Product Name

  • Name

    Aniline hydrochloride

  • EINECS 205-519-8
  • CAS No. 142-04-1
  • Article Data180
  • CAS DataBase
  • Density 1.2215 g/cm3
  • Solubility 1070 g/L (25 °C) in water
  • Melting Point 196-198 °C(lit.)
  • Formula C6H7N.HCl
  • Boiling Point 184.4 °C at 760 mmHg
  • Molecular Weight 129.589
  • Flash Point 70 °C
  • Transport Information UN 1548 6.1/PG 3
  • Appearance white to off-white crystals
  • Safety 26-27-36/37/39-45-61-63
  • Risk Codes 23/24/25-40-41-43-48/23/24/25-50-68
  • Molecular Structure Molecular Structure of 142-04-1 (Aniline hydrochloride)
  • Hazard Symbols ToxicT, DangerousN
  • Synonyms Aniline,hydrochloride (6CI,8CI);Benzenamine, hydrochloride (9CI);Anilinium chloride;C.I. 76001;Phenylamine hydrochloride;Phenylammonium chloride;
  • PSA 26.02000
  • LogP 2.65200

Synthetic route

nitrobenzene
98-95-3

nitrobenzene

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; iron(III)-acetylacetonate; 1,1,3,3-Tetramethyldisiloxane In tetrahydrofuran; water at 60℃; for 24h;99%
Stage #1: nitrobenzene With iron(III) acetylacetonate; 1,1,3,3-Tetramethyldisiloxane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; Sealed tube;
Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether for 0.0833333h;
99%
Stage #1: nitrobenzene With hydrogen In ethanol at 25℃; under 11172.7 Torr; Flow reactor;
Stage #2: With hydrogenchloride In ethanol Flow reactor; chemoselective reaction;
99%
2-anilino-2-hydroxy-1,3-diphenyl-propane-1,3-dione
37596-06-8

2-anilino-2-hydroxy-1,3-diphenyl-propane-1,3-dione

A

1,3-diphenyl-propane-1,2,3-trione
643-75-4

1,3-diphenyl-propane-1,2,3-trione

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In dichloromethane; water at 20℃;A 98%
B n/a
ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

Acetanilid
103-84-4

Acetanilid

A

aniline hydrochloride
142-04-1

aniline hydrochloride

B

butanone
78-93-3

butanone

Conditions
ConditionsYield
Stage #1: Acetanilid With 2-fluoropyridine; trifluoromethylsulfonic anhydride In dichloromethane at 0℃; for 0.5h;
Stage #2: ethylmagnesium bromide With cerium(III) chloride In tetrahydrofuran; dichloromethane at -78℃; for 2h;
Stage #3: With hydrogenchloride In ethyl acetate
A 70%
B n/a
isovaleranilide
2364-50-3

isovaleranilide

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

A

5-methyl-3-hexanone
623-56-3

5-methyl-3-hexanone

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
Stage #1: isovaleranilide With 2-fluoropyridine; trifluoromethylsulfonic anhydride In dichloromethane at 0℃; for 0.5h;
Stage #2: ethylmagnesium bromide With cerium(III) chloride In tetrahydrofuran; dichloromethane at -78℃; for 2h;
Stage #3: With hydrogenchloride In ethyl acetate
A n/a
B 63%
bis(diphenyl)urea
102-07-8

bis(diphenyl)urea

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With ammonium bromide; ethylenediamine at 80℃; for 5h; Microwave irradiation;76%
aniline
62-53-3

aniline

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 20℃; for 1.5h; Cooling with ice;100%
With hydrogenchloride In acetic acid at 0.5℃;
With hydrogenchloride In isopropyl ether
2-phenylimino-4,4,5,5-tetramethyl-1,3-dioxolane
25815-21-8

2-phenylimino-4,4,5,5-tetramethyl-1,3-dioxolane

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; methanol In diethyl ether at 20℃; for 1.5h;96%
4-nitro-1-(2'-N-methylimidazoyl)benzene

4-nitro-1-(2'-N-methylimidazoyl)benzene

4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; trifluoroacetic acid; palladium In ethanol
4-chlorobenzonitrile
100-00-5

