• Name

  4-Pyridineethanesulfonic acid

• EINECS 258-331-3
• CAS No. 53054-76-5
• Density 1.397 g/cm³
• Solubility soluble in acid and alkaline, almost insoluble water, cold methanol and ethanol.
• Melting Point 297-299 ºC (dec.)
• Formula C7H9 N O3 S
• Boiling Point °Cat760mmHg
• Molecular Weight 187.219
• Flash Point °C
• Transport Information UN 2585
• Appearance Off-White to light yellow Powder
• Safety S26 S36/37/39 45
• Risk Codes R36/37/38   
• Molecular Structure
• Hazard Symbols
• Synonyms 2-(4-Pyridyl)ethanesulfonicacid; 4-(2-Sulfoethyl)pyridine; 4-Pyridylethylsulfonic acid; NSC 87853; g-(2-Sulfoethyl)pyridine
• PSA 75.64000
• LogP 1.59270

Synthetic route

100-43-6

4-vinylpyridine

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

Conditions

Conditions	Yield
With sodium hydrogensulfite In water at 20℃;	90%
With water; sodium hydrogensulfite
With ethanol; sulfur dioxide

100-43-6

4-vinylpyridine

7732-18-5

water

sodium hydrogensulfite

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

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53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

7732-18-5

water

20667-12-3

silver(l) oxide

[μ3-2-(4-pyridyl)ethanesulfonato-N,O,O']-aqua-silver(I)

Conditions

Conditions	Yield
In methanol; water mixt. of 2-(4-pyridyl)ethanesulfonic acid and Ag2O in CH3OH/H2O heated to 40°C for 1 h with vigorously stirring; cooled; filtered; crystals were obtained from mother liquor by slow evapn. at room temp. for several ds; elem. anal.;	85%

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53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

2-(pyridin-4-yl)ethanesulfonyl chloride hydrochloride

Conditions

Conditions	Yield
With phosphorus pentachloride In trichlorophosphate at 0 - 60℃; for 2h;	78%
With trichlorophosphate In tetrachloromethane

108-78-1

2,4,6-triamino-s-triazine

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

silver perchlorate

736149-73-8

melamine-[2-(4-pyridyl)ethanesulfonato-N]-silver(I)

Conditions

Conditions	Yield
In methanol mixt. of 2-(4-pyridyl)ethanesulfonic acid, melamine and AgClO4 in CH3OH heated to 40°C for 1 h with vigorously stirring; cooled; filtered; ppt. dissolved in DMSO; crystals were obtained by slow evapn. at room temp. for several ds; elem. anal.;	62%

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66-71-7

1,10-Phenanthroline

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

copper(II) nitrate trihydrate

diaqua(1,10-phenanthroline)copper(II) sulfate

Conditions

Conditions	Yield
In methanol; water at 130℃; for 72h; Autoclave;	60%

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53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

123-08-0

4-hydroxy-benzaldehyde

111260-13-0

3-(4-Hydroxyphenyl)-2-(4-pyridinio)-2-propenesulfonate

Conditions

Conditions	Yield
With piperidine In dimethyl sulfoxide at 110℃; for 12h;	5%

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

123-11-5

4-methoxy-benzaldehyde

111260-14-1

3-(4-Methoxyphenyl)-2-(4-pyridinio)-2-propenesulfonate

Conditions

Conditions	Yield
With piperidine In dimethyl sulfoxide	5%

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

N-3-(4-piperidineethanesulfonyl)-nipecotyl-3-aminopropionic acid.HCl

Conditions

Conditions	Yield
With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzyl chloroformate; platinum(IV) oxide

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

Zn(ClO4)2·2H2O

7732-18-5

water

292859-25-7

tetraaquabis[2-(4-pyridyl)ethanesulfonato-N]zinc(II)

Conditions

Conditions	Yield
With pyridine; water 2-(4-pyridyl)ethanesulfonic acid and Zn(ClO4)2*2H2O added to water and pyridine; soln. was evapd. at room temp. for a few days;

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53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

501-53-1

benzyl chloroformate

198959-43-2

2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}ethanesulfonic acid

Conditions

Conditions	Yield
Stage #1: 2-(pyridin-4-yl)-ethanesulfonic acid With ammonia; hydrogen; 5% rhodium on activated aluminium oxide In water at 30℃; under 3800.26 Torr; Stage #2: benzyl chloroformate In water at 0 - 20℃; for 1h;

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

(R)-1-{3-(3,5-difluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}-4-[2-(piperidin-1-ylsulfonyl)ethyl]piperidine hydrochloride

Conditions

Conditions

Yield

Multi-step reaction with 5 steps 1.1: ammonia; hydrogen / 5% rhodium on activated aluminium oxide / water / 30 °C / 3800.26 Torr 1.2: 1 h / 0 - 20 °C 2.1: thionyl chloride / 4 h / Heating / reflux 3.1: dichloromethane / 2 h / 5 - 20 °C 4.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 24 h / 20 °C 5.1: potassium carbonate / acetonitrile / 6 h / Heating / reflux View Scheme

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

184965-14-8

2-{1-[(benzyloxy)carbonyl]piperidin-4-yl}ethanesulfonyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: ammonia; hydrogen / 5% rhodium on activated aluminium oxide / water / 30 °C / 3800.26 Torr 1.2: 1 h / 0 - 20 °C 2.1: thionyl chloride / 4 h / Heating / reflux View Scheme

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

833491-17-1

benzyl 4-[2-(piperidin-1-ylsulfonyl)ethyl]piperidine-1-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: ammonia; hydrogen / 5% rhodium on activated aluminium oxide / water / 30 °C / 3800.26 Torr 1.2: 1 h / 0 - 20 °C 2.1: thionyl chloride / 4 h / Heating / reflux 3.1: dichloromethane / 2 h / 5 - 20 °C View Scheme

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

833491-18-2

1-[(2-piperidin-4-ylethyl)sulfonyl]piperidine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: ammonia; hydrogen / 5% rhodium on activated aluminium oxide / water / 30 °C / 3800.26 Torr 1.2: 1 h / 0 - 20 °C 2.1: thionyl chloride / 4 h / Heating / reflux 3.1: dichloromethane / 2 h / 5 - 20 °C 4.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 24 h / 20 °C View Scheme

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

2-(pyridin-4-yl)ethanesulfonyl chloride

Conditions

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide for 0.5h; Reflux;

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

2-(pyridin-4-yl)ethanesulfonamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride; N,N-dimethyl-formamide / 0.5 h / Reflux 2: ammonium hydroxide / dichloromethane / 12 h / 0 - 20 °C View Scheme

53054-76-5

2-(pyridin-4-yl)-ethanesulfonic acid

100-21-0

terephthalic acid

chromium(III) chloride hexahydrate

7664-39-3

hydrogen fluoride

68-12-2, 33513-42-7

N,N-dimethyl-formamide

Cr6O2F2(12+)*6C8H4O4(2-)*5.6C3H7NO*1.45C7H9NO3S

Conditions

Conditions	Yield
at 210℃; for 24h; Autoclave;

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4-Pyridineethanesulfonic acid Chemical Properties

4-Pyridineethanesulfonic acid Uses

4-Pyridineethanesulfonic acid Safety Profile