D-Serine methyl ester hydrochloride supplier

Name
D-Serine methyl ester hydrochloride
EINECS 611-745-1
CAS No. 5874-57-7
Article Data40
CAS DataBase
Density 1.62 g/cm³
Solubility
Melting Point 163-166 °C(lit.)
Formula C₄H₁₀ClNO₃
Boiling Point 234.7 °C at 760 mmHg
Molecular Weight 155.581
Flash Point 95.8 °C
Transport Information
Appearance White Solid
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms D-Serine,methyl ester, hydrochloride (9CI);Serine, methyl ester, hydrochloride, D-(8CI);(R)-2-Amino-3-hydroxypropionic acid methyl ester hydrochloride;(R)-Methyl 2-amino-3-hydroxypropanoate hydrochloride;Methyl D-serinatehydrochloride;H-D-Ser-OMe·HCl;
PSA 72.55000
LogP -0.01870

Synthetic route

: 67-56-1
methanol

: 312-84-5
D-Serine

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

Conditions

Conditions	Yield
With acetyl chloride for 2.5h; Heating;	100%
Stage #1: methanol; D-Serine With acetyl chloride at 0℃; Stage #2: In methanol for 3h; Heating;	100%
With hydrogenchloride In water at 55℃;	100%

: 67-56-1
methanol

: 312-84-5
D-Serine

: 75-36-5
acetyl chloride

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

Conditions

Conditions	Yield
Stage #1: methanol; acetyl chloride for 0.0833333h; Cooling with ice; Stage #2: D-Serine for 2h; Reflux;	97%

...Expand

: 312-84-5
D-Serine

: 75-36-5
acetyl chloride

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

Conditions

Conditions	Yield
In methanol for 15.5h; Reflux;	91%

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 501-53-1
benzyl chloroformate

: 93204-36-5
(R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxypropanoate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; Cooling with ice;	100%
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 12h;	91%
With sodium hydrogencarbonate	80%

: 24424-99-5
di-tert-butyl dicarbonate

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 95715-85-8
2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester

Conditions

Conditions	Yield
Stage #1: R-(-)-serine methyl ester hydrochloride With triethylamine In dichloromethane for 0.5h; Cooling with ice; Stage #2: di-tert-butyl dicarbonate In dichloromethane at 20℃; for 16.5h; Cooling with ice;	100%
With triethylamine In tetrahydrofuran at 0 - 140℃; for 0.333333h; Inert atmosphere; Microwave irradiation;	99%
With triethylamine In tetrahydrofuran at 0 - 50℃; for 17h; Inert atmosphere;	97%

: 32315-10-9
bis(trichloromethyl) carbonate

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 144542-43-8
(R)-2-oxo-oxazolidine-4-carboxylic acid methyl ester

Conditions

Conditions	Yield
In tetrahydrofuran for 4h; Heating;	100%
In tetrahydrofuran for 4h; Reflux; Inert atmosphere;	98%
In tetrahydrofuran at 0 - 80℃; for 2h;	75%

: 76-83-5
trityl chloride

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 116457-91-1
(2R)-3-hydroxy-2-(tritylamino)propanoic acid methyl ester

Conditions

Conditions	Yield
With triethylamine In chloroform at 0℃; for 1h;	99%
With triethylamine In 1,2-dichloro-ethane at 50℃; for 12h;	97%
With triethylamine In dichloromethane at 0 - 25℃; for 16h;	95%

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 100-52-7
benzaldehyde

: 123639-56-5, 131110-76-4, 144001-42-3
methyl (2R)-2-(benzylamino)-3-hydroxypropanoate

Conditions

Conditions	Yield
Stage #1: R-(-)-serine methyl ester hydrochloride; benzaldehyde With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 24h; Stage #2: With sodium tetrahydroborate In methanol at 0℃; for 3h; Further stages.;	99%
Stage #1: R-(-)-serine methyl ester hydrochloride With triethylamine In methanol at 0℃; for 0.25h; Inert atmosphere; Stage #2: benzaldehyde In methanol at 20℃; for 2h; Inert atmosphere; Stage #3: With sodium tetrahydroborate In methanol at 0℃; Inert atmosphere;	99%
Stage #1: R-(-)-serine methyl ester hydrochloride; benzaldehyde With triethylamine Stage #2: With sodium tetrahydroborate	79%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 874817-14-8
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxypropionic acid methyl ester