4-chlorobenzonitrile

A

p-chloroaniline hydrochloride
20265-96-7

p-chloroaniline hydrochloride

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
Stage #1: 4-chlorobenzonitrile With hydrogen In ethanol at 25℃; under 7448.5 Torr; Flow reactor;
Stage #2: With hydrogenchloride In ethanol Flow reactor; chemoselective reaction;
A 72%
B n/a
(Z)-7-benzyloxy-3-ethoxymethyl-2-phenylimino-2H-chromene
1195865-07-6

(Z)-7-benzyloxy-3-ethoxymethyl-2-phenylimino-2H-chromene

A

7-benzyloxy-3-ethoxymethylcoumarin
1195865-20-3

7-benzyloxy-3-ethoxymethylcoumarin

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; Cooling with ice;A 87%
B n/a
(Z)-3-ethoxymethyl-8-methoxy-2-phenylimino-2H-chromene
1195865-10-1

(Z)-3-ethoxymethyl-8-methoxy-2-phenylimino-2H-chromene

A

3-ethoxymethyl-8-methoxycoumarin
1195865-23-6

3-ethoxymethyl-8-methoxycoumarin

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; Cooling with ice;A 85%
B n/a
(Z)-3-ethoxymethyl-7-methoxy-2-phenylimino-2H-chromene
1195865-08-7

(Z)-3-ethoxymethyl-7-methoxy-2-phenylimino-2H-chromene

A

3-ethoxymethyl-7-methoxycoumarin
1195865-21-4

3-ethoxymethyl-7-methoxycoumarin

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; Cooling with ice;A 81%
B n/a
(Z)-3-butoxymethyl-2-phenylimino-2H-chromene
1195865-00-9

(Z)-3-butoxymethyl-2-phenylimino-2H-chromene

A

3-butoxymethylcoumarin
1195865-15-6

3-butoxymethylcoumarin

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; Cooling with ice;A 77%
B n/a
(Z)-6-chloro-3-ethoxymethyl-2-phenylimino-2H-chromene
1195865-02-1

(Z)-6-chloro-3-ethoxymethyl-2-phenylimino-2H-chromene

A

6-chloro-3-ethoxymethylcoumarin
1195865-17-8

6-chloro-3-ethoxymethylcoumarin

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; Cooling with ice;A 75%
B n/a
2,4-dichlorothieno[2,3-d]pyrimidine
18740-39-1

2,4-dichlorothieno[2,3-d]pyrimidine

A

aniline hydrochloride
142-04-1

aniline hydrochloride

B

2-Chloro-4-(phenylamino)thieno[2,3-d]pyrimidine
134372-89-7

2-Chloro-4-(phenylamino)thieno[2,3-d]pyrimidine

Conditions
ConditionsYield
With aniline In diethyl ether; ethanol
With aniline In diethyl ether; ethanol
(Z)-6-bromo-3-ethoxymethyl-2-phenylimino-2H-chromene
1195865-03-2

(Z)-6-bromo-3-ethoxymethyl-2-phenylimino-2H-chromene

A

6-bromo-3-ethoxymethylcoumarin
1195865-18-9

6-bromo-3-ethoxymethylcoumarin

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; Cooling with ice;A 71%
B n/a
(Z)-3-methoxymethyl-2-phenylimino-2H-chromene
1195864-95-9

(Z)-3-methoxymethyl-2-phenylimino-2H-chromene

A

3-(methoxymethyl)-2H-chromen-2-one
91344-68-2

3-(methoxymethyl)-2H-chromen-2-one

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; Cooling with ice;A 68%
B n/a
(Z)-3-ethoxymethyl-2-phenylimino-2H-chromene
1195864-97-1

(Z)-3-ethoxymethyl-2-phenylimino-2H-chromene

A

3-ethoxymethylcoumarin
1195865-12-3

3-ethoxymethylcoumarin

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; Cooling with ice;A 73%
B n/a
(Z)-3-isopropoxymethyl-2-phenylimino-2H-chromene
1195864-98-2

(Z)-3-isopropoxymethyl-2-phenylimino-2H-chromene

A

3-isopropoxymethylcoumarin
1195865-13-4

3-isopropoxymethylcoumarin

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In tetrahydrofuran at 20℃; Cooling with ice;A 73%
B n/a
N-Phenylhydroxylamine
100-65-2

N-Phenylhydroxylamine

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
Stage #1: N-Phenylhydroxylamine With iron(III) acetylacetonate; 1,1,3,3-Tetramethyldisiloxane In tetrahydrofuran at 60℃; for 24h; Inert atmosphere; Sealed tube;
Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether for 0.0833333h;
77%
2,2,2-Trichloroethyl chloroformate
17341-93-4

