Analgin supplier | CasNO.5907-38-0

Name
Analgin
EINECS 200-694-7
CAS No. 5907-38-0
Density
Solubility
Melting Point 221℃
Formula C₁₃H₁₆N₃NaO₄S
Boiling Point
Molecular Weight 351.359
Flash Point
Transport Information
Appearance White or almost white crystal powder
Safety 36/37
Risk Codes 63
Molecular Structure
Hazard Symbols Xn
Synonyms Dipyrone;Sulpyrine (TN);Sulpyrine (JAN);Dipyrone (USAN);Metamizole Sodium (Analgin);Benzalagen;
PSA 95.75000
LogP 1.50410

Synthetic route

: 50-00-0
formaldehyd

: 83-07-8
4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

: 77-78-1
dimethyl sulfate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

Conditions

Conditions	Yield
With sodium carbonate at 40℃; Neutralisieren und Erhitzen mit NaHSO3;

...Expand

: 519-98-2
4-methylaminoantipyrine

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

Conditions

Conditions	Yield
With sodium hydrogensulfite dann Behandeln mit Formaldehyd-Loesung und anschliessendem Erwaermen;

: cobalt(II) chloride hexahydrate

: 93-68-5
3-oxo-N-o-tolylbutanamide

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: [cobalt(II)(Cl)(C11H12NO2)(2,3-dimethyl-4-methylaminomethanesulphonate sodium monohydrate-1-phenyl-3-pyrazoline-5-one)(H2O)2]

Conditions

Conditions	Yield
With NH3 In ethanol byproducts: H2O, HCl; addn. of ligands to soln. of co-salt (stirring), refluxing (1 h, 80°C), cooling, neutralization (NH3); filtration, washing (EtOH), drying (vac.); elem. anal.;	69%

...Expand

: cobalt(II) chloride hexahydrate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 102-01-2
N-phenylacetoacetamide

: [cobalt(II)(Cl)(C10H10NO2)(2,3-dimethyl-4-methylaminomethanesulphonate sodium monohydrate-1-phenyl-3-pyrazoline-5-one)(H2O)2]

Conditions

Conditions	Yield
With NH3 In ethanol byproducts: H2O, HCl; addn. of ligands to soln. of co-salt (stirring), refluxing (1 h, 80°C), cooling, neutralization (NH3); filtration, washing (EtOH), drying (vac.); elem. anal.;	68%

...Expand

: 92-15-9
2'-methoxyacetoacetanilide

: cobalt(II) chloride hexahydrate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: [cobalt(II)(Cl)(C11H12NO3)(2,3-dimethyl-4-methylaminomethanesulphonate sodium monohydrate-1-phenyl-3-pyrazoline-5-one)(H2O)2]

Conditions

Conditions	Yield
With NH3 In ethanol byproducts: H2O, HCl; addn. of ligands to soln. of co-salt (stirring), refluxing (1 h, 80°C), cooling, neutralization (NH3); filtration, washing (EtOH), drying (vac.); elem. anal.;	67%

...Expand

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 102-01-2
N-phenylacetoacetamide

: mercury dichloride

: chloro(2,3-dimethyl-4-methylaminomethanesulphonate sodium-1-phenyl-3-pyrazoline-5-one)(acetoacetanilidato)mercury(II)

Conditions

Conditions	Yield
In ethanol mixing stoichiometric quantities of HgCl2, acetoacetanilide and pyrazoline-5-one derivative in ethanol, refluxing for 15-20 min over a hot plate at 80°C to yield a transparent soln., further refluxing for 1-3 h, pptn.; filtn. by suction, washing several times with EtOH, drying in a desiccator over anhyd. CaCl2 at room temp. to a constant weight, elem. anal.;	60%

...Expand

: potassium pentacyanonitrosylchromate(III) monohydrate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 2Na(1+)*(Cr(NO)(CN)2H2O(C6H5NNCH3CCH3(CO)CNCH3CH2SO3)2)(2-)=Cr(NO)(CN)2H2O(C6H5NNCH3CCH3(CO)CNCH3CH2SO3Na)2

Conditions

Conditions	Yield
In water; acetic acid byproducts: CH3COOK, HCN; aq. acetic acid; addn. of aq. soln. of ligand to aq. soln. of K3(Cr(NO)(CN)5), pptn. (heating, 80°C, 35 min), liberating of HCN (purged with CO2, 3 h); sepn. (filtration off), washing (dil. CH3COOH, water), drying (room temp., vac., to const. wt.); elem. anal.;	58%

: 118-93-4
o-hydroxyacetophenone

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: mercury dichloride

: chloro(2,3-dimethyl-4-methylaminomethanesulphonate sodium-1-phenyl-3-pyrazoline-5-one)(o-hydroxyacetophenonato)mercury(II)

