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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 312753-06-3 Indacaterol

Cas:312753-06-3

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Indacaterol[CAS:312753-06-3] 8-Benzyloxy-5-(2-bromoacetyl)-2-Hydroxyquinoline[CAS:100331-89-3] 5,6-Diethyl-2-Amino Indane[CAS:312753-70-1] 5,6 -Diethyl-2-Amino Indane HCl Salt[CAS:312753-53-0] HANGZHOU THINK CHEMICAL CO., LTD. (TH

Supply Indacaterol API and intermediates

Cas:312753-06-3

Min.Order:1 Kilogram

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Indacaterol 312753-06-3 GMP Manufacturer

Cas:312753-06-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Indacaterol

Cas:312753-06-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Indacaterol

Cas:312753-06-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Orga

Indacaterol CAS NO.312753-06-3

Cas:312753-06-3

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Indacaterol CAS: 312753-06-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Indacaterol CAS: 312753-06-3

Cas:312753-06-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2(1H)-Quinolinone,5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-

Cas:312753-06-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Indacaterol

Cas:312753-06-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Indacaterol

Cas:312753-06-3

Min.Order:1 Kilogram

FOB Price: $60.0 / 100.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white crystalline powder Storage:Room temperature, tight from air Package:packaged in foil bags or tins Application:312753-06-3 Transportation: By Express,by air, by sea Port:Qingdao,China

Indacaterol

Cas:312753-06-3

Min.Order:10 Gram

FOB Price: $1.0 / 10.0

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

indacaterol 312753-06-3

Cas:312753-06-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

5-[(1R)-2-[(5,6-DIETHYL-2,3-DIHYDRO-1H-INDEN-2-YL)AMINO]-1-HYDROXYETHYL]-8-HYDROXYQUINOLIN-2(1H)-ONE

Cas:312753-06-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Indacaterol/High quality/Best price

Cas:312753-06-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Indacaterol

Cas:312753-06-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Indacaterol CAS No.:312753-06-3 Molecule Formula:C24H28N2O3 Molecule Weight:392.49 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SP

Best Quality Indacaterol with good supplier

Cas:312753-06-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

5-Bromo-8-nitroisoquinoline Cas NO. 63927-23-1 High quality with competitive price Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established

Indacaterol Cas NO.312753-06-3

Cas:312753-06-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Indacaterol

Cas:312753-06-3

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Indacaterol

Cas:312753-06-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

5-[2-(5,6-Diethyl-2,3-dihydro-1H-inden-2-ylamino)-(1R)-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one

Cas:312753-06-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Indacaterol

Cas:312753-06-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

5-[2-(5,6-Diethyl-2,3-dihydro-1H-inden-2-ylamino)-(1R)-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one

Cas:312753-06-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Indacaterol

Cas:312753-06-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used for active pharmaceutical ingr

Indacaterol

Cas:312753-06-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

5-[2-(5,6-Diethyl-2,3-dihydro-1H-inden-2-ylamino)-(1R)-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one

Cas:312753-06-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Indacaterol

Cas:312753-06-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Indacaterol

Cas:312753-06-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

BOC Sciences

GMP factory Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales seervice available Api, inhibitor, and fine chemicals for more

Indacaterol cas 312753-06-3

Cas:312753-06-3

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

High qualityAppearance:White powder Storage:Room temperature Package:Aluminum bag Application:Used in producing API Transportation:By air Port:Beijing

Indacaterol

Cas:312753-06-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

indacaterol maleate

indacaterol maleate

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
With lithium hydroxide monohydrate In methanol at 35℃; for 1h; Reagent/catalyst;99.84%
(R)-8-(benzyloxy)-5-[2-[(5,6-diethyl-2,3-dihydro-1H-indole-2-yl)amino]-1-hydroxyethyl]quinolin-2(1H)-one
435273-75-9

