6-tert-Butyl-m-cresol supplier

Name
6-tert-Butyl-m-cresol
EINECS 201-842-3
CAS No. 88-60-8
Article Data28
CAS DataBase
Density 0.961 g/cm³
Solubility Insoluble in water
Melting Point 20 °C
Formula C₁₁H₁₆O
Boiling Point 224 °C at 760 mmHg
Molecular Weight 164.247
Flash Point 105.6 °C
Transport Information UN 3145 8/PG 3
Appearance clear colorless viscous liquid
Safety 26-36/37/39-45
Risk Codes 22-36/37/38-34
Molecular Structure
Hazard Symbols Xn,C
Synonyms m-Cresol,6-tert-butyl- (6CI,8CI);2-tert-Butyl-5-methylphenol;3-Methyl-6-tert-butylphenol;5-Methyl-2-tert-butylphenol;6-tert-Butyl-3-methylphenol;NSC 48467;Phenol,2-(1,1-dimethylethyl)-5-methyl-;
PSA 20.23000
LogP 2.99810

Synthetic route

: 108-39-4
3-methyl-phenol

: 75-65-0
tert-butyl alcohol

A: 88-60-8
2-tert-Butyl-5-methylphenol

B: 497-39-2
4,6-di-tert-butyl-m-cresol

Conditions

Conditions	Yield
With carbon tetrabromide at 175℃; for 6h; Sealed tube;	A 74% B 8%
With carbon tetrabromide at 175℃; for 6h; Sealed tube;	A 56% B 36%

...Expand

: 88-40-4
2-tert-butyl-5-methylanisole

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
With boron triiodide-N,N-diethylaniline In benzene for 3h; Ambient temperature;	71%

: 108-39-4
3-methyl-phenol

: 75-65-0
tert-butyl alcohol

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
Stage #1: tert-butyl alcohol With sulfuric acid; urea at 10 - 25℃; Stage #2: 3-methyl-phenol at 0 - 20℃;	60%
With phosphoric acid at 50 - 55℃;
With 4 A molecular sieve at 250℃; Product distribution; Further Variations:; Reagents;
With zinc(II) chloride

: 107-39-1
2,4,4-trimethyl-1-pentene

: 108-39-4
3-methyl-phenol

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
With hydrogenchloride; iron(III) chloride

: 78-83-1
2-methyl-propan-1-ol

: 108-39-4
3-methyl-phenol

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
With phosphoric acid at 50 - 55℃;
With sulfuric acid

: 108-39-4
3-methyl-phenol

: 115-11-7
isobutene

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
With aluminium cresylate
With hydrogenchloride; iron(III) chloride
With aluminium(III) phenoxide at 100℃; for 2h;

: 108-39-4
3-methyl-phenol

: 115-11-7
isobutene

A: 88-60-8
2-tert-Butyl-5-methylphenol

B: 497-39-2
4,6-di-tert-butyl-m-cresol

Conditions

Conditions	Yield
With sulfuric acid at 93℃;
With sulfuric acid at 90℃;

...Expand

: 129167-74-4
2-bromo-1-(tert-butyl)-4-methylbenzene

: 594-19-4
tert.-butyl lithium

A: 88-60-8
2-tert-Butyl-5-methylphenol

B: 98-51-1
4-tert-butyltoluene

C: 103391-77-1
3,4-di-t-butyltoluene

Conditions

Conditions	Yield
With Cu2Br2-Me2S; oxygen 1.) hexane, THF, -78 deg C, 1 h, 2.) from -78 deg to RT, 1 h; Multistep reaction;

...Expand

: 129167-74-4
2-bromo-1-(tert-butyl)-4-methylbenzene

A: 88-60-8
2-tert-Butyl-5-methylphenol

B: 98-51-1
4-tert-butyltoluene

C: 103391-77-1
3,4-di-t-butyltoluene

Conditions

Conditions	Yield
With Cu2Br2-Me2S; tert.-butyl lithium; oxygen 1.) hexane, THF,-78 deg C, 1 h, 2.) from -78 deg C to RT, 1 h; Multistep reaction;
With Cu2Br2-Me2S; tert.-butyl lithium; oxygen 1.) hexane, THF, -78 deg C, 1 h, 2.) from -78 deg C to RT, 1 h; Multistep reaction;

