Benzene,4-ethenyl-1,2-dimethoxy- supplier

Name
3,4-DIMETHOXYSTYRENE
EINECS 228-962-9
CAS No. 6380-23-0
Article Data81
CAS DataBase
Density 1.004 g/cm³
Solubility
Melting Point
Formula C₁₀H₁₂O₂
Boiling Point 259.4 °C at 760 mmHg
Molecular Weight 164.204
Flash Point 95.9 °C
Transport Information
Appearance
Safety 26-36/37
Risk Codes 36
Molecular Structure
Hazard Symbols Xi
Synonyms Styrene,3,4-dimethoxy- (7CI,8CI);Veratrole, 4-vinyl- (6CI);1,2-Dimethoxy-4-vinylbenzene;3,4-Dimethoxystyrene;3,4-Dimethoxystyrol;4-Vinyl-1,2-dimethoxybenzene;4-Vinylveratrole;
PSA 18.46000
LogP 2.34680

Synthetic route

: 61078-14-6
1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With sodium hexamethyldisilazane In N,N-dimethyl-formamide at -55 - 20℃; Reagent/catalyst; Temperature; Time; Inert atmosphere;	97%
With sodium hexamethyldisilazane In tetrahydrofuran; N,N-dimethyl-formamide at -55 - 20℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;	97%

: 21852-32-4
4-bromomethyl-1,2-dimethoxybenzene

: 2181-42-2
trimethylsulphonium iodide

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With n-butyllithium; lithium iodide In tetrahydrofuran; hexane from 0 degC to room temp.;	95%

: 21852-32-4
4-bromomethyl-1,2-dimethoxybenzene

: 47025-43-4, 19365-61-8
methylenetriphenylarsorane

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane for 1h; Ambient temperature;	95%

: 141-82-2
malonic acid

: 120-14-9
3,4-dimethoxy-benzaldehyde

A: 6380-23-0
3,4-dimethoxystyrene

B: 14737-89-4
3,4-dimethoxy-trans-cinnamic acid

Conditions

Conditions	Yield
With pyridine; acetic acid at 130℃; for 0.133333h; Knoevenagel-Doebner reaction; microwave irradiation;	A 4 % Spectr. B 91%

...Expand

: 67-71-0
dimethylsulfone

: 93-03-8
(3,4-dimethoxyphenyl)methanol

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With platinum on carbon; potassium tert-butylate; hydrogen In toluene under 1875.19 Torr; for 15h; Inert atmosphere; Reflux;	91%
With C15H25Cl2N3NiO3; potassium tert-butylate In toluene at 110℃; for 12h; Catalytic behavior; Reagent/catalyst; Temperature; Schlenk technique; Inert atmosphere;	76%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran at -78℃; for 4h; Inert atmosphere;	90%
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane; cyclohexane at 0℃; for 4h; Inert atmosphere; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran; hexane; cyclohexane at 20℃; for 10h; Wittig Olefination; Inert atmosphere;	89%
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 2h; Schlenk technique; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran at 0 - 20℃;	89%

: 74-85-1
ethene

: 93-15-2
1,2-dimethoxy-4-(2-propenyl)benzene

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With Hoveyda-Grubbs catalyst second generation; di-μ-bromobis-(tritert-butylphosphine)dipalladium(I) In tetrahydrofuran at 60℃; under 7500.75 Torr; for 16h; Autoclave;	90%

: 13170-43-9
(trimethylsilyl)methylmagnesium chloride

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
Stage #1: (trimethylsilyl)methylmagnesium chloride; 3,4-dimethoxy-benzaldehyde In tetrahydrofuran at 0 - 20℃; Peterson Olefination; Inert atmosphere; Stage #2: With bis(trifluoromethanesulfonyl)amide In 1,2-dichloro-ethane at 20℃; for 0.25h; Peterson Olefination;	89%

: 2065-66-9
methyl-triphenylphosphonium iodide

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
Stage #1: methyl-triphenylphosphonium iodide With potassium tert-butylate In tetrahydrofuran at 0℃; for 1h; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran at 20℃; for 24h;	87%
Stage #1: methyl-triphenylphosphonium iodide With potassium tert-butylate In tetrahydrofuran for 1h; Inert atmosphere; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran at 25℃; for 24h; Wittig reaction; Inert atmosphere;	75.2%
With tert-butoxide In tetrahydrofuran at 0℃; Wittig reaction;	60%

