5-Hydroxy-1,4-naphthalenedione supplier

Name
5-Hydroxy-1,4-naphthalenedione
EINECS 207-567-5
CAS No. 481-39-0
Article Data50
CAS DataBase
Density 1.439 g/cm³
Solubility soluble in hot water
Melting Point 161-163 °C(lit.)
Formula C₁₀H₆O₃
Boiling Point 385.8 °C at 760 mmHg
Molecular Weight 174.156
Flash Point 201.3 °C
Transport Information UN 2811 6.1/PG 3
Appearance Orange to brown crystalline powder
Safety 22-26-36/37/39-45-37/39
Risk Codes 25-36/37/38
Molecular Structure
Hazard Symbols T
Synonyms Juglone (6CI);1,4-Dihydro-1,4-dioxo-5-hydroxynaphthalene;8-Hydroxy-1,4-naphthoquinone;Akhnot;C.I. 75500;C.I.Natural Brown 7;NSC 153189;Natural Brown 7;
PSA 54.37000
LogP 1.32740

Synthetic route

: 83-56-7
1,5-dihydroxynaphthalene

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With air; C32H36Br2N4 In methanol; dichloromethane at 20℃; for 1h; Irradiation;	100%
With C39H50N7O2S(1+)*F6P(1-); N,N,N-trimethyl-N-propylammonium bis(trifluoromethanesulfonyl)imide at 25℃; for 3h; Kinetics; UV-irradiation;	100%
With C171H45BF2N4; oxygen In methanol; dichloromethane at 20℃; Kinetics; Quantum yield; Reagent/catalyst;	99.9%

: 5196-28-1
juglone acetate

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With water; trifluoroacetic acid at 72℃; for 0.75h;	95%

: 569-42-6
1,8-dihydroxynaphthalene

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With K10 montmorillonite; iodic acid for 0.366667h; Heating;	92%
With 1,1,1,3',3',3'-hexafluoro-propanol; urea hydrogen peroxide adduct at 45℃; Sealed tube; Green chemistry;	83%
With potassium nitrososulfonate; acetone

: 130-15-4
[1,4]naphthoquinone

A: 481-39-0
5-hydroxynaphtho-1,4-quinone

B: 475-38-7
5,8-Dihydroxy-1,4-naphthoquinone

Conditions

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; trifluoroacetic acid; trifluoroacetic anhydride; bis-[(trifluoroacetoxy)iodo]benzene at 80℃; for 12h; Reagent/catalyst; Sealed tube; chemoselective reaction;	A 92% B 3%

: 83-56-7
1,5-dihydroxynaphthalene

A: 481-39-0
5-hydroxynaphtho-1,4-quinone

B: 38028-39-6
5-hydroxy-1,2-naphthoquinone

Conditions

Conditions	Yield
With oxygen; salcomine In acetonitrile Product distribution; without catalyst-using methylene blue/irradiation instead, with various quenchers;	A 90% B 7%
With salcomine; oxygen In acetonitrile Product distribution; Ambient temperature; other solvents, other temp., other reactive oxygen-compounds;	A 90% B 7%
With salcomine; oxygen In acetonitrile for 0.5h; Ambient temperature;	A 71% B 14%

: 4923-61-9
5-methoxynaphthoquinone

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 20℃;	81%

: 116752-27-3
2-Methyl-1,5-naphthalindiol-5-acetat

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With oxygen; methylene blue In acetonitrile at 20℃; for 4h; Irradiation;	78%

: 94807-85-9
5-hydroxynaphthalen-1-yl acetate

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With Rose Bengal on Merrifield resin; oxygen In acetone at 20℃; for 5h; UV-irradiation;	68%
With oxygen; methylene blue In acetonitrile at 20℃; for 4h; Irradiation;	61%
With rose bengal In tert-Amyl alcohol Irradiation; Heating;	30%

: 1012-98-2
2,5-dihydroxy-2,3-dihydrobenzofuran

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With dihydrogen peroxide	62%