...Expand

: 78-83-1
2-methyl-propan-1-ol

: 86119-84-8, 7664-38-2
phosphoric acid

: 108-39-4
3-methyl-phenol

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
at 60 - 80℃;

...Expand

: 7664-93-9
sulfuric acid

: 108-39-4
3-methyl-phenol

: 115-11-7
isobutene

A: 88-60-8
2-tert-Butyl-5-methylphenol

B: 497-39-2
4,6-di-tert-butyl-m-cresol

Conditions

Conditions	Yield
at 93℃;

...Expand

: 38473-89-1
3-bromo-4-(tert-butyl)benzoic acid

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: conc. H2SO4 / 8 h / Heating 2: 86 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature 3: 90 percent / pyridinium dichromate / CH2Cl2 / 0.17 h 4: 67 percent / 80percent hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 3 h / Heating 5: 1.) t-butyllithium, Cu2Br2-Me2S, 2.) O2 / 1.) hexane, THF, -78 deg C, 1 h, 2.) from -78 deg C to RT, 1 h View Scheme

Yield

Multi-step reaction with 5 steps
1: conc. H2SO4 / 8 h / Heating
2: 86 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature
3: 90 percent / pyridinium dichromate / CH2Cl2 / 0.17 h
4: 67 percent / 80percent hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 3 h / Heating
5: 1.) t-butyllithium, Cu2Br2-Me2S, 2.) O2 / 1.) hexane, THF, -78 deg C, 1 h, 2.) from -78 deg C to RT, 1 h
View Scheme

: 14034-08-3
methyl 3-bromo-4-(tert-butyl)benzoate

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 86 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature 2: 90 percent / pyridinium dichromate / CH2Cl2 / 0.17 h 3: 67 percent / 80percent hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 3 h / Heating 4: 1.) t-butyllithium, Cu2Br2-Me2S, 2.) O2 / 1.) hexane, THF, -78 deg C, 1 h, 2.) from -78 deg C to RT, 1 h View Scheme

: 129167-73-3
3-bromo-4-(tert-butyl)benzaldehyde

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 67 percent / 80percent hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 3 h / Heating 2: 1.) t-butyllithium, Cu2Br2-Me2S, 2.) O2 / 1.) hexane, THF, -78 deg C, 1 h, 2.) from -78 deg C to RT, 1 h View Scheme

: 129167-72-2
3-bromo-4-t-butylbenzyl alcohol

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 90 percent / pyridinium dichromate / CH2Cl2 / 0.17 h 2: 67 percent / 80percent hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 3 h / Heating 3: 1.) t-butyllithium, Cu2Br2-Me2S, 2.) O2 / 1.) hexane, THF, -78 deg C, 1 h, 2.) from -78 deg C to RT, 1 h View Scheme

: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 44 percent / Br2, AgNO3, AcOH, Ac2O, conc. HNO3 / H2O / 1.) RT, 30 min, 2.) from RT to boiling, 1 h 2: conc. H2SO4 / 8 h / Heating 3: 86 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature 4: 90 percent / pyridinium dichromate / CH2Cl2 / 0.17 h 5: 67 percent / 80percent hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 3 h / Heating 6: 1.) t-butyllithium, Cu2Br2-Me2S, 2.) O2 / 1.) hexane, THF, -78 deg C, 1 h, 2.) from -78 deg C to RT, 1 h View Scheme

