Aminopyrazine supplier | CasNO.5049-61-6

Name
Aminopyrazine
EINECS 225-748-7
CAS No. 5049-61-6
Article Data38
CAS DataBase
Density 1.217 g/cm³
Solubility soluble in water
Melting Point 118-120 °C(lit.)
Formula C₄H₅N₃
Boiling Point 250.905 °C at 760 mmHg
Molecular Weight 95.1038
Flash Point 129.08 °C
Transport Information
Appearance slightly yellow to beige crystalline powder
Safety 26-36/37/39
Risk Codes 36/37/38-11
Molecular Structure
Hazard Symbols Xi, F
Synonyms Pyrazinamine;Pyrazine, 1,2-dihydro-2-imino-;Pyrazine, 2-amino-;2-pyrazinamine;2-Amino Pyrazine;
PSA 51.80000
LogP 0.64000

Synthetic route

: 32111-21-0
2-iodopyrazine

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With copper(I) oxide; ammonia; potassium carbonate In 1,4-dioxane at 140℃; under 7757.43 Torr; for 16h;	92%
With copper(I) oxide; ammonium hydroxide; potassium carbonate at 140℃; for 16h; Inert atmosphere;	49%

: 24241-18-7
2-amino-3,5-dibromopyrazine

A: 5049-61-6
2-Aminopyrazine

B: 59489-71-3
5-amino-2-bromopyrazine

Conditions

Conditions	Yield
With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine In dimethyl sulfoxide regioselective reaction;	A 10% B 87%

: 19847-12-2
2-pyrazine carbonitrile

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With sodium hypochlorite; sodium hydroxide at 20 - 60℃; for 5h;	82.6%
With sodium hypochlorite; potassium hydroxide; sodium hydroxide at 40℃; for 2h; pH=8; Temperature;
With sodium hypochlorite; water; sodium hydroxide at -5 - 100℃;	74 g

: 14508-49-7
2-chloropyrazin

A: 5049-61-6
2-Aminopyrazine

B: 533930-18-6
di(pyrazin-2-yl)amine

Conditions

Conditions	Yield
With C46H71Cl3N2Pd; ammonia; sodium t-butanolate In 1,4-dioxane at 100℃; for 16h; Inert atmosphere; Schlenk technique;	A 79% B n/a

: 14508-49-7
2-chloropyrazin

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 50℃; for 24h; Inert atmosphere;	75%
With ammonia; water at 200℃;
With ammonia In dimethyl sulfoxide at 130℃;

: 136918-14-4
phthalimide

A: 5049-61-6
2-Aminopyrazine

B: 457099-33-1
2-(5-Amino-pyrazin-2-ylmethyl)-isoindole-1,3-dione

Conditions

Conditions	Yield
With sodium carbonate In CH2Cl2/MeOH; dichloromethane; trifluoroacetic acid	A n/a B 73%

: 290-37-9
1,4-pyrazine

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With potassium permanganate; potassium amide In ammonia for 0.166667h;	65%

: 4949-13-7
2-fluoropyrazine

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction;	52%

: 94777-52-3
2-(1-hydroxyethyl)pyrazine

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With sodium azide; methanesulfonic acid; trifluoroacetic acid In hexane at 40℃; for 12h;	45%

: N-cyclohexyl-2-phenylimidazo[1,2-a]pyrazin-3-amine

A: 5049-61-6
2-Aminopyrazine

B: 724-92-5
N-cicloesil-α-ossofenilacetamide

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 20℃; for 1h; Schlenk technique; chemoselective reaction;	A n/a B 28%

: 475641-51-1
N-(3',5'-dibromopyrazin-2'-yl)pyridinium aminide

A: 5049-61-6
2-Aminopyrazine

B: 1,4,8a,9-tetraaza-fluorene

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; potassium carbonate In acetonitrile; benzene at 80℃; for 24h;	A 20% B 24%

: 475641-51-1
N-(3',5'-dibromopyrazin-2'-yl)pyridinium aminide

: 71-43-2
benzene

A: 5049-61-6
2-Aminopyrazine

B: 1,4,8a,9-tetraaza-fluorene

C: 3-phenyl-pyrido[1',2':2,3]pyrazolo[5,4-b]pyrazine

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; potassium carbonate In acetonitrile at 80℃; for 24h;	A 20% B 24% C 20%

