Product Name

  • Name

    DL-3-Phenylalanine

  • EINECS 205-756-7
  • CAS No. 150-30-1
  • Article Data164
  • CAS DataBase
  • Density 1.202 g/cm3
  • Solubility 14.11 g/L (25 °C) in water
  • Melting Point 266-267 °C
  • Formula C9H11NO2
  • Boiling Point 307.5 °C at 760 mmHg
  • Molecular Weight 165.192
  • Flash Point 139.771 °C
  • Transport Information
  • Appearance white crystalline powder
  • Safety 37/39-24/25-45-36/37/39-27-26
  • Risk Codes 36/37/38-34
  • Molecular Structure Molecular Structure of 150-30-1 (DL-3-Phenylalanine)
  • Hazard Symbols IrritantXi,CorrosiveC
  • Synonyms alpha-Aminohydrocinnamic acid, dl-;H-DL-Phe-OH;2-Amino-3-phenylpropionic acid, dl-;Phenylalanine DL-form;Alanine, phenyl-, DL- (8CI);DL-alpha-Amino-beta-phenylpropionic acid;(2R)-2-azaniumyl-3-phenyl-propanoate;
  • PSA 63.32000
  • LogP 1.34130

Synthetic route

2-(N-acetylamino)-2-benzylpropanedioic diethyl ester
3235-26-5

2-(N-acetylamino)-2-benzylpropanedioic diethyl ester

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With hydrogenchloride; water at 90℃; for 0.166667h; Microwave irradiation;98%
With water; hydrogen cation Heating;82%
With hydrogen bromide anschliessend Erwaermen mit wss. Schwefelsaeure;
With sodium hydroxide anschliessend Erwaermen mit wss. Schwefelsaeure;
With hydrogenchloride In water at 110℃; Microwave irradiation;
L-phenylalanine
63-91-2

L-phenylalanine

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
salicylaldehyde In acetic acid at 100℃; for 1h;94%
With barium dihydroxide; water at 155 - 160℃;
With hydrogenchloride; ethanethiol at 110℃; Rate constant; various times;
benzyl bromide
100-39-0

benzyl bromide

C21H15N3O3(2-)*Ni(2+)

C21H15N3O3(2-)*Ni(2+)

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With potassium hydroxide; C-7 In dichloromethane at 20℃;90%
2-(Benzhydryl-amino)-3-phenyl-propionic acid tert-butyl ester
126181-40-6

2-(Benzhydryl-amino)-3-phenyl-propionic acid tert-butyl ester

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
palladium on activated charcoal In acetic acid Heating;89%
Multi-step reaction with 2 steps
1: 60 percent / formic acid / 10percent Pd/C / methanol
2: trifluoroacetic acid
View Scheme
2-Benzyl-2-benzyloxycarbonylamino-malonic acid dimethyl ester

2-Benzyl-2-benzyloxycarbonylamino-malonic acid dimethyl ester

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With water; hydrogen cation Heating;88%
2-[2-Benzoylamino-1-methoxy-eth-(Z)-ylideneamino]-3-phenyl-propionic acid

2-[2-Benzoylamino-1-methoxy-eth-(Z)-ylideneamino]-3-phenyl-propionic acid

A

Phenylalanine
150-30-1

Phenylalanine

B

methyl hippurate
1205-08-9

methyl hippurate

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether Yields of byproduct given;A n/a
B 69%
2-[2-Benzoylamino-1-ethoxy-eth-(Z)-ylideneamino]-3-phenyl-propionic acid

2-[2-Benzoylamino-1-ethoxy-eth-(Z)-ylideneamino]-3-phenyl-propionic acid

A

Phenylalanine
150-30-1

Phenylalanine

B

ethyl hippurate
1499-53-2

ethyl hippurate

Conditions
ConditionsYield
With hydrogenchloride In diethyl etherA n/a
B 63%
(±)-N-Boc-2-amino-2-benzylacetonitrile
154279-16-0

(±)-N-Boc-2-amino-2-benzylacetonitrile

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With hydrogenchloride In methanol for 6h; Heating;50%
N-(diphenylmethylene)glycine tert-butyl ester
81477-94-3

