Atropic acid supplier | CasNO.492-38-6

Name
Atropic acid
EINECS 207-753-6
CAS No. 492-38-6
Article Data144
CAS DataBase
Density 1.141 g/cm³
Solubility 1.3g/L(20 oC)
Melting Point 106-107°
Formula C₉H₈O₂
Boiling Point 267.834 °C at 760 mmHg
Molecular Weight 148.161
Flash Point 174.521 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms Atropicacid (6CI,7CI,8CI);2-Phenylacrylic acid;2-Phenylprop-2-enoic acid;2-Propenoic acid, 2-phenyl-;NSC 20987;a-Phenylacrylic acid;atropic acid( alpha-phenylacrylic acid );
PSA 37.30000
LogP 1.78440

Synthetic route

: 201230-82-2
carbon monoxide

: 536-74-3
phenylacetylene

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With aluminium(III) triflate; disodium 2,2'-bis(diphenylphosphino)-1,1'-binaphthalene-5,5'-disulfonate; palladium diacetate In methanol; water at 80 - 84℃; under 26252.6 Torr;	100%
With sodium hydroxide; cetyltrimethylammonim bromide; nickel cyanide In toluene at 90℃; under 760 Torr; for 3h;	62%
With sodium hydroxide; cetyltrimethylammonim bromide; nickel cyanide In toluene at 90℃; under 760 Torr; for 1h; Product distribution; Mechanism; other phase transfer catalyst, other times;

: 1865-29-8
2-phenyl-acrylic acid methyl ester

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With lithium hydroxide monohydrate In tetrahydrofuran; water for 3h; Heating;	100%
With lithium hydroxide In tetrahydrofuran; water for 15h; Heating;	97%
With water; sodium hydroxide for 1h; Reflux;

: 201230-82-2
carbon monoxide

: 98-81-7
1-bromovinylbenzene

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With [bmim]PF6; triethylamine; bis-triphenylphosphine-palladium(II) chloride In water at 100℃; under 15001.2 Torr; for 30h;	99%
With sodium hydroxide; cetyltrimethylammonim bromide; nickel cyanide In toluene at 95℃; under 735.5 Torr; for 3h;	65%

: 22286-82-4
2-phenyl-acrylic acid ethyl ester

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With potassium hydroxide In acetone at 20℃; for 16h;	98%
With sodium hydroxide In water for 1h; Reflux;
Stage #1: 2-phenyl-acrylic acid ethyl ester With lithium hydroxide monohydrate In tetrahydrofuran; water at 20℃; for 72h; Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=1;

: 124-38-9
carbon dioxide

: 98-81-7
1-bromovinylbenzene

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
Stage #1: 1-bromovinylbenzene With lithium chloride; zinc Stage #2: carbon dioxide With lithium chloride In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; for 24h; Stage #3: With hydrogenchloride; water In N,N-dimethyl-formamide	97%
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 65℃; for 0.333333h; Schlenk technique; Stage #2: 1-bromovinylbenzene With palladium diacetate; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 16h; Schlenk technique; Sealed tube;	89%
Stage #1: carbon dioxide With o-phenylenebis(diphenylphosphine); copper(II) acetate monohydrate In 1,4-dioxane at 60℃; for 0.416667h; Schlenk technique; Stage #2: 1-bromovinylbenzene With palladium diacetate; triethylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane; toluene at 100℃; for 5h; Schlenk technique;	89%

: 529-64-6
Tropic acid

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With potassium hydroxide In water for 1h; Heating;	90%
With potassium hydroxide In water for 1h; Inert atmosphere; Reflux;	90%
Stage #1: Tropic acid With potassium hydroxide In water for 10h; Reflux; Stage #2: With hydrogenchloride In water	64%

: 124-38-9
carbon dioxide

: 143825-84-7
4,4,5,5-tetramethyl-2-(1-phenylvinyl)-1,3,2-dioxaborolane

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With copper(l) iodide; cesium fluoride; sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride at 120℃; for 24h; Sealed tube;	89%

: 64-18-6
formic acid

: 536-74-3
phenylacetylene

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With bis(acetylacetonate)nickel(II); (R,R)-(+)-1,2-bis(t-butylmethylphosphino)benzene; acetic anhydride In tetrahydrofuran at 100℃; for 12h; Autoclave; Glovebox; Inert atmosphere; regioselective reaction;	88%
With bis(acetylacetonate)nickel(II); (R,R)-(+)-1,2-bis(t-butylmethylphosphino)benzene; acetic anhydride In tetrahydrofuran at 100℃; for 12h; Green chemistry;	88%