...Expand

: 98-96-4
pyrazinamide

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With sodium hypochlorite Behandeln des erhaltenen Natrium-Salzes der Pyrazinylcarbamidsaeure C5H5N3O2(Kristalle;Verfaerbung ab 257grad)mit wss.Saeuren.;

: 5424-01-1
3-aminopyrazinoic acid

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With diethylene glycol monoethyl ether acetate at 210 - 245℃;
With nitrobenzene
Erhitzen ueber den Schmelzpunkt;

: 487-21-8
Lumazine

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With sulfuric acid at 240 - 245℃;

: 2423-65-6
Pyrazin-N-Oxid(PyzNO)

A: 14508-49-7
2-chloropyrazin

B: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With sodium hydroxide; trichlorophosphate 1) 70 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;

: 88002-29-3
N-(Tetrazolyl-5')-2-pyrazinylamine

A: 5049-61-6
2-Aminopyrazine

B: 88002-33-9
[1,2,4] triazolo[1,5-a]pyrazin-2-amine

Conditions

Conditions	Yield
With PPA at 290℃;

: 17114-78-2
9-tert-butylfluorene

: C4H4N3(1-)*K(1+)

A: 5049-61-6
2-Aminopyrazine

B: 106358-48-9
potassium salt of 9-tert-butylfluorene

Conditions

Conditions	Yield
In dimethyl sulfoxide at 24.9℃; Equilibrium constant;

...Expand

: 98-97-5
2-pyrazylcarboxylic acid

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
With polystyrene Wang resin; diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid 1.) toluene, 100 deg C, 16 h, 2.) CH2Cl2, 5 min; Yield given; Multistep reaction;

: 487-21-8
Lumazine

: 7664-93-9
sulfuric acid

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
at 240 - 245℃;

3-amino-pyrazine-carboxylic acid-(2): 3-amino-pyrazine-carboxylic acid-(2)

: 5049-61-6
2-Aminopyrazine

Conditions

Conditions	Yield
beim Erhitzen ueber den Schmelzpunkt;

: 5049-61-6
2-Aminopyrazine

: 107-20-0
2-chloroethanal

: 274-79-3
imidazo[1,2-a]pyrazine

Conditions

Conditions	Yield
at 70℃;	100%
With sodium hydrogencarbonate at 100℃; for 48h; Inert atmosphere;	50%
With sodium hydrogencarbonate at 100℃; for 48h;	50%

: 5049-61-6
2-Aminopyrazine

: 1074-12-0
phenylglyoxal hydrate

: 27955-58-4
2-phenylimidazo<1,2-a>pyrazin-3(7H)-one

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane for 168h;	100%
With hydrogenchloride In ethanol at 20 - 25℃; for 18h;	49%
With hydrogenchloride In ethanol; water at 20℃; for 15h; Cyclization;	20%

: 5049-61-6
2-Aminopyrazine

: 4998-15-6
4-chlorophenylglyoxal

: 123488-69-7
2-(4-Chloro-phenyl)-7H-imidazo[1,2-a]pyrazin-3-one

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane for 264h;	100%

: 5049-61-6
2-Aminopyrazine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: (E)-N,N-dimethyl-N'-(pyrazin-2-yl)formimidamide

Conditions

Conditions	Yield
In toluene for 2.25h; Heating / reflux;	100%

: 5049-61-6
2-Aminopyrazine

: 203866-18-6
methyl (2S,4R)-N-(tert-butyloxy)carbonyl-4-fluoropyrrolidine-2-carboxylate

: 1109790-67-1
(2S,4R)-1-(4-(3-cyclopropyl-1H-pyrazol-5-ylamino)-6-morpholino-1,3,5-triazin-2-yl)-4-fluoro-N-(pyrazin-2-yl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
Stage #1: 2-Aminopyrazine With isopropylmagnesium chloride In tetrahydrofuran at 0 - 20℃; Stage #2: methyl (2S,4R)-N-(tert-butyloxy)carbonyl-4-fluoropyrrolidine-2-carboxylate In tetrahydrofuran at 20℃; for 4h;	100%