: 496-64-0
3-hydroxy-2-pyrone

: 106-51-4
p-benzoquinone

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With triethylamine In chloroform at -20℃; for 0.5h; Diels-Alder reaction;	60%

: 771-60-8
2,3,4,5,6-pentafluoroaniline

: 83-56-7
1,5-dihydroxynaphthalene

A: 481-39-0
5-hydroxynaphtho-1,4-quinone

B: 5-hydroxy-4-pentafluorophenylimino-4H-naphthalen-1-one

Conditions

Conditions	Yield
With iodic acid In ethanol; water at 20℃; for 2h;	A 25% B 45%

...Expand

: 1012-98-2
2,5-dihydroxy-2,3-dihydrobenzofuran

A: 481-39-0
5-hydroxynaphtho-1,4-quinone

B: 6312-53-4
juglone

Conditions

Conditions	Yield
With acid	A 15% B 44%

: 15255-29-5
2,3-epoxy-5-hydroxy-2,3-dihydro-1,4-naphthoquinone

A: 481-39-0
5-hydroxynaphtho-1,4-quinone

B: 4923-58-4
3,5-dihydroxy-2,3-dihydro-1,4-naphthoquinone

C: 4923-55-1
2-Hydroxyjuglon

Conditions

Conditions	Yield
With sodium acetate; acetic acid; sodium iodide; zinc for 1.5h; Ambient temperature;	A 33% B n/a C n/a

...Expand

: 80781-03-9
C31H26O9

A: 481-39-0
5-hydroxynaphtho-1,4-quinone

B: 80781-02-8
1,8-dihydroxy-11-methoxy-7,8,9,10-tetrahydronaphthacece-5,12-dione

Conditions

Conditions	Yield
With base In methanol	A n/a B 7%

: 481-40-3
1,4,5-trihydroxynaphthalene

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With iron(III) chloride
With bromine
With air
Multi-step reaction with 3 steps 1.1: sulphuric acid / 18 h 2.1: 420 mg / potassium carbonate / acetone / 3 h / Heating 3.1: hydrochloric acid 3.2: oxygen View Scheme

: 1077-69-6
5,8-dihydroxy-1-tetralone

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With iron(III) chloride; acetic acid

: 130-15-4
[1,4]naphthoquinone

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With diacetylnitric acid

: 3588-80-5
5-methoxynaphthalen-1-ol

A: 481-39-0
5-hydroxynaphtho-1,4-quinone

B: 4923-61-9
5-methoxynaphthoquinone

C: 101303-83-7
8-Hydroxy-4-methoxy-1,2-naphthochinon

Conditions

Conditions	Yield
With oxygen; methylene blue In methanol at 22℃; for 12h; Irradiation;

...Expand

: 569-42-6
1,8-dihydroxynaphthalene

A: 481-39-0
5-hydroxynaphtho-1,4-quinone

B: 101459-03-4
8,8'-bijuglone

Conditions

Conditions	Yield
Product distribution; oxidation;

: 68217-36-7
5-amino-8-hydroxy-[1,4]naphthoquinone

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With sodium hydroxide; hypophosphorous acid; sodium nitrite 1.) water, 2.) 40 deg C, 2 h; room temp., 10 h; Yield given. Multistep reaction;

: 97308-88-8
5-Methoxy-1-methylbenzindazol-4,9-chinon

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With aluminium trichloride In chloroform Heating;

: 54712-38-8, 51114-98-8, 62332-73-4, 137494-04-3
(-)-(4S)-4,8-dihydroxy-α-tetralone

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene for 8h; Heating;	10 mg

β-hydrojuglone: β-hydrojuglone

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With ethanol; iron(III) chloride nach vorhergegangener Bildung von α-Hydrojuglon;

1,4-diamino-<5>naphthol: 1,4-diamino-<5>naphthol

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With water; iron(III) chloride