N-(diphenylmethylene)glycine tert-butyl ester

benzyl bromide
100-39-0

benzyl bromide

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
Stage #1: N-(diphenylmethylene)glycine tert-butyl ester; benzyl bromide With sodium hydroxide; (R)-2-amino-2'-hydroxy-1,1'-binaphthyl In dichloromethane at 20℃; for 1h;
Stage #2: With hydrogenchloride In methanol; water Heating;		50%
(E)-3-phenylacrylic acid
140-10-3

(E)-3-phenylacrylic acid

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With ammonium bicarbonate Ambient temperature; detonation; also with (NH4)2CO3;45%
With ammonium bicarbonate Ambient temperature; detonation; also with (NH4)2CO3;45%
With ammonium hydroxide; Anabaena variabilis phenylalanine ammonia lyase at 30℃; pH=9.5; Kinetics; Enzymatic reaction;
With ammonium hydroxide; phenylalanine ammonia-lyase from Anabaena variabilis N347A mutant In aq. buffer at 35℃; for 12h;
With phenylalanine ammonia lyase from Anabaena variabilis; ammonium carbamate at 30℃; for 22h; pH=9.9; Catalytic behavior; pH-value; Enzymatic reaction;99 %Chromat.
(2R)-N-(diphenylmethylene)[1,2-13 C2, 15 N, 2,2-2 H2 ]glycylbornane-10,2-sultam

(2R)-N-(diphenylmethylene)[1,2-13 C2, 15 N, 2,2-2 H2 ]glycylbornane-10,2-sultam

iodomethylbenzene
620-05-3

iodomethylbenzene

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With hydrogenchloride; lithium hydroxide; n-butyllithium In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; water45%
2-oxo-3-(phenyl)propionic acid
156-06-9

2-oxo-3-(phenyl)propionic acid

A

Phenylalanine
150-30-1

Phenylalanine

B

Phac-DL-Phe-NH2
83556-31-4

Phac-DL-Phe-NH2

Conditions
ConditionsYield
Stage #1: 2-oxo-3-(phenyl)propionic acid With ammonia; hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer; 2,2'-bis[[bis(3-sulfophenyl)phosphino]methyl]-4,4',7,7'-tetrasulfo-1,1'-binaphthyl octasodium salt In ethanol; water at 60℃; under 31503.2 Torr; for 24h;
Stage #2: With hydrogenchloride In ethanol; water Product distribution / selectivity;		A 15%
B 43%
4-benzyl-2-phenyl-2-oxazolin-5-one
5874-61-3, 21453-79-2, 51127-19-6, 75658-67-2

4-benzyl-2-phenyl-2-oxazolin-5-one

A

Phenylalanine
150-30-1

Phenylalanine

B

benzoic acid
65-85-0

benzoic acid

Conditions
ConditionsYield
With potassium In tetrahydrofuran for 4h;A 37%
B 33%
phenyllactic acid
828-01-3

phenyllactic acid

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With ammonium hydroxide; hydrogen at 219.84℃; under 7500.75 Torr; for 2h; Autoclave;30%
With ammonium hydroxide; hydrogen at 180℃; under 7500.75 Torr; for 2h; Autoclave;51.5 %Spectr.
2-Bromo-3-phenyl-propionic acid; compound with ammonia

2-Bromo-3-phenyl-propionic acid; compound with ammonia

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
at 19.9℃; under 37503000 Torr; Product distribution; under shear deformation (360 deg);0.95%
5-benzylidene-2-thiohydantoin
583-46-0

5-benzylidene-2-thiohydantoin

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With hydrogenchloride; tin
4-benzyl-oxazolidine-2,5-dione
583-47-1

4-benzyl-oxazolidine-2,5-dione

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With hydrogenchloride
5-phenylimidazolidine-2,4-dione
89-24-7

