Product Name

  • Name

    8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

  • EINECS 700-257-5
  • CAS No. 31251-41-9
  • Article Data13
  • CAS DataBase
  • Density 1.314 g/cm3
  • Solubility
  • Melting Point 90-92 °C
  • Formula C14H10ClNO
  • Boiling Point 433.614 °C at 760 mmHg
  • Molecular Weight 243.692
  • Flash Point 216.042 °C
  • Transport Information
  • Appearance Yellow solid
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 31251-41-9 (8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one)
  • Hazard Symbols IrritantXi
  • Synonyms 8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptan-5-one;
  • PSA 29.96000
  • LogP 3.06460

Synthetic route

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile
31255-57-9

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Stage #1: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile With trifluorormethanesulfonic acid at 60℃; for 1h;
Stage #2: With hydrogenchloride In water at 20℃; for 1h; Heating / reflux;
94%
With PPA at 200℃;45%
With PPA Heating;
3-[2-(5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide
251353-79-4

3-[2-(5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid methyl-phenyl-amide

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 0.166667h;91%
With n-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 0.166667h;78%
C14H11ClN2

C14H11ClN2

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
With water at 0 - 35℃; for 25 - 35h;76.4%
C14H11Cl2NO

C14H11Cl2NO

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
With aluminum (III) chloride In carbon disulfide40%
2-iodoyl-3,5-dichlorobenzoic acid
15396-37-9

2-iodoyl-3,5-dichlorobenzoic acid

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 121 g / (MeO)3B; BH3*Me2S / tetrahydrofuran / 18 h / 20 °C
2.1: PPh3; Br2 / acetonitrile / 1 h / 20 °C
3.1: LDA; t-BuOMe / various solvent(s); tetrahydrofuran / -30 - 0 °C
4.1: NaH / dimethylformamide / 1 h / 0 °C
4.2: 10 g / dimethylformamide / 0.25 h / 0 °C
5.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C
View Scheme
5-chloro-2-iodobenzyl alcohol
82386-90-1

5-chloro-2-iodobenzyl alcohol

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: PPh3; Br2 / acetonitrile / 1 h / 20 °C
2.1: LDA; t-BuOMe / various solvent(s); tetrahydrofuran / -30 - 0 °C
3.1: NaH / dimethylformamide / 1 h / 0 °C
3.2: 10 g / dimethylformamide / 0.25 h / 0 °C
4.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C
View Scheme
2-(bromomethyl)-4-chloro-1-iodobenzene
82386-91-2

2-(bromomethyl)-4-chloro-1-iodobenzene

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: LDA; t-BuOMe / various solvent(s); tetrahydrofuran / -30 - 0 °C
2.1: NaH / dimethylformamide / 1 h / 0 °C
2.2: 10 g / dimethylformamide / 0.25 h / 0 °C
3.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C
View Scheme
3-[2-(5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide
251353-78-3

3-[2-(5-chloro-2-iodo-phenyl)-ethyl]-pyridine-2-carboxylic acid phenylamide

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide / 1 h / 0 °C
1.2: 10 g / dimethylformamide / 0.25 h / 0 °C
2.1: 91 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.17 h / -78 °C
View Scheme
N-tert-butyl-3-methylpyridine-2-carboxamide
32998-95-1

N-tert-butyl-3-methylpyridine-2-carboxamide

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) n-BuLi / 1.) THF, -40 deg C
2: POCl3 / Heating
3: PPA / Heating
View Scheme
3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
107285-30-3

3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: POCl3 / Heating
2: PPA / Heating
View Scheme
1-Chloro-3-chloromethyl-benzene
620-20-2

1-Chloro-3-chloromethyl-benzene

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) n-BuLi / 1.) THF, -40 deg C
2: POCl3 / Heating
3: PPA / Heating
View Scheme
3-[2-(3-Chlorophenyl)ethyl]-pyridine-2-carboxylic acid hydrochloride
255861-49-5

3-[2-(3-Chlorophenyl)ethyl]-pyridine-2-carboxylic acid hydrochloride

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Stage #1: 3-[2-(3-Chlorophenyl)ethyl]-pyridine-2-carboxylic acid hydrochloride With thionyl chloride at 30 - 60℃;
Stage #2: aluminum (III) chloride In 1,2-dichloro-ethane at -5 - 20℃;
N-phenyl-3-[2-(3-chlorophenyl)ethyl]-2-pyridine carboxamide
271252-79-0

N-phenyl-3-[2-(3-chlorophenyl)ethyl]-2-pyridine carboxamide

phosphorus pentachloride
10026-13-8, 874483-75-7

phosphorus pentachloride

pyrographite
7440-44-0

pyrographite

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
aluminium trichloride In hexane; dichloromethane; toluene44.2 g (61%)
N-phenyl-3-[2-(3-chlorophenyl)ethyl]-2-pyridine carboxamide
271252-79-0

