5-Chloro-2-Fluoroaniline supplier

Name
5-Chloro-2-fluoroaniline
EINECS 218-284-1
CAS No. 2106-05-0
Article Data5
CAS DataBase
Density 1.349 g/cm³
Solubility
Melting Point
Formula C₆H₅ClFN
Boiling Point 214.4 °C at 760 mmHg
Molecular Weight 145.564
Flash Point 83.5 °C
Transport Information UN 2810
Appearance COLORLESS TO BROWN LIQUID
Safety 26-36-2636/37/39-23-36/37/39-45
Risk Codes 36/37/38-20/21/22-23/24/25
Molecular Structure
Hazard Symbols Xn, Xi, T
Synonyms Aniline,5-chloro-2-fluoro- (6CI,8CI);(5-Chloro-2-fluorophenyl)amine;3-Chloro-6-fluoroaniline;5-Chloro-2-fluorobenzenamine;NSC 10291;
PSA 26.02000
LogP 2.64250

Synthetic route

: 345-18-6
2-fluoro-5-chloronitrobenzene

: 2106-05-0
5-chloro-2-fluoroaniline

Conditions

Conditions	Yield
With hydrogen; platinum on activated charcoal In 1,2-dimethoxyethane under 2585.74 Torr; for 24h; Catalytic hydrogenation;

: 89-61-2
2,5-dichloronitrobenzene

potassium-compound of 1-<4-hydroxy-phenyl>-ethanone: potassium-compound of 1-<4-hydroxy-phenyl>-ethanone

: 2106-05-0
5-chloro-2-fluoroaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 52 percent / KF; 18-crown-6 / tetrahydrothiophene 1,1-dioxide / 32 h / 180 °C 2: H2 / 5 percent Pt/C / 1,2-dimethoxy-ethane / 24 h / 2585.74 Torr View Scheme

: 345-18-6
2-fluoro-5-chloronitrobenzene

A: 348-54-9
2-Fluoroaniline

B: 2106-05-0
5-chloro-2-fluoroaniline

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrazine hydrate In methanol at 80℃; for 0.0833333h; Overall yield = 25 %;

: C15H14ClFN2

: 2106-05-0
5-chloro-2-fluoroaniline

Conditions

Conditions	Yield
With sodium tetrahydroborate; copper(l) chloride In ethanol at 20℃;	24 mg

: 15426-14-9, 106131-20-8, 106131-24-2
3,3'-dichloroazobenzene

: 2106-05-0
5-chloro-2-fluoroaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 90 °C / Sealed tube 2: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C View Scheme

: 1-(3-chlorophenyl)-2-(2,4,6-trimethylphenyl)diazene

: 2106-05-0
5-chloro-2-fluoroaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 100 °C / Sealed tube 2: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C View Scheme

: C12H7Cl2FN2

: 2106-05-0
5-chloro-2-fluoroaniline

Conditions

Conditions	Yield
With sodium tetrahydroborate; copper(l) chloride In ethanol at 20℃;	28.8 mg

: 2106-05-0
5-chloro-2-fluoroaniline

: C6H4ClFIN

Conditions

Conditions	Yield
With iodine; silver sulfate In ethanol at 0 - 20℃; for 1h; Large scale;	98%

: 1089278-78-3
methyl 3-(3-{2-[(3-{[2-(dimethylamino)ethyl]oxy}phenyl)amino]-4-pyrimidinyl}-imidazo[1,2-a]pyridin-2-yl)benzoate

: 2106-05-0
5-chloro-2-fluoroaniline

: 1089278-77-2
N-(5-chloro-2-fluorophenyl)-3-(3-{2-[(3-{[2-(dimethylamino)ethyl]oxy}phenyl)amino]-4-pyrimidinyl}imidazo[1,2-a]pyridin-2-yl)benzamide

Conditions

Conditions	Yield
Stage #1: methyl 3-(3-{2-[(3-{[2-(dimethylamino)ethyl]oxy}phenyl)amino]-4-pyrimidinyl}-imidazo[1,2-a]pyridin-2-yl)benzoate; 5-chloro-2-fluoroaniline With sodium hexamethyldisilazane In tetrahydrofuran at 20℃; for 0.5h; Stage #2: With methanol In tetrahydrofuran	94%