Yield

Multi-step reaction with 6 steps
1: 44 percent / Br2, AgNO3, AcOH, Ac2O, conc. HNO3 / H2O / 1.) RT, 30 min, 2.) from RT to boiling, 1 h
2: conc. H2SO4 / 8 h / Heating
3: 86 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature
4: 90 percent / pyridinium dichromate / CH2Cl2 / 0.17 h
5: 67 percent / 80percent hydrazine hydrate, KOH / bis-(2-hydroxy-ethyl) ether / 3 h / Heating
6: 1.) t-butyllithium, Cu2Br2-Me2S, 2.) O2 / 1.) hexane, THF, -78 deg C, 1 h, 2.) from -78 deg C to RT, 1 h
View Scheme

: 108-39-4
3-methyl-phenol

: 95-48-7
ortho-cresol

: 88-60-8
2-tert-Butyl-5-methylphenol

: 108-39-4
3-methyl-phenol

: 88-60-8
2-tert-Butyl-5-methylphenol

: 108-39-4
3-methyl-phenol

: 75-65-0
tert-butyl alcohol

A: 88-60-8
2-tert-Butyl-5-methylphenol

B: 2219-72-9
4-tert-butyl-3-methyl-phenol

C: 15359-97-4
tert-butyl 3-methylphenyl ether

D: 608-49-1
3-methyl-2,6-di-tert-butyl-phenol

Conditions

Conditions	Yield
With N,N,N-triethyl-N-butanesulfonic acid ammonium hydrogen sulfate In cyclohexane at 69.84℃; for 1h;

...Expand

: 98-51-1
4-tert-butyltoluene

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: (1,5-cyclooctadiene)(methoxy)iridium(l) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / tetrahydrofuran / 40 h / 80 °C / Inert atmosphere 2: dihydrogen peroxide; sodium hydroxide / methanol; tetrahydrofuran / 1 h / 0 °C / Inert atmosphere View Scheme

: C13H19BO2

: 88-60-8
2-tert-Butyl-5-methylphenol

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium hydroxide In tetrahydrofuran; methanol at 0℃; for 1h; Inert atmosphere;

: 108-39-4
3-methyl-phenol

: 75-65-0
tert-butyl alcohol

A: 88-60-8
2-tert-Butyl-5-methylphenol

B: 2219-72-9
4-tert-butyl-3-methyl-phenol

Conditions

Conditions	Yield
With carbonized polymer-silica-triethanolamine-SO3H triphasic nanosphere at 129.84℃; for 2h; Reagent/catalyst;

...Expand

: 88-69-7
2-(1-methylethyl)phenol

propylphenol: propylphenol

butylphenol: butylphenol

A: mono-tert-butyl-m-cresol

B: 88-60-8
2-tert-Butyl-5-methylphenol

C: 40625-96-5
2,4-diisopropyl-5-methylphenol

Conditions

Conditions	Yield
With molybdenum(VI) oxide In ethanol at 280℃; for 4h; Inert atmosphere;

...Expand

: 88-60-8
2-tert-Butyl-5-methylphenol

: 51345-97-2
4-Bromo-2-tert-butyl-5-methyl-phenol

Conditions

Conditions	Yield
With tetra-N-butylammonium tribromide In methanol; dichloromethane at 20℃; for 1h;	99%
With N-Bromosuccinimide for 15h; Inert atmosphere;	93%
With N-Bromosuccinimide In N,N-dimethyl-formamide	92%
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 6h;	87%
With bromine In tetrachloromethane

: 88-60-8
2-tert-Butyl-5-methylphenol

: 73779-18-7
3-cyclohexylsalicyl alcohol

: 78576-66-6
6-tert-Butyl-2-(3-cyclohexyl-2-hydroxy-benzyl)-3-methyl-phenol

Conditions

Conditions	Yield
In xylene at 175℃; for 10h;	97%

: 121-00-6
3-tert-Butyl-4-hydroxyanisole

: 88-60-8
2-tert-Butyl-5-methylphenol

: C22H30O3

Conditions

Conditions	Yield
With 4,4'-di-tert-butylbiphenyl; 10-methyl-9-(2,4,6-trimethylphenyl) acridinium tetrafluoroborate at 35℃; for 48h; Reagent/catalyst; Irradiation;	97%

