4-Methylaminophenol sulfate supplier

Name
4-Methylaminophenol sulfate
EINECS 200-237-1
CAS No. 55-55-0
Article Data2
CAS DataBase
Density 1.577
Solubility 50 g/L (20 ºC)
Melting Point 260 °C
Formula 2(C₇H₉NO)^.H₂SO₄
Boiling Point 262.7 °C at 760 mmHg
Molecular Weight 344.389
Flash Point 148.6 °C
Transport Information
Appearance white crystalline powder
Safety 36/37-46-60-61
Risk Codes 22-43-48/22-50/53
Molecular Structure
Hazard Symbols Xn, N
Synonyms N-Methyl-p-aminophenol sulfate;Phenol, p-methylamino-, sulfate (salt);Bis(4-hydroxy-N-methylanilinium) sulphate;Verol;Phenol, 4-(methylamino)-, sulfate salt (2:1);p-Methylaminophenol sulphate (2:1);Elon (VAN);4-(Methylamino)phenol sulfate (2:1) salt;Phenol, p-(methylamino)-, sulfate (2:1) (salt);
PSA 115.24000
LogP 1.93490

Synthetic route

: 13031-47-5
acetic acid-(4-benzylidenamino-phenyl ester)

: 77-78-1
dimethyl sulfate

: 55-55-0
4-(methylamino)phenol sulphate

Conditions

Conditions	Yield
at 135℃; Zersetzen mit Wasser und Kochen mit konz.Salzsaeure;

: 51-78-5
p-aminophenol hydrochloride

: 77-78-1
dimethyl sulfate

: 55-55-0
4-(methylamino)phenol sulphate

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 55-55-0
4-(methylamino)phenol sulphate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 90446-71-2
4-((tert-butyldimethylsilyl)oxy)-N-methylaniline

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at -78℃;	97%

: 50-00-0
formaldehyd

: 55-55-0
4-(methylamino)phenol sulphate

: 78-93-3
butanone

: 1,3,4-trimethyl-6-hydroxyquinolinium perchlorate

Conditions

Conditions	Yield
With perchloric acid In nitrobenzene; butan-1-ol at 95℃; for 7h;	79.8%

...Expand

: 108-24-7
acetic anhydride

: 55-55-0
4-(methylamino)phenol sulphate

: 579-58-8
N-methyl-(4-acetamido)phenol

Conditions

Conditions	Yield
In water for 0.0333333h; Heating;	73%

: 55-55-0
4-(methylamino)phenol sulphate

: 530-62-1
1,1'-carbonyldiimidazole

: 186393-31-7
(3R,4R)-pyrrolidine-3,4-diol

: (3R,4R)-3,4-Dihydroxy-pyrrolidine-1-carboxylic acid (4-hydroxy-phenyl)-methyl-amide

Conditions

Conditions	Yield
Multistep reaction;	67%

...Expand

: 40499-83-0
pyrrolidin-3-ol

: 55-55-0
4-(methylamino)phenol sulphate

: 530-62-1
1,1'-carbonyldiimidazole

: 3-hydroxy-pyrrolidine-1-carboxylic acid (4-hydroxy-phenyl)-methyl-amide

Conditions

Conditions	Yield
Multistep reaction;	63%

...Expand

: 55-55-0
4-(methylamino)phenol sulphate

: 40499-83-0, 83220-72-8, 100243-39-8, 2799-21-5
(3R)-pyrrolidinol

: 530-62-1
1,1'-carbonyldiimidazole

: (R)-3-Hydroxy-pyrrolidine-1-carboxylic acid (4-hydroxy-phenyl)-methyl-amide

Conditions

Conditions	Yield
Multistep reaction;	60%

...Expand

: 96-42-4
pyrrolidin-3-one

: 55-55-0
4-(methylamino)phenol sulphate

: 530-62-1
1,1'-carbonyldiimidazole

: 3-oxo-pyrrolidine-1-carboxylic acid (4-hydroxy-phenyl)-methyl-amide

Conditions

Conditions	Yield
Multistep reaction;	48%

...Expand

: C23H32ClN2Si(1+)

: 55-55-0
4-(methylamino)phenol sulphate

: C30H40N3OSi(1+)

Conditions

Conditions	Yield
Stage #1: 4-(methylamino)phenol sulphate With triethylamine In acetonitrile for 0.5h; Stage #2: C23H32ClN2Si(1+) In acetonitrile for 0.0833333h;	29%