N-phenyl-3-[2-(3-chlorophenyl)ethyl]-2-pyridine carboxamide

pyrographite
7440-44-0

pyrographite

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
With trichlorophosphate In hexane; water; chlorobenzene44.1 g (50.8%)
3-(2-(3-chlorophenyl)ethenyl)pyridine-2-carboxylate

3-(2-(3-chlorophenyl)ethenyl)pyridine-2-carboxylate

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 4 h / 760.05 Torr
2: sodium hydroxide; water / ethanol / 48 h
3: thionyl chloride
4: aluminum (III) chloride / carbon disulfide
View Scheme
methyl 3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylate

methyl 3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylate

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; water / ethanol / 48 h
2: thionyl chloride
3: aluminum (III) chloride / carbon disulfide
View Scheme
3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylic acid

3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylic acid

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride
2: aluminum (III) chloride / carbon disulfide
View Scheme
isopropyl 3-(2-(3-chlorophenyl)ethenyl)pyridine-2-carboxylate

isopropyl 3-(2-(3-chlorophenyl)ethenyl)pyridine-2-carboxylate

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 48 h / 760.05 Torr
2: sodium hydroxide; water / ethanol / 5 h / Reflux
3: thionyl chloride
4: aluminum (III) chloride / carbon disulfide
View Scheme
isopropyl 3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylate

isopropyl 3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylate

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; water / ethanol / 5 h / Reflux
2: thionyl chloride
3: aluminum (III) chloride / carbon disulfide
View Scheme
C20H15ClN2

C20H15ClN2

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Conditions
ConditionsYield
With water; sodium hydroxide In tetrahydrofuran at 80 - 90℃; pH=10-11;
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

8-Chloro-6,11-Dihydro-11-Hydroxy-5H-Benzo[5,6]-Cyclohepta[1,2-b]Pyridine
133330-72-0

8-Chloro-6,11-Dihydro-11-Hydroxy-5H-Benzo[5,6]-Cyclohepta[1,2-b]Pyridine

Conditions
ConditionsYield
Stage #1: 8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h;
Stage #2: With hydrogenchloride In methanol; water
100%
With sodium tetrahydroborate In methanol at 10 - 20℃; for 2.75h;96.9%
With sodium tetrahydroborate In methanol a) 0 deg C, 2.5 h, b) from 0 deg C to 25 deg C, 1 h;
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

(1-methyl-4-piperidyl)magnesium chloride
63463-36-5

(1-methyl-4-piperidyl)magnesium chloride

8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
38089-93-9

8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol

Conditions
ConditionsYield
In tetrahydrofuran Reflux;95%
With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride In tetrahydrofuran; diethyl ether at 0℃; for 2h; Inert atmosphere;90%
In tetrahydrofuran at -95 - -15℃; for 2 - 3h;71.1%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

5,6-Dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one
3964-73-6

5,6-Dihydro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen; triethylamine In tetrahydrofuran at 20℃; for 24h;89%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

diethyl N-ethoxycarbonylpiperidine-4-phosphonate
216870-24-5

diethyl N-ethoxycarbonylpiperidine-4-phosphonate

C24H28ClN2O5P

C24H28ClN2O5P

Conditions
ConditionsYield
Stage #1: diethyl N-ethoxycarbonylpiperidine-4-phosphonate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -25 - -5℃; for 2h;
Stage #2: 8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one In tetrahydrofuran; hexane at -25 - -20℃; for 2h;
82%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

1-methylpiperidin-2-one
931-20-4

1-methylpiperidin-2-one

3-(8-Chloro-11-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-methyl-piperidin-2-one
212390-12-0

3-(8-Chloro-11-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-methyl-piperidin-2-one

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane 1.) -78 deg C, 30 min; -78 deg C to -5 deg C, 60 min, 2.) -78 deg C, 1 h; -78 deg C to -10 deg C, 1 h;76%
2-(4-formylphenyl)pyridine
127406-56-8

2-(4-formylphenyl)pyridine

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

C26H18ClN3

C26H18ClN3

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 10h; Reflux;75%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

methyl 4-formylbenzoate
1571-08-0

methyl 4-formylbenzoate

C23H17ClN2O2

C23H17ClN2O2

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 10h; Reflux;75%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

4-phenylsulfanyl-benzaldehyde
1208-88-4

4-phenylsulfanyl-benzaldehyde

C27H19ClN2S

C27H19ClN2S

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 8h; Reflux;74%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

Phenanthrene-9-carboxaldehyde
4707-71-5

Phenanthrene-9-carboxaldehyde

C29H19ClN2

C29H19ClN2

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 7h; Reflux;74%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

triethyl phosphite
122-52-1

triethyl phosphite

C18H21ClNO3P

C18H21ClNO3P

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 20℃; for 24h;73.8%
4-chloro-1-methylpiperidine
5570-77-4