: 2106-05-0
5-chloro-2-fluoroaniline

: 116369-24-5
4-bromo-5-chloro-2-fluoroaniline

Conditions

Conditions	Yield
With N-Bromosuccinimide In acetonitrile at 25℃; for 1h;	91%

: 86-98-6
4,7-dichloroquinoline

: 2106-05-0
5-chloro-2-fluoroaniline

: 4-(5'-chloro-2'-fluorophenyl)amino-7-chloroquinoline

Conditions

Conditions	Yield
for 0.0583333h; microwave irradiation;	90%

: 2106-05-0
5-chloro-2-fluoroaniline

: 471-25-0
Propiolic acid

: N-(5-chloro-2-fluorophenyl)prop-2-ynamide

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In toluene at 5℃; for 2h;	88%

: 1246443-58-2
2-(chloromethyl)-8-((2-chloro-5-thiazolyl)methyl)-1,4-dioxa-8-azaspiro[4,5]decane

: 2106-05-0
5-chloro-2-fluoroaniline

: 1246443-53-7
N-(5-chloro-2-fluorophenyl)-N-({8-((2-chloro-5-thiazolyl)methyl)-1,4-dioxa-8-aza-spiro[4,5]dec-2-yl}methyl)amine

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 28 - 140℃;	85%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 140℃; for 20h;	85%

: 2106-05-0
5-chloro-2-fluoroaniline

: 504-02-9
1,3-cylohexanedione

: 3-(5-chloro-2-fluorophenylamino)cyclohex-2-enone

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 25 - 30℃; for 8h;	85%

: 2106-05-0
5-chloro-2-fluoroaniline

: tin(ll) chloride

: 396074-99-0
(5-Chloro-2-fluoro-phenyl)-hydrazine

Conditions

Conditions	Yield
With sodium nitrite In hydrogenchloride; water	83%

: 2106-05-0
5-chloro-2-fluoroaniline

: 73183-34-3
bis(pinacol)diborane

: 1003575-43-6
2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Conditions

Conditions	Yield
With tris(trimethylphosphine)nickel(II) chloride; (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride In tetrahydrofuran at 100℃; for 12h; Inert atmosphere;	81%
With (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride; dichlorobis(trimethylphosphine)nickel In tetrahydrofuran at 100℃; for 12h; Inert atmosphere; Sealed tube;	81%

: 2106-05-0
5-chloro-2-fluoroaniline

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 1-(5-Chloro-2-fluorophenyl)-piperazine

Conditions

Conditions	Yield
In 1,2-dichloro-benzene; hexan-1-ol for 11h; Heating / reflux;	76.6%

: 357204-44-5
C7H6ClN3OS

: 2106-05-0
5-chloro-2-fluoroaniline

: 1392131-61-1
1-(5-chloro-2-fluorophenyl)-3-(5-chloro-1,3-dimethyl-1H-pyrazole-4-carbonyl)thiourea

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 4h;	72.1%

: 2106-05-0
5-chloro-2-fluoroaniline

: (S)-(–)-1-isocyanato-4,7,7-trimethyl-2-oxabicyclo[2.2.1]heptan-3-one

: N-(5-chloro-2-fluorophenyl)-N′-{(S)-(–)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptan-1-yl}-urea

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 20℃; for 12h;	72%

: 2290-65-5
trimethylsilyl isothiocyanate

: 2106-05-0
5-chloro-2-fluoroaniline

: 99-73-0
para-bromophenacyl bromide

: 1449223-29-3
C15H9BrClFN2S*BrH

Conditions

Conditions	Yield
In ethanol at 70℃;	69%

...Expand

: 2106-05-0
5-chloro-2-fluoroaniline

: 76-05-1
trifluoroacetic acid

: 93416-35-4
N-(5-chloro-2-hydroxyphenyl)trifluoroacetamide

Conditions

Conditions	Yield
With Oxone In 1,4-dioxane at 90℃; Schlenk technique; Inert atmosphere; chemoselective reaction;	66%

