The IUPAC name of Anthranilic acid is 2-aminobenzoic acid. With the CAS registry number 118-92-3, it is also named as 1-Amino-2-carboxybenzene; 2-Carboxyaniline; 4-27-00-07875 (Beilstein Handbook Reference); AI3-02408; Benzoic acid, o-amino-; Kyselina anthranilova; Vitamin L; ortho-Aminobenzoic acid. The product's categories are aromatic carboxylic acids, amides, anilides, anhydrides & salts, pharmacetical and organic acids.
The Anthranilic acid is white to off white crystalline powder with a sweetish taste which is soluble in hot water, ethanol and ether. It may be sensitive to prolonged exposure to air and light. In addition, it is stable and incompatible with strong oxidizing agents. This product can be used as intermediates of dye, medicine and perfume. It is also used as complexometric reagent and laboratory reagent. Anthranilic acid is biosynthesized from chorismic acid. It is the precursor to the amino acid tryptophan via the attachment of phosphoribosyl pyrophosphate to the amine group.
The Anthranilic acid is highly toxic. It is flammable and will produce toxic nitrogen oxide fumes when buring. So the storage environment should be ventilate, low-temperature and dry. This chemical is irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing and eye / face protection.
The other characteristics of Anthranilic acid can be summarized as: (1)ACD/LogP: 1.21; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.14; (4)ACD/LogD (pH 7.4): -1.52; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 9.13; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.637; (13)Molar Refractivity: 37.41 cm3; (14)Molar Volume: 104.2 cm3; (15)Polarizability: 14.83×10-24 cm3; (16)Surface Tension: 64.3 dyne/cm; (17)Enthalpy of Vaporization: 58.37 kJ/mol; (18)Vapour Pressure: 0.000234 mmHg at 25°C; (19)Rotatable Bond Count: 1; (20)Tautomer Count: 4; (21)Exact Mass: 137.047678; (22)MonoIsotopic Mass: 137.047678; (23)Topological Polar Surface Area: 63.3; (24)Heavy Atom Count: 10.
People can use the following data to convert to the molecule structure.
(1)SMILES: O=C(O)c1ccccc1N;
(2)InChI: InChI=1/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10);
(3)InChIKey: RWZYAGGXGHYGMB-UHFFFAOYAS;
The following is the toxicity data of Anthranilic acid:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 750mg/kg (750mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
mammal (species unspecified) | LD50 | unreported | 6310mg/kg (6310mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 22, 1983. | |
mouse | LD50 | intraperitoneal | 2500mg/kg (2500mg/kg) | Russian Pharmacology and Toxicology Vol. 37, Pg. 105, 1974. | |
mouse | LD50 | intravenous | > 500mg/kg (500mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1392, 1990. | |
mouse | LD50 | oral | 1400mg/kg (1400mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 19, Pg. 483, 1946. | |
rat | LD50 | oral | 5410mg/kg (5410mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 27(3), Pg. 52, 1983. |
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