5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water for 10h; Reflux; | 92.6% |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Stage #1: C13H17N3 With palladium 10% on activated carbon; hydrogen In methanol under 3800.26 Torr; Autoclave; Stage #2: With hydrogenchloride In ethyl acetate | 92% |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether under 760.051 Torr; Inert atmosphere; | 77% |
With hydrogenchloride In Isopropyl acetate at 20 - 25℃; for 2.66667h; | 70.8 g |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 5,6-diethyl-3-oxime-1H-indene-1,2(3H)-dione With sulfuric acid; hydrogen; 5%-palladium/activated carbon In acetic acid for 5h; Stage #2: With sodium hydroxide pH=10; Stage #3: With hydrogenchloride In diethyl ether |
N-(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In Isopropyl acetate; water |
N-(2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: aluminum (III) chloride / neat (no solvent) / 0.25 h / 0 - 5 °C 1.2: 255 / 1 h / 0 - 10 °C 2.1: hydrogen; 5%-palladium/activated carbon / ethanol; water / 25 °C / 2250.23 Torr / Inert atmosphere 3.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C 3.2: 1 h / 0 - 5 °C 4.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere 5.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere 6.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C View Scheme |
N-(5-acetyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogen; 5%-palladium/activated carbon / ethanol; water / 25 °C / 2250.23 Torr / Inert atmosphere 2.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C 2.2: 1 h / 0 - 5 °C 3.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere 4.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere 5.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C View Scheme |
N-(5-ethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C 1.2: 1 h / 0 - 5 °C 2.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere 3.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere 4.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C View Scheme |
N-(5-acetyl-6-ethyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere 2: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere 3: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C View Scheme |
2,3-dihydro-1H-inden-2-amine
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: Isopropyl acetate / 3.17 h / 0 - 25 °C 2.1: aluminum (III) chloride / neat (no solvent) / 0.25 h / 0 - 5 °C 2.2: 255 / 1 h / 0 - 10 °C 3.1: hydrogen; 5%-palladium/activated carbon / ethanol; water / 25 °C / 2250.23 Torr / Inert atmosphere 4.1: aluminum (III) chloride / dichloromethane / 0.75 h / 0 °C 4.2: 1 h / 0 - 5 °C 5.1: palladium 10% on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / Inert atmosphere 6.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / Inert atmosphere 7.1: hydrogenchloride / Isopropyl acetate / 2.67 h / 20 - 25 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: triethylamine / dichloromethane / 2 h / 10 - 20 °C 2.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 2.2: 1 h / 10 - 20 °C 3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 4.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 4.2: 1 h / 0 - 10 °C 5.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 6.1: hydrogenchloride / water / 10 h / Reflux View Scheme |
N-indan-2-yl-acetamide
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 1.2: 1 h / 10 - 20 °C 2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 3.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 3.2: 1 h / 0 - 10 °C 4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 5.1: hydrogenchloride / water / 10 h / Reflux View Scheme |
N-(5-acetyl-2,3-dihydro-1H-inden-2-yl)acetamide
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 2.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 2.2: 1 h / 0 - 10 °C 3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 4.1: hydrogenchloride / water / 10 h / Reflux View Scheme |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 10 °C 1.2: 1 h / 0 - 10 °C 2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 20 °C 3.1: hydrogenchloride / water / 10 h / Reflux View Scheme |
indan-2-ol
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 0 - 20 °C 2: bromine; N-Bromosuccinimide / acetonitrile / 20 °C / Darkness 3: tetrahydrofuran / 20 °C / Inert atmosphere 4: pyridine / dichloromethane / 20 °C 5: sodium azide / N,N-dimethyl-formamide / 20 °C 6: palladium 10% on activated carbon; hydrogen / methanol / 3800.26 Torr / Autoclave View Scheme |
2-acetoxyindane
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: bromine; N-Bromosuccinimide / acetonitrile / 20 °C / Darkness 2: tetrahydrofuran / 20 °C / Inert atmosphere 3: pyridine / dichloromethane / 20 °C 4: sodium azide / N,N-dimethyl-formamide / 20 °C 5: palladium 10% on activated carbon; hydrogen / methanol / 3800.26 Torr / Autoclave View Scheme |
5,6-dibromoindan-2-ol acetate