: 74-87-3
methylene chloride

: 88-60-8
2-tert-Butyl-5-methylphenol

: 88-40-4
2-tert-butyl-5-methylanisole

Conditions

Conditions	Yield
With sodium hydroxide; phosphonium resin In dichloromethane; water for 12h; Ambient temperature;	96%
With sodium hydroxide In dichloromethane; water Product distribution; Ambient temperature; various catalyst, various yield;

: 88-60-8
2-tert-Butyl-5-methylphenol

: 96-34-4
methyl chloroacetate

: 1011532-01-6
methyl 2-(2-tert-butyl-5-methylphenoxy)acetate

Conditions

Conditions	Yield
With potassium carbonate Heating / reflux;	96%

: 88-60-8
2-tert-Butyl-5-methylphenol

: ((1R,3S,5r,7r)-1'-(2,6-diisopropylphenyl)-4',4'-dimethylspiro[adamantane-2,3'-pyrrolidin]-2'-ylidene)copper(I)chloride

: C38H54CuNO

Conditions

Conditions	Yield
With sodium t-butanolate In tetrahydrofuran Schlenk technique; Inert atmosphere;	96%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 33534-87-1
α-(p-Methoxyphenyl)-malononitrile

: 2-(5-(tert-butyl)-4-hydroxy-2-methylphenyl)-2-(4-methoxyphenyl)malononitrile

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 60℃; for 15h; Inert atmosphere; Sealed tube;	95%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 157768-40-6
dimethyl 4-chlorophenylsulfonyloxymethylphosphonate

: dimethyl 2-tert-butyl-5-methylphenoxymethylphosphonate

Conditions

Conditions	Yield
With sodium hydride In dimethyl sulfoxide Ambient temperature;	94%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 108-24-7
acetic anhydride

: 198641-42-8
acetic acid-(2-tert-butyl-5-methyl-phenyl ester)

Conditions

Conditions	Yield
	93%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 123-38-6
propionaldehyde

: 4081-20-3
4,4'-propylidenebis(3-methyl-6-tert-butylphenol)

Conditions

Conditions	Yield
With hydrogenchloride In ethanol at 10 - 20℃; for 7h; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere;	92.4%
With hydrogenchloride In nitromethane at 80 - 90℃; for 6h;	17.4%
With hydrogenchloride

: 88-60-8
2-tert-Butyl-5-methylphenol

: 140668-87-7
p-methoxyphenylmalononitrile dimer

: 2-(5-(tert-butyl)-4-hydroxy-2-methylphenyl)-2-(4-methoxyphenyl)malononitrile

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 60℃; for 15h; Inert atmosphere; Sealed tube;	92%

: 50-00-0
formaldehyd

: 88-60-8
2-tert-Butyl-5-methylphenol

: 17977-47-8
2,2'-methylene-bis(6-tert.-butyl-3-methylphenol)

Conditions

Conditions	Yield
In xylene at 175℃; for 10h;	91%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 563-47-3
3-Chloro-2-methylpropene

: 1126854-69-0
1-tert-butyl-4-methyl-2-(2-methylallyloxy)benzene

Conditions

Conditions	Yield
Stage #1: 2-tert-Butyl-5-methylphenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Stage #2: 3-Chloro-2-methylpropene In N,N-dimethyl-formamide; mineral oil at 20℃;	91%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 90905-81-0
3-tert-butyl-2-hydroxybenzyl alcohol

: 78576-65-5
6-tert-Butyl-2-(3-tert-butyl-2-hydroxy-benzyl)-3-methyl-phenol

Conditions

Conditions	Yield
In xylene at 175℃; for 10h;	89%

: 92-39-7
2-chlorophenothiazine

: 88-60-8
2-tert-Butyl-5-methylphenol

: C23H22ClNOS

Conditions

Conditions	Yield
With oxygen; potassium carbonate In 1,2-dichloro-benzene at 130℃; for 6h;	89%

