5-Fluorouracil supplier | CasNO.51-21-8

Name
5-Fluorouracil
EINECS 200-085-6
CAS No. 51-21-8
Article Data130
CAS DataBase
Density 1.53 g/cm³
Solubility insoluble in water
Hazard Symbols Xn,T,C,Xi
Synonyms Ro-2-9757;Phtoruracil;2,4(1H,3H)-Pyrimidinedione,5-fluoro-;Phthoruracil;5-Fluoro-2,4(1H, 3H)-pyrimidinedione;Fluoroplex;5-Fluoracyl;Efudex;Effluderm (free base);U 8953;Adrucil;Efurix;5-Ftouracyl;U-8953;Arumel;Kecimeton;Fluro Uracil;Uracil, 5-fluoro- (VAN 8CI);Fluracil;Efudix;Ro 2-9757;Fluracilum;5-FU;5-Fluoro-2,4-pyrimidinedione;
PSA 65.72000
LogP -0.79770

Synthetic route

: 56311-36-5, 100814-55-9, 100814-58-2
trans-5-fluoro-6-acetoxy-5,6-dihydrouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With triethylamine at 60℃;	100%

: 65906-75-4, 76481-58-8, 81033-59-2, 84471-52-3, 84471-53-4
(+/-)-t-6-butoxy-r-5-ethoxycarbonyl-5-fluoro-5,6-dihydrouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With hydrogenchloride for 1h; Product distribution; Heating; variation of reagent, temperature; in ethanol;	95%

: 65905-96-6
methyl 5-fluoro-4-methoxy-2,6-dioxohexahydro-5-pyrimidinecarboxylate

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With hydrogenchloride In water for 2.5h;	95%

: 99429-06-8
2,5-difluoro-4-chloro-pyrimidine

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With sodium hydroxide In water at 80℃; for 4h;	93%

: 5-bromo-5-fluoro-6-hydroxy-5,6-dihydrouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With sulfuric acid In water at 80℃; for 7h;	93%

: 13593-36-7
5-fluoro-6-chlorouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With acetic acid; zinc at 100℃; for 5h; var.: reag.: hydrogen, Et3N or NaOH, cat.: Pd/C, in EtOH, RT;	91%

: 66-22-8
uracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With C19XeF6 In dichloromethane for 24h; Ambient temperature;	90%
With fluorine; trifluoroacetic acid at -10℃; under 2250.23 Torr; Reagent/catalyst; Temperature; Pressure; Inert atmosphere;	89.4%
	81.4%

: 824-28-2
1,3-dimethyl-5-azauracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With fluoroacetamide; lithium diisopropyl amide In diethyl ether at 0℃; for 4h;	88%
With fluoroacetamide; lithium diisopropyl amide In diethyl ether at 0℃; for 4h; a novel ring transformation reaction;	88%

: fluorine fluorosulfonate

: 71-30-7
Cytosine

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
In water	87.7%

trifluoromethyl hypofluorite (CF3 OF): trifluoromethyl hypofluorite (CF3 OF)

: 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid monohydrate

A: 51-21-8
5-fluorouracil

B: 220141-70-8
5-fluoroorotic acid hydrate

Conditions

Conditions	Yield
In trichloromonofluoromethane (CFCl3); water; trifluoroacetic acid; Polytetrafluoroethylene	A n/a B 86%

...Expand

: 4330-22-7
2,4-dimethoxy-5-fluoropyrimidine

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With hydrogenchloride	81.3%

: 75500-02-6
N1,N3-dibenzyl-5-fluorouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With boron tribromide In various solvent(s) at 138℃; for 24h;	80%

: 71-30-7
Cytosine

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With trifluoroacetic acid In water	80%
With calcium hydroxide In hydrogen fluoride; water	76.2%
In water	67%

: 1480-96-2
2-methoxy-5-fluorouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 28℃; for 5h; Temperature;	78.3%
With hydrogenchloride In water at 55℃; for 3h; Large scale;	65.24 kg

