Cyclopropanecarboxylic acid chloride supplier

Name
Cyclopropanecarbonyl Chloride
EINECS 223-684-4
CAS No. 4023-34-1
Article Data57
CAS DataBase
Density 1.317 g/cm³
Solubility decomposes in water
Melting Point 77.5-78.5 °C(Solv: hexane (110-54-3))
Formula C₄H₅ClO
Boiling Point 119 °C at 760 mmHg
Molecular Weight 104.536
Flash Point 23.3 °C
Transport Information UN 2920 8/PG 2
Appearance clear colorless to slightly yellow liquid
Safety 26-36/37/39-45-8-16
Risk Codes 10-34-29-25-36-38
Molecular Structure
Hazard Symbols C, F
Synonyms Cyclopropanecarbonyl chloride;Cyclopropane Carbonyl Chloride;Cyclopropanoyl Chloride;
PSA 17.07000
LogP 1.16180

Synthetic route

: 1759-53-1
cyclopropanecarboxylic acid

: 4023-34-1
cyclopropanecarboxylic acid chloride

Conditions

Conditions	Yield
With thionyl chloride In toluene Heating;	100%
With thionyl chloride for 3h; Heating;	95%
With thionyl chloride for 4h; Heating;	88%

: 155-22-6
cyclopropanecarboxylic acid Na-salt

: 4023-34-1
cyclopropanecarboxylic acid chloride

Conditions

Conditions	Yield
With oxalyl dichloride
With oxalyl dichloride In dichloromethane at 0 - 20℃; for 1h;

: 79-37-8
oxalyl dichloride

: 1759-53-1
cyclopropanecarboxylic acid

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1759-53-1
cyclopropanecarboxylic acid

A: 663618-19-7
5-cyclopropanepentanoyl chloride

B: 4023-34-1
cyclopropanecarboxylic acid chloride

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 6228-73-5
Cyclopropancarbamid

Conditions

Conditions	Yield
With ammonia In dichloromethane at 20℃; for 2h;	100%
With ammonia In dichloromethane; water at 20℃; for 2h;	100%
With diethyl ether; ammonia
With ammonium hydroxide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1489-69-6
Cyclopropanecarboxaldehyde

Conditions

Conditions	Yield
With sodium tris(tert-butoxo)aluminium hydride In tetrahydrofuran; diethylene glycol dimethyl ether at -78℃; for 3h;	100%
With diethylene glycol dimethyl ether; lithium tri-t-butoxyaluminum hydride
With sodium tetrahydroborate; cadmium(II) chloride In N,N,N,N,N,N-hexamethylphosphoric triamide; acetonitrile at -5℃; for 0.0833333h; Yield given;
With thexyl-s-butoxyborane In tetrahydrofuran at 25℃; for 96h; Yield given;
Stage #1: cyclopropanecarboxylic acid chloride With aluminium hydride In tetrahydrofuran at 20℃; for 1h; Metallation; Stage #2: With pyridinium chlorochromate In tetrahydrofuran; dichloromethane at 20℃; for 6h; Oxidation;	98 % Chromat.

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 466-97-7, 13396-02-6, 99295-16-6, 142864-36-6
normorphine

: 81815-58-9
3-O,N-dicyclopropylcarbonylnormorphine

Conditions

Conditions	Yield
With triethylamine In chloroform for 8h; Heating;	100%

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 162930-74-7
10,11-dihydro-4-nitro-5H-dibenzo<1,4>diazepine

: 1026556-44-4
Cyclopropyl-(4-nitro-5,11-dihydro-dibenzo[b,e][1,4]diazepin-10-yl)-methanone

Conditions

Conditions	Yield
In dichloromethane for 16h; Ambient temperature;	100%

: 2033-24-1
cycl-isopropylidene malonate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 146380-13-4
5-(cyclopropyl(hydroxy)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; Acylation;	100%
Stage #1: cycl-isopropylidene malonate With pyridine In dichloromethane at 0℃; for 0.25h; Stage #2: cyclopropanecarboxylic acid chloride In dichloromethane at 0 - 20℃; for 3h;	60%
With pyridine In dichloromethane at 0 - 20℃; for 3h; Acylation;