(R)-8-(benzyloxy)-5-[2-[(5,6-diethyl-2,3-dihydro-1H-indole-2-yl)amino]-1-hydroxyethyl]quinolin-2(1H)-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Stage #1: (R)-8-(benzyloxy)-5-[2-[(5,6-diethyl-2,3-dihydro-1H-indole-2-yl)amino]-1-hydroxyethyl]quinolin-2(1H)-one With 5%-palladium/activated carbon; hydrogen In ethanol at 20℃; for 2h;
Stage #2: With 5%-palladium/activated carbon; hydrogen In ethanol at 40℃; under 757.576 Torr; for 4h;
97%
With 5%-palladium/activated carbon; hydrogen; acetic acid In methanol at 20℃;85%
With palladium 10% on activated carbon; hydrogen In methanol at 19 - 22℃; for 1h; Inert atmosphere;83%
5-[(1R)-2-[N-benzyl-(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(benzyloxy)-2(1H)-quinolone

5-[(1R)-2-[N-benzyl-(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(benzyloxy)-2(1H)-quinolone

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen; acetic acid In methanol at 20℃;86.2%
With palladium 10% on activated carbon; hydrogen; acetic acid at 40℃; under 15201 Torr; Pressure; Reagent/catalyst; Temperature;
(R)-5- [2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-benzyloxy-1H-quinolin-2-one hydrochloride

(R)-5- [2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-benzyloxy-1H-quinolin-2-one hydrochloride

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen; acetic acid In methanol at 25 - 30℃; under 2250.23 - 3000.3 Torr; for 4h;85.5%
5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-triethylsilyloxyethyl]-8-(benzyloxy)-2(1H)-quinolone

5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-triethylsilyloxyethyl]-8-(benzyloxy)-2(1H)-quinolone

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen; acetic acid; tetra-n-butylammoniumfluoride trihydrate In methanol at 20℃;84.5%
5-[(1R)-2-[N-benzyl-(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-triethylsilyloxyethyl]-8-(benzyloxy)-2(1H)-quinolone

5-[(1R)-2-[N-benzyl-(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-triethylsilyloxyethyl]-8-(benzyloxy)-2(1H)-quinolone

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen; acetic acid; tetra-n-butylammoniumfluoride trihydrate In methanol at 20℃;83.7%
8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate
753498-33-8

8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In methanol under 225.023 Torr; Inert atmosphere;77%
With 5%-palladium/activated carbon; hydrogen In methanol under 225.023 Torr; Inert atmosphere;77%
5-{2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxy-1H-quinolin-2-one

5-{2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxy-1H-quinolin-2-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
With triethylamine In ethanol; hexane at 25℃; Resolution of racemate;49%
(R)-5- [2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-benzyloxy-1H-quinolin-2-one benzoic acid salt

(R)-5- [2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-benzyloxy-1H-quinolin-2-one benzoic acid salt

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
With hydrogen; 5%-palladium/activated carbon In acetic acid for 2 - 8h;
With hydrogen; 5%-palladium/activated carbon In acetic acid for 2 - 8h;
5,6-diethyl-2,3-dihydro-1H-inden-2-amine
312753-70-1