: 201230-82-2
carbon monoxide

: 108-98-5
thiophenol

: 536-74-3
phenylacetylene

A: 492-38-6
2-phenylacrylic acid

B: 2-phenyl-thioacrylic acid S-phenyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; palladium diacetate; 1,3-bis-(diphenylphosphino)propane In tetrahydrofuran at 110℃; under 15514.4 Torr; for 6h;	A 15% B 84%

...Expand

: 124-38-9
carbon dioxide

: 14900-39-1
phenylvinylboronic acid

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With potassium methanolate; copper(l) chloride In N,N-dimethyl acetamide at 70℃; under 760.051 Torr; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;	82%
With potassium methanolate; copper(l) chloride In N,N-dimethyl acetamide at 70℃; for 24h; Sealed tube; Schlenk technique;	82%

: 124-38-9
carbon dioxide

: 536-74-3
phenylacetylene

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); phenylsilane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine In N,N-dimethyl-formamide at 80℃; under 15001.5 Torr; for 12h; Autoclave;	82%
With tetrakis(triphenylphosphine) palladium(0); phenylsilane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine In N,N-dimethyl-formamide at 80℃; under 15001.5 Torr; for 12h; Catalytic behavior; Reagent/catalyst; regioselective reaction;	82%

: 124-38-9
carbon dioxide

: 67300-99-6
1-phenylethenylmagnesium bromide

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
In tetrahydrofuran at -78℃;	76%

: 938080-25-2
5,5-dimethyl-2-(1-phenylethen-1-yl)-1,3,2-dioxaborinane

: 124-38-9
carbon dioxide

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
Stage #1: 5,5-dimethyl-2-(1-phenylethen-1-yl)-1,3,2-dioxaborinane; carbon dioxide With [Ni(N,N'-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazole-2-ylidene)(allyl)Cl]; potassium tert-butylate In toluene at 100℃; under 760.051 Torr; for 15h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water; ethyl acetate; toluene at 20℃;	75%
Stage #1: 5,5-dimethyl-2-(1-phenylethen-1-yl)-1,3,2-dioxaborinane; carbon dioxide With copper(l) iodide; cesium fluoride In N,N-dimethyl-formamide at 90℃; under 760.051 Torr; for 10h; Stage #2: With hydrogenchloride; water In N,N-dimethyl-formamide	60%

: 4432-63-7
2-phenylacrolein

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide In acetonitrile at 10℃; for 1h;	70%

: 3979-14-4
tropic acid ethyl ester

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With potassium hydroxide for 3h; Heating;	68%
With potassium hydroxide Heating;	56%

: 124-38-9
carbon dioxide

: 4545-21-5
acetophenone p-toluenesulfonylhydrazone

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
Stage #1: carbon dioxide; acetophenone p-toluenesulfonylhydrazone With caesium carbonate In dimethyl sulfoxide at 80℃; under 760.051 Torr; for 12h; Schlenk technique; Sealed tube; Green chemistry; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 20℃; Reagent/catalyst; Solvent; Temperature; Schlenk technique; Sealed tube; Green chemistry;	68%

: 124-38-9
carbon dioxide

: 4545-21-5
acetophenone p-toluenesulfonylhydrazone

A: 492-38-6
2-phenylacrylic acid

B: 24422-77-3
1-methyl-4-((1-phenylethyl)sulfonyl)benzene

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide at 80℃; under 760.051 Torr; for 12h; Schlenk technique; Sealed tube;	A 68% B n/a

...Expand

: 103-82-2
phenylacetic acid

: 3446-89-7
4-(Methylthio)benzaldehyde

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With acetic anhydride; triethylamine In water	61%

: 75-25-2
Bromoform

: 98-86-2
acetophenone

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
Stage #1: Bromoform; acetophenone With lithium hydroxide monohydrate; N-benzyl-N,N,N-triethylammonium chloride; water In tert-butyl alcohol at 20℃; for 24h; Stage #2: With hydrogenchloride In water pH=1;	50%
With N-benzyl-N,N,N-triethylammonium chloride; water; lithium hydroxide In tert-butyl alcohol at 20℃;

: 124-38-9
carbon dioxide

: 28143-79-5
1-phenyl vinyl triflate

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; under 760 Torr; electrolyses, carbon cathode, Mg anode, E=-1.7 V;	32%
With nBuNBF4; bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 20℃; electrochemical reaction;	32%

: 124-38-9
carbon dioxide

: 98-81-7
1-bromovinylbenzene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 292638-84-7
styrene

B: 2548-47-2
2,3-diphenyl-1,3-butadiene

C: 492-38-6
2-phenylacrylic acid

D: 81616-78-6
N, N-dimethyl-2-phenylacrylamide

Conditions

Conditions	Yield
With tetrabutylammonium tetrafluoroborate; Ni(CO)2(2,2'-bipyridine) In various solvent(s) Product distribution; Mechanism; Ambient temperature; electrolysis, -1.6 V, further catalyst;	A 10 % Chromat. B 15 % Chromat. C 15% D 50 % Chromat.

