4-Piperidineethanol supplier

Name
4-Piperidineethanol
EINECS 210-727-7
CAS No. 622-26-4
Article Data14
CAS DataBase
Density 0.939 g/cm³
Solubility
Melting Point 46-47 °C(lit.)
Formula C₇H₁₅NO
Boiling Point 228.3 °C at 760 mmHg
Molecular Weight 129.202
Flash Point 101.7 °C
Transport Information
Appearance white crystalline low melting solid
Safety 26-37/39-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-(4-Piperidyl)ethanol;2-(Piperidin-4-yl)-1-ethanol;2-(Piperidin-4-yl)ethanol;4-(2-Hydroxyethyl)piperidine;NSC 93818;
PSA 32.26000
LogP 0.69720

Synthetic route

: 383865-57-4
4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine

A: 622-26-4
4-(2-Hydroxyethyl)piperidine

B: 4-(2-Hydroxy-ethyl)-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

Conditions

Conditions	Yield
	A n/a B 64%

: 51052-78-9
4-piperidinylacetic acid

: 622-26-4
4-(2-Hydroxyethyl)piperidine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 25℃; Cooling with ice; Inert atmosphere;	62.5%

: 5344-27-4
4-(2-hydroxyethyl)pyridine

: 622-26-4
4-(2-Hydroxyethyl)piperidine

Conditions

Conditions	Yield
With sodium; butan-1-ol und Hydrieren des vermutlich als 2-<1,2,3,6-Tetrahydro-<4>pyridyl>-aethanol C7H13NO zu formulierenden Reaktionsprodukts in Essigsaeure an Palladium;
With acetic acid; platinum Hydrogenation;

: 28356-58-3
pyridine-4-acetic acid

: 622-26-4
4-(2-Hydroxyethyl)piperidine

Conditions

Conditions	Yield
With platinum on activated charcoal; dimethylsulfide borane complex; hydrogen 2.) 1 atm; Multistep reaction;

4-<β-oxy-ethyl>-pyridine: 4-<β-oxy-ethyl>-pyridine

: 622-26-4
4-(2-Hydroxyethyl)piperidine

Conditions

Conditions	Yield
With ethanol; sodium

: 872850-91-4
2-(1,2,3,6-tetrahydro-[4]pyridyl)-ethanol

: 64-19-7
acetic acid

palladium: palladium

: 622-26-4
4-(2-Hydroxyethyl)piperidine

Conditions

Conditions	Yield
Hydrogenation;

...Expand

: 175213-46-4
1-t-Butoxycarbonyl-4-(methoxycarbonylmethyl)piperidine

: 622-26-4
4-(2-Hydroxyethyl)piperidine

Conditions

Conditions	Yield
With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); hydrogen; sodium methylate In methanol at 100℃; under 38002.6 Torr; for 12h; Reagent/catalyst;

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 89151-44-0
4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With sodium hydroxide In tert-butyl alcohol at 23℃; for 30h;	100%
With triethylamine In chloroform at 0 - 20℃; for 1h;	100%
With sodium hydroxide In water; tert-butyl alcohol at 10 - 23℃;	100%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 162046-62-0
2-methoxy-pyridin-3-ylmethyl chloride

: 351410-17-8
1-[(2-methoxy-pyridin-3-yl)methyl]-4-piperidineethanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;	100%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 34619-03-9
tert-butyldicarbonate

: 89151-44-0
4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	100%
In methanol at 20℃; for 2h; Inert atmosphere;	95%
In dichloromethane at 20℃;	52 g

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 107-14-2
chloroacetonitrile

: 1228762-45-5
2-(4-(2-hydroxyethyl)piperidin-1-yl)acetonitrile

Conditions

Conditions	Yield
With triethylamine at 20℃; for 14h;	100%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 1350607-38-3
2-[3-(3-chloropyrazin-2-yloxy)azetidin-1-yl]quinoline

: 1350603-88-1
2-(1-(3-((1-(quinolin-2-yl)azetidin-3-yl)oxy)pyrazin-2-yl)piperidin-4-yl)ethanol

Conditions

Conditions	Yield
With potassium carbonate In water; isopropyl alcohol at 160℃; for 5h; Microwave irradiation;	100%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 98-88-4
benzoyl chloride

: 152902-80-2
(4-(2-hydroxyethyl)piperidin-1-yl)(phenyl)methanone

Conditions

Conditions	Yield
With sodium hydroxide at 0℃;	98%
With triethylamine In dichloromethane at 20℃;

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 108-23-6
isopropyl chloroformate

