Conditions | Yield |
---|---|
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; triethylamine In dichloromethane at 20℃; for 0.5h; | 95% |
With PEG-1000; sulfated zirconia at 40℃; for 3h; neat (no solvent); | 85% |
at 230℃; under 2574.3 Torr; |
4-Ethoxyphenyltellurium oxochloride
butyryl chloride
A
butanoic acid anhydride
B
p-ethoxyphenyltellurium(IV) trichloride
Conditions | Yield |
---|---|
In tetrachloromethane for 1h; Heating; prototype reaction, oth. acylchlorides, oth. arenetellurinyl chloride; | A 89% B 93% |
(dibutyrylhydroxy)triphenylarsorane
A
butanoic acid anhydride
B
triphenyl-arsane
C
triphenylarsineoxide
Conditions | Yield |
---|---|
Product distribution; Heating; | A 76% B 38% C 43% |
Conditions | Yield |
---|---|
With phosphorus trichloride at 40 - 50℃; 4-5h; | A n/a B 67% |
With phosphorus trichloride at 40 - 50℃; 4-5h; | A 10.54% B 49.3% |
Conditions | Yield |
---|---|
With oxygen; cobalt(II) chloride In acetonitrile at 25℃; for 15h; | 43% |
butyraldehyde
acrylic acid methyl ester
A
butanoic acid anhydride
D
butyric acid
Conditions | Yield |
---|---|
With acetic anhydride; cobalt(II) In acetonitrile at 25℃; for 24h; | A n/a B 18% C 20% D n/a |
Conditions | Yield |
---|---|
With nickel Hydrogenation; |
peroxybutyric acid
butyraldehyde
ethyl acetate
A
butanoic acid anhydride
B
butyric acid
Conditions | Yield |
---|---|
at 20 - 50℃; Rate constant; auch nach Zusatz Kupfer(II)-, Mangan(II)-, Eisen(II)-, Kobalt(II)- und Nickel(II)-butyrat; |
Conditions | Yield |
---|---|
With oxygen; copper diacetate; cobalt(II) acetate at 50℃; under 1471.02 Torr; | |
With oxygen; cobalt(II) carbonate at 50℃; under 1471.02 Torr; | |
With oxygen; manganese(II) acetate at 50℃; under 1471.02 Torr; |
Conditions | Yield |
---|---|
at 120 - 180℃; |
Conditions | Yield |
---|---|
zeitlicher Verlauf; | |
With potassium chloride | |
at 120 - 180℃; |
Conditions | Yield |
---|---|
With lead(II) nitrate |
acetone
butyric acid
A
butanoic acid anhydride
B
acetic butyric anhydride
Conditions | Yield |
---|---|
With copper at 635℃; |
Conditions | Yield |
---|---|
With sulfuric acid; mercury(II) oxide at 60 - 65℃; |
Ketene
butyric acid
A
butanoic acid anhydride
B
acetic anhydride
Conditions | Yield |
---|---|
anschliessendes Erhitzen der Reaktionsprodukte; | |
anschliessendes Erhitzen der Reaktionsprodukte; |
Conditions | Yield |
---|---|
With benzene |
ethynyl methyl ether
butyric acid
A
butanoic acid anhydride
B
acetic acid methyl ester
Conditions | Yield |
---|---|
analoge Reaktionen mit weiteren Saeuren; |
vinyl n-butyrate
butyric acid
A
butanoic acid anhydride
B
acetaldehyde
Conditions | Yield |
---|---|
With sulfuric acid | |
With sulfur dichloride |
butanoic acid anhydride
methyl (2RS,3RS)-2-hydroxy-3-(p-methoxyphenyl)-3-(o-nitrophenylthio)propanoate
Conditions | Yield |
---|---|
With dmap In tetrahydrofuran at 22℃; for 48h; lipase from Pseudomonas cepacia; | 100% |
butanoic acid anhydride
10-Deacetylbaccatine III
Conditions | Yield |
---|---|
With cerium(III) chloride In tetrahydrofuran at 25℃; for 3h; | 100% |
With cerium(III) chloride In tetrahydrofuran at 25℃; for 3h; | 100% |
With cerium(III) chloride In tetrahydrofuran at 25℃; for 3h; Under N2; | 100% |
butanoic acid anhydride
Conditions | Yield |
---|---|
With pyridine at 20℃; for 0.5h; Acetylation; | 100% |
butanoic acid anhydride
3,4-dimethoxy-4-[[[2-(3-methoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin; 3,5-dimethoxy-4-[[[2-(2,5-dimethoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin
Conditions | Yield |
---|---|