: 1141462-25-0
C18H15FN4O6S2

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With Enterobacter cloacae β-lactamase for 20h; pH=7.0; aq. phosphate buffer;	78%

: 71-30-7
Cytosine

: sodium hydrogensulfite

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
In water	75.4%

: 98224-73-8
2-[2-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-isopropoxy-ethyl]-isoindole-1,3-dione

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With L-valine In acetic acid	71%

: (Z)-N-(2-fluoro-3-methoxyprop-2-enoyl)urea

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With sodium hydroxide at 80℃; for 1h;	67%

: 1784-08-3
Cytosine hydrochloride

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
In water	66%

: 65726-47-8
5-fluoro-6-hydroxy-5-methoxycarbonyl-5,6-dihydrouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With hydrogenchloride In water for 1h; Heating;	65%

: 65906-75-4, 76481-58-8, 81033-59-2, 84471-52-3, 84471-53-4
(4R,5R)-4-Butoxy-5-fluoro-2,6-dioxo-hexahydro-pyrimidine-5-carboxylic acid ethyl ester

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With hydrogenchloride for 1h; Product distribution; Heating; variation of reagent, temperature; in ethanol;	62%

: 75500-03-7
1,3-bis-((benzyloxy)methyl)-5-fluoropyrimidine-2,4(1H,3H)-dione

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With boron tribromide In benzene for 1h; Ambient temperature;	60%
With trimethylsilyl iodide; water 1.) chloroform, reflux, 6 h, 2.) reflux, 30 min; 160-180 deg C, 15 min; reflux; Yield given. Multistep reaction;

: 5-methoxycarbonyluracil

A: 51-21-8
5-fluorouracil

B: 58532-67-5
5-chloro-5-fluoro-6-hydroxy-5,6-dihydrouracil

Conditions

Conditions	Yield
With hydrogenchloride; fluorine In water for 1.16667h; Heating;	A 59% B 14%

: 1134-30-1, 77449-87-7, 81033-60-5, 83409-64-7
(+/-)-cis-6-butoxy-5-fluoro-5,6-dihydrouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With hydrogenchloride for 1h; Product distribution; Heating; variation of reagent, temperature; in ethanol;	48%

: 1191-99-7
2,3-dihydro-2H-furan

: 17242-85-2
5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine

A: 51-21-8
5-fluorouracil

B: 17902-23-7
tegafur

Conditions

Conditions	Yield
With pyridine hydrochloride In chloroform at 60 - 70℃; Product distribution; other temperature, other solvents;	A 0.6 g B 44.5%

...Expand

: 1134-30-1, 77449-87-7, 81033-60-5, 83409-64-7
5-fluoro-6-butoxy-5,6-dihydrouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With hydrogenchloride for 1h; Product distribution; Heating; variation of reagent, temperature; in ethanol;	42%
at 150℃; sublimation under cacuum; Yield given;

: 1005-80-7, 1005-82-9, 1820-76-4
5-bromo-5-fluoro-6-hydroxy-5,6-dihydrouracil

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With acetic anhydride at 140℃; for 5h;	40%

: 98224-77-2
2-[2-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-methoxy-ethyl]-isoindole-1,3-dione

: 51-21-8
5-fluorouracil

Conditions

Conditions	Yield
With L-valine In acetic acid	38%

: 50-00-0
formaldehyd

: 51-21-8
5-fluorouracil

: 74179-14-9
N1,N3-bis(hydroxymethyl)-5-fluorouracil

Conditions

Conditions	Yield
With water at 60℃; for 6h;	100%
In water at 70℃; for 0.25h; Yield given;
at 60℃; for 0.75h;

: 51-21-8
5-fluorouracil

: 692-29-5
Succinic semialdehyde

: 17902-23-7
tegafur

Conditions

Conditions	Yield
With indium(III) bromide; 1,1,3,3-Tetramethyldisiloxane In tetrahydrofuran at 15 - 20℃; for 12h; Solvent; Reagent/catalyst; Temperature;	99.8%