5-phenylimidazolidine-2,4-dione

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With hydrogen iodide
With phosphorus; iodine
With barium dihydroxide; water
diethyl ether
60-29-7

diethyl ether

4-(phenyl-trans-azo)-phenol; compound with phenylalanine

4-(phenyl-trans-azo)-phenol; compound with phenylalanine

A

Phenylalanine
150-30-1

Phenylalanine

B

4-Oxy-azoxybenzol
16054-49-2

4-Oxy-azoxybenzol

...Expand
2-bromo-3-phenylpropanoic acid
16503-53-0

2-bromo-3-phenylpropanoic acid

Phenylalanine
150-30-1

Phenylalanine

Conditions
ConditionsYield
With ammonia
With ammonia; water
With ammonia; water at 100℃; im Druckrohr;
With ammonia
formic acid
64-18-6

formic acid

Phenylalanine
150-30-1

Phenylalanine

N-formyl-phenylalanine
4289-95-6

N-formyl-phenylalanine

Conditions
ConditionsYield
With acetic anhydride at 20℃; for 1h;100%
With acetic anhydride at 20℃; for 19h;87%
In N,N-dimethyl-formamide for 0.166667h; Heating;81%
Phenylalanine
150-30-1

Phenylalanine

rac-phenylalaninol
1795-98-8, 3182-95-4, 5267-64-1, 16088-07-6

rac-phenylalaninol

Conditions
ConditionsYield
With sodium tetrahydroborate; iodine100%
With zirconium(IV) borohydride In tetrahydrofuran at 25℃; Reduction;90%
With sodium tetrahydroborate; iodine In tetrahydrofuran for 15h; Heating;60%
ethanol
64-17-5

ethanol

Phenylalanine
150-30-1

Phenylalanine

phenylalanine ethyl ester
1795-96-6

phenylalanine ethyl ester

Conditions
ConditionsYield
Stage #1: ethanol; Phenylalanine With thionyl chloride Reflux;
Stage #2: With sodium hydrogencarbonate		100%
With toluene-4-sulfonic acid In toluene at 80℃; for 16h;83%
With hydrogenchloride
methanol
67-56-1

methanol

Phenylalanine
150-30-1

Phenylalanine

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 5 - 50℃; for 25h;100%
With thionyl chloride at 50℃; for 25h; Cooling with ice;100%
With thionyl chloride at 0 - 20℃; for 20h;99%
Phenylalanine
150-30-1

Phenylalanine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2-(tert-butoxycarbonylamino)-3-phenylpropionic acid
4530-18-1

2-(tert-butoxycarbonylamino)-3-phenylpropionic acid

Conditions
ConditionsYield
With sodium hydroxide; sodium hydrogencarbonate In 1,4-dioxane; water at 20℃;100%
With tetramethyl ammoniumhydroxide91%
With sodium hydroxide In 1,4-dioxane; water at 0 - 20℃; for 5h;81%
Phenylalanine
150-30-1

Phenylalanine

bis(2,4-dinitrophenyl) carbonate
7497-12-3

bis(2,4-dinitrophenyl) carbonate

4-benzyl-oxazolidine-2,5-dione
583-47-1

4-benzyl-oxazolidine-2,5-dione

Conditions
ConditionsYield
In tetrahydrofuran at 60℃; for 91h; Product distribution / selectivity;100%
Phenylalanine
150-30-1

Phenylalanine

2-chloro-4-fluorobenzonitrile
60702-69-4

2-chloro-4-fluorobenzonitrile

N-(3-chloro-4-cyanophenyl)phenylalanine
1114547-56-6

N-(3-chloro-4-cyanophenyl)phenylalanine

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 90℃;100%
3-aminopropyltriethoxysilane
919-30-2

3-aminopropyltriethoxysilane

Phenylalanine
150-30-1

Phenylalanine

C18H32N2O4Si

C18H32N2O4Si

Conditions
ConditionsYield
at 160℃; for 0.05h; Product distribution / selectivity; Microwave irradiation (300 W);100%
Phenylalanine
150-30-1