: 1046815-85-3
isopropyl 4-(2-hydroxyethyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydroxide In toluene at 20℃; for 2h; Carboxylation;	98%
With triethylamine In 1,2-dimethoxyethane; toluene at 20℃;
In dichloromethane; toluene at 20℃; for 2.5h;

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 1579-72-2
2,2,2-trifluoroethyl benzoate

: 1012802-95-7
tert-butyl 4-(2-(benzoyloxy)ethyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 4-(2-Hydroxyethyl)piperidine; 2,2,2-trifluoroethyl benzoate With (μ-oxo)bis[(1,2-ethanediamino-N,N'-bis(salicylidene))iron(III)] In toluene at 120℃; for 2h; Inert atmosphere; Schlenk technique; Stage #2: di-tert-butyl dicarbonate With triethylamine In dichloromethane at 4 - 20℃; for 4h; Inert atmosphere; Schlenk technique; chemoselective reaction;	98%

...Expand

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 1334647-42-5
5-((tert-butyl)sulfanyl)-6-chloropyrazine-2,3-dicarbonitrile

: 5-(tert-butylsulfanyl)-6-[4-(2-hydroxyethyl)piperidin-1-yl]-pyrazine-2,3-dicarbonitrile

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	97%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 4-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)piperidine

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃; for 18h;	97%
Stage #1: tert-butyldimethylsilyl chloride With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 1h; Stage #2: 4-(2-Hydroxyethyl)piperidine In N,N-dimethyl-formamide at 25℃; for 8h;	82.45%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 111196-81-7
2-chloro-5-ethylpyrimidine

: 2-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethan-1-ol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 110℃;	97%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 107-31-3
Methyl formate

: 141047-47-4
N-formyl-4-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
at 0 - 20℃; for 1h;	95%
With sodium hydroxide In methanol

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 56413-95-7
2,3-dichloro-5,6-dicyanopyrazine

: 5-chloro-6-(4-(2-hydroxyethyl)piperidin-1-yl)pyrazine-2,3-dicarbonitrile

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 1h; Cooling with ice;	95%
In tetrahydrofuran at 0℃;	95%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: tert-butyl (3-cyano-4,6-dimethylpyridin-2-yl) carbonate

: 89151-44-0
4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
In ethanol for 1h; Reflux;	95%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 65281-95-0
5-chloro-6-(diethylamino)pyrazine-2,3-dicarbonitrile

: 5-(diethylamino)-6-(4-(2-hydroxyethyl)piperidin-1-yl)pyrazine-2,3-dicarbonitrile

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 1.5h;	95%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 93-58-3
benzoic acid methyl ester

: 1012797-96-4
2-(piperidine-4-yl)ethyl benzoate

Conditions

Conditions	Yield
With tetramethylammonium methyl carbonate In toluene for 3h; Molecular sieve; Reflux; Green chemistry;	94%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 72966-79-1
2,6-bis(3-chloropropionamido)anthracene-9,10-dione

: 134888-44-1
2,6-bis<3-<4-(2-hydroxyethyl)piperidino>propionamido>anthracene-9,10-dione

Conditions

Conditions	Yield
In ethanol for 5h; Heating;	93%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 93-58-3
benzoic acid methyl ester

A: 1012797-96-4
2-(piperidine-4-yl)ethyl benzoate

B: 1012798-08-1
N-benzoylpiperidine-4-ylethyl benzoate

Conditions

Conditions	Yield
Zn4(OCOCF3)6O In toluene for 18h; Inert atmosphere; Reflux;	A 92% B 7%

...Expand

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 1279027-08-5
tert-butyl (2-{[3-(2-chloropyrimidin-5-yl)benzyl](methyl)amino}-2-oxoethyl)carbamate

: 1279028-47-5
tert-butyl {2-[(3-{2-[4-(2-hydroxyethyl)piperidin-1-yl]pyrimidin-5-yl}benzyl)(methyl)amino]-2-oxoethyl}carbamate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	92%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 2-(1-(3-chloro-5,6-dicyanopyrazin-2-yl)piperidin-4-yl)ethyl acetate

: 2-(1-(5,6-dicyano-3-(4-(2-hydroxyethyl)piperidin-1-yl)pyrazin-2-yl)piperidin-4-yl)ethyl acetate

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h; Cooling with ice;	91%
In tetrahydrofuran at 20℃;	91%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 4-(4-(2-(λ1-oxidaneyl)ethyl)piperidin-1-yl)-6,7-dimethoxyquinazoline