Conditions

Conditions	Yield
In ethanol mixing stoichiometric quantities of HgCl2, o-hydroxyacetophenone and pyrazoline-5-one derivative in ethanol, refluxing for 15-20 min over a hot plate at 80°C to yield a transparent soln., further refluxing for 1-3 h, pptn.; filtn. by suction, washing several times with EtOH, drying in a desiccator over anhyd. CaCl2 at room temp. to a constant weight, elem. anal.;	58%

...Expand

: nickel(II) chloride hexahydrate

: 59261-47-1
4-benzoyloxime-3-methyl-1-phenyl-2-pyrazoline-5-one

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: bis(4-benzoyloxime-3-methyl-1-phenyl-2-pyrazoline-5-ono)bis(2,3-dimethyl-4-methylaminomethanesulfonate sodium-1-phenyl-3-pyrazoline-5-one)nickel(II)

Conditions

Conditions	Yield
In ethanol; water mixt. of aq. soln. of NiCl2 and ethanolic soln. of ligands refluxed for 30-60 min; ppt. filtered by suction, washed (ethanol), dried in vac.; elem. anal.;	56%

...Expand

: vanadyl(IV) sulphate pentahydrate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 50433-20-0
potassium succinimide

: di(succinimido)aqua(2,3-dimethyl-4-methylamino(methanesulfonate sodium)-1-phenyl-3-pyrazoline-5-one)oxovanadium(IV)

Conditions

Conditions	Yield
In ethanol; water to mixt. of aq. soln. of VOSO4 and KN(C(O)CH2)2 ethanolic soln. of pyrazoline derivative added, soln. refluxed for 30-40 min at 80 °C, stand for 30 min; ppt. filtered, washed (1:1 H2O/C2H5OH), dried (dessicator over anhydrousCaCl2); elem. anal.;	56%

...Expand

: ammonium thiocyanate

: 10213-10-2
sodium tungstate (VI) dihydrate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: WO2(NCS)2(C13H16N3O4S)(1-)*Na(1+)*H2O=NaWC15H18N5O7S3

Conditions

Conditions	Yield
In hydrogenchloride; water room temp., pptn.; filtration, washing (HCl(aq.)); elem. anal.;	55%

...Expand

: 2H(1+)*[Mo(NO)(CN)5](2-)=H2[Mo(NO)(CN)5]

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: Mo(NO)(CN)3[(C6H5)C3N2(O)(CH3)2[N(CH3)CH2SO3]](1-)*Na(1+)*H2O=Mo(NO)(CN)3[(C6H5)C3N2(O)(CH3)2[N(CH3)CH2SO3Na*H2O]]

Conditions

Conditions	Yield
In acetic acid aq. acetic acid; to Mo-comp. pyrazoline-comp. in H2O-CH3COOH mixture 1:1 added with shaking, refluxed for 3 h; filtered by suction, washed with 5% dilute CH3COOH and H2O, dried in vac. at room temp., elem. anal.;	52%

: cobalt(II) nitrate hexahydrate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 3449-05-6
2-(salicylideneamino)thiophenol

: (2,3-dimethyl-4-methyl-aminomethanesulphonate sodium-1-phenyl-3-pyrazoline-5-one)(2-hydroxybenzalidene-aminothiophenolato)(H2O)cobalt(II)

Conditions

Conditions	Yield
In ethanol byproducts: HNO3, H2O; refluxing ethanolic solns. of metal(II) salt and ligands for 2-5 h, pptn.; filtn., washing several times with ethanol, drying in a desiccator over anhyd. CaCl2, elem. anal.;	50%

...Expand

: 557-42-6
zinc(II) thiocyanate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: Zn(NCS)2(C13H16N3OSO3)2(2-)*2Na(1+)*2H2O = Zn(NCS)2(C13H16N3OSO3Na)2*2H2O

Conditions

Conditions	Yield
In ethanol refluxing (6 h); filtn., washing (EtOH), drying (vac., room temp.); elem anal.;	50%

: copper(II) choride dihydrate

: 122630-45-9, 150063-91-5, 7361-93-5
salicylaldehyde anthranilic acid

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: (2,3-dimethyl-4-methyl-aminomethanesulphonate sodium-1-phenyl-3-pyrazoline-5-one)(2-hydroxybenzalidene-anthranilato)(H2O)copper(II)

Conditions

Conditions	Yield
In ethanol byproducts: HCl, H2O; refluxing ethanolic solns. of metal(II) salt and ligands for 2-5 h, pptn.; filtn., washing several times with ethanol, drying in a desiccator over anhyd. CaCl2, elem. anal.;	48%

...Expand

: copper(II) choride dihydrate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 3449-05-6
2-(salicylideneamino)thiophenol

: (2,3-dimethyl-4-methyl-aminomethanesulphonate sodium-1-phenyl-3-pyrazoline-5-one)(2-hydroxybenzalidene-aminothiophenolato)(H2O)copper(II)

