2-aminopropanamide hydrochloride
D-Alanine
Conditions | Yield |
---|---|
Escherichia coli JM109; pCl38DP In various solvent(s) at 30℃; for 0.15h; | 100% |
(3R,6S,1'S)-3,6-dimethyl-4-N-(1'-phenethyl)-1,4-morpholin-2,5-dione
D-Alanine
Conditions | Yield |
---|---|
With hydrogen iodide for 1h; Heating; | 100% |
D-Alanine
Conditions | Yield |
---|---|
With ammonia; lithium In tetrahydrofuran; tert-butyl alcohol at -78℃; for 0.5h; | 99% |
D-Alanine
Conditions | Yield |
---|---|
With ammonia; lithium In tetrahydrofuran; tert-butyl alcohol at -78℃; for 0.5h; Birch reduction; | 99% |
Conditions | Yield |
---|---|
With isopropylamine In aq. buffer at 37℃; for 24h; pH=7.0; Enzymatic reaction; | 95% |
With D-glucose; Bacillus subtilis glucose dehydrogenase; Symbiobacterium thermophilum meso-Diaminopimelate dehydrogenase W121L/H227I mutant; NADP; ammonium chloride In aq. buffer at 37℃; for 24h; pH=8.5; Kinetics; Reagent/catalyst; Enzymatic reaction; | 49% |
With ammonium hydroxide; D-amino acid oxidase In phosphate buffer for 10h; pH=6.5; Reduction; Electrochemical reaction; |
Boc-(R)-Ala
D-Alanine
Conditions | Yield |
---|---|
With water at 170℃; for 0.05h; Microwave irradiation; | 95% |
(R)-(+)-2-hydrazinopropionic acid
D-Alanine
Conditions | Yield |
---|---|
With hydrogen; platinum(IV) oxide | 92% |
Conditions | Yield |
---|---|
With CC10H14NOSCH2CH2CH3N(CH3)2 (5); zinc diacetate In methanol at 30℃; Product distribution; pH 4.00; other reagents; | A 9% B 91% |
With 5-((3-(dimethylamino)propyl)thio)-4-(aminomethyl)-3-hydroxyl-5,6,7,8-tetraquinoline In methanol at 30℃; Product distribution; stereoselective transamination at pH=4.00, various reagents and pH; | A 7 % Chromat. B 93 % Chromat. |
With ethylenediaminetetraacetic acid; D-(R)-phenylalanine at 20℃; for 24h; pH=8; Product distribution; Further Variations:; Reagents; transamination; |
(3R,6R)-1,4-N,N-((S)-1-phenyleth-1-yl)-3,6-dimethylpiperazine-2,5-dione
D-Alanine
Conditions | Yield |
---|---|
With hydrogen iodide for 1h; Heating; | 90% |
D-Alanine
Conditions | Yield |
---|---|
With trimethylsilyl iodide In chloroform for 0.0833333h; | 88% |
(R)-N-phthaloylalanine
D-Alanine
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol; acetone Heating; | 86% |
Conditions | Yield |
---|---|
With hydrogenchloride; water | A 86% B n/a |
With hydrogenchloride | A 86% B n/a |
With hydrogenchloride; water for 24h; Heating; |
D-Alanine
Conditions | Yield |
---|---|
With hydrogen bromide In water at 130℃; for 24h; | 85% |
(R)-1-(furan-2-yl)ethanamine
D-Alanine
Conditions | Yield |
---|---|
With ozone In methanol at -78℃; for 0.25h; | 81% |
DL-α-alanyl-DL-norvaline
A
L-alanin
B
D-Alanine
C
D-norvaline
D
L-Norvaline
Conditions | Yield |
---|---|
With (S)-1-(N,N-dimethylaminomethyl)-2-formylcymantrene; sodium methylate; copper (I) acetate for 1h; Ambient temperature; | A 78.31% B 21.69% C 60.57% D 39.43% |
With (S)-1-(N,N-dimethylaminomethyl)-2-formylcymantrene; sodium methylate; copper (I) acetate for 3h; Ambient temperature; | A 76.83% B 23.15% C 73.8% D 26.2% |