Stage #1: butanoic acid anhydride; 3,4-dimethoxy-4-[[[2-(3-methoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin; 3,5-dimethoxy-4-[[[2-(2,5-dimethoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin With pyridine; dmap at 50℃; for 12h; Solid phase reaction; acylation; Stage #2: With dimethylsulfide; water; trifluoroacetic acid In dichloromethane at 20℃; for 15h; Solid phase reaction; cleavage of amide; | 100% |
butanoic acid anhydride
3-fluoro-4-[5-(4-methoxy-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 24h; | 100% |
butanoic acid anhydride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 24h; | 100% |
butanoic acid anhydride
3-fluoro-4-[5-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 24h; | 100% |
Conditions | Yield |
---|---|
Stage #1: butanoic acid anhydride With molybdenium(VI) dioxodichloride In dichloromethane at 20℃; for 0.5h; Stage #2: 2-phenylethanol In dichloromethane at 20℃; for 0.15h; | 100% |
With iron(III) p-toluenesulfonate hexahydrate In neat (no solvent) at 20℃; for 1h; | 85% |
phenyl 2-O-benzyl-1-thio-α-L-rhamnopyranoside
butanoic acid anhydride
phenyl 3,4-di-O-butyryl-2-O-benzyl-1-thio-α-L-rhamnopyranoside
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 2h; | 100% |
With dmap; triethylamine In dichloromethane at 20℃; for 2h; | 100% |
butanoic acid anhydride
3-(6-fluoro-1H-benzimidazol-2-yl)-D-alanine
C14H16FN3O3
Conditions | Yield |
---|---|
Stage #1: butanoic acid anhydride; 3-(6-fluoro-1H-benzimidazol-2-yl)-D-alanine With sodium carbonate In water; acetonitrile at 25℃; for 15h; Stage #2: With hydrogenchloride In water; acetonitrile at 0℃; pH=2; | 100% |
butanoic acid anhydride
2,4,4'-trihydroxy deoxybenzoin
7-hydroxy-3-(4-hydroxy-phenyl)-2-propyl-chromen-4-one
Conditions | Yield |
---|---|
Stage #1: butanoic acid anhydride; 2,4,4'-trihydroxy deoxybenzoin With triethylamine for 22h; Heating / reflux; Stage #2: With hydrogenchloride In water at 20℃; for 2h; pH=5; Stage #3: With hydrogenchloride; sodium hydroxide; water more than 3 stages; | 100% |
butanoic acid anhydride
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 25℃; for 16h; Inert atmosphere; | 100% |
butanoic acid anhydride
Conditions | Yield |
---|---|
In methanol at 20℃; | 100% |
butanoic acid anhydride
Conditions | Yield |
---|---|
With pyridine; dmap at 20℃; | 99.8% |
butanoic acid anhydride
Conditions | Yield |
---|---|
With pyridine; dmap at 20 - 50℃; | 99.8% |
butanoic acid anhydride
1,3,5-triphenylhexahydro-1,3,5-triazine
Butyric acid (butyryl-phenyl-amino)-methyl ester
Conditions | Yield |
---|---|
at 140℃; for 1h; | 99% |
butanoic acid anhydride
3,4,5,6-tetra-O-benzyl inositol
D-3,4,5,6-Tetra-O-benzyl-1,2-di-O-butyryl-myo-inositol
Conditions | Yield |
---|---|
With pyridine; dmap for 1h; Ambient temperature; | 99% |
With pyridine at 50℃; for 24h; | 95% |
butanoic acid anhydride
2-amino-6-fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl)purine
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide for 0.5h; Ambient temperature; | 99% |
butanoic acid anhydride
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane | 99% |
butanoic acid anhydride
2-phenyl-4-(D-erithro-1',2',3'-trihydroxypropyl)-2H-1,2,3-triazole
Conditions | Yield |
---|---|
With Candida antarctica lipase B In di-isopropyl ether at 42 - 45℃; for 1h; | 99% |
butanoic acid anhydride
2-phenyl-4-(D-arabino-1',2',3',4'-tetrahydroxybutyl)-2H-1,2,3-triazole
Conditions | Yield |
---|---|
With Candida antarctica lipase B In di-isopropyl ether at 42 - 45℃; for 2.5h; | 99% |
Conditions | Yield |
---|---|
With pyridine at 20℃; for 25h; | 99% |
butanoic acid anhydride
6-(5,5-dimethyl-1,3-dioxan-2-yl)-6-methyldihydro-2H-pyran-2,4(3H)-dione