2,2,2-Trichloroethyl chloroformate

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With sodium hydrogencarbonate; triethylamine In diethyl ether
aniline
62-53-3

aniline

A

aniline hydrochloride
142-04-1

aniline hydrochloride

B

[(PhNH)PNPh]3
79957-32-7, 106864-77-1

[(PhNH)PNPh]3

Conditions
ConditionsYield
With phosphorus trichloride In dichloromethane at 0℃; for 2h;
aniline
62-53-3

aniline

A

aniline hydrochloride
142-04-1

aniline hydrochloride

B

hexakis(phenylamino)cyclotriphosphazene
13264-13-6

hexakis(phenylamino)cyclotriphosphazene

Conditions
ConditionsYield
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine In 1,2,4-Trimethylbenzene at 160℃; for 2h; Inert atmosphere;A 100%
B 100%
1,3,4-triphenyl-2,5-dihydro-1H-2,5-azoledione
5191-53-7

1,3,4-triphenyl-2,5-dihydro-1H-2,5-azoledione

A

2,3-diphenylmaleic anhydride
4808-48-4

2,3-diphenylmaleic anhydride

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
Stage #1: 1,3,4-triphenyl-2,5-dihydro-1H-2,5-azoledione With potassium hydroxide In ethanol; water at 80℃; for 2h; Green chemistry;
Stage #2: With hydrogenchloride In ethanol; water pH=4; Green chemistry;
A 95%
B 80%
3,4,4,5-tetrachloro-4H-1,2,6-thiadiazine
51915-27-6

3,4,4,5-tetrachloro-4H-1,2,6-thiadiazine

aniline
62-53-3

aniline

A

3,5-dichloro-N-phenyl-4H-1,2,6-thiadiazin-4-imine

3,5-dichloro-N-phenyl-4H-1,2,6-thiadiazin-4-imine

B

(Z)-5-chloro-N-phenyl-4-(phenylimino)-4H-1,2,6-thiadiazin-3-amine

(Z)-5-chloro-N-phenyl-4-(phenylimino)-4H-1,2,6-thiadiazin-3-amine

C

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
In acetonitrile at 0 - 20℃; for 0.5h;A 86%
B 3%
C 94%
4-methyl-N-phenylbenzamide
6833-18-7

4-methyl-N-phenylbenzamide

1,3-Dimethoxybenzene
151-10-0

1,3-Dimethoxybenzene

A

aniline hydrochloride
142-04-1

aniline hydrochloride

B

(2,4-dimethoxyphenyl)(p-tolyl)methanone
78589-05-6

(2,4-dimethoxyphenyl)(p-tolyl)methanone

Conditions
ConditionsYield
Stage #1: 4-methyl-N-phenylbenzamide With 2-fluoropyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78 - 0℃; for 0.166667h; Inert atmosphere;
Stage #2: 1,3-Dimethoxybenzene In dichloromethane at 0 - 20℃; Inert atmosphere;
Stage #3: With hydrogenchloride; water In ethanol for 2h; Inert atmosphere; Reflux; chemoselective reaction;
A 83%
B 88%
salicylanilide
87-17-2

salicylanilide

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; water at 100℃; for 24h;70%
ammonium hydroxide
1336-21-6

ammonium hydroxide

diethyl ether
60-29-7

diethyl ether

5-methoxy-1,3-dimethyl-2-nitrobenzene
61019-03-2

5-methoxy-1,3-dimethyl-2-nitrobenzene

A

2,6-dimethyl-4-methoxyaniline hydrochloride
102440-03-9

2,6-dimethyl-4-methoxyaniline hydrochloride

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; zinc In dichloromethane; water; acetic acid; toluene
bis(trifluoromethyl)chlorophosphine
650-52-2

bis(trifluoromethyl)chlorophosphine

A

anilino-bis-trifluoromethyl-phosphine
348-71-0

anilino-bis-trifluoromethyl-phosphine

B

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With aniline In neat (no solvent) 0°C;A 65%
B n/a
With aniline In neat (no solvent) 0°C;
With aniline In neat (no solvent) 0°C;
Acetanilid
103-84-4