: 2106-05-0
5-chloro-2-fluoroaniline

: 621-82-9
Cinnamic acid

: (2E)-N-(5-chloro-2-fluorophenyl)-3-phenylprop-2-enamide

Conditions

Conditions	Yield
With phosphorus trichloride In chlorobenzene at 130℃; for 0.5h; Microwave irradiation;	59%

: 2106-05-0
5-chloro-2-fluoroaniline

: C13H6ClFN2O3

: N-(5-chloro-2-fluorophenyl)-2-fluoro-5-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)benzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 12h;	52.8%

: 2106-05-0
5-chloro-2-fluoroaniline

: 199327-59-8
4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline

: 909863-34-9
4-[(5-chloro-2-fluorophenyl)amino]-6-[3-(morpholin-4-yl)propyloxy]-7-methoxyquinazoline

Conditions

Conditions	Yield
With acetic acid at 80℃; for 7h;	42%

: 2106-05-0
5-chloro-2-fluoroaniline

: 2-fluoro-5-chlorophenol

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-fluoroaniline With sulfuric acid; sodium nitrite In water at -5 - -2℃; for 0.5h; Stage #2: With sulfuric acid; copper(II) sulfate In water at 160℃; for 2h;	40%

: 2106-05-0
5-chloro-2-fluoroaniline

A: 2-fluoro-5-chlorophenol

B: 108-95-2
phenol

Conditions

Conditions	Yield
With copper(II) sulfate; sodium nitrite In sulfuric acid; water	A n/a B 40%

: 2106-05-0
5-chloro-2-fluoroaniline

: 4-chloro-7-iodo-6-nitroquinazoline

: N-(5-chloro-2-fluorophenyl)-7-iodo-6-nitroquinazolin-4-amine

Conditions

Conditions	Yield
With formic acid In dichloromethane; isopropyl alcohol at 0 - 20℃; for 0.5h;	37%

: 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

: 2106-05-0
5-chloro-2-fluoroaniline

: 530-62-1
1,1'-carbonyldiimidazole

: 1290546-55-2
4-(4-(3-(5-chloro-2-fluorophenyl)ureido)phenoxy)-N-methylpicolinamide

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-fluoroaniline; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 22.1667h; Stage #2: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide In dichloromethane for 4h;	35%

...Expand

: 4411-25-0
1-adamantyl isocyanate

: 2106-05-0
5-chloro-2-fluoroaniline

A: 29559-44-2
N,N'-bis(1-adamantyl)urea

B: 1-(adamantan-1-yl)-3-(5-chloro-2-fluorophenyl)urea

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 20℃; for 12h; Curtius Rearrangement;	A n/a B 35%

...Expand

: 2106-05-0
5-chloro-2-fluoroaniline

: 5-isocyanatoadamantan-2-one

: N-(5-chloro-2-fluorophenyl)-N′-(4-oxoadamantan-1-yl)urea

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 20℃; for 12h;	33%

: 573-54-6
2-bromo-3-nitro-benzoic acid

: 2106-05-0
5-chloro-2-fluoroaniline

: 103942-81-0
2-(5-Chloro-2-fluoro-phenylamino)-3-nitro-benzoic acid

Conditions

Conditions	Yield
With N-ethylmorpholine;; copper; copper(l) chloride In various solvent(s) at 70 - 80℃; for 15h;	31%
With N-ethylmorpholine;; copper; copper(l) chloride In various solvent(s) at 70℃; for 18h; Yield given;

: 832740-37-1
5-(3-hydroxyphenyl)isoxazole-3-carboxylic acid

: 2106-05-0
5-chloro-2-fluoroaniline

: N-(5-chloro-2-fluorophenyl)-5-(3-hydroxyphenyl)isoxazole-3-carboxamide

Conditions

Conditions	Yield
Stage #1: 5-(3-hydroxyphenyl)isoxazole-3-carboxylic acid With thionyl chloride In tetrahydrofuran for 0.5h; Reflux; Stage #2: 5-chloro-2-fluoroaniline With triethylamine In tetrahydrofuran at 20 - 35℃; for 2h;	24%