: 75-77-4
chloro-trimethyl-silane

: 51-21-8
5-fluorouracil

: 17242-85-2
5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine

Conditions

Conditions	Yield
With 1,1,1,3,3,3-hexamethyl-disilazane Ambient temperature;	99%
With 1,1,1,3,3,3-hexamethyl-disilazane
With 1,1,1,3,3,3-hexamethyl-disilazane at 140 - 150℃; for 5h;

: 51-21-8
5-fluorouracil

: 24424-99-5
di-tert-butyl dicarbonate

: 402849-04-1
1-tert-butyl 5-fluoro-2,4-dioxone-3,4-dihydropyrimidine-1(2H)-carboxylate

Conditions

Conditions	Yield
With dmap In acetonitrile at 20℃; for 19h; Inert atmosphere;	99%
With dmap In acetonitrile at 20℃; for 3h;	92%
With dmap	78%

: 51-21-8
5-fluorouracil

: 3,5-di-O-p-methoxybenzoyl-2-deoxy-D-ribofuranosyl ortho-hexynylbenzoate

: 1384553-43-8
5-fluoro-1-(3',5'-di-O-p-methoxybenzoyl-2'-deoxy-D-ribofuranosyl)uracil

Conditions

Conditions	Yield
Stage #1: 5-fluorouracil; 3,5-di-O-p-methoxybenzoyl-2-deoxy-D-ribofuranosyl ortho-hexynylbenzoate With N,O-Bis(trimethylsilyl)trifluoroacetamide In acetonitrile at 20℃; for 0.5h; Inert atmosphere; Stage #2: With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I) In 1,2-dichloro-ethane at 20℃; for 12h; Molecular sieve; diastereoselective reaction;	99%

: 1191-99-7
2,3-dihydro-2H-furan

: 51-21-8
5-fluorouracil

: 17902-23-7
tegafur

Conditions

Conditions	Yield
With bis(acetylacetonate)nickel(II); tris(2,2′-bipyridine)ruthenium(II) bis(tetrafluoroborate) In tetrahydrofuran at 25 - 30℃; Temperature; Solvent; Wavelength; Reagent/catalyst; Irradiation;	98.7%
With calcium chloride; trifluoroacetic acid In chloroform; N,N-dimethyl-formamide; toluene	85.2%
With dimethylmonochlorosilane; triethylamine In acetonitrile at 16℃; Temperature;	85%

: 51-21-8
5-fluorouracil

: 1450-14-2
1,1,1,2,2,2-hexamethyldisilane

: 17242-85-2
5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine

Conditions

Conditions	Yield
With ammonium sulfate for 14h; Heating;	98%

: 51-21-8
5-fluorouracil

: 120-89-8
parabanic acid

Conditions

Conditions	Yield
With oxygen; ozone In acetic acid at 20℃; for 0.75h;	98%
With oxygen; ozone In acetic acid at 20℃; for 0.75h; Product distribution;	98%

: 51-21-8
5-fluorouracil

: 5122-82-7
1-adamantyl bromomethyl ketone

: 1-<2-(1-adamantyl)-2-oxo-ethyl>-5-fluorouracide

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 22h;	98%

: 51-21-8
5-fluorouracil

: C34H28O7

: 77180-87-1
2',3'-di-O-benzoyl-5'-deoxy-5-fluorouridine

Conditions

Conditions	Yield
Stage #1: 5-fluorouracil With N,O-Bis(trimethylsilyl)trifluoroacetamide In acetonitrile at 50℃; for 0.5h; Inert atmosphere; Stage #2: C34H28O7 In acetonitrile at 20℃; for 0.75h; Inert atmosphere; Molecular sieve; Stage #3: With N-iodo-succinimide; trimethylsilyl trifluoromethanesulfonate In acetonitrile at 0 - 20℃; for 2h; Inert atmosphere; Molecular sieve;	98%

