• Name

  Acesulfame

• EINECS 251-622-6
• CAS No. 33665-90-6
• Article Data23
• CAS DataBase
• Density 1.512 g/cm³
• Solubility 270 g/L at 20 °C in water
• Melting Point 123-123.5°
• Formula C₄H₅NO₄S
• Boiling Point
• Molecular Weight 163.154
• Flash Point
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one2,2-dioxide;6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide;Acesulfam;Acesulfam H;Acetosulfam;
• PSA 80.85000
• LogP 0.69100

Synthetic route

6-methyl-2,3-dihydro-1,3-oxazin-2,4-dione-3-sulfo-fluoride

33665-90-6

acetosulfam

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetone	86%
With triethylamine In water; ethyl acetate	81%
With sodium hydroxide	81%
With potassium hydroxide In dichloromethane; water

99911-48-5

Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure

33665-90-6

acetosulfam

Conditions

Conditions	Yield
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With disulfuric acid In dichloromethane at -30 - 4℃; for 0.00116667 - 0.00569444h; Stage #2: With water In dichloromethane at 0 - 35℃; Product distribution / selectivity;	37 - 91 %Chromat.
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane at -30 - -10℃; Stage #2: With sulfuric acid; water In dichloromethane at 15 - 25℃; Product distribution / selectivity;	70 %Chromat.
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane at -35 - -25℃; Stage #2: With water at -22 - -5℃; for 0.166667h;
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane for 1.38889E-05h; Flow reactor; Stage #2: With water Time;	85 %Chromat.
Stage #1: Triethylammoniumsalz der Acetoacetamid-N-sulfonsaeure With sulfur trioxide In dichloromethane Stage #2: With water

5977-14-0

acetoacetamido

13637-84-8

fluorosulfonylchloride

33665-90-6

acetosulfam

Conditions

Conditions	Yield
With sodium hydroxide; triethylamine In sulfur dioxide

55589-62-3

potassium acesulfame

33665-90-6

acetosulfam

Conditions

Conditions	Yield
With hydrogenchloride In water pH=2;
With hydrogenchloride In water
With hydrogenchloride In water
With hydrogenchloride In water
With hydrogenchloride In water

33665-90-6

acetosulfam

55589-62-3

potassium acesulfame

Conditions

Conditions	Yield
With potassium hydroxide In methanol pH=6.8; pH-value;	97%
With potassium hydroxide In methanol; water at 35℃; Product distribution / selectivity;

copper (II) carbonate hydroxide

7732-18-5

water

33665-90-6

acetosulfam

tetraaqua-bis(6-methyl-1,2,3-oxathiazin-4(3H)-onato-2,2-dioxide)copper(II)

Conditions

Conditions	Yield
at 75℃; for 0.5h;	95%

...Expand

603-33-8

triphenylbismuthane

33665-90-6

acetosulfam

1422436-51-8

C14H13BiN2O8S2

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 4h; Temperature; Time;	91.8%

33665-90-6

acetosulfam

72827-09-9

4-Chloro-6-methyl-[1,2,3]oxathiazine 2,2-dioxide

Conditions

Conditions	Yield
With phosphorus pentachloride In tetrachloromethane Heating;	90%

603-33-8

triphenylbismuthane

33665-90-6

acetosulfam

A

Bi(3+)*3C4H4NO4S(1-)

B

71-43-2

benzene

Conditions

Conditions	Yield
In neat (no solvent) at 90℃; for 1h;	A 86% B n/a

...Expand

2022-85-7

Flucytosine

33665-90-6

acetosulfam

2C4H4FN3O*C4H5NO4S

Conditions

Conditions	Yield
at 20℃;

33665-90-6

acetosulfam

ammonium 6-methyl-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide

Conditions

Conditions	Yield
With ammonium carbonate In water at 75℃; for 0.5h;	Ca. 0.25 g

58-55-9

theophylline

33665-90-6

acetosulfam

THPAH12

Conditions

Conditions	Yield
In neat (no solvent, solid phase)

495-84-1

salicylaldehyde isonicotinoylhydrazone

33665-90-6

acetosulfam

C13H11N3O2*C4H5NO4S

Conditions

Conditions	Yield
In methanol at 20 - 60℃;

739319-89-2

cadmium(II) carbonate

7732-18-5

water

33665-90-6

acetosulfam

Cd(acesulfamate)2(H2O)2

Conditions

Conditions	Yield
at 75℃; for 0.5h;	Ca.0.4 g

...Expand

2CO3(2-)*2Pb(2+)*H2O*PbO

33665-90-6

acetosulfam

lead(II) acesulfamate

Conditions

Conditions	Yield
In water at 75℃; for 0.5h;	Ca.0.8 g

33665-90-6

acetosulfam

130-95-0

Quinine

C4H5NO4S*C20H24N2O2

Conditions

Conditions	Yield
In ethyl acetate for 336h; Solvent;

33665-90-6

acetosulfam

130-95-0

Quinine

2C4H5NO4S*C20H24N2O2

Conditions

Conditions	Yield
In ethanol Solvent;

33665-90-6

acetosulfam

A

5-chloroacesulfame potassium

B

55589-62-3

potassium acesulfame

Conditions

Conditions	Yield
With potassium hydroxide at 25℃; for 0.333333h;

C28H62N2(2+)*2HO(1-)

33665-90-6

acetosulfam

C28H62N2(2+)*2C4H4NO4S(1-)

Conditions

Conditions	Yield
In methanol

C30H66N2(2+)*2HO(1-)

33665-90-6

acetosulfam

C30H66N2(2+)*2C4H4NO4S(1-)

Conditions

Conditions	Yield
In methanol

C32H70N2(2+)*2HO(1-)

33665-90-6

acetosulfam

C32H70N2(2+)*2C4H4NO4S(1-)

Conditions

Conditions	Yield
In methanol

C34H74N2(2+)*2HO(1-)

33665-90-6

acetosulfam

C34H74N2(2+)*2C4H4NO4S(1-)

Conditions

Conditions	Yield
In methanol

C36H78N2(2+)*2HO(1-)

33665-90-6

acetosulfam

C36H78N2(2+)*2C4H4NO4S(1-)

Conditions

Conditions	Yield
In methanol

Acesulfame Chemical Properties

Acesulfame Uses

Acesulfame Specification