Creatine supplier | CasNO.57-00-1

Name
Creatine
EINECS 200-306-6
CAS No. 57-00-1
Article Data80
CAS DataBase
Density 1.38 g/cm³
Solubility Soluble in water.
Melting Point ~295°C (dec.)
Formula C₄H₉N₃O₂
Boiling Point 271.6 °C at 760 mmHg
Molecular Weight 131.134
Flash Point 118.1 °C
Transport Information
Appearance White powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Creatine(8CI);Cosmocair C 100;Kre-Alkalyn;Methylguanidoacetic acid;N-Methyl-N-guanylglycine;NSC 8752;Neotine;Phosphagen;Tego Cosmo C 100;Creatine;
PSA 90.41000
LogP -0.30370

Synthetic route

: 156-62-7
calcium cyanamide

: 4316-73-8
sodium sarcosinate

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With phosphoric acid; sulfuric acid	86%
phosphoric acid	75%
sulfuric acid

: 107-97-1
sarcosine

: 1758-73-2
Aminoiminomethanesulfinic acid

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With sodium hydroxide at 20℃; Substitution; N-Formamidinylation;	83.2%

: 420-04-2
CYANAMID

: 4316-73-8
sodium sarcosinate

: 57-00-1
Creatinine

Conditions

Conditions	Yield
Stage #1: sodium sarcosinate With hydrogenchloride In water pH=9.6; Cooling; Stage #2: CYANAMID In water at 75 - 80℃; for 3.5h;	76.2%
In 2-Methyl-1,2-propanediol	75%
With carbon dioxide In water at 75℃; for 6h; pH=9 - 10;	75%
With formic acid In tert-butyl methyl ether at 50℃; for 1h; pH=9.8;	70%
With ammonium chloride	68%

: 352-97-6
guanidineacetic acid

: 616-38-6
carbonic acid dimethyl ester

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With aluminum (III) chloride; potassium carbonate at 95℃; for 3h; Temperature; Large scale;	75.61%

: 60-27-5
Creatinine

: 57-00-1
Creatinine

: 60-27-5
creatinine

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With calcium hydroxide
With water
With water at 36℃; Ein Gleichgewicht zwischen Kreatin und Kreatinin stellt sich nach 11 Monaten ein;
With ammonia

: 107-97-1
sarcosine

: 420-04-2
CYANAMID

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With ammonia
With ethanol at 100℃;

: 107-97-1
sarcosine

: 124-46-9, 20734-13-8, 100224-74-6, 593-85-1
guanidine hydrogen carbonate

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With creatinine; water

: 107-97-1
sarcosine

: 14527-26-5, 867-44-7
2-methylisothiourea sulphate

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With ammonium hydroxide
With ammonium hydroxide

: 107-97-1
sarcosine

: 57-00-1
Creatinine

Conditions

Conditions	Yield
in Muskel-Praeparaten;

: 812-00-0
methylphosphate

: 352-97-6
guanidineacetic acid

: 57-00-1
Creatinine

Conditions

Conditions	Yield
unter der Einwirkung von Leber-Praeparaten;
in Gegenwart von Rattenleberbrei unter anaeroben Bedingungen;

: 63-68-3
L-methionine

: 352-97-6
guanidineacetic acid

: 57-00-1
Creatinine

Conditions

Conditions	Yield
im Organismus von Ratten und Kaninchen;
unter der Einwirkung von Weizenkeim-Praeparaten;
unter der Einwirkung von Leber-Praeparaten;
unter der Einwirkung von Muskel-Praeparaten;

: 1184-78-7
trimethylamine-N-oxide

: 62-49-7
choline

: 57-00-1
Creatinine

: 62-49-7
choline

: 352-97-6
guanidineacetic acid

: 57-00-1
Creatinine

Conditions

Conditions	Yield
unter der Einwirkung von Muskel-Praeparaten;
im Organismus von Ratten bei gleichzeitiger Verabreichung von Homocystin;

: 352-97-6
guanidineacetic acid

: 57-00-1
Creatinine

Conditions

Conditions	Yield
biochemische Methylierung;
im Organismus des Kaninchens;

: 67-07-2
Phosphocreatine

: 57-00-1
Creatinine

: 107-43-7
betaine

: 57-00-1
Creatinine

Conditions

Conditions	Yield
im Organismus der Ratte;