1-oxy-8-amino-naphthalene: 1-oxy-8-amino-naphthalene

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With 4-sulfobenzenediazonium Reduzieren des Gebildeten Azofarbstoffs mit Zn und HCl und Oxidieren des Reduktionsprodukts mit FeCl3;

4-amino-naphthalenediol-(1.5)-hydrochloride: 4-amino-naphthalenediol-(1.5)-hydrochloride

: 481-39-0
5-hydroxynaphtho-1,4-quinone

Conditions

Conditions	Yield
With hydrogenchloride; iron(III) chloride

: 569-42-6
1,8-dihydroxynaphthalene

chromic acid mixture: chromic acid mixture

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 481-40-3
1,4,5-trihydroxynaphthalene

: 7726-95-6
bromine

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 481-40-3
1,4,5-trihydroxynaphthalene

: 7705-08-0
iron(III) chloride

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 74-88-4
methyl iodide

: 4923-61-9
5-methoxynaphthoquinone

Conditions

Conditions	Yield
With silver(l) oxide In dichloromethane for 25h; Ambient temperature;	100%
With silver(l) oxide In chloroform at 20℃;	100%
With silver(l) oxide In chloroform Heating;	98%

: 75-30-9
2-iodo-propane

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 97308-90-2
5-isopropoxy-1,4-naphthoquinone

Conditions

Conditions	Yield
With silver(l) oxide In dichloromethane at 20℃; for 20h; Green chemistry; regioselective reaction;	100%
With silver(l) oxide In chloroform for 0.333333h; Ambient temperature;	77%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 542-92-7
cyclopenta-1,3-diene

: 163180-66-3
(1R*,4S*,4aR*,9aS*)-1,4,4a,9a-tetrahydro-5-hydroxy-1,4-methano-9,10-anthracenedione

Conditions

Conditions	Yield
In chloroform for 0.5h; Ambient temperature;	100%
In propan-1-ol at 25℃; Thermodynamic data; Rate constant; other solvents and their mixture with water; isobaric activation parameters;
In dichloromethane at 20℃; Reflux;

: 348-54-9
2-Fluoroaniline

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 2-(2-fluoroanilino)-5-hydroxy-1,4-naphthoquinone

Conditions

Conditions	Yield
Stage #1: 5-hydroxynaphtho-1,4-quinone In ethanol for 0.25h; Stage #2: 2-Fluoroaniline In ethanol for 4h; Reflux;	100%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 481-40-3
1,4,5-trihydroxynaphthalene

Conditions

Conditions	Yield
With sodium dithionite In water; ethyl acetate at 30℃; for 0.5h; Inert atmosphere;	99%
With sodium dithionite In water; ethyl acetate at 30℃; for 0.5h; Inert atmosphere;	98.8%
With sodium dithionite In diethyl ether; dichloromethane; water at 20℃; for 0.25h; Solvent; Temperature;	68%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 100-39-0
benzyl bromide

: 75445-61-3
5-(benzyloxy)-1,4-dihydronaphthalene-1,4-dione

Conditions

Conditions	Yield
With silver(l) oxide In chloroform at 20℃; for 24h;	99%
With silver(l) oxide In chloroform	90%
With silver(l) oxide In chloroform for 2h;	80%
With silver(II) oxide In dichloromethane	65%
With silver(l) oxide In chloroform

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 75-03-6
ethyl iodide

: 22924-19-2
5-ethoxy-1,4-dihydronaphthalene-1,4-dione

Conditions

Conditions	Yield
With silver(l) oxide In dichloromethane at 20℃; for 20h; Green chemistry; regioselective reaction;	99%
With silver(l) oxide In chloroform at 20℃; for 24h;	97%
Stage #1: 5-hydroxynaphtho-1,4-quinone With potassium carbonate In acetone at 20℃; for 0.0833333h; Stage #2: ethyl iodide In acetone at 80℃; for 1h;	88%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 108-24-7
acetic anhydride