: 4023-34-1
cyclopropanecarboxylic acid chloride

3,4-dimethoxy-4-[[[2-(3-methoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin; 3,5-dimethoxy-4-[[[2-(2,5-dimethoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin: 3,4-dimethoxy-4-[[[2-(3-methoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin; 3,5-dimethoxy-4-[[[2-(2,5-dimethoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin

N-[2-(3-methoxyphenyl)ethyl]cyclopropylformamide; N-[2-(2,5-dimethoxyphenyl)ethyl]cyclopropylformamide; mixture of: N-[2-(3-methoxyphenyl)ethyl]cyclopropylformamide; N-[2-(2,5-dimethoxyphenyl)ethyl]cyclopropylformamide; mixture of

Conditions

Conditions	Yield
Stage #1: cyclopropanecarboxylic acid chloride; 3,4-dimethoxy-4-[[[2-(3-methoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin; 3,5-dimethoxy-4-[[[2-(2,5-dimethoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin With triethylamine In 1,2-dichloro-ethane at 20℃; for 20h; Solid phase reaction; acylation; Stage #2: With dimethylsulfide; water; trifluoroacetic acid In dichloromethane at 20℃; for 15h; Solid phase reaction; cleavage of amide;	100%

Yield

Stage #1: cyclopropanecarboxylic acid chloride; 3,4-dimethoxy-4-[[[2-(3-methoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin; 3,5-dimethoxy-4-[[[2-(2,5-dimethoxyphenyl)ethyl]amino]methyl]phenoxy-Merrifield resin With triethylamine In 1,2-dichloro-ethane at 20℃; for 20h; Solid phase reaction; acylation;
Stage #2: With dimethylsulfide; water; trifluoroacetic acid In dichloromethane at 20℃; for 15h; Solid phase reaction; cleavage of amide;

100%

: 4023-34-1
cyclopropanecarboxylic acid chloride

: trinexapac ethyl

: 4-cyclopropanecarbonyl-3-cyclopropanecarbonyloxy-5-oxo-cyclohex-3-enecarboxylic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 101386-00-9
2-isobutyryl-1,3-cyclohexanedione

: cyclopropanecarboxylic acid 2-isobutyryl-3-oxo-cyclohex-1-enyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%

: 420-04-2
CYANAMID

: 4023-34-1
cyclopropanecarboxylic acid chloride

: C5H6N2O

Conditions

Conditions	Yield
With sodium hydroxide In acetone	100%

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 99-09-2
3-nitro-aniline

: 101946-39-8
N-(3-nitrophenyl) cyclopropanecarboxamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃; for 2h;	100%
With triethylamine In N,N-dimethyl-formamide at 25℃; for 3h; Cooling with ice;	71.6%
With triethylamine In dichloromethane	71%
With triethylamine In dichloromethane	71%
With potassium carbonate In dichloromethane at 20℃; for 2h;

: 209331-16-8
(4aR,5R,6R,7R)-6-hydroxy-7-methoxy-4a,5,6,7-tetrahydro-1,3,4a,5-tetramethylbenz[f]indol-2(4H)-one

: 4023-34-1
cyclopropanecarboxylic acid chloride

: (4AR,5R,6R,7R)-6-Cyclopropylcarbonyloxy-7-methoxy-4a,5,6,7-tetrahydro-1,3,4a,5-tetramethylbenz[f]indol-2(4H)-one

Conditions

Conditions	Yield
With pyridine at 20℃;	100%
In pyridine; dichloromethane	100%

: 1000334-09-7
N-[2-(6-amino-7-hydroxy-2,3-dihydro-1H-inden-1-yl)ethyl]acetamide hydrochloride

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1000334-17-7
N-(3-(2-(acetylamino)ethyl)-4-hydroxy-2,3-dihydro-1H-inden-5-yl)cyclopropanecarboxamide