Conditions

Conditions	Yield
In isopropyl alcohol at 100℃; for 16h; Sealed tube;	91%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 2-bromo-9-methyl-9H-pyrrolo[2,3-b:4,5-c’]dipyridine

: 2-(1-(9-methyl-9H-pyrrolo[2,3-b:4,5-c’]dipyridin-2-yl)piperidin-4-yl)ethanol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 200℃; for 4h; Sealed tube;	91%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 2-(1-(6,7-dimethoxyquinolin-4-yl)piperidin-4-yl)ethan-1-ol

Conditions

Conditions	Yield
In isopropyl alcohol at 100℃; for 16h; Sealed tube;	91%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 945906-57-0
2-(3,4-dimethoxyphenyl)-1-[4-(2-hydroxyethyl)piperidin-1-yl]ethanone

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;	90%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h;	90%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 3-(6-formyl-5-methyl-4-oxo-7-propyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-propoxybenzene-1-sulfonyl chloride

: 2-(5-((4-(2-hydroxyethyl)piperidin-1-yl)sulfonyl)-2-propoxyphenyl)-5-methyl-4-oxo-7-propyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2h;	90%

: 182344-65-6
2-(6-bromo-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N,N-dimethylethanamine

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: C23H29N3O3

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 2-methoxy-ethanol at 120℃; for 24h; Inert atmosphere;	89%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 142873-46-9
2-bromomethyl-2,3-dihydro-2,4,6,7-tetramethyl-5-benzofuranamine

: 1-[(5-amino-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-2-yl)methyl]-4-piperidineethanol

Conditions

Conditions	Yield
	88%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 501-53-1
benzyl chloroformate

: 115909-91-6
1-(Benzyloxycarbonyl)-4-(2-hydroxyethyl)piperidine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetonitrile at 25℃; for 12h; Inert atmosphere;	86%
With sodium carbonate In dichloromethane; water at 0 - 25℃; for 6h; Inert atmosphere;	82%
With triethylamine In acetonitrile at 20℃;	81%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: (S)-phenyl-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)carbamate

: (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(2-hydroxyethyl)piperidine-1-carboxamide

Conditions

Conditions	Yield
In tetrahydrofuran at 70℃; for 4h;	86%

: 622-26-4
4-(2-Hydroxyethyl)piperidine

: 4548-45-2
2-chloro-5-nitropyridine

: 2-(1-(5-nitropyridin-2-yl)piperidin-4-yl)ethan-1-ol

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 80℃; for 12h; Inert atmosphere;	86%

4-Piperidineethanol Specification

The CAS register number of 4-Piperidineethanol is 622-26-4. It also can be called as 4-(2-Hydroxyethyl)piperidine and the IUPAC name about this chemical is 2-piperidin-4-ylethanol. The molecular formula about this chemical is C₇H₁₅NO and the molecular weight is 129.20. It belongs to the Piperidine. If you want to store this chemical, please keep containers tightly closed and store it in a cool, dry, well-ventilated area away from incompatible substances.

Physical properties about 4-Piperidineethanol are: (1)ACD/LogP: -0.05; (2)ACD/LogD (pH 5.5): -3.15; (3)ACD/LogD (pH 7.4): -3.05; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Polar Surface Area: 12.47Å²; (12)Index of Refraction: 1.454; (13)Molar Refractivity: 37.26 cm³; (14)Molar Volume: 137.5 cm³; (15)Polarizability: 14.77x10^-24cm³; (16)Surface Tension: 34.6 dyne/cm; (17)Enthalpy of Vaporization: 54.04 kJ/mol; (18)Boiling Point: 228.3 °C at 760 mmHg; (19)Vapour Pressure: 0.0144 mmHg at 25°C.

Uses of 4-Piperidineethanol: it can be used to produce N-formyl-4-(2-hydroxyethyl)piperidine with formic acid methyl ester at temperature of 0 - 20 ℃. This reaction time is 1 hours. The yield is about 95%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection, you also need avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

You can still convert the following datas into molecular structure:
(1)SMILES: OCCC1CCNCC1
(2)InChI: InChI=1/C7H15NO/c9-6-3-7-1-4-8-5-2-7/h7-9H,1-6H2
(3)InChIKey: LDSQQXKSEFZAPE-UHFFFAOYAB
(4)Std. InChI: InChI=1S/C7H15NO/c9-6-3-7-1-4-8-5-2-7/h7-9H,1-6H2
(5)Std. InChIKey: LDSQQXKSEFZAPE-UHFFFAOYSA-N

Product Name

4-Piperidineethanol

Synthetic route

4-Piperidineethanol Specification

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