: 5196-28-1
juglone acetate

Conditions

Conditions	Yield
With triethylamine at 120℃; for 0.5h;	98%
With sulfuric acid for 0.25h; Cooling with ice;	93%
With sulfuric acid for 2h; Cooling with ice;	91%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 75909-37-4
(S)-(E)-1-(O-methylmandeloxy)butadiene

: 75920-38-6
(S)-Methoxy-phenyl-acetic acid (1R,4aS,9aS)-8-hydroxy-9,10-dioxo-1,4,4a,9,9a,10-hexahydro-anthracen-1-yl ester

Conditions

Conditions	Yield
With triacetoxyborane In chloroform 1.) 0 deg C, 2.) room temperature;	98%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 112-64-1
tetradecanoyl chloride

: 64817-83-0
juglone myristate

Conditions

Conditions	Yield
Stage #1: 5-hydroxynaphtho-1,4-quinone With triethylamine In diethyl ether at 20℃; for 0.5h; Stage #2: tetradecanoyl chloride In diethyl ether at 20℃; for 1h;	98%
With triethylamine In benzene Heating;
With dmap In dichloromethane at 0 - 20℃;

: 112-77-6
(Z)-9-octadecenoyl chloride

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 1340543-24-9
5-{(Z)-octadec-9-enoyloxy}-1,4-naphthoquinone

Conditions

Conditions	Yield
Stage #1: 5-hydroxynaphtho-1,4-quinone With triethylamine In diethyl ether at 20℃; for 0.5h; Stage #2: (Z)-9-octadecenoyl chloride In diethyl ether at 20℃; for 1h;	98%
With pyridine; dmap at 20℃; for 3h;

: 112-16-3
n-dodecanoyl chloride

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 1340543-22-7
5-O-dodecanoyloxy-1,4-naphthoquinone

Conditions

Conditions	Yield
Stage #1: 5-hydroxynaphtho-1,4-quinone With triethylamine In diethyl ether at 20℃; for 0.5h; Stage #2: n-dodecanoyl chloride In diethyl ether at 20℃; for 1h;	98%
With dmap In dichloromethane at 0 - 20℃;

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 77507-72-3
2-amino-8-hydroxy-naphthalene-1,4-dione

Conditions

Conditions	Yield
With hydrogenchloride; sodium azide In methanol; water for 6h; Ambient temperature;	97%
With hydrogenchloride; sodium azide In methanol; water at 30 - 35℃; for 22h; pH=4; Inert atmosphere;	94%
With trimethylsilylazide; triethylamine In N,N-dimethyl-formamide for 1h; Ambient temperature;	91%

: 1515-76-0
1-acetoxy-1,3-butadiene

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 86668-63-5
1-acetoxy-8-hydroxy-9,10-dioxo-1,4,4a,9,9a,10-hexahydroanthracene

Conditions

Conditions	Yield
	96.8%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 620-05-3
iodomethylbenzene

: 75445-61-3
5-(benzyloxy)-1,4-dihydronaphthalene-1,4-dione

Conditions

Conditions	Yield
With silver(l) oxide In chloroform Heating;	96%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 112-76-5
Stearoyl chloride

: 1340543-23-8
5-O-octadecanoyloxy-1,4-naphthoquinone

Conditions

Conditions	Yield
Stage #1: 5-hydroxynaphtho-1,4-quinone With triethylamine In diethyl ether at 20℃; for 0.5h; Stage #2: Stearoyl chloride In diethyl ether at 20℃; for 1h;	96%
With pyridine; dmap at 20℃; for 3h;

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 112-67-4
n-hexadecanoyl chloride

: 5-O-hexadecanoyloxy-1,4-naphthoquinone

Conditions

Conditions	Yield
Stage #1: 5-hydroxynaphtho-1,4-quinone With triethylamine In diethyl ether at 20℃; for 0.5h; Stage #2: n-hexadecanoyl chloride In diethyl ether at 20℃; for 1h;	96%
With dmap In dichloromethane at 0 - 20℃;	49%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 18855-92-0
3-chlorojuglone