Conditions

Conditions	Yield
With pyridine at 0℃; for 3h;	100%
With pyridine at 0℃; for 0.25h;

: 1603-91-4
4-methylthiazol-2-ylamine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 354547-70-9
N-(4-methylthiazol-2-yl)cyclopropanecarboxamide

Conditions

Conditions	Yield
With pyridine at 20℃; for 2h;	100%
With pyridine at 0 - 20℃;

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 147356-78-3
cyclopropanecarboxylic acid N-methoxy-N-methylamide

Conditions

Conditions	Yield
Stage #1: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane at 0℃; Stage #2: cyclopropanecarboxylic acid chloride In dichloromethane at 4 - 23℃;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	90%
With triethylamine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;	90%

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 178250-09-4
(3R,4S)-3-triisopropylsilyloxy-4-(2-methylprop-1-enyl)azetidin-2-one

: 1031784-15-2
(3R,4S)-1-cyclopropanecarbonyl-3-triisopropylsiloxy-4-(2-methylprop-1-enyl)azetidin-2-one

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 2h;	100%

: 582-33-2
3-aminobenzoic acid ethyl ester

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 723759-58-8
ethyl 3-((cyclopropylcarbonyl)amino)benzoate

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%

: 1155856-77-1
1-[(2R,6S)-8-amino-9-hydroxy-6,11,11-trimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl]-2,2,2-trifluoro-ethanone

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1155857-31-0
cyclopropanecarboxylic acid [(2R,6S)-9-hydroxy-6,11,11-trimethyl-3-(2,2,2-trifluoro-acetyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl]-amide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	100%
With triethylamine In dichloromethane at 20℃;

: 1123837-34-2
tert-butyl ((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)(2-methoxyethyl)carbamate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1187214-01-2
tert-butyl (6-(7-(4-(cyclopropanecarboxamido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	100%

: 6-(1-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-amine trifluoroacetate

: 4023-34-1
cyclopropanecarboxylic acid chloride

N-(6-(1-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide: N-(6-(1-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

Conditions

Conditions	Yield
Stage #1: 6-(1-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)imidazo[1,2-b]pyridazin-2-amine trifluoroacetate; cyclopropanecarboxylic acid chloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h; Stage #2: With ammonium hydroxide In methanol at 20℃; for 1h;	100%

: 1080641-18-4
(S)-methyl 2-(8-(N-hydroxycarbamimidoyl)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1080641-74-2
(S)-methyl 2-(8-(N-(cyclopropanecarbonyl)-N'-hydroxycarbamimidoyl)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; water at 0 - 20℃;	100%

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 4487-50-7
2-amino-4-nitropyridine

: 942076-75-7
N-(4-nitropyridin-2-yl)-cyclopropanecarboxamide

Conditions

Conditions	Yield
With pyridine at 0 - 20℃;	100%
With pyridine at 0 - 20℃;	100%
With pyridine at 20℃; for 30h;	98%

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1,1-dimethylethyl (3S)-3-[2-(ethyloxy)-2-oxoethyl]-1-pyrrolidinecarboxylate

: 1332333-17-1
ethyl[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]acetate

Conditions

Conditions	Yield
Stage #1: 1,1-dimethylethyl (3S)-3-[2-(ethyloxy)-2-oxoethyl]-1-pyrrolidinecarboxylate With hydrogenchloride In 1,4-dioxane at 20℃; for 1h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.0833333h; Stage #3: cyclopropanecarboxylic acid chloride at 0 - 20℃; for 1h;	100%

: 1382848-69-2
4-bromo-7-(5-fluoro-2-methylphenyl)isoquinolin-3-amine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1382841-06-6
N-(4-bromo-7-(5-fluoro-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 1h;	100%

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 7679-18-7
N-desmethylthebaine hydrochloride

: 25098-38-8
17-cyclopropylcarbonylnorthebaine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; Cooling with ice;	100%
With triethylamine In dichloromethane at 0 - 20℃;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 10h;	99%
With triethylamine In dichloromethane at 0 - 20℃;	91%