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrahydrofuran / 20 °C / Inert atmosphere 2: pyridine / dichloromethane / 20 °C 3: sodium azide / N,N-dimethyl-formamide / 20 °C 4: palladium 10% on activated carbon; hydrogen / methanol / 3800.26 Torr / Autoclave View Scheme |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / dichloromethane / 20 °C 2: sodium azide / N,N-dimethyl-formamide / 20 °C 3: palladium 10% on activated carbon; hydrogen / methanol / 3800.26 Torr / Autoclave View Scheme |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
di-tert-butyl dicarbonate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 5℃; for 4.5h; | 96% |
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Stage #1: (R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one; 5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride With sodium hydrogencarbonate In dimethyl sulfoxide at 65 - 125℃; for 6h; Inert atmosphere; Large scale; Stage #2: With hydrogenchloride In ethanol; water at 0 - 72℃; for 27h; Large scale; | 71% |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 20℃; |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
N,N'-(1,1'-(6-chloro-1,3,5-triazine-2,4-diyl)bis(piperidine-4,1-diyl))bis(azanediyl)bis(iminomethylene)bis(3,5-diamino-6-chloropyrazine-2-carboxamide)
A
N,N'-(1,1'-(6-(dimethylamino)-1,3,5-triazine-2,4-diyl)bis(piperidine-4,1-diyl))bis(azanediyl)bis(aminomethan-1-yl-1-ylidene)bis(3,5-diamino-6-chloropyrazine-2-carboxamide)
B
N,N'-(1,1'-(6-(5,6-diethyl-2,3-dihydro-1H-inden-2-ylamino)-1,3,5-triazine-2,4-diyl)bis(piperidine-4,1-diyl))bis(azanediyl)bis(aminomethan-1-yl-1-ylidene)bis(3,5-diamino-6-chloropyrazine-2-carboxamide)
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60 - 70℃; for 44.5h; Microwave irradiation; |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
C24H28BrNO4
Conditions | Yield |
---|---|
With sodium carbonate In water at 100℃; for 20h; |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / water; methanol / 0.5 h 2: butan-1-ol / 3 h / 100 - 110 °C 3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere View Scheme |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: sodium hydroxide / water; methanol / 0.5 h 2: butan-1-ol / 3 h / 100 - 110 °C 3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere 4: potassium carbonate / water; methanol / 1 h 5: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 0 - 8 °C / 750.08 - 1500.15 Torr / Inert atmosphere 6: methanol / 0.5 h / 60 °C View Scheme |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
5,6-diethyl-2,3-dihydro-1H-inden-2-amine
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water for 0.5h; |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water; methanol / 0.5 h 2: butan-1-ol / 3 h / 100 - 110 °C View Scheme |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
(R)-8-(benzyloxy)-5-[2-[(5,6-diethyl-2,3-dihydro-1H-indole-2-yl)amino]-1-hydroxyethyl]quinolin-2(1H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide / water; methanol / 0.5 h 2: butan-1-ol / 3 h / 100 - 110 °C 3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere 4: potassium carbonate / water; methanol / 1 h View Scheme |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
indacaterol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydroxide / water; methanol / 0.5 h 2: butan-1-ol / 3 h / 100 - 110 °C 3: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere 4: potassium carbonate / water; methanol / 1 h 5: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 0 - 8 °C / 750.08 - 1500.15 Torr / Inert atmosphere View Scheme |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 4.5 h / 0 - 5 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / -5 - 20 °C 2.2: 2 h / 20 °C View Scheme |
5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 4.5 h / 0 - 5 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 4 h / -5 - 20 °C 2.2: 2 h / 20 °C 3.1: potassium carbonate / ethyl acetate / pH 9 / Cooling with ice 3.2: 2 h View Scheme |
The 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride, with the CAS registry number 312753-53-0, is also known as 1H-Inden-2-amine, 5,6-diethyl-2,3-dihydro-, hydrochloride (1:1). This chemical's molecular formula is C13H19N.HCl and formula weight is 225.76. What's more, its systematic name is called 5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride (1:1).
Physical properties of 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride: (1)ACD/LogP: 3.73; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1; (4)ACD/LogD (pH 7.4): 1; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 2; (7)ACD/KOC (pH 5.5): 2; (8)ACD/KOC (pH 7.4): 14; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 3.24 Å2; (13)Flash Point: 127.6 °C; (14)Enthalpy of Vaporization: 52.42 kJ/mol; (15)Boiling Point: 285.2 °C at 760 mmHg; (16)Vapour Pressure: 0.00285 mmHg at 25°C; (17)Melting Point: >250 °C.
You can still convert the following datas into molecular structure:
(1)SMILES: Cl.c1c(c(cc2c1CC(N)C2)CC)CC
(2)InChI: InChI=1/C13H19N.ClH/c1-3-9-5-11-7-13(14)8-12(11)6-10(9)4-2;/h5-6,13H,3-4,7-8,14H2,1-2H3;1H
(3)InChIKey: ZOVIYWYFBOQKIA-UHFFFAOYAF
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