...Expand

: 510-25-8, 5878-33-1, 6696-63-5, 23852-32-6
(+/-)-1-phenyl-1,2,3,4-tetrahydro-naphthalene-1r,4t-dicarboxylic acid di-tropane-3endo-yl ester

A: 492-38-6
2-phenylacrylic acid

B: 7432-10-2, 911648-75-4
Tropanol

Conditions

Conditions	Yield
With barium dihydroxide; ethanol; water weitere Nebenprodukt:β-Isatropasaeure;
With potassium hydroxide; ethanol weitere Nebenprodukt:β-Isatropasaeure;

: 109-72-8, 29786-93-4
n-butyllithium

: 98-81-7
1-bromovinylbenzene

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With carbon dioxide

: 6362-66-9
4-phenyl-dihydro-furan-2,3-dione

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
at 220℃;

: 51545-26-7
3-chloro-2-phenyl-propionic acid

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 515-30-0
2-phenyllactic acid

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With hydrogenchloride
man destilliert im Quarzkolben unter vermindertem Druck;
With PPA for 5h; Ambient temperature; Yield given;
bei der Destillation unter vermindertem Druck im Quarzkolben;
Multi-step reaction with 2 steps 1: fuming hydrobromic acid 2: natrium carbonate View Scheme

: 4370-95-0
3-amino-2-phenyl-propionic acid

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With water

: 1062207-46-8
2-ethoxy-2-phenylpropanoic acid

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 87786-35-4
2-bromo-2-phenyl-propionic acid

: 492-38-6
2-phenylacrylic acid

Conditions

Conditions	Yield
With sodium ethanolate
Multi-step reaction with 3 steps 1: natrium carbonate 2: fuming hydrobromic acid 3: natrium carbonate View Scheme

: 492-38-6
2-phenylacrylic acid

: 100-39-0
benzyl bromide

: 151206-37-0
benzyl 2-phenylacrylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	100%

: 492-38-6
2-phenylacrylic acid

: 492-37-5, 2328-24-7
hydratropic acid

Conditions

Conditions	Yield
With water for 1h; Catalytic behavior; UV-irradiation;	99%
With formic acid; triethylamine; N-tosylethylenediamine; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 In dichloromethane at 30℃; for 2h;	97%
With phenylsilane; C12H23N2O2P In tetrahydrofuran at 23℃; for 2h; Catalytic behavior; Reagent/catalyst; Solvent;	97%

: 492-38-6
2-phenylacrylic acid

: 7782-24-3
(S)-2-Phenylpropionic acid

Conditions

Conditions	Yield
With C48H50Cl4N2O2P2Ru3; hydrogen; sodium hydrogencarbonate In methanol at 20℃; under 3750.38 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Pressure; Autoclave; enantioselective reaction;	99%
With C42H48CoP2; hydrogen; triethylamine; zinc In methanol at 50℃; under 25858.1 Torr; for 16h; enantioselective reaction;	93%
With BF4(1-)*C36H46O4P2Rh(1+); hydrogen In methanol at 20℃; under 7500.75 Torr; for 2h; optical yield given as %ee;

: 492-38-6
2-phenylacrylic acid

: 7782-26-5
(R)-2-Phenylpropionic acid

Conditions

Conditions	Yield
With benzene ruthenium dichloride; C50H40N3OP2(1+)*Cl(1-); hydrogen; triethylamine In methanol at 20℃; under 45603.1 Torr; for 12h; Inert atmosphere; Glovebox;	99%
With C54H68IrNP(1+)*C32H12BF24(1-); hydrogen; caesium carbonate In methanol at 45℃; under 4500.45 Torr; for 0.25h; Pressure; Temperature; Time; Glovebox; Sealed tube;	97%
With C54H72IrNP(1+)*C32H12BF24(1-); hydrogen; caesium carbonate In methanol at 45℃; under 4500.45 Torr; for 0.25h; Pressure; Glovebox;	97%

: 1121-60-4
pyridine-2-carbaldehyde

: 931-53-3
Cyclohexyl isocyanide

: 492-38-6
2-phenylacrylic acid

: 2393-23-9
4-methoxy-benzylamine

: N-(2-(tert-butylamino)-2-oxo-1-(pyridin-2-yl)ethyl)-N-(4-methoxybenzyl)-2-phenylacrylamide