Conditions

Conditions	Yield
With iodine; mercury dichloride; copper dichloride In acetic acid at 60℃; for 3h;	95%
Stage #1: 5-hydroxynaphtho-1,4-quinone With chlorine; acetic acid at 20℃; for 0.5h; Stage #2: In ethanol for 0.25h; Heating;	85%
Stage #1: 5-hydroxynaphtho-1,4-quinone With chlorine In acetic acid for 0.5h; Stage #2: With ethanol for 0.5h; Reflux;	56%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 69008-03-3
2-bromo-5-hydroxy-[1,4]naphthoquinone

Conditions

Conditions	Yield
With trichloro(N,N'-ethylene-bis-aminobenzamide)lanthanum(III); bromine In tetrachloromethane at 50℃; for 0.416667h; further reagent: trichloro(N,N'-ethylene-bis-aminobenzamide)samarium(III);	95%
With aluminum oxide; bromine for 1.5h; Ambient temperature; other reagents: iodine monobromide, acetic acid;	94%
With copper(II) bromide supported on alumina In various solvent(s) at 128℃; for 42h;	40%
With bromine In chloroform for 0.233333h;

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 542-92-7
cyclopenta-1,3-diene

: 73921-57-0, 132016-32-1, 144299-62-7, 144299-64-9
(1R*,4S*,4aR*,9aS*)-1,4,4a,9a-tetrahydro-5-hydroxy-1,4-methano-anthracene-9,10-quinone

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 2h; Diels-Alder reaction;	95%
In benzene for 1h; Heating;	75%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 77377-52-7
N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide

: 5-(dimethyl-t-butylsilyloxy)-1,4-naphthoquinone

Conditions

Conditions	Yield
With tert-butyldimethylsilyl chloride In acetonitrile at 60℃; for 0.5h;	95%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 4923-55-1
2-Hydroxyjuglon

Conditions

Conditions	Yield
Stage #1: 5-hydroxynaphtho-1,4-quinone With dimethyl amine In water for 1h; Stage #2: With hydrogenchloride; water for 24h; Reflux;	95%
Multi-step reaction with 2 steps 1: 20 percent / 30percent H2O2, K / toluene / 0.25 h / Ambient temperature 2: ccHCl View Scheme
Multi-step reaction with 2 steps 1: 30 percent / H2O / Ambient temperature 2: 90 percent / cond. HCl View Scheme
Multi-step reaction with 2 steps 1: dodecatungstosilic acid / 48 h / 20 °C 2: potassium hydroxide / methanol / 6 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: toluene; tetrahydrofuran / 24 h / -20 °C 2: hydrogenchloride; water / 1,4-dioxane / 5 h / Reflux View Scheme

: nickel(II) acetate hydrate

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 30846-01-6, 82512-18-3, 92219-51-7
Ni(C10H5O3)2(H2O)2

Conditions

Conditions	Yield
With NH3 In ethanol; water to aq. soln. Ni(OAc)2*H2O soln. 5-HNQ in boiling ethanol added slowly with stirring, pH adjusted to 5 with 25% NH3 and mixt. left stirring at room temp. for 3 h and kept in refrigerator overnight; ppt. washed with warm water, ethanol, diethyl ether and dried in vac. desiccator over P2O5; elem. anal.;	95%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 75-36-5
acetyl chloride

: 5196-28-1
juglone acetate

Conditions

Conditions	Yield
Stage #1: 5-hydroxynaphtho-1,4-quinone; acetyl chloride With dmap In dichloromethane at 20℃; for 1h; Stage #2: With triethylamine In dichloromethane	95%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 130814-75-4
(-)-{1-(R)-[(1E)-2-methylbuta-1,3-dienyloxy]ethyl}benzene

: 130814-84-5
1,4,4a,9a-Tetrahydro-8-hydroxy-2-methyl-1-(1-phenylethoxy)-9,10-anthraquinone

