Bromisoval supplier | CasNO.496-67-3

Name
Bromisoval
EINECS 207-825-7
CAS No. 496-67-3
Density 1.504 g/cm³
Solubility 19.03g/L(temperature not stated)
Melting Point 152 °C
Formula C₆H₁₁BrN₂O₂
Boiling Point
Molecular Weight 223.07
Flash Point
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Urea,(2-bromo-3-methylbutyryl)- (6CI,8CI);(RS)-2-Bromoisovalerylurea;(a-Bromoisovaleryl)urea;2-Bromo-3-methylbutyrylurea;2-Bromoisovalerylurea;Abroval;Alluval;Alural;BVU;Bromaral;Bromcarbamide;Bromisovalerylurea;Bromisovalum;Bromizoval;Bromocarbamide;Bromoisovalum;Bromovaleroylurea;Bromovalerylurea;Bromoxil;Bromuvan;Bromvalerylurea;Brovalin;Brovalurea;Calmotin;Dagrabromyl;Dormigene;Isobromyl;Pivadorm;Pivadorn;Upiol;a-Bromo-b-dimethylpropanoylurea;a-Bromoisovaleric acid ureide;a-Bromoisovaleroylurea;
PSA 72.19000
LogP 1.69200

Synthetic route

: 27109-47-3, 27318-02-1, 66067-58-1, 52574-82-0
2-bromoisovaleryl chloride

: 57-13-6
urea

: 496-67-3
bromisoval

Conditions

Conditions	Yield
at 35 - 40℃; for 6h; Time;	86%

: 860762-74-9
N-(α-bromo-isovaleryl)-O-methyl-isourea

: 496-67-3
bromisoval

Conditions

Conditions	Yield
With hydrogenchloride

: O-ethyl-N-(α-bromo-isovaleryl)-isourea

: 496-67-3
bromisoval

Conditions

Conditions	Yield
With hydrogenchloride

: N,N'-bis-(α-bromo-isovaleryl)-urea

: 496-67-3
bromisoval

Conditions

Conditions	Yield
With sodium hydroxide

: 26464-05-1
2-bromo-3-methyl-butyryl bromide

: 57-13-6
urea

: 496-67-3
bromisoval

: N,N'-bis-(α-bromo-isovaleryl)-urea

diluted NaOH-solution: diluted NaOH-solution

: 496-67-3
bromisoval

: 26464-05-1
2-bromo-3-methyl-butyryl bromide

mercurocyanate: mercurocyanate

: 496-67-3
bromisoval

Conditions

Conditions	Yield
With Petroleum ether und Behandeln des entstandenen <α-Brom-isovaleryl>-isocyanats mit Ammoniak;

: 7647-01-0
hydrogenchloride

: 860762-74-9
N-(α-bromo-isovaleryl)-O-methyl-isourea

A: 74-87-3
methylene chloride

B: 496-67-3
bromisoval

...Expand

: 7647-01-0
hydrogenchloride

: O-ethyl-N-(α-bromo-isovaleryl)-isourea

A: 496-67-3
bromisoval

B: 75-00-3
chloroethane

...Expand

: 26464-05-1
2-bromo-3-methyl-butyryl bromide

: 496-67-3
bromisoval

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: water; benzene; NaOH-solution 2: hydrochloric acid View Scheme
Multi-step reaction with 2 steps 1: diethyl ether 2: hydrochloric acid View Scheme

: 496-67-3
bromisoval

: 2274-08-0
N-carbamoyl-3-methylbutanamide

Conditions

Conditions	Yield
With water; zinc In acetonitrile at 80℃; for 7h; Sealed tube; Inert atmosphere;	94%
With water; zinc In acetonitrile at 80℃; for 9h; Inert atmosphere; Sealed tube;	94%
With sodium hydroxide; potassium dihydrogenphosphate; rat liver microsomes; NADPH In water at 37℃; Product distribution; other reagents;

: 496-67-3
bromisoval

: N-carbamoyl-3-methylbutanamide-2-d

Conditions

Conditions	Yield
With water-d2; zinc In acetonitrile at 80℃; for 18h; Time; Inert atmosphere; Sealed tube;	91%
With water-d2; zinc In acetonitrile at 80℃; for 18h; Inert atmosphere; Sealed tube;	84%

: 496-67-3
bromisoval

: 333-20-0
potassium thioacyanate

: 3805-17-2
2-amino-5-isopropyl-thiazol-4-one

Conditions

Conditions	Yield
With butanone

: 496-67-3
bromisoval

: 15900-26-2
2-amino-5-isopropyl-oxazol-4-one

Conditions

Conditions	Yield
With ammonium carbonate

: 496-67-3
bromisoval

: 3338-24-7
sodium O,O-diethyl phosphorodithioate

: (α-diethoxythiophosphorylsulfanyl-isovaleryl)-urea

Conditions

Conditions	Yield
With 4-methyl-2-pentanone

: 496-67-3
bromisoval

: 26843-84-5
2,4-diisopropyl-3-thia-glutaric acid-diureide

Conditions

Conditions	Yield
With potassium sulphide; ethanol
With sodium sulfide In ethanol

: 496-67-3
bromisoval

: 61226-21-9
Antipyrinsaeurechlorid

: N-(α-bromo-isovaleryl)-N'-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbonyl)-urea

