Product Name

  • Name

    Bisacodyl

  • EINECS 210-044-4
  • CAS No. 603-50-9
  • Article Data12
  • CAS DataBase
  • Density 1.2 g/cm3
  • Solubility Soluble in alcohol (slightly), ether (slightly), chloroform, and acetone. Insoluble in water.
  • Melting Point 138 °C
  • Formula C22H19NO4
  • Boiling Point 492.333 °C at 760 mmHg
  • Molecular Weight 361.397
  • Flash Point 251.554 °C
  • Transport Information
  • Appearance white crystalline powder
  • Safety 26-36
  • Risk Codes 22-36/37/38
  • Molecular Structure Molecular Structure of 603-50-9 (Bisacodyl)
  • Hazard Symbols IrritantXi
  • Synonyms Phenol,4,4'-(2-pyridinylmethylene)bis-, diacetate (ester) (9CI);Phenol,4,4'-(2-pyridylmethylene)di-, diacetate (6CI,7CI);Phenol,4,4'-(2-pyridylmethylene)di-, diacetate (ester) (8CI);4,4'-(2-Pyridylmethylene)diphenol diacetate;Bicol;Bis(p-acetoxyphenyl)-2-pyridylmethane;Bisacodyl;Brocalax;Broxalax;Contralax;Correctol Caplets;Dulcolan;Durolax;Eulaxan;Godalax;Hillcolax;Ivilax;Laco;Laxanin N;Laxine;Laxorex;Neolax;Perilax;Prepacol;Pyrilax;SK-Bisacodyl;Ulcol;Zetrax;
  • PSA 65.49000
  • LogP 4.11240

Synthetic route

4,4'-(2-pyridylmethylene)diphenol
603-41-8

4,4'-(2-pyridylmethylene)diphenol

acetic anhydride
108-24-7

acetic anhydride

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
With sodium acetate at 100 - 140℃; Temperature; Large scale;95%
With pyridine In dichloromethane at 0 - 20℃; for 2h;88%
With sodium acetate
With pyridine
With sodium acetate
acetic anhydride
108-24-7

acetic anhydride

3-(4-methoxyphenyl)-[1,2,3]triazolo[1,5-a]pyridine
78539-92-1

3-(4-methoxyphenyl)-[1,2,3]triazolo[1,5-a]pyridine

(4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid
159191-56-7

(4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Stage #1: 3-(4-methoxyphenyl)-[l,2,3]triazolo[1,5-a]pyridine; (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid With potassium carbonate In benzene at 20℃; for 10h; UV-irradiation;
Stage #2: With hydrogen bromide; acetic acid Reflux;
Stage #3: acetic anhydride With triethylamine In dichloromethane at 20℃;		74%
...Expand
pyridine-2-carbonyl chloride
29745-44-6

pyridine-2-carbonyl chloride

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 8.4 g / triethylamine / CH2Cl2 / 0 - 20 °C
2: 56 percent / AlCl3 / 4 h / 160 °C
3: 94.5 percent / sodium borohydride / methanol / 2 h / 0 - 20 °C
4: 69 percent / H3PO4 / H2O / 0.5 h / 100 °C
5: 88 percent / pyridine / CH2Cl2 / 2 h / 0 - 20 °C
View Scheme
2-Picolinic acid
98-98-6

2-Picolinic acid

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: thionyl chloride / benzene / 12 h / Heating
2: 8.4 g / triethylamine / CH2Cl2 / 0 - 20 °C
3: 56 percent / AlCl3 / 4 h / 160 °C
4: 94.5 percent / sodium borohydride / methanol / 2 h / 0 - 20 °C
5: 69 percent / H3PO4 / H2O / 0.5 h / 100 °C
6: 88 percent / pyridine / CH2Cl2 / 2 h / 0 - 20 °C
View Scheme
pyridine-2-carboxylic acid phenyl ester
26838-86-8

pyridine-2-carboxylic acid phenyl ester

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 56 percent / AlCl3 / 4 h / 160 °C
2: 94.5 percent / sodium borohydride / methanol / 2 h / 0 - 20 °C
3: 69 percent / H3PO4 / H2O / 0.5 h / 100 °C
4: 88 percent / pyridine / CH2Cl2 / 2 h / 0 - 20 °C
View Scheme
4-hydroxyphenyl(2-pyridyl) carbinol
33455-95-7

4-hydroxyphenyl(2-pyridyl) carbinol

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 69 percent / H3PO4 / H2O / 0.5 h / 100 °C
2: 88 percent / pyridine / CH2Cl2 / 2 h / 0 - 20 °C
View Scheme
(4-hydroxyphenyl)(pyridin-2-yl)methanone
33077-70-2