: 3112-85-4
Methyl phenyl sulfone

: 93-03-8
(3,4-dimethoxyphenyl)methanol

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With sodium hydride In mineral oil at 135℃; for 7h; Inert atmosphere; Schlenk technique;	85%

: 78-08-0
Triethoxyvinylsilane

: 5460-32-2
1-iodo-3,4-dimethoxybenzene

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water at 100℃; for 8h; Hiyama Coupling; Sealed tube;	78%

: 124-38-9
carbon dioxide

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 616-38-6
carbonic acid dimethyl ester

A: [2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-carbamic acid methyl ester

B: 6380-23-0
3,4-dimethoxystyrene

C: 3490-05-9
N,N-dimethyl-3,4-dimethoxy-β-phenethylamine

D: 35690-71-2
[2-(3,4-dimethoxy-phenyl)-ethyl]-carbamic acid methyl ester

Conditions

Conditions	Yield
at 130℃; under 90007.2 - 97507.8 Torr; for 24h;	A n/a B n/a C n/a D 77%

...Expand

: 5653-65-6
1-(3,4-dimethoxyphenyl)ethanol

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With 1-hexyl-3-methyl-1-imidazolium bromide at 140℃; for 0.2h; Microwave irradiation; Combinatorial reaction / High throughput screening (HTS); chemoselective reaction;	74%
With toluene-4-sulfonic acid In chloroform for 8h;	58%
Multi-step reaction with 2 steps 1: diethyl ether; CaCl2; hydrogen chloride / 0 °C 2: pyridine View Scheme
at 120℃; for 0.25h; Microwave irradiation; Ionic liquid;

: 67-71-0
dimethylsulfone

: 93-03-8
(3,4-dimethoxyphenyl)methanol

A: 6380-23-0
3,4-dimethoxystyrene

B: 1333-74-0
hydrogen

Conditions

Conditions	Yield
With 1,10-Phenanthroline; potassium tert-butylate; iron(II) chloride In toluene at 120℃; for 24h; Julia Olefin Synthesis; Inert atmosphere; Schlenk technique;	A 74% B n/a

...Expand

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 19493-09-5
Methylenetriphenylphosphorane

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
In 1,4-dioxane; water Inert atmosphere;	73%
Wittig reaction;
at 20℃; for 10h; Wittig Olefination;

: 67-71-0
dimethylsulfone

: 93-03-8
(3,4-dimethoxyphenyl)methanol

A: 6380-23-0
3,4-dimethoxystyrene

B: 30405-75-5
4-isopropenyl-1,2-dimethoxybenzene

Conditions

Conditions	Yield
With C15H25Br2N3NiO3; potassium tert-butylate In toluene at 110℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;	A 72% B 6%
With C24H20ClN2OPRu; potassium tert-butylate In 1,4-dioxane at 125℃; for 5h; Inert atmosphere; Schlenk technique; Glovebox;	A 69% B 10 %Spectr.

...Expand

: 2859-78-1
4-Bromoveratrole

: C8H16AlNO

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran at 60℃; for 12h;	59%

: 39792-99-9
[2-(3,4-dimethoxyphenyl)-ethyl](ethyl)amine

: 106-89-8
epichlorohydrin

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
In chlorobenzene at 115℃;	56%

: 40173-90-8
3,4-dimethoxyphenethyl bromide

: 299-42-3
ephedrine

A: 6380-23-0
3,4-dimethoxystyrene

B: 130459-47-1
(-)-(1R,2S)-N-(3,4-dimethoxyphenethyl)ephedrine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 48h; Heating;	A 54% B 34%

...Expand

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 106-89-8
epichlorohydrin

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
In chlorobenzene at 115℃;	47%

: 40173-90-8
3,4-dimethoxyphenethyl bromide

: 1-(1-phenylethyl)-1,2,3,4-tetrahydroquinoline-2-carbonitrile

A: 6380-23-0
3,4-dimethoxystyrene

B: 1087319-37-6
2-[2-(3,4-dimethoxyphenyl)ethyl]-1-(1-phenylethyl)-1,2,3,4-tetrahydroquinoline-2-carbonitrile

Conditions

Conditions	Yield
Stage #1: 1-(1-phenylethyl)-1,2,3,4-tetrahydroquinoline-2-carbonitrile With lithium diisopropyl amide In tetrahydrofuran; hexane at -78 - -20℃; Inert atmosphere; Stage #2: 3,4-dimethoxyphenethyl bromide In tetrahydrofuran; Hexachlorobutadiene at -60 - 20℃; for 12h;	A n/a B 35%