: 2106-05-0
5-chloro-2-fluoroaniline

: 1190891-89-4
N-(5-chloro-2-fluorophenyl)iminodiacetic acid

Conditions

Conditions	Yield
	22%

: 2106-05-0
5-chloro-2-fluoroaniline

: tert-butyl 5-chloropyrazolo[1,5-a]pyrimidin-7-yl(2-morpholinopropyl)carbamate

: N5-(5-chloro-2-fluorophenyl)-N7-(2-morpholinopropyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); lithium hexamethyldisilazane; XPhos In tetrahydrofuran; dichloromethane at 65℃; for 1h; Sealed tube;	21%

: 2106-05-0
5-chloro-2-fluoroaniline

: 5-(3-hydroxy-4-methoxyphenyl)isoxazole-3-carboxylic acid

: N-(5-chloro-2-fluorophenyl)-5-(3-hydroxy-4-methoxyphenyl)isoxazole-3-carboxamide

Conditions

Conditions	Yield
Stage #1: 5-(3-hydroxy-4-methoxyphenyl)isoxazole-3-carboxylic acid With thionyl chloride In tetrahydrofuran for 0.5h; Reflux; Stage #2: 5-chloro-2-fluoroaniline With triethylamine In tetrahydrofuran at 20 - 35℃; for 2h;	20%

: 70978-37-9
1-(azidomethyl)-4-methoxybenzene

: 2106-05-0
5-chloro-2-fluoroaniline

: 3-fluoro-4-(3,3,3-trifluoroprop-1-yn-1-yl)pyridine

: N-(5-chloro-2-fluorophenyl)-4-[5-(trifluoromethyl)-1H-1,2,3-triazol-4-yl]pyridin-3-amine

Conditions

Conditions	Yield
Stage #1: 1-(azidomethyl)-4-methoxybenzene; 3-fluoro-4-(3,3,3-trifluoroprop-1-yn-1-yl)pyridine In tert-butyl methyl ether; tert-butyl alcohol at 80℃; for 2h; Stage #2: 5-chloro-2-fluoroaniline With potassium carbonate In dimethyl sulfoxide at 180℃; for 5h; Stage #3: With trifluoroacetic acid at 50℃;	17%

...Expand

: 1931-60-8
3-methylenebutanedioyl dichloride

: 2106-05-0
5-chloro-2-fluoroaniline

A: 4-((5-chloro-2-fluorophenyl)amino)-2-methylene-4-oxobutanoic acid

B: N,N'-bis(5-chloro-2-fluorophenyl)-2-methylenesuccinamide

Conditions

Conditions	Yield
In dichloromethane at -4 - 20℃; Molecular sieve;	A 9.9% B 11.7%

...Expand

5-Chloro-2-Fluoroaniline Chemical Properties

MF: C₆H₅ClFN
Synonyms: BUTTPARK 44\01-98;5-CHLORO-2-FLUOROPHENYLAMINE;5-CHLORO-2-FLUOROANILINE;5-Chloro-2-fluoroaniline 98%;5-Chloro-2-fluoroaniline98%
MW: 145.56
EINECS: 218-284-1
Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Aniline;Miscellaneous
density : 1.29 g/mL at 25 °C(lit.)
bp : 102-105 °C20 mm Hg(lit.)
refractive index : n 20/D 1.561(lit.)
Fp : 219 °F

5-Chloro-2-Fluoroaniline Safety Profile

Risk Statements : 36/37/38-20/21/22-23/24/25
Safety Statements : 26-36-2636/37/39-23-36/37/39-45
Hazard Codes : Xi,T,Xn
Hazard Note : Toxic
RIDADR : UN2810
WGK Germany : 3
HazardClass : 6.1
PackingGroup : III

Product Name

5-Chloro-2-fluoroaniline

Synthetic route

5-Chloro-2-Fluoroaniline Chemical Properties

5-Chloro-2-Fluoroaniline Safety Profile

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