Conditions

Conditions	Yield
In toluene Heating;	93%

: 108-73-6
3,5-dihydroxyphenol

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 8-hydroxy-2-(2,4,6-trihydroxyphenyl)naphthalene-1,4-dione

Conditions

Conditions	Yield
With sulfuric acid In acetic acid at 20℃; under 760.051 Torr; for 2h; Inert atmosphere;	93%

: 481-39-0
5-hydroxynaphtho-1,4-quinone

: 107-30-2
chloromethyl methyl ether

: 176040-42-9
5-(methoxymethoxy)-1,4-naphthoquinone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 25℃; Substitution;	92%
With N-ethyl-N,N-diisopropylamine In dichloromethane for 14.25h; Inert atmosphere;	92%
With sodium hydride In tetrahydrofuran at 25℃; for 18h;	85%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 16h; Green chemistry; regioselective reaction;	79%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3h;

5-Hydroxy-1,4-naphthalenedione Chemical Properties

Chemistry informtion about 5-Hydroxy-1,4-naphthalenedione (CAS NO.481-39-0) is:
IUPAC Name: 5-Hydroxynaphthalene-1,4-dione
Synonyms: 1,4-Naphthalenedione,5-hydroxy- ; 1,4-Naphthoquinone, 5-hydroxy- ; 1,4-Naphthoquinone, 8-hydroxy- ; 4-Naphthalenedione,5-hydroxy-1 ; 5-Hydroxy-1,4-naftochinon ; 5-hydroxy-4-naphthalenedione ; 5-hydroxy-4-naphthoquinone ; 5-Hydroxynaphthoquinone
MF: C₁₀H₆O₃
MW: 174.15
EINECS: 207-567-5
Melting Point: 161-163 °C(lit.)
Density: 1.439 g/cm³
Flash Point: 201.3 °C
Boiling Point: 385.8 °C at 760 mmHg
Vapour Pressure: 1.67E-06 mmHg at 25°C
Enthalpy of Vaporization: 65.95 kJ/mol
Water Solubility: Soluble in hot water
Storage temp.: Refrigerator (+4°C)
Merck: 5269
Following is the molecular structure of 5-Hydroxy-1,4-naphthalenedione (CAS NO.481-39-0) is:

5-Hydroxy-1,4-naphthalenedione Production

Raw materials: N-Hydroxyphthalimide

5-Hydroxy-1,4-naphthalenedione Toxicity Data With Reference

1.	hma-mus/ast 10 mg/kg	PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 126 (1967),583.
2.	skn-mus TDLo:394 mg/kg/53W-I:NEO	JMCMAR Journal of Medicinal Chemistry. 21 (1978),26.
3.	orl-mus LD50:2500 µg/kg	SCIEAS Science. 134 (1961),1617.

5-Hydroxy-1,4-naphthalenedione Safety Profile

Poison by ingestion. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
T: Toxic
Risk Statements:
R25: Toxic if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements:
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S37/39: Wear suitable gloves and eye/face protection.
S28A: After contact with skin, wash immediately with plenty of water.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: QJ5775000
HazardClass: 6.1
PackingGroup: III

5-Hydroxy-1,4-naphthalenedione Specification

5-Hydroxy-1,4-naphthalenedione (CAS NO.481-39-0) is a oange to brown crystalline powder.It i insoluble in water.
First Aid Measures:
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Handling and Storage:
Storage:Store in a tightly closed container. Store in a cool, dry area away from incompatible substances.
Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Do not ingest or inhale. Use only in a chemical fume hood.

Product Name

5-Hydroxy-1,4-naphthalenedione

Synthetic route

5-Hydroxy-1,4-naphthalenedione Chemical Properties

5-Hydroxy-1,4-naphthalenedione Production

5-Hydroxy-1,4-naphthalenedione Toxicity Data With Reference

5-Hydroxy-1,4-naphthalenedione Safety Profile

5-Hydroxy-1,4-naphthalenedione Specification

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