: 3622-35-3
benzothiazole-6-carboxylic acid

: 55-55-0
4-(methylamino)phenol sulphate

: 1354404-59-3
N-(4-hydroxyphenyl)-N-methylbenzo[d]thiazole-6-carboxamide

Conditions

Conditions	Yield
Stage #1: benzothiazole-6-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 4-(methylamino)phenol sulphate With triethylamine In N,N-dimethyl-formamide at 20℃; for 120h;	26%

: 86-98-6
4,7-dichloroquinoline

: 55-55-0
4-(methylamino)phenol sulphate

: 108-95-2
phenol

: 92873-40-0
4-[(7-chloro-quinolin-4-yl)-methyl-amino]-phenol

...Expand

: 50425-29-1
4,5-methylenedioxy-2-nitrobenzoyl chloride

: 55-55-0
4-(methylamino)phenol sulphate

: 109411-55-4
6-nitro-benzo[1,3]dioxole-5-carboxylic acid-(4-hydroxy-N-methyl-anilide)

Conditions

Conditions	Yield
With 1,4-dioxane; water; sodium hydrogencarbonate

: 55-55-0
4-(methylamino)phenol sulphate

: 107-07-3
2-chloro-ethanol

: 13278-69-8
2-(4-hydroxy-N-methyl-anilino)-ethanol

: 55-55-0
4-(methylamino)phenol sulphate

: (S)-3-Hydroxy-pyrrolidine-1-carboxylic acid (4-hydroxy-phenyl)-methyl-amide

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 97 percent / NaH / tetrahydrofuran / -78 °C 2: 91 percent / tetrahydrofuran / 20 °C 3: 92 percent / acetonitrile / 20 °C 4: 81 percent / Et3N / CH2Cl2 / 20 °C 5: 89 percent / TBAF / tetrahydrofuran / 20 °C View Scheme

: 55-55-0
4-(methylamino)phenol sulphate

: 872168-52-0
imidazole-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 97 percent / NaH / tetrahydrofuran / -78 °C 2: 91 percent / tetrahydrofuran / 20 °C View Scheme

: 55-55-0
4-(methylamino)phenol sulphate

: 872168-54-2
3-hydroxy-pyrrolidine-1-carboxylic acid [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-amide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 97 percent / NaH / tetrahydrofuran / -78 °C 2: 91 percent / tetrahydrofuran / 20 °C 3: 92 percent / acetonitrile / 20 °C 4: 81 percent / Et3N / CH2Cl2 / 20 °C View Scheme

: 55-55-0
4-(methylamino)phenol sulphate

: 3-{[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methyl-carbamoyl}-1-methyl-3H-imidazol-1-ium; iodide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 97 percent / NaH / tetrahydrofuran / -78 °C 2: 91 percent / tetrahydrofuran / 20 °C 3: 92 percent / acetonitrile / 20 °C View Scheme

: 55-55-0
4-(methylamino)phenol sulphate

: 120548-05-2
N,N'-bis-(2-hydroxy-ethyl)-N,N'-dimethyl-4,4'-heptanediyldioxy-di-aniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: ethanolic NaOH View Scheme

: 55-55-0
4-(methylamino)phenol sulphate

: 115121-74-9
6-amino-benzo[1,3]dioxole-5-carboxylic acid-(4-benzoyloxy-N-methyl-anilide)

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dioxane; sodium hydrogencarbonate; water 2: aqueous alkaline solution 3: palladium/charcoal; ethanol / 70 °C / Hydrogenation View Scheme

: 55-55-0
4-(methylamino)phenol sulphate

: 857388-87-5
6-nitro-benzo[1,3]dioxole-5-carboxylic acid-(4-benzoyloxy-N-methyl-anilide)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dioxane; sodium hydrogencarbonate; water 2: aqueous alkaline solution View Scheme

: 55-55-0
4-(methylamino)phenol sulphate

: 121446-20-6
6-benzylidenamino-benzo[1,3]dioxole-5-carboxylic acid-(4-benzoyloxy-N-methyl-anilide)

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: dioxane; sodium hydrogencarbonate; water 2: aqueous alkaline solution 3: palladium/charcoal; ethanol / 70 °C / Hydrogenation 4: ethanol View Scheme

: 1837-57-6
ethacridine lactate

: 55-55-0
4-(methylamino)phenol sulphate

: 2C7H7NO*C15H15N3O

Conditions

Conditions	Yield
With potassium iodate In methanol pH=3.1; aq. buffer;