Conditions

Conditions	Yield
In ethanol byproducts: HCl, H2O; refluxing ethanolic solns. of metal(II) salt and ligands for 2-5 h, pptn.; filtn., washing several times with ethanol, drying in a desiccator over anhyd. CaCl2, elem. anal.;	47%

...Expand

: cobalt(II) nitrate hexahydrate

: 122630-45-9, 150063-91-5, 7361-93-5
salicylaldehyde anthranilic acid

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: (2,3-dimethyl-4-methyl-aminomethanesulphonate sodium-1-phenyl-3-pyrazoline-5-one)(2-hydroxybenzalidene-anthranilato)(H2O)cobalt(II)

Conditions

Conditions	Yield
In ethanol byproducts: HNO3, H2O; refluxing ethanolic solns. of metal(II) salt and ligands for 2-5 h, pptn.; filtn., washing several times with ethanol, drying in a desiccator over anhyd. CaCl2, elem. anal.;	45%

...Expand

: 592-85-8
mercury(II) thiocyanate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: Hg(NCS)2(C13H16N3OSO3)2(2-)*2Na(1+)*2H2O = Hg(NCS)2(C13H16N3OSO3Na)2*2H2O

Conditions

Conditions	Yield
In ethanol refluxing (4 h); filtn., washing (EtOH), drying (vac., room temp.); elem anal.;	30%

: potassium monoaquatetracyanonitrosylcobaltate(I) monohyderate

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: K2[Co(NO)(CN)4(2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one)]

Conditions

Conditions	Yield
In ethanol; water addn. of alcoholic soln. of ligand to aq. soln. of Co-complex, shaking, refluxing (4 - 5 h, 80°C, pptn.); filtration, washing (alcohol), drying (vac., over CaCl2, room temp.); elem. anal.;	28%

: bis(acetylacetonate)oxidovanadium(IV)

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: oxovanadium(IV)(acetylacetone)2(2,3-dimethyl-4-methylaminomethanesulphonate sodiummonohydrate-1-phenyl-3-pyrazoline-5-one) complex

Conditions

Conditions	Yield
In ethanol; chloroform molar ratio V-complex (in chloroform) / ligand (in ethanol) = 1:1, refluxing (3 h); washing (chloroform), drying (over CaCl2, room temp.); elem. anal.;	20%

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: cadmium(II) iodide

: (1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate sodium)I2cadmium(II)

Conditions

Conditions	Yield
In ethanol refluxing ethanolic solns. of the Cd-halide and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.;

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 10108-64-2
cadmium(II) chloride

: (1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate sodium)Cl2cadmium(II)

Conditions

Conditions	Yield
In ethanol refluxing ethanolic solns. of the Cd-halide and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.;

: cobalt(II)

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 84110-65-6
(1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate)cobalt(II)

Conditions

Conditions	Yield
In ethanol refluxing ethanolic solns. of the metal(II) halide or perchlorate and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.;

: copper(II) ion

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 791031-41-9, 84110-67-8
(1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate)copper(II)

Conditions

Conditions	Yield
In ethanol refluxing ethanolic solns. of the metal(II) halide or perchlorate and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.;

: nickel(II)

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 84110-66-7
(1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate)nickel(II)

Conditions

Conditions	Yield
In ethanol refluxing ethanolic solns. of the metal(II) halide or perchlorate and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.;

: zinc(II) cation

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: 84110-68-9
(1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate)zinc(II)

Conditions

Conditions	Yield
In ethanol refluxing ethanolic solns. of the metal(II) halide or perchlorate and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.;

: 5907-38-0
2,3-dimethyl-4-dimethylaminomethanesulphonatesodium monohydrate-1-phenyl-3-pyrazoline-5-one

: cadmium(II) bromide

: (1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sulphonate sodium)Br2cadmium(II)

Conditions

Conditions	Yield
In ethanol refluxing ethanolic solns. of the Cd-halide and analgin for ca 30 min in 1:2 metal:ligand ratio; recrystn. from EtOH and drying over fused CaCl2; elem. anal.;

Analgin Chemical Properties

Molecular Formula of Analgin (CAS NO.5907-38-0): C₁₃H₁₈N₃NaO₅S
Molecular Weight: 351.35
storage temp.: 2-8 °C
Appearance: White or light yellow crystalline powder, odorless, tiny bitter
Structure of Analgin (CAS NO.5907-38-0):

IUPAC Name: Sodium[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-methylamino]methanesulfonate

Analgin Uses

Analgin (CAS NO.5907-38-0) is antipyretic analgesics of pyrazolones. It is indicated for treatment diseases caused by high fever and various pain. It is also indicated in fever, headache, rheumatic pain, neuralgia and dysmenorrheal ect.

Analgin Specification

Analgin , its cas register number is 5907-38-0. It also can be called Dipyron ; Metamizol ; Methapyrone ; Sulpyrine ; and Sodium [(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-methyl-amino]methanesulfonate .

Product Name

Analgin

Synthetic route

Analgin Chemical Properties

Analgin Uses

Analgin Specification

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