: 5049-61-6
2-Aminopyrazine

: 7732-18-5
water

: 543-90-8
cadmium(II) acetate

: Cd(aminopyrazine)(acetate)2(H20)

Conditions

Conditions	Yield
In ethanol at 25℃;	100%

...Expand

: 5049-61-6
2-Aminopyrazine

: 21720-40-1
2-aminopyrazine 1-oxide

Conditions

Conditions	Yield
With hydrogen fluoride; 3-chloro-benzenecarboperoxoic acid In methanol; N,N-dimethyl-formamide at 25℃; for 1h;	99%
With 3-chloro-benzenecarboperoxoic acid In acetone for 24h; Ambient temperature;	63%

: 5049-61-6
2-Aminopyrazine

: 931-53-3
Cyclohexyl isocyanide

: 100-52-7
benzaldehyde

: N-cyclohexyl-2-phenylimidazo[1,2-a]pyrazin-3-amine

Conditions

Conditions	Yield
With lanthanum chloride heptahydrate In neat (no solvent) at 60℃; for 0.416667h; Green chemistry;	99%
In neat (no solvent) at 20℃; for 2.5h; Sealed tube; Irradiation; Green chemistry;	96%
In neat (no solvent) at 160℃; for 1.5h; Green chemistry;	95%

...Expand

: 5049-61-6
2-Aminopyrazine

: 609-73-4
o-nitroiodobenzene

: N-(2-nitrophenyl)pyrazin-2-amine

Conditions

Conditions	Yield
With sodium phenoxide; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 80℃; for 2h;	99%

: 5049-61-6
2-Aminopyrazine

: 912540-27-3
Cu2(1,1'-(1,3-phenylene)-bis(4,4-dimethylpentane-1,3-dione(2-))2

: 912540-09-1
[Cu2(1,1'-(1,3-phenylene)-bis(4,4-dimethylpentane-1,3-dione(2-))2(aminopyrazine)]2

Conditions

Conditions	Yield
In tetrahydrofuran stirred soln. of Cu-complex and ligand in THF brought to boiling, cooled; Et2O slow diffused; elem. anal.;	99%

: 5049-61-6
2-Aminopyrazine

: 85-46-1
1-Naphthalenesulfonyl chloride

: N-pyrazin-2-yl-1-naphthalenesulfonamide

Conditions

Conditions	Yield
With pyridine at 0℃; for 2h; Inert atmosphere;	99%

: 626-60-8
3-Chloropyridine

: 5049-61-6
2-Aminopyrazine

: 1028223-88-2
N-(pyridin-3-yl)-pyrazin-2-amine

Conditions

Conditions	Yield
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; [(π-crotyl)Pd(BrettPhos)]OTf; potassium carbonate In tert-Amyl alcohol at 110℃; for 2h; Schlenk technique; Inert atmosphere;	99%
With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; [(π-crotyl)Pd(BrettPhos)]OTf; potassium carbonate In tert-Amyl alcohol at 110℃; for 2h; Schlenk technique; Inert atmosphere;	99%

: 5049-61-6
2-Aminopyrazine

: 24241-18-7
2-amino-3,5-dibromopyrazine

Conditions

Conditions	Yield
With N-Bromosuccinimide In acetonitrile at 100℃; for 0.0833333h; Solvent; Microwave irradiation;	98%
With 2,6-dimethylpyridine; bromine In dichloromethane	95%
With bromine; sodium hydrogencarbonate In acetic acid 1.) 2h, 2.) 1h;	91%

: 5049-61-6
2-Aminopyrazine

: 95-46-5
2-methylphenyl bromide

: N-o-tolylpyrazin-2-amine

Conditions

Conditions	Yield
With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In 1,4-dioxane at 100℃; for 20h;	98%
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 100℃; for 24h;	74%