: 123-41-1
cholin hydroxide

A: 60-27-5
creatinine

B: 57-00-1
Creatinine

Conditions

Conditions	Yield
Bei der Einw.von Gemischen aus Gehirn- und Leberbrei von Hunden oder Ratten in Gegenwart von Arginin oder Harnstoff;
Bei der Einw.von Gemischen aus Muskel- und Leberbrei von Hunden oder Ratten in Gegenwart von Arginin oder Harnstoff;

: 107-97-1
sarcosine

: 2440-60-0
2-methyl-isourea

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With methanol

: 74-79-3
L-arginine

: 56-40-6
glycine

: 57-00-1
Creatinine

Conditions

Conditions	Yield
in Leber und Muskel-Praeparaten sowie im Organismus;

: 107-97-1
sarcosine

: 4338-95-8
S-methylthiouronium iodide

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With sodium hydroxide

: 60-27-5
Creatinine

: 7664-41-7
ammonia

: 57-00-1
Creatinine

: 60-27-5
Creatinine

: 7732-18-5
water

: 57-00-1
Creatinine

Conditions

Conditions	Yield
at 36℃;

: 60-27-5
Creatinine

: ammonium hydroxide

: 57-00-1
Creatinine

Conditions

Conditions	Yield
at 20℃;

: 60-27-5
Creatinine

4water: 4water

: 57-00-1
Creatinine

Conditions

Conditions	Yield
at 20℃;

: 60-27-5
Creatinine

: 7732-18-5
water

lead hydroxide: lead hydroxide

: 57-00-1
Creatinine

...Expand

flesh-extract: flesh-extract

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With mercury(II) sulfate sowie aus Geweben und Fluessigkeiten des Koerpers;
With hydrochloride of HgCl2 sowie aus Geweben und Fluessigkeiten des Koerpers;

Liebig's flesh-extract: Liebig's flesh-extract

: 57-00-1
Creatinine

Conditions

Conditions	Yield
With ethanol

Liebig's urine: Liebig's urine

: 57-00-1
Creatinine

Conditions

Conditions	Yield
ueber das Kreatinin-ZnCl2-Doppelsalz;

: 1077-28-7, 62-46-4
Thioctic acid

: 57-00-1
Creatinine

: creatine α-lipoate

Conditions

Conditions	Yield
at 75℃; for 0.166667h;	98%

: 56-40-6
glycine

: 57-00-1
Creatinine

: 859980-98-6
creatine glycinate

Conditions

Conditions	Yield
In water at 50℃; for 1h;	97%

: 5080-50-2
O-acetyl-L-carnitine hydrochloride

: 57-00-1
Creatinine

: acetyl L-carnitine creatinate hydrochloride

Conditions

Conditions	Yield
In 2-methyl-propan-1-ol; water at 40℃;	96%

: 541-15-1
L-carnitine

: 57-00-1
Creatinine

: L-carnitine creatinate phosphate

Conditions

Conditions	Yield
With phosphoric acid In 2-methyl-propan-1-ol; water at 40℃;	95%

: 1313397-92-0
5-(1-oxo-1,3-dihydroisobenzofuran-5-yl)thiophene-2-carbaldehyde

: 57-00-1
Creatinine

: 1313397-09-9
(E,Z)-2-imino-1-methyl-5-((5-(1-oxo-1,3-dihydroisobenzofuran-5-yl)thiophen-2-yl)methylene)imidazolidin-4-one

Conditions

Conditions	Yield
With acetic acid; 3-amino propanoic acid for 15h; Reflux;	95%

: 57-00-1
Creatinine

: 60-27-5
Creatinine

Conditions

Conditions	Yield
With acetic acid for 2h; Reagent/catalyst; Reflux;	93.4%
With water
With hydrogenchloride

: 57-00-1
Creatinine

: Disodium phosphocreatine

Conditions

Conditions	Yield
With triethylamine; trichlorophosphate In acetonitrile at -4 - 0℃; for 15.1h; Time;	92.9%

: 57-00-1
Creatinine

: 640265-22-1
7-methyl-2,3-dihydro-3-dimethylaminomethylenethiopyrano[2,3-b]pyridin-4(4H)-one

: 8-methyl-N-methyl-N-(5H-pyrido[3',2';5,6]thiopyrano[3,4-d]pyrimidin-2-yl)glycine