: 51-21-8
5-fluorouracil

: micheliolide

: C19H23FN2O5

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 20℃; Inert atmosphere;	97.5%

: 51-21-8
5-fluorouracil

: 107-07-3
2-chloro-ethanol

A: 3-(2-hydroxyethyl)-5-fluorouracil

B: 55185-82-5
5-Fluoro-1,3-bis(2-hydroxyethyl)-uracil

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water Heating;	A 3% B 97%

...Expand

: 51-21-8
5-fluorouracil

: 100-39-0
benzyl bromide

: 75500-02-6
N1,N3-dibenzyl-5-fluorouracil

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	96%
With potassium carbonate In N,N-dimethyl-formamide Ambient temperature;
With potassium hydroxide; tetrabutylammomium bromide 1.) 80 deg C, 2 h, 2.) 1 h; Yield given. Multistep reaction;

: 51-21-8
5-fluorouracil

: 92641-15-1
N-(1,3-dihydro-3-oxoisobenzofuran-1-yl)-N,N,N-triethyl ammonium p-toluenesulfonate

: 81820-68-0, 104861-73-6, 104889-91-0
1-(3-oxo-1,3-dihydro-1-isobenzofuranyl)-5-fluorouracil

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide for 15h; Ambient temperature;	96%

: 51-21-8
5-fluorouracil

: 292638-85-8
acrylic acid methyl ester

: 3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)propionic acid methyl ester

Conditions

Conditions	Yield
With lipozyme Thermomyces lanuginosus IM In dimethyl sulfoxide at 50℃; for 0.5h; Michael Addition; Flow reactor; Enzymatic reaction;	96%
With triethylamine In N,N-dimethyl-formamide at 60℃; Aza-Micheal reaction;	95%
With triethylamine In N,N-dimethyl-formamide at 60℃; for 4h; Michael Addition;	95%

: 51-21-8
5-fluorouracil

: 2177-18-6
vinyl acrylate

: 884308-97-8
3-(5-fluorouracil-1-yl)propionic acid vinyl ester

Conditions

Conditions	Yield
With D-aminoacylase from Escherichia coli In dimethyl sulfoxide at 25℃; for 0.416667h; Michael addition; Enzymatic reaction; regioselective reaction;	96%

: 51-21-8
5-fluorouracil

: 3333-44-6
tetrahydrofuran-2-yl benzoate

: 17902-23-7
tegafur

Conditions

Conditions	Yield
With sodium acetate; tetra-(n-butyl)ammonium iodide In dichloromethane; water at 35℃; for 2h; Solvent; Temperature; Reagent/catalyst;	95.2%

: 51-21-8
5-fluorouracil

: 92641-11-7
N-(1,3-dihydro-3-oxoisobenzofuran-1-yl)-N,N,N-triethyl ammonium chloride

: 81820-68-0, 104861-73-6, 104889-91-0
1-(3-oxo-1,3-dihydro-1-isobenzofuranyl)-5-fluorouracil

Conditions

Conditions	Yield
With triethylamine In dimethyl sulfoxide for 15h; Ambient temperature;	95%

: 51-21-8
5-fluorouracil

: 92641-14-0
N-(1,3-dihydro-3-oxoisobenzofuran-1-yl)-N,N,N-triethyl ammonium methanesulfonate

: 81820-68-0, 104861-73-6, 104889-91-0
1-(3-oxo-1,3-dihydro-1-isobenzofuranyl)-5-fluorouracil

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide for 15h; Ambient temperature;	95%

: 51-21-8
5-fluorouracil

: 92641-17-3
N-(1,3-dihydro-3-oxoisobenzofuran-1-yl)-N,N,N-triethyl ammonium trifluoroacetate

: 81820-68-0, 104861-73-6, 104889-91-0
1-(3-oxo-1,3-dihydro-1-isobenzofuranyl)-5-fluorouracil