5,6-diethyl-2,3-dihydro-1H-inden-2-amine

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid; -butyl vinyl ether / tetrahydrofuran; toluene / 0.5 h / 20 - 25 °C / Molecular sieve
1.2: 100 °C
2.1: 5%-palladium/activated carbon; hydrogen / methanol / 225.02 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 1 h / 20 °C
1.2: 16 h / 0 - 20 °C
2.1: Chiralcel AS-V / aq. phosphate buffer; acetonitrile / 25 °C / Resolution of racemate
3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 2 h / 20 °C
3.2: 4 h / 40 °C / 757.58 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 1 h / 20 °C
1.2: 16 h / 0 - 20 °C
2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / 20 - 40 °C / 757.58 Torr
3.1: triethylamine / ethanol; hexane / 25 °C / Resolution of racemate
View Scheme
Multi-step reaction with 4 steps
1: sodium cyanoborohydride / ethanol / 4 h / -25 - 80 °C / Inert atmosphere
2: sodium carbonate; potassium iodide / acetonitrile / 24 h / -25 - 80 °C
3: (-)-diisopinocamphenylborane chloride / dichloromethane; tetrahydrofuran / 25 h / 10 - 20 °C
4: hydrogen; acetic acid; palladium 10% on activated carbon / 40 °C / 15201 Torr
View Scheme
Multi-step reaction with 4 steps
1: butan-1-ol / 3 h / 100 - 110 °C
2: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0 - 3 °C / Inert atmosphere
3: potassium carbonate / water; methanol / 1 h
4: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 0 - 8 °C / 750.08 - 1500.15 Torr / Inert atmosphere
View Scheme
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one
530084-79-8

8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid; -butyl vinyl ether / tetrahydrofuran; toluene / 0.5 h / 20 - 25 °C / Molecular sieve
1.2: 100 °C
2.1: 5%-palladium/activated carbon; hydrogen / methanol / 225.02 Torr / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: 1H-imidazole / chloroform / 10 h / 25 °C / Reflux
2.1: 1-methyl-pyrrolidin-2-one / 12 h / 95 - 100 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 50 - 55 °C
3.2: 1 h / 25 - 30 °C
4.1: acetic acid; palladium on activated charcoal; hydrogen / methanol / 4 h / 25 - 30 °C / 2250.23 - 3000.3 Torr
View Scheme
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 90 °C
2.1: hydrazine hydrate / ethanol / 6 h / Reflux
2.2: 80 °C
3.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 - 90 °C
4.1: acetic acid; 5%-palladium/activated carbon; hydrogen / methanol
View Scheme
5-(2,2-Dihydroxyacetyl)-8-(benzyloxy)-carbostyril
100331-91-7

5-(2,2-Dihydroxyacetyl)-8-(benzyloxy)-carbostyril

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 1 h / 20 °C
1.2: 16 h / 0 - 20 °C
2.1: Chiralcel AS-V / aq. phosphate buffer; acetonitrile / 25 °C / Resolution of racemate
3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 2 h / 20 °C
3.2: 4 h / 40 °C / 757.58 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 1 h / 20 °C
1.2: 16 h / 0 - 20 °C
2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / 20 - 40 °C / 757.58 Torr
3.1: triethylamine / ethanol; hexane / 25 °C / Resolution of racemate
View Scheme
5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-benzyloxy-(1H)-quinolin-2-one

5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-benzyloxy-(1H)-quinolin-2-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 5%-palladium/activated carbon; hydrogen / ethanol / 8 h / 20 - 40 °C / 757.58 Torr
2: triethylamine / ethanol; hexane / 25 °C / Resolution of racemate
View Scheme
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one
100331-89-3

8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / tetrahydrofuran / 0 - 30 °C / Inert atmosphere
1.2: 0 - 30 °C
2.1: 1H-imidazole / chloroform / 10 h / 25 °C / Reflux
3.1: 1-methyl-pyrrolidin-2-one / 12 h / 95 - 100 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 50 - 55 °C
4.2: 1 h / 25 - 30 °C
5.1: acetic acid; palladium on activated charcoal; hydrogen / methanol / 4 h / 25 - 30 °C / 2250.23 - 3000.3 Torr
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 1.33 h / 50 °C
2.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane N,N-diethylaniline complex / dichloromethane; toluene; tetrahydrofuran / 2 h / -10 °C
3.1: hydrazine hydrate / ethanol / 6 h / Reflux
3.2: 80 °C
4.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 - 90 °C
5.1: acetic acid; 5%-palladium/activated carbon; hydrogen / methanol
View Scheme
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one
530084-74-3