Conditions

Conditions	Yield
In methanol at 20℃; for 48h; Ugi Condensation;	99%

...Expand

: 492-38-6
2-phenylacrylic acid

: 67-63-0
isopropyl alcohol

: 24812-09-7
isopropyl 2-phenylacrylate

Conditions

Conditions	Yield
Stage #1: 2-phenylacrylic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: isopropyl alcohol With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h;	99%

: 877-65-6
4-tert-Butylbenzyl alcohol

: 492-38-6
2-phenylacrylic acid

: 4-(tert-butyl)benzyl 2-phenylacrylate

Conditions

Conditions	Yield
Stage #1: 2-phenylacrylic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: p-tert-butylbenzyl alcohol With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h;	98%

: 622-76-4
1-phenyl-1-butyne

: 492-38-6
2-phenylacrylic acid

: 5-ethyl-3,6-diphenyl-2H-pyran-2-one

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; tetrabutylammonium acetate In methanol at 60℃; for 12h; Electrochemical reaction; regioselective reaction;	98%

: 492-38-6
2-phenylacrylic acid

: 66505-81-5
2-(tetrahydro-4H-pyran-4-ylidene)ethan-1-ol

: 2-(tetrahydro-4H-pyran-4-ylidene)ethyl 2-phenylacrylate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 3h; Inert atmosphere;	97%

: 673-32-5
1-Phenylprop-1-yne

: 492-38-6
2-phenylacrylic acid

: 5-methyl-3,6-diphenyl-2H-pyran-2-one

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; tetrabutylammonium acetate In methanol at 60℃; for 12h; Electrochemical reaction; regioselective reaction;	97%

: 492-38-6
2-phenylacrylic acid

: 100-51-6
benzyl alcohol

: 151206-37-0
benzyl 2-phenylacrylate

Conditions

Conditions	Yield
Stage #1: 2-phenylacrylic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: benzyl alcohol With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h;	96%

: 492-38-6
2-phenylacrylic acid

: 107-18-6
allyl alcohol

: allyl 2-phenylacrylate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 3h; Inert atmosphere;	96%

: 492-38-6
2-phenylacrylic acid

: 173410-08-7
pent-1-yne-1,5-diyldibenzene

: 3,6-diphenyl-5-(3-phenylpropyl)-2H-pyran-2-one

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; tetrabutylammonium acetate In methanol at 60℃; for 12h; Electrochemical reaction; regioselective reaction;	96%

: 64-17-5
ethanol

: 492-38-6
2-phenylacrylic acid

: 22286-82-4
2-phenyl-acrylic acid ethyl ester

Conditions

Conditions	Yield
With benzenesulfonic acid In benzene Heating;	95%
Stage #1: 2-phenylacrylic acid With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Stage #2: ethanol With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h;	89%
With sulfuric acid for 12h; Reflux;
Acidic conditions;

: 492-38-6
2-phenylacrylic acid

: 501-65-5
diphenyl acetylene

: 70982-94-4
3,5,6-triphenyl-(2H)-pyran-2-one

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; tetrabutylammonium acetate In methanol at 60℃; for 12h; Solvent; Temperature; Reagent/catalyst; Electrochemical reaction;	95%
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver carbonate In N,N-dimethyl-formamide at 120℃; Inert atmosphere;	77%
With dichloro[1,3-di(ethoxycarbonyl)-2,4,5-trimethylcyclopentadienyl]rhodium(III) dimer; copper(II) acetate monohydrate; silver(I) triflimide In dichloromethane at 20℃; for 24h; Sealed tube;	67%

: 492-38-6
2-phenylacrylic acid

: 24424-99-5
di-tert-butyl dicarbonate

: 133025-60-2
tert-butyl 2-phenylacrylate

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃;	95%

: 492-38-6
2-phenylacrylic acid

: 75-65-0
tert-butyl alcohol

: 133025-60-2
tert-butyl 2-phenylacrylate

Conditions

Conditions	Yield
With dmap; di-tert-butyl dicarbonate at 20℃; for 12h;	94%

: 492-38-6
2-phenylacrylic acid

A: 7782-24-3
(S)-2-Phenylpropionic acid

B: 7782-26-5
(R)-2-Phenylpropionic acid

Conditions

Conditions	Yield
With hydrogen; (S)-Ru(OAc)2-BINAP In methanol at 15 - 30℃; under 85120.1 Torr; for 24h; Title compound not separated from byproducts;	A 92% B 8%
With hydrogen; 2; triethylamine In tetrahydrofuran under 760 Torr; for 1h; Product distribution; Ambient temperature; different chiral catalysts;
With (bicyclo<2.2.1>heptadiene) <(R)-trans-4,5-bis<(diphenylphosphino)methyl>-2,2-dimethyldioxolan>rhodium(I) tetrafluoroborate; hydrogen; triethylamine at 20℃; under 760 Torr; Product distribution; Mechanism; var. solvents and α,β-unsaturated acids and amides;

