Chlorophthalic anhydride Safety Profile

4-Chlorophthalic anhydride Specification

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