Conditions

Conditions	Yield
With sodium hydrogencarbonate In 1,4-dioxane; water cooling;	99%
With sodium hydrogencarbonate In 1,4-dioxane; water at 0 - 20℃; for 4.33333h;	95%

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 5659-93-8
2,2-Dimethylmalonyl chloride

: N,N'-bis[(1R)-(1-methoxycarbonyl)-2-hydroxyethyl]-2,2-propanedicarboxamide

Conditions

Conditions	Yield
With triethylamine In chloroform at 0 - 20℃; Inert atmosphere;	99%

: 51673-84-8
dimethoxyacetaldehyde

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: (2R)-2-(2,2-dimethoxyethylamino)-3-hydroxypropionic acid methyl ester

Conditions

Conditions	Yield
With hydrogen; triethylamine; palladium on activated charcoal In methanol; water at 20℃; for 16h;	98%
With palladium 10% on activated carbon; hydrogen; triethylamine In methanol; water at 20℃;

: 383-63-1
ethyl trifluoroacetate,

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 312-84-5
(R)-3-Hydroxy-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

Conditions

Conditions	Yield
In methanol at 20℃; for 15h;	98%

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 407-25-0
trifluoroacetic anhydride

: 312-84-5
(R)-3-Hydroxy-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 6h;	98%

: 34619-03-9
tert-butyldicarbonate

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 58479-61-1
tert-butylchlorodiphenylsilane

: 171564-48-0
methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-(tert-butyldiphenylsilyloxy)propanoate

Conditions

Conditions	Yield
Stage #1: tert-butyldicarbonate; R-(-)-serine methyl ester hydrochloride With sodium hydrogencarbonate In tetrahydrofuran; water Stage #2: tert-butylchlorodiphenylsilane With 1H-imidazole In dichloromethane	98%

...Expand

: 1613522-41-0
1-(benzyloxy)-3-((2,4-difluorobenzyl)carbamoyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl 4-methylbenzenesulfonate

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 1613522-64-7
methyl (R)-2-((1-(benzyloxy)-3-((2,4-difluorobenzyl)carbamoyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)amino)-3-hydroxypropanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 50℃; for 1h;	97%

: 1740-19-8
dehydroabietic acid

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: methyl N-(abiet-8,11,13-trien-18-yl)-D-serinate

Conditions

Conditions	Yield
Stage #1: dehydroabietic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: R-(-)-serine methyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In water; N,N-dimethyl-formamide at 20℃; for 1h;	97%

: 201230-82-2
carbon monoxide

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 22885-95-6
(1R)-2-iodo-1,7,7-trimethylbicyclo<2.2.1>hept-2-ene

: C15H23NO4

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; triphenylphosphine In N,N-dimethyl-formamide at 50℃; for 1h; diastereoselective reaction;	96%

...Expand

: 100-39-0
benzyl bromide

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 202478-34-0
(R)-methyl 2-(dibenzylamino)-3-hydroxypropanoate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; for 24h; Alkylation;	95%
With sodium hydrogencarbonate; sodium iodide In tetrahydrofuran; dimethyl sulfoxide for 2h; Heating;	92%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 20℃; for 5h;	91.7%

: 77-77-0
Divinyl sulfone

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: methyl (R)-2-(1,1-dioxidothiomorpholino)-3-hydroxy propanoate

Conditions

Conditions	Yield
With ethanol; triethylamine In 1,4-dioxane at 85℃; for 3h;	95%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: C18H26N2O6

Conditions

Conditions	Yield
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃;	95%

: 201230-82-2
carbon monoxide

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: (1S,4S)-2-iodobornene

: C15H23NO4

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; triphenylphosphine In N,N-dimethyl-formamide at 50℃; for 1h; diastereoselective reaction;	95%

...Expand

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 170787-77-6
JP-7

: 328236-00-6
(R)-2-[(1-{4-[(3,5-Dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-3-hydroxy-propionic acid methyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; for 24h;	94.7%

: 62910-63-8
5-bromo-2-methoxybenzoyl chloride

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 380223-64-3
(R)-2-(5-Bromo-2-methoxy-benzoylamino)-3-hydroxy-propionic acid methyl ester