Acetanilid

aniline hydrochloride
142-04-1

aniline hydrochloride

Conditions
ConditionsYield
With thionyl chloride In methanol for 4h; Reflux;98.5%
potassium cyanide
151-50-8

potassium cyanide

aniline hydrochloride
142-04-1

aniline hydrochloride

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

2-(4-fluorophenyl)-2-(phenylamino) acetonitrile
124573-71-3

2-(4-fluorophenyl)-2-(phenylamino) acetonitrile

Conditions
ConditionsYield
In ethanol; water 1.) 1 h cooling; 2.) 20 h room temperature;100%
aniline hydrochloride
142-04-1

aniline hydrochloride

sodium dicyanamide
1934-75-4

sodium dicyanamide

1-phenyl-3-cyanoguanidine
41410-39-3

1-phenyl-3-cyanoguanidine

Conditions
ConditionsYield
In butan-1-ol Reflux;100%
(R)-3-Naphthalen-1-yl-2-oxo-1-((R)-1-phenyl-ethyl)-imidazolidine-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
862251-00-1

(R)-3-Naphthalen-1-yl-2-oxo-1-((R)-1-phenyl-ethyl)-imidazolidine-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

aniline hydrochloride
142-04-1

aniline hydrochloride

(R)-3-Naphthalen-1-yl-2-oxo-1-((R)-1-phenyl-ethyl)-imidazolidine-4-carboxylic acid phenylamide

(R)-3-Naphthalen-1-yl-2-oxo-1-((R)-1-phenyl-ethyl)-imidazolidine-4-carboxylic acid phenylamide

Conditions
ConditionsYield
With isopropylmagnesium chloride In tetrahydrofuran at 20℃;99%
aniline hydrochloride
142-04-1

aniline hydrochloride

3-Phenylpropionic acid
501-52-0

3-Phenylpropionic acid

hydrocinnamanilide
3271-81-6

hydrocinnamanilide

Conditions
ConditionsYield
Stage #1: 3-Phenylpropionic acid With dmap; nicotinic anhydride In dichloromethane at 0℃; for 0.166667h;
Stage #2: aniline hydrochloride In dichloromethane at 0℃; for 12h;
97%
With tetrakis(2-methylimidazol-1-yl)silane In dichloromethane at 20℃; for 24h;71%
(R)-3-(2,4-Dimethoxy-phenyl)-2-oxo-1-((R)-1-phenyl-ethyl)-imidazolidine-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
862251-07-8

(R)-3-(2,4-Dimethoxy-phenyl)-2-oxo-1-((R)-1-phenyl-ethyl)-imidazolidine-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

aniline hydrochloride
142-04-1

aniline hydrochloride

(R)-3-(2,4-Dimethoxy-phenyl)-2-oxo-1-((R)-1-phenyl-ethyl)-imidazolidine-4-carboxylic acid phenylamide

(R)-3-(2,4-Dimethoxy-phenyl)-2-oxo-1-((R)-1-phenyl-ethyl)-imidazolidine-4-carboxylic acid phenylamide

Conditions
ConditionsYield
With isopropylmagnesium chloride In tetrahydrofuran at 20℃;97%
methyl acetylmethanesulfonate
61801-32-9

methyl acetylmethanesulfonate

aniline hydrochloride
142-04-1

aniline hydrochloride

methyl α-phenylhydrazoneacetylmethanesulfonate

methyl α-phenylhydrazoneacetylmethanesulfonate

Conditions
ConditionsYield
Stage #1: methyl acetylmethanesulfonate With potassium carbonate In acetone at 20℃; for 0.5h;
Stage #2: aniline hydrochloride With hydrogenchloride; sodium nitrite In water; acetone at 0 - 5℃;
97%
C12H16N2O3

C12H16N2O3

aniline hydrochloride
142-04-1

aniline hydrochloride

C19H21N3O3

C19H21N3O3

Conditions
ConditionsYield
Stage #1: C12H16N2O3 With C12H14ClNOS In N,N-dimethyl-formamide at 110℃; for 3h;
Stage #2: aniline hydrochloride In N,N-dimethyl-formamide at 120℃; for 3h;
97%
2-imino-2H-1-benzopyran-3-carboxamide
52218-17-4