(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1-methyl-pyrrolidin-2-one / 12 h / 95 - 100 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 50 - 55 °C
2.2: 1 h / 25 - 30 °C
3.1: acetic acid; palladium on activated charcoal; hydrogen / methanol / 4 h / 25 - 30 °C / 2250.23 - 3000.3 Torr
View Scheme
(R)-8-(benzyloxy)-5-[1-((tert-butyldimethylsilyl)oxy)-2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)ethyl]quinolin-2(1H)-one

(R)-8-(benzyloxy)-5-[1-((tert-butyldimethylsilyl)oxy)-2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)ethyl]quinolin-2(1H)-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 50 - 55 °C
1.2: 1 h / 25 - 30 °C
2.1: acetic acid; palladium on activated charcoal; hydrogen / methanol / 4 h / 25 - 30 °C / 2250.23 - 3000.3 Torr
View Scheme
N-benzyl-5,6-diethyl-2,3-dihydro-1H-inden-2-amine
312753-79-0

N-benzyl-5,6-diethyl-2,3-dihydro-1H-inden-2-amine

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium carbonate; potassium iodide / acetonitrile / 24 h / -25 - 80 °C
2: (-)-diisopinocamphenylborane chloride / dichloromethane; tetrahydrofuran / 25 h / 10 - 20 °C
3: hydrogen; acetic acid; palladium 10% on activated carbon / 40 °C / 15201 Torr
View Scheme
Multi-step reaction with 2 steps
1: triethylamine; sodium iodide / N,N-dimethyl-formamide / 3 h / 20 °C
2: acetic acid; 5%-palladium/activated carbon; hydrogen; tetra-n-butylammoniumfluoride trihydrate / methanol / 20 °C
View Scheme
5-{2-[N-benzyl(5,6-diethyl-2,3-dihydro-1H-indan-2-yl)amino]acetyl}-8-(benzyloxy)-1H-quinolin-2-one

5-{2-[N-benzyl(5,6-diethyl-2,3-dihydro-1H-indan-2-yl)amino]acetyl}-8-(benzyloxy)-1H-quinolin-2-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (-)-diisopinocamphenylborane chloride / dichloromethane; tetrahydrofuran / 25 h / 10 - 20 °C
2: hydrogen; acetic acid; palladium 10% on activated carbon / 40 °C / 15201 Torr
View Scheme
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one
530084-79-8

8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

5,6-diethyl-2,3-dihydro-1H-inden-2-amine
312753-70-1

5,6-diethyl-2,3-dihydro-1H-inden-2-amine

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; sodium iodide / N,N-dimethyl-formamide / 3 h / 20 °C
2: acetic acid; 5%-palladium/activated carbon; hydrogen / methanol / 20 °C
View Scheme
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one
530084-79-8

8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

N-benzyl-5,6-diethyl-2,3-dihydro-1H-inden-2-amine
312753-79-0

N-benzyl-5,6-diethyl-2,3-dihydro-1H-inden-2-amine

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; sodium iodide / N,N-dimethyl-formamide / 3 h / 20 °C
2: acetic acid; 5%-palladium/activated carbon; hydrogen / methanol / 20 °C
View Scheme
Reaxys ID: 32936244

Reaxys ID: 32936244

indacaterol
312753-06-3

indacaterol

Reaxys ID: 32936246

Reaxys ID: 32936246

indacaterol
312753-06-3

indacaterol

Reaxys ID: 32936247

Reaxys ID: 32936247

indacaterol
312753-06-3

indacaterol

2-chloro-5,6-diethylindan

2-chloro-5,6-diethylindan

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 - 90 °C
2: acetic acid; 5%-palladium/activated carbon; hydrogen / methanol
View Scheme
5-(2-phthalimido-1-oxo-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one