With (R)-1-(N,N-dimethylaminomethyl)-2-formylcymantrene; sodium methylate; copper (I) acetate for 1h; Ambient temperature; | A 26.8% B 73.2% C 42.16% D 57.84% |
With (R)-1-(N,N-dimethylaminomethyl)-2-formylcymantrene; sodium methylate; copper (I) acetate for 1h; Ambient temperature; | A 26.8% B 73.2% C 42.16% D 57.84% |
(1'S,5R)-1-(benzyloxycarbonyl)-3-(1'-phenyleth-1'-yl)-5-methylimidazolidin-4-one
D-Alanine
Conditions | Yield |
---|---|
With hydrogenchloride In methanol for 24h; Heating; | 73% |
D-Alanine
Conditions | Yield |
---|---|
Stage #1: C28H29N3NiO3 With hydrogenchloride In methanol at 70℃; Stage #2: In water | 71% |
(1R,2S,5R,8S)-1,5,11,11-tetramethyl-3-oxa-6-azatricyclo[6.2.1.02,7]undec-6-en-4-one
D-Alanine
Conditions | Yield |
---|---|
Stage #1: (1R,2S,5R,8S)-1,5,11,11-tetramethyl-3-oxa-6-azatricyclo[6.2.1.02,7]undec-6-en-4-one With hydrogenchloride at 87℃; for 2h; Stage #2: With methyloxirane In ethanol at 20℃; for 0.5h; Further stages.; | 70% |
Conditions | Yield |
---|---|
70% |
N-trichloroacetyl-D-alanine
D-Alanine
Conditions | Yield |
---|---|
With hydrogen cation | 69% |
With hydrogenchloride at 120℃; for 5h; | 69% |
D-Alanine
Conditions | Yield |
---|---|
With hydrogenchloride at 110℃; for 12h; | 37% |
Conditions | Yield |
---|---|
mittels Hefe nach reichlichem Zusatz von Zucker; | |
durch Penicillium glaucum; | |
durch Aspergillus niger; |
(S)-2-bromopropanoic acid
D-Alanine
Conditions | Yield |
---|---|
With ammonia; water | |
With ammonia |
AlaOEt
D-Alanine
Conditions | Yield |
---|---|
und Erhitzen des erhaltenen -d-alanin-aethylester mit konz.Salzsaeure und zerlegt das entstandene d(-)-Alaninhydrochlorid mit Bleihydroxyd; | |
ueber N--D-alanin-aethylester; |
Conditions | Yield |
---|---|
With water |
(R)-2-(acetylamino)propanoic acid
D-Alanine
Conditions | Yield |
---|---|
With hydrogenchloride | |
With hydrogen bromide |
Conditions | Yield |
---|---|
durch ein im Speichel vorkommendes Ferment.Hydrolysis; |
D-N-benzoylalanine
D-Alanine
Conditions | Yield |
---|---|
With hydrogenchloride |
Conditions | Yield |
---|---|
Behandeln mit Brucin, Zerlegen das Brucinsalz in die aktiven Salze, die man mit 20prozentiger Salzsaeure bei 100grad verseift; |
Conditions | Yield |
---|---|
for 0.05h; microwave irradiation; | 100% |
With triethylamine In toluene Heating; | 90% |
With pyridine for 12h; Heating; | 88% |
D-Alanine
di-tert-butyl dicarbonate
Boc-(R)-Ala
Conditions | Yield |
---|---|
Stage #1: D-Alanine With sodium hydroxide In water at 0℃; for 0.166667h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water at 20℃; | 100% |
With sodium hydroxide In tetrahydrofuran; water at 0 - 30℃; for 4.5h; | 98% |
With triethylamine; sodium hydroxide In tetrahydrofuran; water at 20℃; for 10.5h; | 92% |
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 20℃; for 20h; | 100% |
With sodium hydroxide In water at 0 - 20℃; | 92.7% |
Stage #1: D-Alanine; benzyl chloroformate With sodium hydroxide In water at 0 - 20℃; Stage #2: With hydrogenchloride In water pH=4 - 5; | 89% |