Conditions

Conditions	Yield
Stage #1: R-(-)-serine methyl ester hydrochloride With triethylamine In chloroform at -5℃; for 0.0833333h; Stage #2: 5-bromo-2-methoxybenzoyl chloride With triethylamine In chloroform at 0 - 20℃; for 0.25h;	94%

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 75-36-5
acetyl chloride

: (R)-methyl 2-acetamido-3-hydroxypropionate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1h; Inert atmosphere;	94%
With triethylamine In dichloromethane at -10 - 5℃; for 3h;	90%
With triethylamine In dichloromethane at -10 - 0℃; for 3h; Green chemistry;	90%

: 4480-47-1
t-butylglyoxal

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 257291-68-2
methyl (R)-2-tert-butyloxazolidine-4-carboxylate

Conditions

Conditions	Yield
With triethylamine In pentane at 55℃; for 72h; Dean Stark conditions; optical yield given as %de;	94%

: C25H24N8O8S

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: C29H31N9O10S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 20℃; for 1h;	94%

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 73731-37-0
Fmoc-Thr-OH

: 609359-05-9
(R)-2-[(2S,3R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butyrylamino]-3-hydroxy-propionic acid methyl ester

Conditions

Conditions	Yield
With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 25℃; for 3h;	93%
With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 25℃; for 2h;	70%

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 98-88-4
benzoyl chloride

: 1040384-28-8
N-benzoyl-D-serine methyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	92%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 2h;	92%
With triethylamine In methanol at 0℃;

: 98204-51-4
(S)-2-[{(allyloxy)carbonyl}amino]-4-methylpentanoic acid

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: N-(N-(prop-2-enyloxycarbonyl)-L-leucyl)-D-serine methyl ester

Conditions

Conditions	Yield
Stage #1: (S)-2-[{(allyloxy)carbonyl}amino]-4-methylpentanoic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 1h; Stage #2: R-(-)-serine methyl ester hydrochloride With triethylamine In dichloromethane at 20℃; for 48h;	92%

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 825-60-5
benzimidic acid ethyl ester

: 105308-52-9
(R)-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Conditions

Conditions	Yield
In 1,2-dichloro-ethane	91.4%
In dichloromethane; water for 24h; Ambient temperature;	75.3%
In 1,2-dichloro-ethane for 20h; Heating / reflux;

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 2243-83-6
2-naphthaloyl chloride

: 1312671-66-1
N-(2-naphthoyl)-D-serine methyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 2h;	91%

D-Serine methyl ester hydrochloride Chemical Properties

Molecular Structure of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7):

The Molecular formula of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7): C₄H₁₀ClNO₃
The Molecular Weight of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7): 155.58
IUPAC Name: (E)-2-cyano-3-(1-phenyl-3-thiophen-2-ylpyrazol-4-yl)prop-2-enamide
H bond acceptors: 4
H bond donors: 3
Freely Rotating Bonds: 5
Polar Surface Area: 38.77Å²
Melting point: 163-166 °C(lit.)
Boiling Point: 234.7 °C at 760 mmHg
Flash Point: 95.8 °C
Enthalpy of Vaporization: 54.8 kJ/mol
Vapour Pressure: 0.00953 mmHg at 25°C
Appearance: White Solid
Storage temp: -15°C
Product Categories: Amino Acids series; Amino Acids; Amino Acids and Derivatives; All Aliphatics; Amino hydrochloride; Aliphatics; Amino Acids & Derivatives; Amino Acid Derivatives; Peptide Synthesis; Serine

D-Serine methyl ester hydrochloride Safety Profile

The Hazard Codes of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7): Xi
The Risk Statements information of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 3

D-Serine methyl ester hydrochloride Specification

D-Serine methyl ester hydrochloride , with CAS number of 5874-57-7, can be called (R)-2-Amino-3-hydroxypropionic acid methyl ester hydrochloride ; (R)-Methyl 2-amino-3-hydroxypropanoate hydrochloride ; Methyl D-serinatehydrochloride ; DL-Serine, methyl ester, hydrochloride ; L-Serine, methyl ester, hydrochloride ; L-serine, methyl ester, hydrochloride (1:1) ; Methyl L-serinate hydrochloride (1:1) . It is a white solid.

Product Name

D-Serine methyl ester hydrochloride

Synthetic route

D-Serine methyl ester hydrochloride Chemical Properties

D-Serine methyl ester hydrochloride Safety Profile

D-Serine methyl ester hydrochloride Specification

Related Products

Hot Products