...Expand

: 40173-90-8
3,4-dimethoxyphenethyl bromide

: 321-97-1
(1R,2R)-pseudoephedrine

A: 6380-23-0
3,4-dimethoxystyrene

B: 130459-44-8
(-)-(1R,2R)-N-(3,4-dimethoxyphenethyl)pseudoephedrine

Conditions

Conditions	Yield
With sodium hydrogencarbonate; sodium iodide In ethanol for 60h; Heating;	A n/a B 29%

...Expand

: 109-97-7
pyrrole

: 40173-90-8
3,4-dimethoxyphenethyl bromide

A: C14H17NO2

B: 6380-23-0
3,4-dimethoxystyrene

C: 56014-51-8
1-[2-(3,4-dimethoxyphenyl)ethyl]-1H-pyrrole

Conditions

Conditions	Yield
Stage #1: pyrrole With potassium hydroxide; 18-crown-6 ether In benzene for 2h; Heating; Stage #2: 3,4-dimethoxyphenethyl bromide In benzene Heating; Further stages.;	A 23% B 27% C 27%

...Expand

: 109-97-7
pyrrole

: 75010-39-8
1-(3,4-dimethoxyphenyl)-2-(p-toluenesulfonyloxy)ethane

A: C14H17NO2

B: 6380-23-0
3,4-dimethoxystyrene

C: 56014-51-8
1-[2-(3,4-dimethoxyphenyl)ethyl]-1H-pyrrole

Conditions

Conditions	Yield
Stage #1: pyrrole With potassium hydroxide; 18-crown-6 ether In benzene for 2h; Heating; Stage #2: 1-(3,4-dimethoxyphenyl)-2-(p-toluenesulfonyloxy)ethane In benzene Heating; Further stages.;	A 4% B 4% C 9%

...Expand

: 110-86-1
pyridine

: 50919-04-5
4-(1-chloro-ethyl)-1,2-dimethoxy-benzene

: 6380-23-0
3,4-dimethoxystyrene

: 50919-04-5
4-(1-chloro-ethyl)-1,2-dimethoxy-benzene

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With pyridine

: 917-64-6
methyl magnesium iodide

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
und Destillation des Reaktionsprodukts;
With diethyl ether Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts unter vermindertem Druck auf Siedetemperatur;

: 14737-89-4
3,4-dimethoxy-trans-cinnamic acid

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With quinoline; copper(II) sulfate at 220℃;

: 1019628-47-7
N-<3,4-Dimethoxy-α-methyl-benzyl>-glycin-methyl-ester

: 6380-23-0
3,4-dimethoxystyrene

Conditions

Conditions	Yield
With sodium hydroxide In ethanol

: 120-93-4
imidazolidone

: 40173-90-8
3,4-dimethoxyphenethyl bromide

A: 6380-23-0
3,4-dimethoxystyrene

B: 74996-66-0
1-<2-(3,4-dimethoxyphenyl)ethyl>imidazolidin-2-one

Conditions

Conditions	Yield
With sodium hydride 1) benzene, reflux, 4 h 2) benzene, reflux, 16 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 6380-23-0
3,4-dimethoxystyrene

: 1131-62-0
1-(3,4-dimethoxyphenyl)ethanone

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; C21H19N5Pd(2+)*2BF4(1-) In decane; acetonitrile at 45℃; for 4h; Wacker Oxidation;	100%
With perchloric acid; oxygen; palladium diacetate; p-benzoquinone; sodium nitrite In methanol; water at 20℃; for 24h; Wacker Oxidation; Schlenk technique; Sealed tube; Green chemistry;	95%
With palladium diacetate; Dess-Martin periodane In water; acetonitrile at 50℃; Wacker-Tsuji Olefin Oxidation; Inert atmosphere;	87%
With chromium(VI) oxide; palladium dichloride In water; acetonitrile at 20 - 60℃; for 24h; Wacker-Tsuji Olefin Oxidation;	75%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; C22H24CuN4; dihydrogen peroxide In water at 40℃; for 7.5h; pH=2; Reagent/catalyst;