Conditions

Conditions	Yield
Stage #1: Creatinine With sodium ethanolate In ethanol at 20℃; for 0.25h; Stage #2: 7-methyl-2,3-dihydro-3-dimethylaminomethylenethiopyrano[2,3-b]pyridin-4(4H)-one In ethanol for 4h; Heating;	91%

: 57-00-1
Creatinine

: C4H8ClN3O

Conditions

Conditions	Yield
With thionyl chloride In dichloromethane at 0 - 5℃; for 1h; Inert atmosphere;	90%

: 64-17-5
ethanol

: 57-00-1
Creatinine

: 15366-32-2
ethyl 2-(3-methylguanidino)acetate hydrochloride

Conditions

Conditions	Yield
With phosgene; dmap at 10℃; for 0.5h; Reagent/catalyst; Sealed tube;	89%
With chlorophosphonic acid at 0 - 60℃; for 0.75h;	73%
at 37℃; for 20h; Product distribution / selectivity; Acidic conditions;	54%

: 40682-97-1
7-methyl-4-oxo-(4H)-1-benzopyran-3-carbaldehyde

: 57-00-1
Creatinine

: [{5-[(2-hydroxy-4-methylphenyl)carbonyl]pyrimidin-2-yl}(methyl)amino]acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 14h; Reflux;	86%

: 144455-11-8
1-(1-dimethylaminomethylene-2-oxo-2-phenylethyl)-3,5-diphenyl-1H-pyrazole

: 57-00-1
Creatinine

: 144454-94-4
{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-acetic acid

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 12h; Heating;	85%

: 100-51-6
benzyl alcohol

: 57-00-1
Creatinine

: 404576-05-2
creatine benzyl ester hydrochloride

Conditions

Conditions	Yield
With chlorophosphonic acid at 20℃; for 2h;	85%

: copper(II) nitrate trihydrate

: hydrazine hydrate

: 57-00-1
Creatinine

: [bis(2-(carbamimidoyl(methyl)amino)acetate)-bis(hydrazinate)copper(II)]

Conditions

Conditions	Yield
In water for 1h;	84%

...Expand

: 98-59-9
p-toluenesulfonyl chloride

: 57-00-1
Creatinine

: N-(imino{[(4 methylphenyl)sulfonyl]amino}methyl)-Nmethylglycine

Conditions

Conditions	Yield
With sodium carbonate In water	82.7%

: 98-59-9
p-toluenesulfonyl chloride

: 57-00-1
Creatinine

: N-[{bis[(4-methylphenyl)sulfonyl]amino}(imino)methyl]-N-methylglycine

Conditions

Conditions	Yield
With sodium carbonate In water	82.2%

: 98-09-9
benzenesulfonyl chloride

: 57-00-1
Creatinine

: N-[[bis(phenylsulfonyl)amino](imino)methyl]-N-methylglycine

Conditions

Conditions	Yield
With sodium carbonate In water	81.3%

: 64-17-5
ethanol

: 57-00-1
Creatinine

A: 15366-32-2
ethyl 2-(3-methylguanidino)acetate hydrochloride

B: 141-78-6
ethyl acetate

Conditions

Conditions	Yield
Stage #1: ethanol With acetyl chloride at 35 - 60℃; Stage #2: Creatinine at 35 - 50℃; for 2 - 8h;	A 80% B n/a
Stage #1: ethanol With acetyl chloride Stage #2: Creatinine at 37℃; for 10 - 20h; Product distribution / selectivity;	A 37% B n/a

...Expand

: cobalt(II) nitrate hexahydrate

: copper(II) nitrate trihydrate

: nickel(II) nitrate hexahydrate

: zinc(II) nitrate hexahydrate

: hydrazine hydrate

: 57-00-1
Creatinine

: 0.14,0.2,0.08,

Conditions

Conditions	Yield
In water for 1h;	77%

...Expand

: 34773-02-9
2-(Dimethylaminomethylene)-3,4-dihydro-1(2H)-naphthalenone

: 57-00-1
Creatinine

: [(5,6-dihydro-benzo[h]quinazolin-2-yl)-methyl-amino]-acetic acid

Conditions

Conditions	Yield
Stage #1: Creatinine With sodium ethanolate In ethanol at 20℃; for 0.25h; Metallation; Stage #2: 2-(Dimethylaminomethylene)-3,4-dihydro-1(2H)-naphthalenone In ethanol for 10h; Cyclization; Heating;	74%

