Conditions | Yield |
---|---|
In acetic anhydride reflux; washed with acetic anhydride and ether;; | 93% |
In acetic anhydride reflux; washed with acetic anhydride and ether;; | 93% |
In neat (no solvent) on warming;; | |
In neat (no solvent) on warming;; |
Conditions | Yield |
---|---|
In dichloromethane N2, acid added at room temp.; | A n/a B 85% |
Conditions | Yield |
---|---|
With copper(II) nitrate at 30 - 35℃; |
Conditions | Yield |
---|---|
With copper(II) nitrate |
Conditions | Yield |
---|---|
at 30 - 45℃; |
copper diacetate
copper diacetate
Conditions | Yield |
---|---|
With toluene azeotrope Destillation; |
copper diacetate
Conditions | Yield |
---|---|
In neat (no solvent, solid phase) byproducts: H2O; acetate was heated in vac. at 150°C for 3 h; |
Conditions | Yield |
---|---|
In not given CH3CO2H passed over CuO at 230°C; CuO obtained by heating Cu(NO3)2 to red heat;; | |
In not given CH3CO2H passed over CuO at 230°C; CuO obtained by heating Cu(NO3)2 to red heat;; |
copper
acetic acid
copper diacetate
Conditions | Yield |
---|---|
In nitric acid aq. HNO3; Dissolving copper metal in a mixt. of HNO3 and distd. water followed twice by evapn. to near dryness and addn. of a mixt. of acetic acid and distd. water.; Not isolated.; |
Conditions | Yield |
---|---|
In acetic acid treatment of CuCO3 with CH3COOH; recrystn. from aq. methanol, drying; | |
In acetic acid Cu(II) carbonate treated with acetic acid according to Prabhumirashi, L.S., Khoje J. K., Thermochim Acta, 383 (2002) 109; |
Conditions | Yield |
---|---|
In neat (no solvent) | |
In neat (no solvent) |
copper
copper diacetate
Conditions | Yield |
---|---|
With acetic acid In not given 5% acetic acid; | >99 |
With acetic acid In not given 5% acetic acid; | >99 |
Conditions | Yield |
---|---|
at 140°C;; | |
In neat (no solvent) byproducts: H2O; vac. dehydration at 363 K, according to: G. Maslowska, A. Baranowska, Prod. Eighth Conf. Coord. Chem., Smolenice, Bratislava, 1980, pp. 269-273; | |
In neat (no solvent) heating to 90°C;; |
copper diacetate
Conditions | Yield |
---|---|
In neat (no solvent) 110°C, vac.; | |
In acetic anhydride 24 h, refluxing, dry atmosphere; filtration, washing (Et2O), drying (8 h, 100°C, vac.); |
copper diacetate
Conditions | Yield |
---|---|
In not given |
copper diacetate
Conditions | Yield |
---|---|
In neat (no solvent) Kinetics; byproducts: 4-benzoylpyridine; thermal decompn. at 215°C;; |
copper diacetate
Conditions | Yield |
---|---|
In acetic anhydride 3 h, excess of Ac2O, refluxing; filtn., washing (CH2Cl2), drying (vac.); |
copper hydroxide
copper diacetate
Conditions | Yield |
---|---|
With acetic acid In acetic acid copper hydroxide dissoln.; | |
With acetic acid In water pH 5-6; evapn. (70°C), drying (70°C); elem. anal.; |
copper diacetate
Conditions | Yield |
---|---|
In neat (no solvent) at 50°C;; | |
In neat (no solvent) at 50°C;; |
Conditions | Yield |
---|---|
With water In water hydrolysis;; | |
With H2O In water hydrolysis;; |
copper diacetate
Conditions | Yield |
---|---|
With acetic acid 5% acetic acid; | >99 |
With acetic acid leaching with 5% acetic acid; | >99 |
With acetic acid 5% acetic acid; | >99 |
N-(pyridine-2-ylethyl)-2-hydroxy-benzylideneamine
(Cu(C5H4NCH2CH2NCHC6H4O)2)
B
copper diacetate
Conditions | Yield |
---|---|
In methanol under Ar; MeOH soln. of ligand, CuCl2 and NaOH (molar ratio 1:1:1) heated under reflux for 3 h; cooled to room temp.; recrystd. from MeOH under Ar; |
Conditions | Yield |
---|---|
With ammonium hydroxide In water heating to 90°C;; | |
With aq. NH3 In water heating to 90°C;; |
A
copper diacetate
B
copper hydroxide
Conditions | Yield |
---|---|
at ambient temp.;; | |
at ambient temp.;; |
copper diacetate
Conditions | Yield |
---|---|
In neat (no solvent) dry distn.;; |
[((CH3)3SiC2Si(CH3)3)[Cu(μ-acetate)]2]2
A
copper diacetate
B
copper
Conditions | Yield |
---|---|
In not given N2 atmosphere; |
copper diacetate
(3S,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)-ethyl]-4-phenylthio-2-azetidinone
(3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one
Conditions | Yield |
---|---|
With acetic acid at 100℃; for 0.75h; | 100% |
at 100℃; for 0.75h; |
Conditions | Yield |
---|---|
for 0.166667h; | 100% |
In ethanol deposition on colloidal polystyrene crystal array; |