Phenylalanine

benzoyl chloride
98-88-4

benzoyl chloride

DL-N-benzoylphenylalanine
2566-22-5, 2901-76-0, 37002-52-1

DL-N-benzoylphenylalanine

Conditions
ConditionsYield
With sodium hydroxide; N-ethyl-N,N-diisopropylamine In water 1.) 0 deg C, 30 min; 2.) up to RT, 30 min;99%
With sodium hydroxide In water; acetonitrile at 0℃; for 2h;88%
With sodium hydroxide In water for 0.5h;79%
methanol
67-56-1

methanol

Phenylalanine
150-30-1

Phenylalanine

DL-phenylalanine methyl ester
15028-44-1

DL-phenylalanine methyl ester

Conditions
ConditionsYield
With thionyl chloride at -20℃; for 3.66667h; Reflux;99%
With thionyl chloride for 3h; Heating;98%
With sulfuric acid Reflux;92%
Phenylalanine
150-30-1

Phenylalanine

1-benzylisatin
1217-89-6

1-benzylisatin

(2-oxo-1,2-dihydro-indol-3-ylidene)-acetic acid ethyl ester
21728-28-9

(2-oxo-1,2-dihydro-indol-3-ylidene)-acetic acid ethyl ester

C35H31N3O4

C35H31N3O4

Conditions
ConditionsYield
In methanol at 30℃; for 4h; Solvent; Time; Concentration; diastereoselective reaction;99%
...Expand
1-benzyl-5-chloroisatin
26960-68-9

1-benzyl-5-chloroisatin

Phenylalanine
150-30-1

Phenylalanine

(2-oxo-1,2-dihydro-indol-3-ylidene)-acetic acid ethyl ester
21728-28-9

(2-oxo-1,2-dihydro-indol-3-ylidene)-acetic acid ethyl ester

C35H30ClN3O4

C35H30ClN3O4

Conditions
ConditionsYield
In methanol at 30℃; for 24h; diastereoselective reaction;99%
...Expand
Phenylalanine
150-30-1

Phenylalanine

1-benzyl-7-fluoroindoline-2,3-dione
1190109-45-5

1-benzyl-7-fluoroindoline-2,3-dione

(2-oxo-1,2-dihydro-indol-3-ylidene)-acetic acid ethyl ester
21728-28-9

(2-oxo-1,2-dihydro-indol-3-ylidene)-acetic acid ethyl ester

C35H30FN3O4

C35H30FN3O4

Conditions
ConditionsYield
In methanol at 30℃; for 24h; diastereoselective reaction;99%
...Expand
Phenylalanine
150-30-1

Phenylalanine

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 18h;99%
formaldehyd
50-00-0

formaldehyd

Phenylalanine
150-30-1

Phenylalanine

(R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
67123-97-1

(R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In water for 4.5h; Heating / reflux;98.9%
With hydrogenchloride69%
With hydrogenchloride In water for 6h; Reflux;33%
phthalic anhydride
85-44-9

phthalic anhydride

Phenylalanine
150-30-1

Phenylalanine

N-phthaloylphenylalanine
3588-64-5

N-phthaloylphenylalanine

Conditions
ConditionsYield
at 170℃; for 2h;98%
In acetonitrile at 145℃; Sealed tube;96%
at 170℃; for 2.5h;93%
maleic anhydride
108-31-6

maleic anhydride

Phenylalanine
150-30-1

Phenylalanine

N-maleyl-D,L-phenylalanine
96661-85-7

N-maleyl-D,L-phenylalanine

Conditions
ConditionsYield
In acetic acid at 20℃;98%
In acetic acid for 0.166667h; Heating;81%
Phenylalanine
150-30-1

Phenylalanine

Bz-Gly-ONPh
3101-11-9

Bz-Gly-ONPh

N-hippuroyl-3-phenyl-alanine
4703-39-3

N-hippuroyl-3-phenyl-alanine

Conditions
ConditionsYield
With sodium hydroxide In water; butan-1-ol Ambient temperature;98%
m-carborane-1,7-dicarboxylic acid dichloride
23810-52-8

m-carborane-1,7-dicarboxylic acid dichloride

Phenylalanine
150-30-1

Phenylalanine

C2B10H10(CONHCH(CH2C6H5)COOH)2
186822-50-4

C2B10H10(CONHCH(CH2C6H5)COOH)2

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In water byproducts: NaCl; stirring (20-30°C, 2-3 h), aq. HCl addn.; washing (water), drying (vac.); elem. anal.;98%
(S)-benzyl 4-(1-benzo[d][1m2m3]triazol-1-yl)-3-(benzyloxycarbonylamino)-4-oxobutanoate
1052265-49-2