D-Alanine
chloroformic acid ethyl ester
(R)-N-carbethoxy-2-aminopropanoic acid
Conditions | Yield |
---|---|
With sodium hydroxide at 15℃; for 1h; pH=9; | 100% |
With sodium hydrogencarbonate In water at 20℃; for 24h; | 90% |
With sodium hydrogencarbonate | |
Stage #1: D-Alanine; chloroformic acid ethyl ester With sodium hydroxide at 15℃; pH=9 - 9.5; Stage #2: With phosphoric acid In water at 0 - 5℃; pH=1; | |
Stage #1: D-Alanine With sodium hydroxide In water at 15℃; Stage #2: chloroformic acid ethyl ester In water pH=9 - 9.5; Stage #3: With phosphoric acid In water pH=1; |
Conditions | Yield |
---|---|
With sodium carbonate In water at 0 - 20℃; for 3h; | 100% |
With sodium carbonate In 1,4-dioxane; water at 0 - 20℃; for 3.08333h; Inert atmosphere; | 96% |
Conditions | Yield |
---|---|
With thionyl chloride at 20℃; for 2h; | 99% |
With thionyl chloride for 8h; Heating; | 97% |
With thionyl chloride | 95% |
Conditions | Yield |
---|---|
With thionyl chloride | 99% |
With thionyl chloride at 40℃; for 4h; | 86% |
D-Alanine
Allyl chloroformate
(R)-2-(((allyloxy)carbonyl)amino)propanoic acid
Conditions | Yield |
---|---|
With sodium hydroxide for 3h; | 99% |
Conditions | Yield |
---|---|
With potassium carbonate In ethanol; water at 100℃; for 10h; | 98.2% |
With potassium carbonate In ethanol; water for 10h; Reflux; | 91% |
With potassium carbonate In ethanol; water at 80℃; for 8h; | 87% |
formaldehyd
D-Alanine
butane-2,3-dione mono-oxime
(R)-2-(4,5-Dimethyl-3-oxy-imidazol-1-yl)-propionic acid
Conditions | Yield |
---|---|
In ethanol for 3h; Heating; | 98% |
D-Alanine
isopropyl alcohol
(R)-1-isopropoxy-1-oxopropan-2-aminium chloride
Conditions | Yield |
---|---|
Stage #1: D-Alanine; isopropyl alcohol With thionyl chloride at 85℃; for 4h; Inert atmosphere; Stage #2: With hydrogenchloride | 98% |
With thionyl chloride at 85℃; for 4h; Inert atmosphere; | 98% |
With thionyl chloride at 20 - 85℃; for 4h; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene Reflux; | 97.6% |
D-Alanine
ethyl trifluoroacetate,
(R)-2-(2,2,2-trifluoroacetamido)propanoic acid
Conditions | Yield |
---|---|
Stage #1: D-Alanine; ethyl trifluoroacetate, With N,N,N',N'-tetramethylguanidine In methanol at 20℃; for 5h; Stage #2: With hydrogenchloride In methanol; water | 97.3% |
With triethylamine In methanol at 20℃; for 24h; | 95% |
With triethylamine In methanol for 24h; | 86% |
With triethylamine In methanol at 20℃; for 8h; Product distribution / selectivity; | 86% |
Stage #1: D-Alanine; ethyl trifluoroacetate, With triethylamine In methanol at 20℃; for 24h; Stage #2: for 0.166667h; Acidic conditions; | 80.8% |
Conditions | Yield |
---|---|
With thionyl chloride at 60℃; for 3h; | 97% |
With thionyl chloride at 0 - 40℃; for 4h; | 86% |
With thionyl chloride at 20℃; for 6h; |
D-Alanine
2-Chloroethyl chloroformate
N-(2-chloroethyloxycarbonyl)-D-Ala-OH
Conditions | Yield |
---|---|
Stage #1: D-Alanine; 2-Chloroethyl chloroformate With sodium hydrogencarbonate In 1,4-dioxane; water Stage #2: With hydrogenchloride In water pH=3; | 97% |