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide for 15h; Ambient temperature;	95%

: 67-56-1
methanol

: 51-21-8
5-fluorouracil

: 5-chloro-5-fluoro-6-methoxy-5,6-dihydrouracil

Conditions

Conditions	Yield
With chlorine at 20℃; for 2h;	95%
With N-chloro-succinimide at 50℃;	91%

: 51-21-8
5-fluorouracil

: 97-00-7
1-chloro-2,4-dinitro-benzene

: 1-(2,4-dinitro-phenyl)-5-fluoro-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With zinc(II) oxide at 130℃; for 0.1h; Ionic liquid; Microwave irradiation;	95%
With tetrabutylammomium bromide; silica gel; caesium carbonate for 0.416667h; Heating;	83%
With silica gel; caesium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	82%

: 51-21-8
5-fluorouracil

: 5-fluoro-6-hydroxy-5-nitro-5,6-dihydrouracil

Conditions

Conditions	Yield
With sulfuric acid; nitric acid In water at 0 - 10℃;	95%

: 51-21-8
5-fluorouracil

: 5-bromo-5-fluoro-6-hydroxy-5,6-dihydrouracil

Conditions

Conditions	Yield
With sulfuric acid; dihydrogen peroxide; potassium bromide In water at 20℃;	95%

: 51-21-8
5-fluorouracil

: 106-94-5
propyl bromide

: 89501-11-1
5-Fluoro-1,3-dipropyl-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydroxide In dichloromethane Ambient temperature;	94%

: 51-21-8
5-fluorouracil

: 92641-10-6
4-(1,3-dihydro-3-oxoisobenzofuran-1-yl)-4-methyl morpholinium bromide

: 81820-68-0, 104861-73-6, 104889-91-0
1-(3-oxo-1,3-dihydro-1-isobenzofuranyl)-5-fluorouracil

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 15h; Ambient temperature;	94%

5-Fluorouracil Chemical Properties

Molecular structure of Fluorouracil (CAS NO.51-21-8) is:

Product Name: Fluorouracil
CAS Registry Number: 51-21-8
IUPAC Name: 5-fluoro-1H-pyrimidine-2,4-dione
Molecular Weight: 130.077223 [g/mol]
Molecular Formula: C₄H₃FN₂O₂
XLogP3: -0.9
H-Bond Donor: 2
H-Bond Acceptor: 3
EINECS: 200-085-6
Melting Point: 282-286 °C (dec.)(lit.)
Surface Tension: 46.1 dyne/cm
Density: 1.53 g/cm³
Flash Point: 196.5 °C
Enthalpy of Vaporization: 67.78 kJ/mol
Boiling Point: 401.4 °C at 760 mmHg
Vapour Pressure: 5.13E-07 mmHg at 25°C
Water Solubility: 12.2 g/L 20 °C
Sensitive: Air Sensitive
Stability: Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases.
Product Categories: Pharmaceutical Raw Materials;PYRIMIDINE;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Phenylacetic acid;Tegafur Carmofur;Nucleotides and Nucleosides;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleic acids;Bases & Related Reagents;Nucleotides;API's;Antitumour

5-Fluorouracil History

Fluorouracil (CAS NO.51-21-8) was synthesized by Robert Duschinsky in the late 1950s.

5-Fluorouracil Uses

Fluorouracil (CAS NO.51-21-8) can be used in against cancer for about 40 years, acts in several ways, but principally as a thymidylate synthase inhibitor. It can be used in colorectal cancer and pancreatic cancer,also it can be used for treating actinic (solar) keratoses and some types of basal cell carcinomas of the skin.