5-(2-phthalimido-1-oxo-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane N,N-diethylaniline complex / dichloromethane; toluene; tetrahydrofuran / 2 h / -10 °C
2.1: hydrazine hydrate / ethanol / 6 h / Reflux
2.2: 80 °C
3.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 - 90 °C
4.1: acetic acid; 5%-palladium/activated carbon; hydrogen / methanol
View Scheme
5-(R)-(2-amino-1-hydroxy-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one
774222-23-0

5-(R)-(2-amino-1-hydroxy-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 - 90 °C
2: acetic acid; 5%-palladium/activated carbon; hydrogen / methanol
View Scheme
5-(R)-(2-phthalimido-1-hydroxy-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one

5-(R)-(2-phthalimido-1-hydroxy-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrazine hydrate / ethanol / 6 h / Reflux
1.2: 80 °C
2.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 - 90 °C
3.1: acetic acid; 5%-palladium/activated carbon; hydrogen / methanol
View Scheme
5-acetyl-8-hydroxy-2(1H)-quinolinone
62978-73-8

5-acetyl-8-hydroxy-2(1H)-quinolinone

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
1.2: 2.5 h / 20 °C
2.1: boron trifluoride diethyl etherate / dichloromethane / 0.17 h / 0 °C
2.2: 2.75 h / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
3.2: 1.33 h / 50 °C
4.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane N,N-diethylaniline complex / dichloromethane; toluene; tetrahydrofuran / 2 h / -10 °C
5.1: hydrazine hydrate / ethanol / 6 h / Reflux
5.2: 80 °C
6.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 - 90 °C
7.1: acetic acid; 5%-palladium/activated carbon; hydrogen / methanol
View Scheme
5-acetyl-8-benzyloxy-1H-quinolin-2-one
93609-84-8

5-acetyl-8-benzyloxy-1H-quinolin-2-one

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / 0.17 h / 0 °C
1.2: 2.75 h / Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C
2.2: 1.33 h / 50 °C
3.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; borane N,N-diethylaniline complex / dichloromethane; toluene; tetrahydrofuran / 2 h / -10 °C
4.1: hydrazine hydrate / ethanol / 6 h / Reflux
4.2: 80 °C
5.1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 - 90 °C
6.1: acetic acid; 5%-palladium/activated carbon; hydrogen / methanol
View Scheme
C31H34N2O3*BrH

C31H34N2O3*BrH

indacaterol
312753-06-3

indacaterol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / water; methanol / 1 h
2: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 6 h / 0 - 8 °C / 750.08 - 1500.15 Torr / Inert atmosphere
View Scheme
indacaterol
312753-06-3

indacaterol

succinic acid
110-15-6

succinic acid

Indacaterol succinate

Indacaterol succinate

Conditions
ConditionsYield
In isopropyl alcohol at 20 - 80℃; for 18.0833h;96.3%
indacaterol
312753-06-3

indacaterol

malonic acid
141-82-2

malonic acid

Indacaterol malonate

Indacaterol malonate

Conditions
ConditionsYield
In butan-1-ol at 20 - 80℃; for 18.25h;95.28%
indacaterol
312753-06-3

indacaterol

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

Indacaterol tosylate

Indacaterol tosylate

Conditions
ConditionsYield
In ethyl acetate at 20 - 60℃;94.8%
indacaterol
312753-06-3

indacaterol

acetic acid
64-19-7

acetic acid

Indacaterol acetate

Indacaterol acetate

Conditions
ConditionsYield
In dichloromethane; ethyl acetate; isopropyl alcohol at 5 - 35℃; for 11h; Temperature; Solvent;93.73%
In isopropyl alcohol at 20 - 80℃; for 17h;84.9%
indacaterol
312753-06-3

indacaterol

maleic acid
110-16-7

maleic acid

indacaterol maleate

indacaterol maleate

Conditions
ConditionsYield
In isopropyl alcohol for 1h; Reflux;92.5%
In ethanol at 60℃; for 0.166667h;83%
In ethanol at 50 - 60℃;
indacaterol
312753-06-3