: 6135-19-9
2-((dimethylamino)methylene)cyclohexanone

: 57-00-1
Creatinine

: [methyl-(5,6,7,8-tetrahydro-quinazolin-2-yl)-amino]-acetic acid

Conditions

Conditions	Yield
Stage #1: Creatinine With sodium ethanolate In ethanol at 20℃; for 0.25h; Metallation; Stage #2: 2-((dimethylamino)methylene)cyclohexanone In ethanol for 10h; Cyclization; Heating;	72%

: cobalt(II) nitrate hexahydrate

: magnesium(II) nitrate hexahydrate

: copper(II) nitrate trihydrate

: nickel(II) nitrate hexahydrate

: zinc(II) nitrate hexahydrate

: hydrazine hydrate

: 57-00-1
Creatinine

: 0.16,0.14,0.08,0.06,1.56

Conditions

Conditions	Yield
In water for 1h;	71%

...Expand

: 6-chloro-5-7-dimethyl-4oxo-4H-chromene-3-carbaldehyde

: 57-00-1
Creatinine

: [{5-[(3-chloro-6-hydroxy-2,4-dimethylphenyl)carbonyl]pyrimidin-2-yl}(methyl)amino]acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 14h; Reflux;	70%

: 98-09-9
benzenesulfonyl chloride

: 57-00-1
Creatinine

: N-{imino[(phenylsulfonyl)amino]methyl}-N-methylglycine

Conditions

Conditions	Yield
With sodium carbonate In water	64.7%

: 74396-87-5
3-(Dimethylaminomethylene)-4-chromanone

: 57-00-1
Creatinine

: 176717-37-6
[Methyl-(10H-9-oxa-2,4-diaza-phenanthren-3-yl)-amino]-acetic acid

Conditions

Conditions	Yield
With sodium ethanolate In ethanol 1.) 15 min, 2.) reflux, 4 h;	63%

: 6-(Dimethylaminomethylene)-2-cyclohexen-1-one

: 57-00-1
Creatinine

: [(5,6-dihydro-quinazolin-2-yl)-methyl-amino]-acetic acid

Conditions

Conditions	Yield
Stage #1: Creatinine With sodium ethanolate In ethanol at 20℃; for 0.25h; Metallation; Stage #2: 6-(dimethylaminomethylene)cyclohex-2-en-1-one In ethanol for 10h; Cyclization; Heating;	62%

Creatine Specification

Creatine, with the CAS registry number 57-00-1, has the IUPAC name of 2-[carbamimidoyl(methyl)amino]acetic acid. Its product categories are including Amino Acids; CO - CZEnvironmental Standards; Alphabetic; Metabolites; Pesticides&Metabolites and it is usually used for biochemical research. Creatine is a chemical that is normally found in the body, mostly in muscles. It is made by the body and can also be obtained from certain foods. Fish and meats are good sources of creatine. Creatine can also be made in the laboratory.

Physical properties about Creatine are: (1)ACD/LogP: -1.258; (2)ACD/LogD (pH 5.5): -3.75; (3)ACD/LogD (pH 7.4): -3.76; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 5; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 2; (11)Index of Refraction: 1.552; (12)Molar Refractivity: 30.279 cm³; (13)Molar Volume: 94.736 cm³; (14)Polarizability: 12.004 10-24cm³; (15)Surface Tension: 57.6500015258789 dyne/cm; (16)Density: 1.384 g/cm³; (17)Flash Point: 118.083 °C; (18)Enthalpy of Vaporization: 56.12 kJ/mol; (19)Boiling Point: 271.638 °C at 760 mmHg; (20)Vapour Pressure: 0.0020000000949949 mmHg at 25°C

Uses of Creatine: Creatine is most commonly used for improving exercise performance and increasing muscle mass in athletes and older adults. Creatine use is widespread among professional and amateur athletes and has been acknowledged by well-known athletes such as Mark McGuire, Sammy Sosa, and John Elway.

When you are dealing with this chemical, you should be much more cautious. For being among the irritant chemicals, it is irritating to eyes, respiratory system and skin and may cause inflammation to the skin or other mucous membranes. Therefore, you should wear suitable protective clothing. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9);
(2)InChIKey=CVSVTCORWBXHQV-UHFFFAOYSA-N;
(3)SmilesN(CC(=O)O)(C(=N)N)C

Product Name

Creatine

Synthetic route

Creatine Specification

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