: 496-67-3
bromisoval

: 108-24-7
acetic anhydride

: N-acetyl-N'-(2-bromo-isovaleryl)-urea

Conditions

Conditions	Yield
With sulfuric acid at 60℃;

: 496-67-3
bromisoval

: 75-87-6
chloral

: N-(α-bromo-isovaleryl)-N'-(2,2,2-trichloro-1-hydroxy-ethyl)-urea

: 496-67-3
bromisoval

: 63-74-1
sulfanilamide

: 4-(5-isopropyl-2,4-dioxo-imidazolidin-1-yl)-benzenesulfonic acid amide

Conditions

Conditions	Yield
at 155℃;

: 496-67-3
bromisoval

: 140-89-6
potassium ethyl xanthogenate

: 26843-82-3
Dithiocarbonic acid O-ethyl ester S-(2-methyl-1-ureidocarbonyl-propyl) ester

Conditions

Conditions	Yield
In ethanol

: 496-67-3
bromisoval

: 100-53-8
phenylmethanethiol

: 26843-83-4
(2-Benzylsulfanyl-3-methyl-butyryl)-urea

Conditions

Conditions	Yield
In ethanol

: 496-67-3
bromisoval

: 507-09-5
thioacetic acid

: 26843-85-6
Thioacetic acid S-(2-methyl-1-ureidocarbonyl-propyl) ester

Conditions

Conditions	Yield
With sodium hydroxide In ethanol

: 496-67-3
bromisoval

alcoholic KOH: alcoholic KOH

4-oxo-2-imino-5-isopropyl-oxazolidine: 4-oxo-2-imino-5-isopropyl-oxazolidine

: 496-67-3
bromisoval

alcoholic KOH-solution: alcoholic KOH-solution

dimethylacrylic acid ureide: dimethylacrylic acid ureide

: 64-17-5
ethanol

: 496-67-3
bromisoval

ammonium sulfite: ammonium sulfite

A ammonium salt of α-sulfoisovaleric acid-ureide: ammonium salt of α-sulfoisovaleric acid-ureide

B isovalerylurea(?): isovalerylurea(?)

...Expand

Bromisoval Chemical Properties

IUPAC Name: Bromisoval [INN]
The MF of Bromisoval [INN] (496-67-3) is C₆H₁₁BrN2O₂.

The MW of Bromisoval [INN] (496-67-3) is 223.07.
Synonyms of Bromisoval [INN] (496-67-3): Rarechem ax ki 5046 ; 1-(2-Bromoisovaleryl)urea ; A-(Bromoisovaleryl)urea ; Alpha(bromoisovaleryl)urea ; Labotest-bb lt00134620 ; Bromovalerylurea ; Bromoisovalerylurea ; Bromo-iso-valerylurea (alpha)
Index of Refraction: 1.514
EINECS: 207-825-7
Density: 1.504 g/ml
Melting point: 152 °C
Merck: 1397

Bromisoval Uses

Bromisoval [INN] (496-67-3) has a mild sedative and hypnotic effects, serving markedly after 5 minutes.Eeffect last for 4 hours, no habit.Can be made into powder, tablets and injections.

Bromisoval Production

With isoamyl alcohol as raw material, the first oxidation of isovalerate, and then brominated to α-bromo-isovaleryl bromide and finally generate the bromine and urea condensation of iso-amyl urea.

Bromisoval Toxicity Data With Reference

1.	orl-wmn TDLo:400 mg/kg:CNS	BMJOAE British Medical Journal. 1 (1955),1238.
2.	orl-hmn LDLo:57 mg/kg	TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 7 (1960),513.
3.	orl-rat LD50:1000 mg/kg	FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. 7 (1948),262.
4.	orl-mus LD50:2 g/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 11 (1976),693.
5.	orl-cat LD50:450 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),738.
6.	orl-rbt LD50:1200 mg/kg	MEIEDD Merck Index. 10 (1983),193.

Bromisoval Consensus Reports

Reported in EPA TSCA Inventory.

Bromisoval Safety Profile

Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, and coma. A sedative and hypnotic agent. When heated to decomposition it emits very toxic fumes of Br⁻ and NO_x.Safety information of Bromisoval [INN] (496-67-3):
RTECS YS3150000

Product Name

Bromisoval

Synthetic route

Bromisoval Chemical Properties

Bromisoval Uses

Bromisoval Production

Bromisoval Toxicity Data With Reference

Bromisoval Consensus Reports

Bromisoval Safety Profile

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