Conditions | Yield |
---|---|
for 0.166667 - 6h; Product distribution / selectivity; Neat (no solvent); Mechanochemistry; | 100% |
Conditions | Yield |
---|---|
Refluxing of Schiff base and metal acetate in 2:1 molar ratio for 2-4 h.; Filtn. of resulting complex, washing, drying and collecting at room temp., elem. anal.; | 100% |
5,10,15,20-tetraphenyl-21H,23H-porphine
copper diacetate
(tetraphenylporphyrin)copper(II)
Conditions | Yield |
---|---|
In solid High Pressure; 2000 MPa at room temp.; extrd. (chloroform), chromy.(alumina); UV; | 100% |
In 1,4-dioxane refluxing of C44H30N4 and copper(II) acetate in dioxane for 2.5 h;; evapn. in vac.; chromy. (trichloroethylene); recrystn. from CHCl3/methanol;; | 86% |
In 1,4-dioxane refluxing of C44H30N4 and copper(II) acetate in dioxane for 2.5 h;; evapn. in vac.; chromy. (trichloroethylene); recrystn. from CHCl3/methanol;; | 86% |
nickel(II) salen
copper diacetate
N,N'-ethylenebis(salicylideneiminato)copper(II)
Conditions | Yield |
---|---|
In pyridine Kinetics; boiling pyridine; | 100% |
In pyridine Kinetics; boiling pyridine; | 100% |
copper diacetate
Conditions | Yield |
---|---|
In methanol to ligand in boiling CHCl3 is added a saturated soln. of Cu(OAc)2 in MeOH, mixt. is refluxed for 1 h; evapn., residue is dissolved in CHCl3 and the soln. is loaded on a neutral alumina column, eluated by CHCl3, eluate is evapd. and MeOH is added, crystals are filtered and air-dried, elem. anal.; | 100% |
copper diacetate
3,5-bis-(o-hydroxyphenyl)-1,2,4-oxadiazole
Cu(2+)*C2N2O(C6H4O)2(2-)=Cu(C2N2O(C6H4O)2)
Conditions | Yield |
---|---|
In methanol; propan-1-ol adding the acetate in a min. vol. of hot MeOH to a soln. of the ligand in propanol, boiling until the cryst. product appears (5 - 10 min); cooling, filtering, washing (EtOH), drying (vac., 100°C); elem. anal.; | 100% |
Conditions | Yield |
---|---|
In methanol stirring, (reflux, 2-3 h); concn., cooling, filtn., recryst. (MeOH), drying (air); elem. anal.; | 100% |
Conditions | Yield |
---|---|
In dimethyl sulfoxide stirring; filtn., washing (DMSO, hot H2O, acetone), drying (60°C, 24 h); elem. anal.; | 100% |
Conditions | Yield |
---|---|
In tetrahydrofuran; methanol ligand in THF added dropwise to CH3OH soln. of Cu salt (1.1 equiv.), treated with CH3OH, reacted for 16 h; elem. anal.; | 100% |
copper diacetate
(S)-N-(5-nitro-salicylidene)-2-amino-1,1-di-(5-tert-butyl-2-butoxy-phenyl)-propan-1-ol
[(2S)-N-(5-nitrosalicylidene)-2-amino-1,1-di(5-tert-butyl-2-n-butoxyphenyl)-1-propanol] copper complex
Conditions | Yield |
---|---|
In toluene at 80℃; for 5h; Product distribution / selectivity; | 100% |
copper diacetate
Cu(5,10,15,20-tetramesitylporphyrin)
Conditions | Yield |
---|---|
100% |
Conditions | Yield |
---|---|
In methanol; dichloromethane Inert atmosphere; Heating; | 100% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; Darkness; | 100% |
Conditions | Yield |
---|---|
In methanol; chloroform for 0.5h; Reflux; | 100% |
copper diacetate
Conditions | Yield |
---|---|
In ethanol at 20℃; | 100% |
copper diacetate
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 80℃; for 8h; | 100% |
Conditions | Yield |
---|---|
In tetrahydrofuran | 100% |
Conditions | Yield |
---|---|
at 20℃; for 5h; | 100% |
copper diacetate
Conditions | Yield |
---|---|
Stage #1: copper diacetate; 2,2'-(1,8-dithia-4,11-diazacyclotetradecane-4,11-diyl)diacetic acid dihydrochloride In water; acetonitrile at 23℃; for 0.166667h; Inert atmosphere; Stage #2: In water; acetonitrile at 23℃; for 0.0833333h; Inert atmosphere; Sonication; | 100% |
Conditions | Yield |
---|---|
In methanol Milling; Green chemistry; | 99.3% |
copper diacetate
Conditions | Yield |
---|---|
In methanol; chloroform at 20℃; for 12h; | 99% |
copper diacetate
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide heated under Ar; UV; | 99% |
(C6H5)4(CH3(CH2)3)(C5H2N)4H3O2
copper diacetate
Conditions | Yield |
---|---|
In methanol; dichloromethane a ligand in boiling CH2Cl2 was treated with excess of Cu acetate in warmMeOH; soln. washed with water and dried over Na2SO4; | 99% |
copper diacetate
1,3-bis[4-(4-tert-butylphenyl)-2,2':6',2''-terpyridin-6-yl]benzene
Conditions | Yield |
---|---|
In methanol refluxing the Cu salt and the ligand in MeOH for 30 min, filtration, addn. of satd. methanolic NH4PF6; recrystn. by diffusion of Et2O into a MeCN soln.; elem. anal.; | 99% |