3-butyryl-6-(5,5-dimethyl-1,3-dioxan-2-yl)-6-methyldihydro-2H-pyran-2,4(3H)-dione
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16.17h; | 99% |
butanoic acid anhydride
rac-tert-butyl 2-(1-hydroxy-3-methylbutyl)thiazole-4-carboxylate
rac-tert-butyl 2-(1-(butyryloxy)-3-methylbutyl)thiazole-4-carboxylate
Conditions | Yield |
---|---|
With pyridine; dmap In dichloromethane at 20℃; for 0.5h; | 99% |
butanoic acid anhydride
rac-1-(4-bromothiazol-2-yl)ethanol
rac-1-(4-bromothiazol-2-yl)ethyl butyrate
Conditions | Yield |
---|---|
With pyridine; dmap In dichloromethane at 20℃; for 0.5h; | 99% |
butanoic acid anhydride
1,6:3,4-bis-myo-inositol
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 25℃; for 16h; Inert atmosphere; | 99% |
Reported in EPA TSCA Inventory.
DOT Classification: 8; Label: Corrosive
The Butyric anhydride, with the CAS registry number 106-31-0, is also known as Butanoic anhydride. It belongs to the product categories of Pharmaceutical Intermediates; Organics. Its EINECS registry number is 203-383-4. This chemical's molecular formula is C8H14O3 and molecular weight is 158.19. What's more, its IUPAC name is called Butanoyl butanoate. It should be stored in a cool, dry and well-ventilated place. It is a colorless liquid that smells strongly of butyric acid, formed by its reaction with the moisture in the air. It is used for the production of plastics, plasticizers, surfactants and textile auxiliaries. It is also used in food additives, flavorings, varnishes, perfumes, pharmaceuticals and disinfectants. It is used in the synthesis of butyrate ester widely used as perfumes and flavours.
Physical properties about Butyric anhydride are: (1)ACD/LogP: 1.879; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.88; (4)ACD/LogD (pH 7.4): 1.88; (5)ACD/BCF (pH 5.5): 15.78; (6)ACD/BCF (pH 7.4): 15.78; (7)ACD/KOC (pH 5.5): 250.72; (8)ACD/KOC (pH 7.4): 250.72; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 43.37 Å2; (13)Index of Refraction: 1.421; (14)Molar Refractivity: 40.916 cm3; (15)Molar Volume: 161.191 cm3; (16)Polarizability: 16.22×10-24cm3; (17)Surface Tension: 30.961 dyne/cm; (18)Density: 0.981 g/cm3; (19)Flash Point: 87.778 °C; (20)Enthalpy of Vaporization: 43.448 kJ/mol; (21)Boiling Point: 198.279 °C at 760 mmHg; (22)Vapour Pressure: 0.363 mmHg at 25 °C.
Uses of Butyric anhydride: it is used to produce other chemicals. For example, it can react with 2,5-dimethyl-furan to get 1-(2,5-dimethyl-[3]furyl)-butan-1-one. This reaction needs reagent BF3·OEt2. The reaction time is 45 min. The yield is 87 %.
When you are dealing with this chemical, you should be very careful. This chemical may destroy living tissue on contact and it reacts violently with water. It may cause burns. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell seek medical advice immediately.
You can still convert the following datas into molecular structure:
(1) SMILES: O=C(OC(=O)CCC)CCC
(2) InChI: InChI=1S/C8H14O3/c1-3-5-7(9)11-8(10)6-4-2/h3-6H2,1-2H3
(3) InChIKey: YHASWHZGWUONAO-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LC | inhalation | > 50mg/m3 (50mg/m3) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 4, Pg. 29, 1962. | |
mouse | LDLo | oral | 1gm/kg (1000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 4, Pg. 29, 1962. |
rat | LC | inhalation | > 50mg/m3 (50mg/m3) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 4, Pg. 29, 1962. | |
rat | LD50 | oral | 8790mg/kg (8790mg/kg) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 321, 1986. |
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