: 221044-05-9
N-(2-pyrimidyl)indole

: 492-38-6
2-phenylacrylic acid

: 2-(1-phenyl-vinyl)-1-pyrimidin-2-yl-1H-indole

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; 2,2-dimethylpropanoic anhydride In toluene at 140℃; for 2h; Inert atmosphere; regioselective reaction;	92%

: 492-38-6
2-phenylacrylic acid

: 1-(pyrimidin-2-yl)quinolin-4(1H)-one

: 2-(1-phenylvinyl)-1-(pyrimidin-2-yl)quinolin-4(1H)-one

Conditions

Conditions	Yield
With di(rhodium)tetracarbonyl dichloride; 2,2-dimethylpropanoic anhydride In toluene at 140℃; Sealed tube;	92%

: 492-38-6
2-phenylacrylic acid

: 2-(pyrimidin-2-yl)isoquinolin-1(2H)-one

: 3-(1-phenylvinyl)-2-(pyrimidin-2-yl)isoquinolin-1(2H)-one

Conditions

Conditions	Yield
With di(rhodium)tetracarbonyl dichloride; 2,2-dimethylpropanoic anhydride In toluene at 140℃; Sealed tube;	92%

: 492-38-6
2-phenylacrylic acid

: 618-41-7
Benzenesulfinic acid

: 3406-03-9
2-(phenylsulfonyl)acetophenone

Conditions

Conditions	Yield
With oxygen; copper(ll) bromide In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;	92%

: 492-38-6
2-phenylacrylic acid

: 28091-62-5
N-hydroxy-N-phenyl-carbamic acid methyl ester

: C16H15NO4

Conditions

Conditions	Yield
With copper(II) choride dihydrate; oxygen In N,N-dimethyl-formamide at 60℃; under 760.051 Torr; for 4h; Reagent/catalyst; Solvent; Temperature; Schlenk technique;	92%

: 492-38-6
2-phenylacrylic acid

: 28091-62-5
N-hydroxy-N-phenyl-carbamic acid methyl ester

: C16H15NO3(18)O

Conditions

Conditions	Yield
With copper dichloride; oxygen-18 In N,N-dimethyl-formamide at 60℃; under 760.051 Torr; for 4h; Schlenk technique; Inert atmosphere;	92%

: 1942-46-7
5-decyne

: 492-38-6
2-phenylacrylic acid

: 5,6-dibutyl-3-phenyl-2H-pyran-2-one

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; tetrabutylammonium acetate In methanol at 60℃; for 12h; Electrochemical reaction;	92%

Atropic acid Chemical Properties

Product Name: Atropic acid (CAS NO.492-38-6)

Molecular Formula: C₉H₈O₂
Molecular Weight: 148.16g/mol
Mol File: 492-38-6.mol
Einecs: 207-753-6
Boiling point: 267.8 °C at 760 mmHg
Flash Point: 174.5 °C
Density: 1.14 g/cm³
Surface Tension: 43.8 dyne/cm
Enthalpy of Vaporization: 53.44 kJ/mol
Vapour Pressure: 0.00395 mmHg at 25°C
Structure Descriptors of Atropic acid (CAS NO.492-38-6):
InChI : InChI=1/C9H8O2/c1-7(9(10)11)8-5-3-2-4-6-8/h2-6H,1H2,(H,10,11)
Smiles: c1ccccc1C(=C)C(=O)O
Product Categories: Pharmaceutical Intermediates

Atropic acid Safety Profile

Safety Information of Atropic acid (CAS NO.492-38-6):
Risk Statements: 36/37/38
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 26-36/37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection

Atropic acid Specification

Atropic acid ,its CAS NO. is 492-38-6,the synonyms is 2-Phenylacrylic acid ; 2-Propenoic acid, 2-phenyl- ; Acrylic acid, 2-phenyl- ; EINECS 207-753-6 ; NSC 20987 ; alpha-Phenyl acrylic acid ; alpha-Toluic acid, alpha-methylene- ; Benzeneacetic acid, alpha-methylene- .

Product Name

Atropic acid

Synthetic route

Atropic acid Chemical Properties

Atropic acid Safety Profile

Atropic acid Specification

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