: 1429324-16-2
C23H23N7O4S

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1429324-17-3
C27H27N7O5S

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1h; Inert atmosphere;	100%

: (2SS,3RS)-2-(4-methylthiophen-2-yl)-4-oxo-1,2,3,4-tetrahydropyridin-3-yl methyl(phenyl)carbamate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: (2SR,3RS)-1-(cyclopropanecarbonyl)-2-(4-methylthiophen-2-yl)-4-oxo-1,2,3,4-tetrahydropyridin-3-yl methyl(phenyl)-carbamate

Conditions

Conditions	Yield
With dmap In tetrahydrofuran	100%

: (1RS,2RS)-ethyl 2-(4-amino-3-bromophenyl)-3-phenylcyclopropanecarboxylate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: (1RS,2RS,3RS)-ethyl 2-(3-bromo-4-(cyclopropanecarboxamido)phenyl)-3-phenylcyclopropanecarboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;	100%

: 84249-14-9
2-amino-4-bromopyridine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1529768-99-7
N-(4-bromopyridin-2-yl)cyclopropanecarboxamide

Conditions

Conditions	Yield
Stage #1: 2-amino-4-bromopyridine With pyridine In dichloromethane at 20℃; for 0.0833333h; Stage #2: cyclopropanecarboxylic acid chloride In dichloromethane at 20℃; for 2h;	100%
With triethylamine In dichloromethane at 0 - 20℃;	93%
With pyridine In tetrahydrofuran at 0℃; for 4h;	90%

: 6325-93-5
p-nitrobenzenesulfonamide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: N-(4-nitrophenylsulfonyl)cyclopropanecarboxamide

Conditions

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	100%

Cyclopropanecarboxylic acid chloride Chemical Properties

IUPAC Name: Cyclopropanecarbonyl chloride
Molecular Formula:C₄H₅ClO
Molecular Weight:104.534900 g/mol
Appearance:colourless clear liquid
Boiling Point:119 °C(lit.)
Flash Point:74 °F
density:1.152 g/mL at 25 °C(lit.)
refractive index:n20/D 1.452(lit.)
storage temp.:0-6°C
Water Solubility:decomposes
Sensitive:Moisture Sensitive
BRN:471286
Synonyms of Cyclopropane carbony chloride (CAS No. 4023-34-1):
CYCLOPROPYLCARBOXYL CHLORIDE ; CYCLOPROPANECARBONYL CHLORIDE ; CYCLOPROPANECARBOXYLIC ACID CHLORIDE ; Cyclopropyl Carbonyl Chloride ; Cyclopropanecarbonylchloride ,98% ; Cyclopropanecarbonyl ; cyclopropane carbony chloride ; CPCCI
Categories of cyclopropane carbony chloride (CAS No.4023-34-1):
Pharmaceutical Intermediates;Cyclopropanes;Simple 3-Membered Ring Compounds

Cyclopropanecarboxylic acid chloride Uses

Cyclopropane carbony chloride (CAS No.4023-34-1) is used as a intermediate in the fields of agricultural chemical and medicine.

Cyclopropanecarboxylic acid chloride Safety Profile

Safety Information of Cyclopropane carbony chloride (CAS No. 4023-34-1):
Hazard Codes:C ,F
Risk Statements:10-34-29-25-36-38
10:Flammable
34:Causes burns
29:Contact with water liberates toxic gas
25:Toxic if swallowed
36:Irritating to the eyes
38:Irritating to the skin
Safety Statements:26-36/37/39-45-8-16
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
8:Keep container dry
16:Keep away from sources of ignition - No smoking
RIDADR:UN 2920 8/PG 2
WGK Germany:3
F:10-21
HazardClass:8
PackingGroup:II
HS Code:29162000

Product Name

Cyclopropanecarbonyl Chloride

Synthetic route

Cyclopropanecarboxylic acid chloride Chemical Properties

Cyclopropanecarboxylic acid chloride Uses

Cyclopropanecarboxylic acid chloride Safety Profile

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