indacaterol

methanesulfonic acid
75-75-2

methanesulfonic acid

Indacaterol mesylate

Indacaterol mesylate

Conditions
ConditionsYield
In water at 20 - 70℃; for 20.2h;86.9%
indacaterol
312753-06-3

indacaterol

Indacaterol sulfate

Indacaterol sulfate

Conditions
ConditionsYield
With sulfuric acid; acetic acid at 20 - 50℃; for 18.0833h;86.9%
indacaterol
312753-06-3

indacaterol

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one fumarate

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one fumarate

Conditions
ConditionsYield
In methanol at 20 - 50℃; for 3.33333h;86.4%
indacaterol
312753-06-3

indacaterol

L-Tartaric acid
87-69-4

L-Tartaric acid

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one L-tartrate

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one L-tartrate

Conditions
ConditionsYield
In isopropyl alcohol at 50℃; for 15h;84.27%
indacaterol
312753-06-3

indacaterol

Indacaterol hydrochloride

Indacaterol hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol at 20 - 50℃; for 17h;84.27%
indacaterol
312753-06-3

indacaterol

Indacaterol hydrobromide

Indacaterol hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In methanol at 20 - 50℃; for 3.25h;84.27%
indacaterol
312753-06-3

indacaterol

formic acid
64-18-6

formic acid

Indacaterol formate

Indacaterol formate

Conditions
ConditionsYield
In methanol at 25 - 50℃; for 15h;79.37%
indacaterol
312753-06-3

indacaterol

1-hydroxy-2-naphthoic acid
86-48-6

1-hydroxy-2-naphthoic acid

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one xinafoate

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one xinafoate

Conditions
ConditionsYield
In butan-1-ol at 20 - 100℃; for 17h;76%
indacaterol
312753-06-3

indacaterol

Hippuric Acid
495-69-2

Hippuric Acid

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one hippurate

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one hippurate

Conditions
ConditionsYield
In methanol at 20 - 50℃; for 4.16667h;75.7%
indacaterol
312753-06-3

indacaterol

glycolic Acid
79-14-1

glycolic Acid

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one glycolate

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one glycolate

Conditions
ConditionsYield
In methanol at 20 - 50℃;71.37%
indacaterol
312753-06-3

indacaterol

ethanesulfonic acid
594-45-6

ethanesulfonic acid

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one esylate

(R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one esylate

Conditions
ConditionsYield
In water; dimethyl sulfoxide at 20 - 50℃;
indacaterol
312753-06-3

indacaterol

[Br]QAB149

[Br]QAB149

Conditions
ConditionsYield
With bromine In acetic acid at 20℃; for 1h;
indacaterol
312753-06-3

indacaterol

[3H]QAB149

[3H]QAB149

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bromine / acetic acid / 1 h / 20 °C
2: palladium 10% on activated carbon; tritium; triethylamine / 5 h / 20 °C
View Scheme
indacaterol
312753-06-3

indacaterol

C24H30N2O3
1403389-05-8

C24H30N2O3

Conditions
ConditionsYield
With 10% Pd/C; hydrogen at 25℃; under 760.051 Torr; for 360h;
indacaterol
312753-06-3

indacaterol

C24H27ClN2O2

C24H27ClN2O2

Conditions
ConditionsYield
With thionyl chloride In acetonitrile for 0.0833333h; Reflux;
indacaterol
312753-06-3

indacaterol

5-[2-(5,6-diethyl-indan-2-ylamino)-ethyl]-8-hydroxy-1H-quinolin-2-one

5-[2-(5,6-diethyl-indan-2-ylamino)-ethyl]-8-hydroxy-1H-quinolin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: thionyl chloride / acetonitrile / 0.08 h / Reflux
2.1: sodium tetrahydroborate / ethanol / 18 h / 25 °C
2.2: 2 h / Reflux
View Scheme

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