2-imino-2H-1-benzopyran-3-carboxamide

aniline hydrochloride
142-04-1

aniline hydrochloride

2-[(Z)-Phenylimino]-2H-chromene-3-carboxylic acid amide

2-[(Z)-Phenylimino]-2H-chromene-3-carboxylic acid amide

Conditions
ConditionsYield
In isopropyl alcohol for 0.5h; Heating;96%
aniline hydrochloride
142-04-1

aniline hydrochloride

(rac)-N-([2.2]paracyclophane-4-ylmethylene)aniline
88072-30-4

(rac)-N-([2.2]paracyclophane-4-ylmethylene)aniline

Conditions
ConditionsYield
With dichlorodiethylstannane; triethylamine In toluene Heating;96%
aniline hydrochloride
142-04-1

aniline hydrochloride

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

phenyl toluenesulfonamide
68-34-8

phenyl toluenesulfonamide

Conditions
ConditionsYield
With pyridine for 16h; Reflux;96%
C22H23IN2O3

C22H23IN2O3

aniline hydrochloride
142-04-1

aniline hydrochloride

C24H21IN2O2

C24H21IN2O2

Conditions
ConditionsYield
In isopropyl alcohol at 40℃;96%
4-hydroxy-1-methyl-2(1H)-quinolone
1677-46-9

4-hydroxy-1-methyl-2(1H)-quinolone

aniline hydrochloride
142-04-1

aniline hydrochloride

1-methyl-4-(phenylamino)-2(1H)-quinolone
132911-19-4

1-methyl-4-(phenylamino)-2(1H)-quinolone

Conditions
ConditionsYield
With aniline for 2.5h; Heating;95%
With aniline95%
N-phenyl[1-(4-methoxyphenyl)ethylidene]amine
25287-28-9

N-phenyl[1-(4-methoxyphenyl)ethylidene]amine

aniline hydrochloride
142-04-1

aniline hydrochloride

1,3,5-tris(4-methoxyphenyl)benzene
7509-20-8

1,3,5-tris(4-methoxyphenyl)benzene

Conditions
ConditionsYield
at 180 - 200℃; for 0.5h;95%
aniline hydrochloride
142-04-1

aniline hydrochloride

Dinatrium-<3,4-bis(dicyanmethylen)-1-cyclobuten-1,2-diyl>bis(dicyanmethanid)-dihydrat

Dinatrium-<3,4-bis(dicyanmethylen)-1-cyclobuten-1,2-diyl>bis(dicyanmethanid)-dihydrat

Dianilinium-<3,4-bis(dicyanmethylen)-1-cyclobuten-1,2-diyl>bis(dicyanmethanid)-dihydrat

Dianilinium-<3,4-bis(dicyanmethylen)-1-cyclobuten-1,2-diyl>bis(dicyanmethanid)-dihydrat

Conditions
ConditionsYield
In water95%
aniline hydrochloride
142-04-1

aniline hydrochloride

methyl 4-(2-cyano-3-morpholinoallyl)-2,6-dimethoxybenzoate
55687-43-9

methyl 4-(2-cyano-3-morpholinoallyl)-2,6-dimethoxybenzoate

methyl 4-(3-anilino-2-cyanoallyl)-2,6-dimethoxybenzoate
55687-39-3

methyl 4-(3-anilino-2-cyanoallyl)-2,6-dimethoxybenzoate

Conditions
ConditionsYield
In isopropyl alcohol for 0.5h; Heating;95%
potassium cyanide
151-50-8

potassium cyanide

aniline hydrochloride
142-04-1

aniline hydrochloride

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

anilino(4-chlorophenyl)acetonitrile
32377-36-9

anilino(4-chlorophenyl)acetonitrile

Conditions
ConditionsYield
In ethanol; water 1.) 1 h cooling; 2.) 20 h room temperature;95%
phenylglyoxal hydrate
1074-12-0

phenylglyoxal hydrate

2-(phenylthio)-1,3-butadiene
7326-64-9

2-(phenylthio)-1,3-butadiene

aniline hydrochloride
142-04-1

aniline hydrochloride

2-benzoyl-1-phenyl-4-(phenylthio)-1,2,3,6-tetrahydropyridine

2-benzoyl-1-phenyl-4-(phenylthio)-1,2,3,6-tetrahydropyridine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 24h; aza-Diels-Alder reaction;95%

Aniline hydrochloride Chemical Properties

Molecular Structure of BENZENAMINE HYDROCHLORIDE (142-04-1):