: 6380-23-0
3,4-dimethoxystyrene

: 5888-51-7
4-ethylveratrole

Conditions

Conditions	Yield
With 4,4'-di-tert-butylbiphenyl; lithium; isopropyl alcohol; nickel dichloride In tetrahydrofuran at 20 - 76℃; Inert atmosphere; chemoselective reaction;	99%
With hydrogen In methanol at 20℃; for 18h; chemoselective reaction;	99%
With hydrogen at 80℃; under 7500.75 Torr; for 1h; Autoclave;	94%
With hydrogen; platinum(IV) oxide In acetic acid	54.9%
With palladium 10% on activated carbon; hydrogen at 20℃; for 18h; Sealed tube;	83 mg

: 6380-23-0
3,4-dimethoxystyrene

: 100-00-5
4-chlorobenzonitrile

: 51042-54-7
1,2-Dimethoxy-4-[2-(4-nitrophenyl)ethenyl]benzene

Conditions

Conditions	Yield
With C32H27N4O2Pd(1+)*BF4(1-); sodium acetate at 140℃; for 12h; Inert atmosphere; Schlenk technique;	99%
With tetrabutylammomium bromide; palladium diacetate; silica gel; potassium carbonate for 0.75h; Neat (no solvent);	87%

: 6380-23-0
3,4-dimethoxystyrene

: 326491-79-6
(R)-2-hydroxy-1-(3,4-dimethoxyphenyl)ethanol

Conditions

Conditions	Yield
With osmium(VIII) oxide; potassium carbonate; potassium hexacyanoferrate(III); 1,4-bis(9-O-dihydroquinidine)phthalazine In water; toluene; tert-butyl alcohol at 0℃; for 24h; Sharpless asymmetric dihydroxylation;	97%
With AD-mix β In water; tert-butyl alcohol at 0℃; Sharpless Dihydroxylation;

: 6380-23-0
3,4-dimethoxystyrene

: 19978-32-6
3-bromo-2H-pyran-2-one

: C15H15BrO4

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-4-methyl-phenol at 80℃; for 120h; Diels-Alder cycloaddition;	97%

: 6380-23-0
3,4-dimethoxystyrene

: 140687-75-8, 102104-61-0
2-(3,4-dimethoxyphenyl)oxirane

Conditions

Conditions	Yield
With 3,3-dimethyldioxirane In acetone for 0.666667h; Ambient temperature;	96%
With PS-DVB supported phthalic anhydride; urea-hydrogen peroxide In dichloromethane at 20℃;	77%

: 6380-23-0
3,4-dimethoxystyrene

: 141-32-2
acrylic acid n-butyl ester

: n-butyl (E)-3-(3,4-dimethoxyphenyl)acrylate

Conditions

Conditions	Yield
With Cl2Ru=CHPh(PCy3)[bis(1,3-Mes-2-ylimidazolidine)] In dichloromethane at 40℃; for 12h;	96%

: 6380-23-0
3,4-dimethoxystyrene

: 1192036-78-4
C20H24O6

Conditions

Conditions	Yield
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 25℃;	96%

: 6380-23-0
3,4-dimethoxystyrene

: 1864-94-4
phenyl formate

: C17H18O4

Conditions

Conditions	Yield
With formic acid; palladium diacetate; CyJohnPhos In toluene at 90℃; for 24h; Inert atmosphere; Sealed tube; regioselective reaction;	96%

: 6380-23-0
3,4-dimethoxystyrene

: 90-14-2
1-Iodonaphthalene

: 23833-70-7
(E)-1-(3,4-dimethoxystyryl)naphthalene

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; triethylamine; N,N-dimethyl-formamide; lithium chloride at 110℃; for 6h; Heck Reaction; Inert atmosphere;	96%

: 6380-23-0
3,4-dimethoxystyrene

: 13443-56-6
β-hydroxy-3,4-dimethoxy phenethyl alcohol

Conditions

Conditions	Yield
With osmium(VIII) oxide; 4-methylmorpholine N-oxide In tetrahydrofuran; water; tert-butyl alcohol at 20℃; for 12h; Sealed tube;	95%
With osmium(VIII) oxide; 4-methylmorpholine N-oxide In water; acetone at 20℃; for 16h;	94%
With pyridine; osmium(VIII) oxide In diethyl ether at 20℃; for 20h; dihydroxylation;	80%
Upjohn Dihydroxylation; Inert atmosphere;