D-Alanine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In aq. phosphate buffer; water; acetonitrile at 20℃; for 20h; pH=7; | 97% |
Conditions | Yield |
---|---|
Stage #1: 1-decanoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 0.5h; Stage #2: D-Alanine In dichloromethane for 12h; | 96% |
D-Alanine
Conditions | Yield |
---|---|
With potassium carbonate In ethanol; water at 100℃; for 1h; Inert atmosphere; Reflux; | 96% |
D-Alanine
Conditions | Yield |
---|---|
With potassium carbonate In ethanol; N,N-dimethyl-formamide at 100℃; Inert atmosphere; | 96% |
D-Alanine
R-(+)-2-bromopropionic acid
Conditions | Yield |
---|---|
With hydrogen bromide; potassium bromide; sodium nitrite at 0 - 5℃; for 1h; | 95% |
With hydrogen bromide; potassium bromide; sodium nitrite In water at -15 - 20℃; Inert atmosphere; | 82% |
With sulfuric acid; potassium bromide; sodium nitrite at 0 - 20℃; for 2h; | 41% |
benzyl N-[(1S)-1-(1H-1,2,3-benzotriazol-1-ylcarbonyl)-3-(methylsulfanyl)propyl]carbamate
D-Alanine
(R)-2-[(S)-2-benzyloxycarbonylamino-4-methylsulfanylbytyrylamino]propanoic acid
Conditions | Yield |
---|---|
With triethylamine In water; acetonitrile at 20℃; for 1h; | 95% |
D-Alanine
benzyl alcohol
(R)-benzyl 2-aminopropanoate hydrochloride
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 20℃; | 95% |
Conditions | Yield |
---|---|
Stage #1: D-Alanine; perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride With 1H-imidazole at 120℃; for 0.5h; Stage #2: With hydrogenchloride at 85℃; | 95% |
With 1H-imidazole In water at 120℃; Schlenk technique; Inert atmosphere; |
D-Alanine
N-(tert-butoxycarbonyl)-D-alanine methyl ester
Conditions | Yield |
---|---|
94% |
Molecular Structure:
Molecular Formula: C3H7NO2
Molecular Weight: 89.0932
IUPAC Name: (2R)-2-Aminopropanoic acid
Synonyms of D-Alanine (CAS NO.338-69-2): Alanine D-form ; (R)-2-Aminopropionsaeure ; (R)-Alanine ; Alanine, D- ; Ba 2776 ; D-alpha-Aminopropionsaeure ; EINECS 206-418-1 ; NSC 158286
CAS NO: 338-69-2
Classification Code: Amino Acids Derivatives ; Amino ACIDS SERIES ; Amino Acids ; PROTECTED AMINO ACID & PEPTIDES ; Alanine [Ala, A] ; Amino Acids and Derivatives ; alpha-Amino Acids ; Biochemistry ; Amino Acids and Derivatives ; GABA/Glycine receptor ; alanine ; amino acid ; organic acids ; pharmaceutical intermediate
Melting Point: 291 °C
Index of Refraction: 1.459
Molar Refractivity: 21 cm3
Molar Volume: 76.7 cm3
Surface Tension: 45.8 dyne/cm
Density: 1.161 g/cm3
Flash Point: 82.6 °C
Enthalpy of Vaporization: 49.5 kJ/mol
Boiling Point: 212.9 °C at 760 mmHg
Vapour Pressure: 0.0661 mmHg at 25°C
D-Alanine (CAS NO.338-69-2) can be used for synthesis of new sweetener and materials of some chiral drugs' intermediates.
Hazard Codes of D-Alanine (CAS NO.338-69-2): Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25: Avoid contact with skin and eyes.
S36: Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
HazardClass: IRRITANT
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View