Conditions | Yield |
---|---|
In dichloromethane hexaphyrin was treated with anhyd. Cu(II) acetate in CH2Cl2 soln.; | 99% |
copper diacetate
Conditions | Yield |
---|---|
In methanol stoich. amts., room temp.; | 99% |
sodium tetrafluoroborate
copper diacetate
Conditions | Yield |
---|---|
In dichloromethane stoich. mixt.; elem. anal.; | 99% |
copper diacetate
Conditions | Yield |
---|---|
In methanol at room temp.; | 99% |
Copper(II) acetate (CAS NO.142-71-2) is occasionally the primary component of verdigris, the blue-green substance that forms on copper during long exposures to atmosphere. It was historically prepared in vineyards, since acetic acid is a byproduct of fermentation.Copper (cupric) acetate tablets were believed to repel sharks in the mid twentieth century.
Reported in EPA TSCA Inventory. Copper and its compounds are on the Community Right-To-Know List.
ACGIH TLV: TWA 1 mg(Cu)/m3
The IUPAC name of this chemical is copper diacetate. With the CAS registry number 142-71-2, it is also named as Acetate de cuivre. The product's categorie is organic-metal salt. It is green crystalline powder which is soluble in water and ethanol, slightly soluble in ether and glycerol. In addition, it is highly toxic and the storage environment should be ventilate, low-temperature and dry. Keep Copper(II) acetate separate from acids.
The other characteristics of this product can be summarized as: (1)ACD/LogP: -0.29; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.07; (4)ACD/LogD (pH 7.4): -2.86; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 2.73; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 0; (12)Flash Point: 40 °C; (13)Enthalpy of Vaporization: 23.7 kJ/mol; (14)Boiling Point: 117.1 °C at 760 mmHg; (15)Vapour Pressure: 13.9 mmHg at 25°C; (16)Exact Mass: 180.95621; (17)MonoIsotopic Mass: 180.95621; (18)Topological Polar Surface Area: 80.3; (19)Heavy Atom Count: 9; (20)Complexity: 25.5.
Preparation of Copper(II) acetate: It has been synthesized for centuries by the method described in the history section. The overall reaction is as follows:
2 CuSO4.5H2O + 4 NH3 + 4 C2H4O → Cu2(OAc)4(H2O)2 + 2 (NH4)2SO4 + 8 H2O
The hydrate form can be dehydrated by heating at 100 °C in a vacuum:
Cu2(OAc)4(H2O)2 → Cu2(OAc)4 + 2 H2O
Heating a mixture of anhydrous Cu2(OAc)4 and copper metal affords colorless, volatile cuprous acetate:
2 Cu + Cu2(OAc)4 → 4 CuOAc
Uses of Copper(II) acetate: It is used as an insecticide, in the preparation of other chemicals, as a fungicide, and mildew preventive, fungicides, printing and dyeing fixing agent. And it also has been used as intermediate to prepare Paris green.
When you are using this chemical, please be cautious about it as the following:
It is not only harmful if swallowed, but also irritating to eyes, respiratory system and skin. And it is also very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. This material and its container must be disposed of as hazardous waste. Additionally, people should avoid release to the environment.
People can use the following data to convert to the molecule structure.
1. SMILES:[Cu+2].[O-]C(=O)C.[O-]C(=O)C
2. InChI:InChI=1/2C2H4O2.Cu/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
3. InChIKey:OPQARKPSCNTWTJ-NUQVWONBAO
The following are the toxicity data which has been tested.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 2500ug/kg (2.5mg/kg) | Biochemical Pharmacology. Vol. 30, Pg. 771, 1981. | |
mouse | LD50 | intravenous | 20mg/kg (20mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
mouse | LD50 | oral | 196mg/kg (196mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
rabbit | LDLo | oral | 250mg/kg (250mg/kg) | Journal of Medical Research. Vol. 42, Pg. 461, 1919. | |
rat | LD50 | intraperitoneal | 14700ug/kg (14.7mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
rat | LD50 | intravenous | 17100ug/kg (17.1mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
rat | LD50 | oral | 501mg/kg (501mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
rat | LD50 | subcutaneous | 350mg/kg (350mg/kg) | MUSCULOSKELETAL: JOINTS | Progress in Medical Chemistry. Vol. 15, Pg. 211, 1977. |
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