: 10419-77-9
diethyl iodomethanephosphonate

: 88-60-8
2-tert-Butyl-5-methylphenol

: 157768-37-1
4-tert-butyl-3-ethoxytoluene

Conditions

Conditions	Yield
With sodium hydride In N,N,N,N,N,N-hexamethylphosphoric triamide for 2.5h;	88%

: 88-60-8
2-tert-Butyl-5-methylphenol

paraformaldehyde: paraformaldehyde

: 73779-19-8
6-tert-Butyl-2-hydroxymethyl-3-methyl-phenol

Conditions

Conditions	Yield
In 1,2-dimethoxyethane; xylene at 135℃; for 12h;	87%

: 92-84-2
10H-phenothiazine

: 88-60-8
2-tert-Butyl-5-methylphenol

: C23H23NOS

Conditions

Conditions	Yield
With oxygen; potassium carbonate In 1,2-dichloro-benzene at 130℃; for 6h;	86%

: 39531-24-3
5-methyl-3-phenyl-1-benzofuran-2(3H)-one

: 88-60-8
2-tert-Butyl-5-methylphenol

: 3-(5-(tert-butyl)-4-hydroxy-2-methylphenyl)-5-methyl-3-phenylbenzofuran-2(3H)-one

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 60℃; for 15h; Inert atmosphere; Sealed tube;	86%

: 88-60-8
2-tert-Butyl-5-methylphenol

3-(4-methoxyphenyl)-5-isopropylbenzofuran-2(3H)-one: 3-(4-methoxyphenyl)-5-isopropylbenzofuran-2(3H)-one

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 60℃; for 18h; Inert atmosphere; Sealed tube;	85%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 2-bromo-6-tert-butyl-3-methyl-phenol

Conditions

Conditions	Yield
With N-Bromosuccinimide In Petroleum ether at 20℃; for 3h;	83%
With N-Bromosuccinimide In tetrachloromethane at 20℃;	60%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 2-(tert-butyl)-4-iodo-5-methylphenol

Conditions

Conditions	Yield
With sodium hypochlorite; sodium iodide; sodium hydroxide In methanol; water at -2 - 0℃; for 6h;	83%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 13522-86-6
2-iso-propyl-4-methoxyphenol

: C21H28O3

Conditions

Conditions	Yield
With 4,4'-di-tert-butylbiphenyl; 10-methyl-9-(2,4,6-trimethylphenyl) acridinium tetrafluoroborate at 35℃; for 48h; Irradiation;	83%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 5518-09-2
2-(naphthalen-1-yl)malononitrile

: 2-(5-(tert-butyl)-4-hydroxy-2-methylphenyl)-2-(naphthalen-1-yl)malononitrile

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 60℃; for 15h; Inert atmosphere; Sealed tube;	83%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 17302-51-1
2-tert-butyl-5-methyl-[1,4]benzoquinone-4-oxime

Conditions

Conditions	Yield
In water; isopropyl alcohol	82.9%
With hydrogenchloride; sodium nitrite

: 88-60-8
2-tert-Butyl-5-methylphenol

: 123-73-9
crotonaldehyde

: 1,1,1-tris(2-methyl-4-hydroxy-5-tert-butylphenyl)-butane

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water for 2h; Reflux;	82%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 5435-72-3
2-tert-Butyl-5-methyl-4-nitroso-phenol

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In ethanol; hexane; water; ethyl acetate	81%
With hydrogenchloride; sodium nitrite In ethanol; water at 0℃;
With concentrated hydrochloric acid; sodium nitrite In ethanol; hexane; water; ethyl acetate

: 88-60-8
2-tert-Butyl-5-methylphenol

: 80792-13-8
dimethyl <<(p-tolylsulfonyl)oxy>methyl>phosphonate

: dimethyl 2-tert-butyl-5-methylphenoxymethylphosphonate

Conditions

Conditions	Yield
With sodium hydride In dimethyl sulfoxide Ambient temperature;	80%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 2436-85-3
2-N,N-Dimethylaminonaphthalene