: 31617-39-7
1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione

: 6380-23-0
3,4-dimethoxystyrene

: 155270-99-8
istradefylline

Conditions

Conditions	Yield
Stage #1: 1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione With pyridine; palladium diacetate; copper(II) acetate monohydrate; copper(l) chloride In N,N-dimethyl acetamide at 20℃; for 0.0833333h; Heck reaction; Inert atmosphere; Stage #2: 3,4-dimethoxystyrene In N,N-dimethyl acetamide at 120℃; for 20h; Heck reaction; Inert atmosphere;	95%

: 104-92-7
1-bromo-4-methoxy-benzene

: 6380-23-0
3,4-dimethoxystyrene

: 263327-99-7
4,3’,4’-trimethoxystilbene

Conditions

Conditions	Yield
With C33H33N2(1+)*Cl(1-); palladium diacetate; potassium carbonate In water; N,N-dimethyl-formamide for 2h; Heck Reaction; Inert atmosphere; Sealed tube; Heating;	95%

: 6380-23-0
3,4-dimethoxystyrene

: 41172-57-0
5-Methyloxazol-4-carbonsaeure-methylester

: 1096163-95-9
(E)-methyl 2-(3,4-dimethoxystyryl)-5-methyloxazole-4-carboxylate

Conditions

Conditions	Yield
With 1,10-Phenanthroline; palladium(II) trifluoroacetate; silver trifluoroacetate In toluene at 130℃; for 16h;	95%

: potassium cyanide

: 6380-23-0
3,4-dimethoxystyrene

: 51698-53-4
2‐(3,4‐dimethoxyphenyl)propionitrile

Conditions

Conditions	Yield
Stage #1: potassium cyanide With acetic acid In ethylene glycol at 60℃; Sealed tube; Stage #2: 3,4-dimethoxystyrene With bis(1,5-cyclooctadiene)nickel (0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene at 60℃; for 18h; Sealed tube;	95%

: 34418-91-2
2,3,4,5-tetrahydropyridine N-oxide

: 6380-23-0
3,4-dimethoxystyrene

: 79235-48-6
2-(3,4-Dimethoxy-phenyl)-hexahydro-isoxazolo[2,3-a]pyridine

Conditions

Conditions	Yield
In toluene Heating;	93%

: 6380-23-0
3,4-dimethoxystyrene

: 52222-81-8
8-iodo-3′,4′,5,7-tetramethoxyflavone

: C29H28O8

Conditions

Conditions	Yield
With potassium chloride; tetrabutylammomium bromide; potassium carbonate; palladium dichloride In 1-methyl-pyrrolidin-2-one at 100℃; for 24h; Heck Reaction; Inert atmosphere; regioselective reaction;	93%

: 6380-23-0
3,4-dimethoxystyrene

: 1864-94-4
phenyl formate

: C17H18O4

Conditions

Conditions	Yield
With 1,1'-bis(dicyclohexylphosphinocyclopentadienyl)iron; palladium diacetate; acetic acid In toluene at 90℃; for 24h; Inert atmosphere; Sealed tube; regioselective reaction;	93%

: 6380-23-0
3,4-dimethoxystyrene

: 89845-28-3
2-(2-phenylethynyl)-1,4-benzoquinone

: 1432504-67-0
2-(3,4-dimethoxyphenyl)-7-(phenylethynyl)-2,3-dihydrobenzofuran-5-ol

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In acetonitrile at 0℃; Inert atmosphere; Schlenk technique;	92%

: 6380-23-0
3,4-dimethoxystyrene

: 51698-53-4
2‐(3,4‐dimethoxyphenyl)propionitrile

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); hydrogen cyanide; (3aR,8aR)-4,4,8,8-tetrakis(3,5-dimethylphenyl)-6-(2-(diphenylphosphino)-6-isopropylphenoxy)-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine In tetrahydrofuran at 20℃; for 2h; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique; Optical yield = 88 %ee; enantioselective reaction;	92%

: 6380-23-0
3,4-dimethoxystyrene

: C12H10O6

: dimethyl 2-((2-(3,4-dimethoxyphenyl)-5-hydroxy-2,3-dihydrobenzofuran-7-yl)methylene)malonate

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In acetonitrile at 20℃; for 0.166667h; regioselective reaction;	92%

: 6380-23-0
3,4-dimethoxystyrene

: 5-iodo-N,N,8-trimethylnaphthalen-2-amine

: (E)-5-(3,4-dimethoxystyryl)-N,N,8-trimethylnaphthalen-2-amine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; triethylamine; N,N-dimethyl-formamide; lithium chloride at 110℃; for 5h; Heck Reaction; Inert atmosphere;	92%