: 5049-61-6
2-Aminopyrazine

: 104-87-0
4-methyl-benzaldehyde

: 135-19-3
β-naphthol

: 1094443-81-8
1-[p-methylphenyl(2-pyrazinylamino)methyl]naphthalene-2-ol

Conditions

Conditions	Yield
In water at 20℃; for 0.666667h;	98%
at 125℃; for 0.0666667h; Mannich reaction; Neat (no solvent);	89%

...Expand

: 5049-61-6
2-Aminopyrazine

: 104-88-1
4-chlorobenzaldehyde

: 135-19-3
β-naphthol

: 1094443-78-3
1-[p-chlorophenyl(2-pyrazinylamino)methyl]naphthalene-2-ol

Conditions

Conditions	Yield
In water at 20℃; for 0.666667h;	98%
at 125℃; for 0.0666667h; Mannich reaction; Neat (no solvent);	90%

...Expand

: 5049-61-6
2-Aminopyrazine

: 1122-91-4
4-bromo-benzaldehyde

: 135-19-3
β-naphthol

: 1094443-85-2
1-[p-bromophenyl(2-pyrazinylamino)methyl]naphthalene-2-ol

Conditions

Conditions	Yield
In water at 20℃; for 0.416667h;	98%
at 125℃; for 0.1h; Mannich reaction; Neat (no solvent);	93%

...Expand

: 5049-61-6
2-Aminopyrazine

: 2C21H11O6(3-)*C4H4N2*3Cu(2+)*H2O*13C3H7NO

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 2C21H11O6(3-)*C4H5N3*3Cu(2+)*H2O*12C3H7NO

Conditions

Conditions	Yield
at 120℃; for 6h; Autoclave;	98%

...Expand

: 5049-61-6
2-Aminopyrazine

: 383-63-1
ethyl trifluoroacetate,

: 129476-64-8
2,2,2-trifluoro-N-(pyrazin-2-yl)acetamide

Conditions

Conditions	Yield
With dmap In tetrahydrofuran for 48h; Reflux;	97.8%

: 5049-61-6
2-Aminopyrazine

: 603-35-0
triphenylphosphine

: 69982-02-1
1,1,1-triphenyl-N-(pyrazin-2-yl)-λ5-phosphanimine

Conditions

Conditions	Yield
With diethylazodicarboxylate In dichloromethane; toluene at 20℃; for 2.16667h; Mitsunobu type reaction;	97%
With hexachloroethane; triethylamine In acetonitrile 12 h, RT, then, reflux, 6 h;	64%
With hexachloroethane; triethylamine In benzene for 3h; Heating;	64%

: 5049-61-6
2-Aminopyrazine

: 13534-89-9
2,3-dibromopyridine

A: pyrido[3',2':4,5]imidazo[1,2-a]pyrazine

B: pyrido[2',3':4,5]imidazo[1,2-a]pyrazine

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium (0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,2-dimethoxyethane at 140℃; for 24h;	A n/a B 97%

...Expand

: 5049-61-6
2-Aminopyrazine

: 100-52-7
benzaldehyde

: 135-19-3
β-naphthol

: 1094443-75-0
1-[phenyl(2-pyrazinylamino)methyl]naphthalene-2-ol

Conditions

Conditions	Yield
In water at 20℃; for 0.583333h;	97%
at 125℃; for 0.05h; Mannich reaction; Neat (no solvent);	94%

...Expand

: 696-59-3
cis,trans-2,5-dimethoxytetrahydrofuran

: 5049-61-6
2-Aminopyrazine

: 50966-75-1
(pyrrolyl-1)-2 pyrazine

Conditions

Conditions	Yield
In water at 150℃; for 0.5h; Paal-Knorr condensation; Microwave irradiation;	97%

: 620-02-0
5-Methylfurfural

: 5049-61-6
2-Aminopyrazine

: 931-53-3
Cyclohexyl isocyanide

: 879592-50-4
N-cyclohexyl-2-(5-methylfuran-2-yl)imidazo[1,2-a]pyrazin-3-amine

Conditions

Conditions	Yield
Stage #1: 5-Methylfurfural; 2-Aminopyrazine With scandium tris(trifluoromethanesulfonate) In methanol at 20℃; for 1h; Ugi reaction; Stage #2: Cyclohexyl isocyanide In methanol Ugi reaction;	97%