4-chloro-1-methylpiperidine

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol
38089-93-9

8-chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol

Conditions
ConditionsYield
Stage #1: 4-chloro-1-methylpiperidine With magnesium; ethylene dibromide In tetrahydrofuran at 20 - 48℃;
Stage #2: 8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one In tetrahydrofuran at -80 - -70℃; for 2 - 3h; Product distribution / selectivity;
73.6%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

4-cyanobenzaldehyde
105-07-7

4-cyanobenzaldehyde

C22H14ClN3

C22H14ClN3

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 6h; Reflux;73%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

2,6-dibromobenzaldehyde
67713-23-9

2,6-dibromobenzaldehyde

C21H13Br2ClN2

C21H13Br2ClN2

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 6h; Reflux;73%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

4-styrylbenzaldehyde
32555-96-7

4-styrylbenzaldehyde

C29H21ClN2

C29H21ClN2

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 8h; Reflux;72%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

9H-fluorene-2-carbaldehyde
30084-90-3

9H-fluorene-2-carbaldehyde

C28H19ClN2

C28H19ClN2

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 6h; Reflux;71%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

N-(4-formylphenyl)carbazole
110677-45-7

N-(4-formylphenyl)carbazole

C33H22ClN3

C33H22ClN3

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 10h; Reflux;70%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

para-methanesulfonylbenzaldehyde
5398-77-6

para-methanesulfonylbenzaldehyde

C22H17ClN2O2S

C22H17ClN2O2S

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 10h; Reflux;70%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

6-fluorochromone-3-carboxaldehyde
69155-76-6

6-fluorochromone-3-carboxaldehyde

C24H14ClFN2O2

C24H14ClFN2O2

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 8h; Reflux;70%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

2,6-dichlorobenzaldehyde
83-38-5

2,6-dichlorobenzaldehyde

C21H13Cl3N2

C21H13Cl3N2

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 6h; Reflux;69%
1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde
4649-09-6

1H-pyrrolo[2,3-b]pyridin-3-carbaldehyde

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

C22H15ClN4

C22H15ClN4

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 8h; Reflux;68%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

4-(Methylthio)benzaldehyde
3446-89-7

4-(Methylthio)benzaldehyde

C22H17ClN2S

C22H17ClN2S

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 7h; Reflux;68%
4-benzooxazol-2-yl-benzaldehyde
27395-93-3

4-benzooxazol-2-yl-benzaldehyde

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

C28H18ClN3O

C28H18ClN3O

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 7h; Reflux;68%
2,2'-bithiophene-5-carboxaldehyde
3779-27-9

2,2'-bithiophene-5-carboxaldehyde

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

C23H15ClN2S2

C23H15ClN2S2

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 10h; Reflux;67%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

4-(diphenylamino)benzaldehyde
4181-05-9

4-(diphenylamino)benzaldehyde

C33H24ClN3

C33H24ClN3

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 10h; Reflux;66%
8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

dimethyl (8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)phosphonate

dimethyl (8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)phosphonate

Conditions
ConditionsYield
With phosphoric acid In chloroform at 20℃; for 12h;65%
3-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)prop-2-enal

3-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)prop-2-enal

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
31251-41-9

8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one

C35H25ClFN3

C35H25ClFN3

Conditions
ConditionsYield
With ammonium acetate; acetic acid for 7h; Reflux;65%

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Chemical Properties

Molecular structure of 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (CAS NO.31251-41-9) is:

Product Name: 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
CAS Registry Number: 31251-41-9
Systematic Name: 8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
Empirical Formula: C14H10ClNO
Molecular Weight: 243.6883
Melting Point: 90-92°C
Index of Refraction: 1.632
Molar Refractivity: 66.136 cm3
Molar Volume: 185.481 cm3
Surface Tension: 53.838 dyne/cm
Density: 1.314 g/cm3
Flash Point: 216.042 °C
Enthalpy of Vaporization: 68.959 kJ/mol
Boiling Point: 433.614 °C at 760 mmHg
Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Intermediates

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Uses

 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (CAS NO.31251-41-9) can be used as loratadine intermediate.

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Safety Profile

Hazard Codes: IrritantXi

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Specification

 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one , its cas register number is 31251-41-9. It also can be called 8-Chloro-10,11-Dihydro-4-Aza-5h-Dibenzo-(A,D)Cycloheptan-5-One ; 8-Chloro-5,6-Dihydro-11h-Benzo-(5,6)-Cyclohepta-(1,2-B)-Pyrimidine-11-On ; 8-Chloro-10,11-dihydro-4-aza-5 ; 4-Aza-8-chloro-10,11-dihydro-5H-benzo[a,d]cyclo-5-heptanone .It is a yellow solid.

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