: 6380-23-0
3,4-dimethoxystyrene

: 5720-07-0
4-methoxyphenylboronic acid

: (S)-1,2-dimethoxy-4-(1-(4-methoxyphenyl)ethyl)benzene

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel(0); C33H30N2O2; lithium tert-butoxide In methanol at 50℃; for 3h; Inert atmosphere; Glovebox; Sealed tube; enantioselective reaction;	92%

: 6380-23-0
3,4-dimethoxystyrene

: 1593-60-8
p-toluenesulfonylhydroxylamine

: 1377813-97-2
1-(3,4-dimethoxyphenyl)-2-tosylethanone oxime

Conditions

Conditions	Yield
With tetrabutylammonium periodite In dichloromethane at -20 - 40℃; for 3h; Inert atmosphere;	91%

Benzene,4-ethenyl-1,2-dimethoxy- Specification

The Benzene, 4-ethenyl-1, 2-dimethoxy-, with the CAS registry number 6380-23-0, is also known as 3, 4-Dimethoxystyrene. It belongs to the product categories of Monomers; Polymer Science; Styrene and Functionalized Styrene Monomers. And its EINECS registry number is 228-962-9. This chemical's molecular formula is C₁₀H₁₂O₂ and molecular weight is 164.2. What's more, its IUPAC name is 4-Ethenyl-1, 2-dimethoxybenzene. In addition, it must be stored in airtight containers at 2-8 °C.

Physical properties about Benzene, 4-ethenyl-1, 2-dimethoxy- are: (1)ACD/LogP: 2.53; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.53; (4)ACD/LogD (pH 7.4): 2.53; (5)ACD/BCF (pH 5.5): 49.02; (6)ACD/BCF (pH 7.4): 49.02; (7)ACD/KOC (pH 5.5): 564.37; (8)ACD/KOC (pH 7.4): 564.37; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 18.46 Å²; (13)Index of Refraction: 1.53; (14)Molar Refractivity: 50.53 cm³; (15)Molar Volume: 163.3 cm³; (16)Polarizability: 20.03×10^-24 cm³; (17)Surface Tension: 31 dyne/cm; (18)Density: 1.004 g/cm³; (19)Flash Point: 95.9 °C; (20)Enthalpy of Vaporization: 47.7 kJ/mol; (21)Boiling Point: 259.4 °C at 760 mmHg; (22)Vapour Pressure: 0.021 mmHg at 25 °C.

Preparation of Benzene, 4-ethenyl-1, 2-dimethoxy-: this chemical is prepared by reaction of 4-Bromomethyl-1, 2-dimethoxy-benzene with Trimethylsulfonium; iodide. This reaction needs reagents n-BuLi and LiI. Meanwhile, it needs solvents Tetrahydrofuran and Hexane. Other condition of this reaction is from 0 °C to room temp.. The yield is about 95 %.

The Benzene, 4-ethenyl-1, 2-dimethoxy- can be obtained by 4-Bromomethyl-1, 2-dimethoxy-benzene and Trimethylsulfonium; iodide.

Uses of Benzene, 4-ethenyl-1, 2-dimethoxy-: it is used to produce other chemicals. For example, it is used to produce 2-(3, 4-Dimethoxy-phenyl)-hexahydro-pyrrolo[1, 2-b]isoxazole by heating. The reaction needs solvent Toluene. The reaction time is 3 hours. The yield is about 88 %.

Benzene, 4-ethenyl-1, 2-dimethoxy- can react with 3, 4-Dihydro-2H-pyrrole 1-oxide to get 2-(3, 4-Dimethoxy-phenyl)-hexahydro-pyrrolo[1, 2-b]isoxazole.

When you are using this chemical, please be cautious about it as the following:
As a chemical, it is irritating to eyes. In addition, this chemical may cause inflammation to the skin or other mucous membranes. During using it, wear suitable protective clothing and gloves. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O(c1ccc(cc1OC)\C=C)C
(2) InChI: InChI=1/C10H12O2/c1-4-8-5-6-9(11-2)10(7-8)12-3/h4-7H,1H2,2-3H3
(3) InChIKey: NJXYTXADXSRFTJ-UHFFFAOYAG

Product Name

3,4-DIMETHOXYSTYRENE

Synthetic route

Benzene,4-ethenyl-1,2-dimethoxy- Specification

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