...Expand

: 5049-61-6
2-Aminopyrazine

: 67-56-1
methanol

: 32111-28-7
N-methylpyrazin-2-amine

Conditions

Conditions	Yield
With C19H37IrN4(2+)*2I(1-); potassium carbonate at 120℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;	97%
With [Cp*Ir(2-(1H-benzo[d]imidazol-2-yl)-1H-benzo[d]imidazole)Cl][Cl]; caesium carbonate at 120℃; for 12h; Schlenk technique;	95%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydroxide at 150℃; for 12h; Inert atmosphere; Schlenk technique; Green chemistry;	90%

: 1191-99-7
2,3-dihydro-2H-furan

: 5049-61-6
2-Aminopyrazine

: 1-(pyrazin-2-yl)pyrrolidin-2-ol

Conditions

Conditions	Yield
With cerium(III) chloride heptahydrate In acetonitrile at 60℃;	97%

: 5049-61-6
2-Aminopyrazine

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 38846-64-9
2-ethynylbenzaldehyde

: N-(tert-butyl)-2-(2-ethynylphenyl)imidazo[1,2-a]pyrazin-3-amine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol at 20℃; for 12h; Inert atmosphere;	96%

...Expand

: 5049-61-6
2-Aminopyrazine

: 122-51-0
orthoformic acid triethyl ester

: 762-04-9
phosphonic acid diethyl ester

: 586344-70-9
tetraethyl [(pyrazin-2-ylamino)methylene]bis(phosphonate)

Conditions

Conditions	Yield
With copper(II) oxide In neat (no solvent) at 60℃; Microwave irradiation; Green chemistry;	96%

...Expand

: 5049-61-6
2-Aminopyrazine

: 139-66-2
diphenyl sulfide

: 13134-34-4
N-phenylpyrazin-2-ylamine

Conditions

Conditions	Yield
With SingaCycle-A1; potassium hexamethylsilazane In toluene at 100℃; for 24h; Schlenk technique; Inert atmosphere;	96%

: 5049-61-6
2-Aminopyrazine

: 7732-18-5
water

: 5970-45-6
zinc(II) acetate dihydrate

: Zn(2+)*2C4H5N3*2C2H3O2(1-)*4H2O

Conditions

Conditions	Yield
at 25℃; for 2h;	96%

...Expand

Aminopyrazine Chemical Properties

IUPAC Name: Pyrazin-2-amine
Synonyms of 2-Aminopyrazine (CAS NO.5049-61-6): Aminopyrazine ; Pyrazinamine
CAS NO: 5049-61-6
Molecular Formula: C₄H₅N₃
Molecular Weight: 95.10
Molecular Structure:
EINECS:225-748-7
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 0
Polar Surface Area: 29.02 Å²
Index of Refraction: 1.598
Molar Refractivity: 26.67 cm³
Molar Volume: 78.1 cm³
Surface Tension: 64.3 dyne/cm
Density: 1.216 g/cm³
Flash Point: 129.1 °C
Enthalpy of Vaporization: 48.82 kJ/mol
Boiling Point: 250.9 °C at 760 mmHg
Vapour Pressure: 0.0211 mmHg at 25°C
Melting Point: 118-120 °C(lit.)
Storage temp: Flammables area
Water Solubility: soluble
Appearance: slightly yellow to beige crystalline powder
Product Categories of 2-Aminopyrazine (CAS NO.5049-61-6): Fluorobenzene;pharmacetical;Pyrazine;API intermediates;Pyrazines;Chloropyrazines, etc.

Aminopyrazine Safety Profile

Safety Information about 2-Aminopyrazine (CAS NO.5049-61-6):
Hazard Codes: Irritant XiF
Risk Statements: 36/37/38-11
R11: Highly flammable.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3
HS Code: 29339990

Aminopyrazine Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Flammable solid.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Flammables-area.

Product Name

Aminopyrazine

Synthetic route

Aminopyrazine Chemical Properties

Aminopyrazine Safety Profile

Aminopyrazine Specification

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