: 2-(tert-butyl)-4-(2-(dimethylamino)naphthalen-1-yl)-5-methylphenol

Conditions

Conditions	Yield
With (S,S)-(+)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamino chromium(III) chloride at 20℃; for 15h; Sealed tube; regioselective reaction;	79%

: 88-60-8
2-tert-Butyl-5-methylphenol

: 6-tert-butyl-2,3,4-trimethylphenol

Conditions

Conditions	Yield
	78%

6-tert-Butyl-m-cresol Chemical Properties

IUPAC Name: 2-tert-Butyl-5-methylphenol
Molecular Formula: C₁₁H₁₆O
Molecular Weight: 164.25 g/mol
Canonical SMILES: C(c1c(cc(C)cc1)O)(C)(C)C
InChI: InChI=1/C11H16O/c1-8-5-6-9(10(12)7-8)11(2,3)4/h5-7,12H,1-4H3
EINECS: 201-842-3
Product Categories: Industrial / Fine Chemicals; Miscellaneous; Organics
Index of Refraction: 1.513
Molar Refractivity: 51.34 cm³
Molar Volume: 170.8 cm³
Polarizability: 20.35×10^-24cm³
Surface Tension: 32.5 dyne/cm
Density: 0.961 g/cm³
Flash Point: 105.6 °C
Enthalpy of Vaporization: 47.92 kJ/mol
Boiling Point: 224 °C at 760 mmHg
Melting Point: 20 °C
Solubility: Insoluble in water.
Vapour Pressure of 6-tert-Butyl-m-cresol (CAS NO.88-60-8): 0.0626 mmHg at 25 °C

6-tert-Butyl-m-cresol Uses

6-tert-Butyl-m-cresol (CAS NO. 88-60-8) is used as organic synthesis intermediates,mainly for the production of phenolic antioxidants CA, antioxidant 300, antioxidant BBM.

6-tert-Butyl-m-cresol Production

6-tert-Butyl-m-cresol (CAS NO. 88-60-8) is derived from reaction of M-Cresol with Isobutylene in the presence of Aluminum chloride . Reaction carried out in concentrated sulfuric acid, the reaction temperature is 310-320 ℃. Reaction is complete, after neutralization, distillation, deriving 6-tert-Butyl-m-cresol.

6-tert-Butyl-m-cresol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	1080mg/kg (1080mg/kg)		Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 366, 1949.

6-tert-Butyl-m-cresol Safety Profile

Hazard Codes: Harmful Xn, Corrosive C
Risk Statements: 22-36/37/38-34
R22:Harmful if swallowed.
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 3145 8/PG 3
WGK Germany: 2
RTECS: SK1578180
HazardClass: 8
PackingGroup of 6-tert-Butyl-m-cresol (CAS NO.88-60-8): III

6-tert-Butyl-m-cresol Specification

6-tert-Butyl-m-cresol (CAS NO.88-60-8), its Synonyms are 2-(1,1-Dimethylethyl)-5-methylphenol ; 2-tert-Butyl-5-methylphenol ; 3-Methyl-6-tert-butylphenol ; 5-Methyl-2-tert-butylphenol ; 6-tert-Butyl-3-methylphenol ; Benzene, 1-tert-butyl-2-hydroxy-4-methyl- ; Phenol, 2-(1,1-dimethylethyl)-5-methyl- ; Phenol, 2-tert-butyl-5-methyl- ; m-Cresol, 6-tert-butyl- (8CI) . It is clear colorless viscous liquid.

Product Name

6-tert-Butyl-m-cresol

Synthetic route

6-tert-Butyl-m-cresol Chemical Properties

6-tert-Butyl-m-cresol Uses

6-tert-Butyl-m-cresol Production

6-tert-Butyl-m-cresol Toxicity Data With Reference

6-tert-Butyl-m-cresol Safety Profile

6-tert-Butyl-m-cresol Specification

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