EINECS: 205-519-8
IUPAC Name: aniline hydrochloride
Molecular Formula: C6H8ClN
Molecular Weight: 129.587420 g/mol
H-Bond Donor: 2
H-Bond Acceptor: 1
SMILES: C1=CC=C(C=C1)N.Cl
InChI: InChI=1S/C6H7N.ClH/c7-6-4-2-1-3-5-6;/h1-5H,7H2;1H
InChIKey: MMCPOSDMTGQNKG-UHFFFAOYSA-N
Flash Point: 70 °C
Boiling Point: 184.4 °C at 760 mmHg
Melting Point: 196-198 °C(lit.)
Enthalpy of Vaporization: 42.44 kJ/mol
Vapour Pressure: 0.733 mmHg at 25 °C
Sensitive: Hygroscopic
Stability: Stable. Incompatible with strong oxidizing agents, strong acids.
BRN: 3593823

Aniline hydrochloride Toxicity Data With Reference

1.    

skn-rbt 500 mg/24H MOD

    28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,65.
2.    

eye-rbt 20 mg/24H MOD

    28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,65.
3.    

sce-hmn:lym 50 µmol/L

    BLFSBY    Basic Life Sciences, 29b ,1984,561.
4.    

otr-rat:emb 79,500 ng/plate

    JJATDK    JAT, Journal of Applied Toxicology, 1 (1981),190.
5.    

sce-ham:fbr 10 µmol/L

    JNCIAM    Journal of the National Cancer Institute, 58 (1977),1635.
6.    

orl-rat LD50:840 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology, 42 (1977),417.
7.    

ipr-rat LDLo:500 mg/kg

    NCNSA6    National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review, 5 (1953),11.
8.    

orl-mus LD50:841 mg/kg

    NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB214-270 .
9.    

ipr-mus LD50:300 mg/kg

    NTIS**    National Technical Information Service.

Aniline hydrochloride Consensus Reports

IARC Cancer Review: Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man , 27 (1982),p. 39.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay Completed; Results Positive: rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-130 (1978). ; Results Negative: mouse NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-130 (1978). . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Aniline hydrochloride Safety Profile

The safety information of BENZENAMINE HYDROCHLORIDE (142-04-1):
Hazard Codes: T ,N
Risk Statements: 23/24/25-40-41-43-48/23/24/25-50-68
23/24/25: Toxic by inhalation, in contact with skin and if swallowed
40: Limited evidence of a carcinogenic effect
41: Risk of serious damage to eyes
43: May cause sensitization by skin contact
48/23/24/25: Toxic: danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed
50: Very Toxic to aquatic organisms
68: Possible risk of irreversible effects
Safety Statements: 26-27-36/37/39-45-61-63
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
61: Avoid release to the environment. Refer to special instructions safety data sheet
63: In case of accident by inhalation, remove casualty to fresh air and keep at rest
RIDADR: UN 1548 6.1/PG 3
WGK Germany: 2
RTECS: CY0875000
HazardClass: 6.1
PackingGroup: III
HS Code: 29214100
F: 3-9
Suspected carcinogen with experimental carcinogenic and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental teratogenic effects. Human mutation data reported. A skin and eye irritant. Combustible when exposed to heat or flame. When heated to decomposition or on contact with acid or acid fumes, it emits highly toxic fumes of aniline and chlorine compounds. Reacts explosively with aniline at 240°C/7.6 bar. Can react vigorously with oxidizing materials. To fight fire, use water, CO2, water mist or spray, dry chemical. See also ANILINE.

Aniline hydrochloride Standards and Recommendations

DOT Classification:  6.1; Label: KEEP AWAY FROM FOOD

Aniline hydrochloride Specification

 BENZENAMINE HYDROCHLORIDE (142-04-1) is an aromatic ammonium salt with the appearance of white - yellow - semi-transparent flakes. It is also called ANILINE HCL ; ANILINE HYDROCHLORIDE ; Anilinechlofide ; ANILINIUM CHLORIDE ; C.I. 76001 ; benzenamine hydrochloride ; anilinechloride ; chlorhydrated’aniline , etc. BENZENAMINE HYDROCHLORIDE (142-04-1) is used in some fields such as fine chemicals, food. It is also used as reagent for analysis of carbohydrates and food. BENZENAMINE HYDROCHLORIDE (142-04-1) can be prepared by the reaction of aniline with hydrochloric acid:
C6H5NH2 + HCl → C6H5N+H3Cl-

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