(4-hydroxyphenyl)(pyridin-2-yl)methanone

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94.5 percent / sodium borohydride / methanol / 2 h / 0 - 20 °C
2: 69 percent / H3PO4 / H2O / 0.5 h / 100 °C
3: 88 percent / pyridine / CH2Cl2 / 2 h / 0 - 20 °C
View Scheme
phenol
108-95-2

phenol

2-chlorobenzylhalide

2-chlorobenzylhalide

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 69 percent / H3PO4 / H2O / 0.5 h / 100 °C
2: 88 percent / pyridine / CH2Cl2 / 2 h / 0 - 20 °C
View Scheme
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: concentrated sulfuric acid
2: sodium acetate
View Scheme
Multi-step reaction with 2 steps
1: aqueous hydrochloric acid; acetic acid
2: sodium acetate
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride
2: sulfuric acid; sodium nitrite
3: sodium acetate
View Scheme

bisacodyl

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid; sodium nitrite
2: sodium acetate
View Scheme
aniline
62-53-3

aniline

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride
2: sulfuric acid; sodium nitrite
3: sodium acetate
View Scheme
phenol
108-95-2

phenol

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: concentrated sulfuric acid
2: sodium acetate
View Scheme
Multi-step reaction with 2 steps
1: aqueous hydrochloric acid; acetic acid
2: sodium acetate
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid
2: sodium acetate
View Scheme
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

phenol
108-95-2

phenol

bisacodyl
603-50-9

bisacodyl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid
2: sodium acetate
View Scheme

Bisacodyl Consensus Reports

Reported in EPA TSCA Inventory.

Bisacodyl Standards and Recommendations

ASSAY: 99.0% min
RESIDUE ON IGNITION: 0.1% max
HEAVY METALS: 10ppm max
LOSS ON DRYING: 0.5% max

Bisacodyl Specification

The Bisacodyl, with the CAS registry number 603-50-9, is also known as Bis(p-acetoxyphenyl)-2-pyridylmethane. It belongs to the product categories of Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS number is 210-044-4. This chemical's molecular formula is C22H19NO4 and molecular weight is 361.40. What's more, its systematic name is (2-Pyridinylmethylene)di-4,1-phenylene diacetate. Its classification codes are: (1)Cathartics; (2)Gastrointestinal Agents; (3)Laxative. It is a stimulant laxative drug that works directly on the large colon to produce a bowel movement. It is typically prescribed for relief of constipation and for the management of neurogenic bowel dysfunction as well as part of bowel preparation before medical examinations.

Physical properties of Bisacodyl are: (1)ACD/LogP: 3.453; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.39; (4)ACD/LogD (pH 7.4): 3.45; (5)ACD/BCF (pH 5.5): 214.64; (6)ACD/BCF (pH 7.4): 247.54; (7)ACD/KOC (pH 5.5): 1558.81; (8)ACD/KOC (pH 7.4): 1797.78; (9)#H bond acceptors: 5; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 65.49 Å2; (13)Index of Refraction: 1.584; (14)Molar Refractivity: 100.741 cm3; (15)Molar Volume: 301.156 cm3; (16)Polarizability: 39.937×10-24cm3; (17)Surface Tension: 46.97 dyne/cm; (18)Density: 1.2 g/cm3; (19)Flash Point: 251.554 °C; (20)Enthalpy of Vaporization: 75.924 kJ/mol; (21)Boiling Point: 492.333 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(Oc1ccc(cc1)C(c2ccc(OC(=O)C)cc2)c3ncccc3)C
(2)Std. InChI: InChI=1S/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3
(3)Std. InChIKey: KHOITXIGCFIULA-UHFFFAOYSA-N

The toxicity data is as follows:  

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 40mg/kg (40mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 19, 1953.
dog LD50 oral > 15gm/kg (15000mg/kg)   Drugs in Japan Vol. -, Pg. 854, 1990.
dog LDLo intravenous 40mg/kg (40mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 19, 1953.
mouse LD50 oral 17500mg/kg (17500mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BLOOD: HEMORRHAGE		 Toxicology and Applied Pharmacology. Vol. 2, Pg. 243, 1960.
mouse LDLo intravenous 80mg/kg (80mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 243, 1960.
rabbit LDLo intravenous 40mg/kg (40mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 19, 1953.
rat LD50 oral 4320mg/kg (4320mg/kg) BLOOD: CHANGES IN SPLEEN

GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Toxicology and Applied Pharmacology. Vol. 2, Pg. 243, 1960.

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