: 55-55-0
4-(methylamino)phenol sulphate

: 1454918-37-6
C22H19N3O2S

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C 1.2: 120 h / 20 °C 2.1: caesium carbonate; potassium iodide / acetone / 21 h / Reflux View Scheme

: 55-55-0
4-(methylamino)phenol sulphate

: 1454918-38-7
N-(4-(benzo[d]oxazol-2-ylmethoxy)phenyl)-N-methylisonicotinamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C 1.2: 120 h / 20 °C 2.1: caesium carbonate; potassium iodide / acetone / 21 h / Reflux View Scheme

4-Methylaminophenol sulfate Chemical Properties

IUPAC Name: 4-(Methylamino)phenol sulfate
Molecular Formula: (C₇H₁₀NO)₂SO₄
Molecular Weight: 344.38 g/mol
Canonical SMILES: S(O)(O)(=O)=O.c1(ccc(O)cc1)NC.c1(ccc(O)cc1)NC
InChI: InChI=1/2C7H9NO.H2O4S/c2*1-8-6-2-4-7(9)5-3-6;1-5(2,3)4/h2*2-5,8-9H,1H3;(H2,1,2,3,4)
EINECS: 200-237-1
Classification Code: Mutation data
Product Categories: Industrial/Fine Chemicals; Pharmaceutical Raw Materials
Sensitive: Air Sensitive
Density: 1.577
Flash Point: 148.6 °C
Enthalpy of Vaporization: 52.07 kJ/mol
Boiling Point: 262.7 °C at 760 mmHg
Melting Point: 260 °C (dec.)(lit.)
Storage temperature: -20 °C
Solubility: H2O: 50 mg/mL, clear
Water Solubility: 50 g/L (20 °C)
Vapour Pressure of p-Methylaminophenol sulfate (CAS NO.55-55-0): 0.00658 mmHg at 25 °C

4-Methylaminophenol sulfate Uses

p-Methylaminophenol sulfate (CAS NO.55-55-0) is an excellent developing agent for most continuous tone developer applications, and it has been widely used in published developer formulas as well as commercial products.

4-Methylaminophenol sulfate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	skin	> 1gm/kg (1000mg/kg)		Kodak Company Reports. Vol. 21MAY1971,
guinea pig	LD50	unreported	1585mg/kg (1585mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 49(9), Pg. 87, 1984.
mouse	LD50	oral	565mg/kg (565mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	National Technical Information Service. Vol. OTS0570966,
mouse	LD50	unreported	769mg/kg (769mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 49(9), Pg. 87, 1984.
rat	LD50	unreported	705mg/kg (705mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 49(9), Pg. 87, 1984.
rat	LDLo	intraperitoneal	50mg/kg (50mg/kg)		Kodak Company Reports. Vol. 21MAY1971,
rat	LDLo	oral	200mg/kg (200mg/kg)		Kodak Company Reports. Vol. 21MAY1971,

4-Methylaminophenol sulfate Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

4-Methylaminophenol sulfate Safety Profile

Poison by ingestion and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO_x and NO_x.
Hazard Codes: Harmful Xn, Dangerous N
Risk Statements: 22-43-48/22-50/53
R22: Harmful if swallowed.
R43: May cause sensitization by skin contact.
R48/22: Harmful: danger of serious damage to health by prolonged exposure if swallowed.
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 36/37-46-60-61
S36/37: Wear suitable protective clothing and gloves.
S46: If swallowed, seek medical advice immediately and show this container or label.
S60: This material and its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: SL8650000
HazardClass: 6.1
PackingGroup: III

4-Methylaminophenol sulfate Specification

p-Methylaminophenol sulfate (CAS NO.55-55-0), its Synonyms are 4-(Methylamino)phenol sulfate ; Metol ; Paramethylaminophenol sulfate ; Phenol, 4-(methylamino)-, sulfate salt (2:1) ; 4-(Methylamino)phenol sulfate (2:1) salt ; Methyl-p-aminophenol sulfate ; N-Methyl-4-hydroxyaniline hemisulfate ; N-Methyl-p-aminophenol sulfate ; Bis(4-hydroxy-N-methylanilinium) sulphate . It is white crystalline powder.

Product Name

4-Methylaminophenol sulfate

Synthetic route

4-Methylaminophenol sulfate Chemical Properties

4-Methylaminophenol sulfate Uses

4-Methylaminophenol sulfate Toxicity Data With Reference

4-Methylaminophenol sulfate Consensus Reports

4-Methylaminophenol sulfate Safety Profile

4-Methylaminophenol sulfate Specification

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