5-Fluorouracil Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	30mg/kg (30mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 303, 1978.
guinea pig	LD50	intravenous	25mg/kg (25mg/kg)	VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Japanese Journal of Pharmacology. Vol. 30, Pg. 871, 1980.
hamster	LD10	parenteral	140mg/kg (140mg/kg)		Journal of Surgical Oncology. Vol. 15, Pg. 355, 1980.
human	TDLo	intravenous	6mg/kg/3D (6mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	British Medical Journal. Vol. 1, Pg. 547, 1978.
human	TDLo	oral	450mg/kg/30D (450mg/kg)	GASTROINTESTINAL: OTHER CHANGES BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Cancer Vol. 39, Pg. 1936, 1977.
man	TDLo	intravenous	39mg/kg/1D-I (39mg/kg)	CARDIAC: CHANGES IN CORONARY ARTERIES	American Heart Journal. Vol. 114, Pg. 433, 1987.
man	TDLo	intravenous	122mg/kg/9W-I (122mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Australian and New Zealand Journal of Medicine. Vol. 22, Pg. 385, 1992.
mouse	LD50	intracrebral	41600ug/kg (41.6mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	Chemotherapy Vol. 15, Pg. 519, 1967.
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 7, Pg. 100, 1977.
mouse	LD50	intravenous	81mg/kg (81mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
mouse	LD50	oral	115mg/kg (115mg/kg)		Journal of Medicinal Chemistry. Vol. 21, Pg. 738, 1978.
mouse	LD50	subcutaneous	169mg/kg (169mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
mouse	LD50	unreported	171mg/kg (171mg/kg)		Cancer Research. Vol. 46, Pg. 2703, 1986.
mouse	LDLo	intratracheal	200mg/kg (200mg/kg)		Toxicology Letters. Vol. 30, Pg. 63, 1986.
rabbit	LD50	oral	18900ug/kg (18.9mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2603, 1974.
rabbit	LDLo	intravenous	15mg/kg (15mg/kg)	VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Japanese Journal of Pharmacology. Vol. 30, Pg. 871, 1980.
rat	LD50	intramuscular	240mg/kg (240mg/kg)		K'at'ollik Taehak Uihakpu Nonmunjip. Journal of Catholic Medical College. Vol. 38, Pg. 481, 1985.
rat	LD50	intraperitoneal	70mg/kg (70mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 569, 1971.
rat	LD50	intravenous	245mg/kg (245mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 569, 1971.
rat	LD50	oral	230mg/kg (230mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
rat	LD50	parenteral	500mg/kg (500mg/kg)		Recent Results in Cancer Research. Vol. 52, Pg. 76, 1975.
rat	LD50	rectal	884mg/kg (884mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES	Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1309, 1978.
rat	LD50	subcutaneous	217mg/kg (217mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
women	TDLo	intravenous	27mg/kg/4D-C (27mg/kg)	CARDIAC: OTHER CHANGES	British Medical Journal. Vol. 294, Pg. 125, 1987.
women	TDLo	intravenous	150mg/kg/17W- (150mg/kg)	BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA	British Journal of Haematology. Vol. 65, Pg. 357, 1987.

5-Fluorouracil Safety Profile

Hazard Codes: Harmful Xn,Xi ; Toxic T; Corrosive C
Risk Statements: 20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36/37/39-22
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S22: Do not breathe dust.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: YR0350000
F: 10-23
Hazard Note: Irritant/Highly Toxic
TSCA: T
HazardClass: 6.1
PackingGroup: III
HS Code: 29335995

5-Fluorouracil Specification

Fluorouracil , its cas register number is 51-21-8. It also can be called 2,4(1H,3H)-Pyrimidinedione, 5-fluoro- ; 2,4-Dioxo-5-fluoropyrimidine ; 5-FU ; 5-Faracil ; 5-Fluor-2,4(1H,3H)-pyrimidindion ; 5-Fluor-2,4-dihydroxypyrimidin .It is a white to nearly white crystalline powder and insoluble in water.

Product Name

5-Fluorouracil

Synthetic route

5-Fluorouracil Chemical Properties

5-Fluorouracil History

5-Fluorouracil Uses

5-Fluorouracil Toxicity Data With Reference

5-Fluorouracil Safety Profile

5-Fluorouracil Specification

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