(S)-benzyl 4-(1-benzo[d][1m2m3]triazol-1-yl)-3-(benzyloxycarbonylamino)-4-oxobutanoate

Phenylalanine
150-30-1

Phenylalanine

2-((S)-4-(benzyloxy)-2-(benzyloxycarbonylamino)-4-oxobutanamido)-3-phenylpropanoic acid
1052265-93-6

2-((S)-4-(benzyloxy)-2-(benzyloxycarbonylamino)-4-oxobutanamido)-3-phenylpropanoic acid

Conditions
ConditionsYield
With triethylamine In water; acetonitrile at 20℃; for 2h;98%
formaldehyd
50-00-0

formaldehyd

Phenylalanine
150-30-1

Phenylalanine

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride
41994-51-8

1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water for 4.5h; Reflux;98%
Phenylalanine
150-30-1

Phenylalanine

((S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide)
1644308-41-7

((S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide)

nickel(II) acetate tetrahydrate
6018-89-9

nickel(II) acetate tetrahydrate

C34H30Cl3N3NiO3

C34H30Cl3N3NiO3

Conditions
ConditionsYield
With potassium carbonate In methanol at 60℃; for 3h; Temperature; diastereoselective reaction;98%
...Expand
Phenylalanine
150-30-1

Phenylalanine

(S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)-2-methylpyrrolidine-2-carboxamide

(S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)-2-methylpyrrolidine-2-carboxamide

nickel diacetate
373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6

nickel diacetate

nickel(II)-(S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)-2-methylpyrrolidine-2-carboxamide/(S)-phenylalanine Schiff base complex

nickel(II)-(S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)-2-methylpyrrolidine-2-carboxamide/(S)-phenylalanine Schiff base complex

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol at 60℃; for 72h;98%
With potassium carbonate In methanol at 60℃; for 8h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; diastereoselective reaction;98%
...Expand
Phenylalanine
150-30-1

Phenylalanine

N-benzyl-5-fluoroisatin
366799-82-8

N-benzyl-5-fluoroisatin

(2-oxo-1,2-dihydro-indol-3-ylidene)-acetic acid ethyl ester
21728-28-9

(2-oxo-1,2-dihydro-indol-3-ylidene)-acetic acid ethyl ester

C35H30FN3O4

C35H30FN3O4

Conditions
ConditionsYield
In methanol at 30℃; for 24h; diastereoselective reaction;98%
...Expand
benzoic acid N-hydroxysuccinimide ester
23405-15-4

benzoic acid N-hydroxysuccinimide ester

Phenylalanine
150-30-1

Phenylalanine

DL-N-benzoylphenylalanine
2566-22-5, 2901-76-0, 37002-52-1

DL-N-benzoylphenylalanine

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 20℃; for 2h;97%
Phenylalanine
150-30-1

Phenylalanine

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

C21H18ClNO4
1033595-55-9

C21H18ClNO4

Conditions
ConditionsYield
With [bmIm]OH In water Heating;97%
...Expand
Phenylalanine
150-30-1

Phenylalanine

indole-2,3-dione
91-56-5

indole-2,3-dione

(3E)-3-benzylidene-1,3-dihydro-2H-indol-2-one
23782-37-8

(3E)-3-benzylidene-1,3-dihydro-2H-indol-2-one

C31H25N3O2

C31H25N3O2

Conditions
ConditionsYield
In methanol at 60℃; for 3h; diastereoselective reaction;97%
...Expand
1-dodecyl alcohol
112-53-8

1-dodecyl alcohol

Phenylalanine
150-30-1

Phenylalanine

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

racemic 1-(dodecyloxy)-1-oxo-3-phenylpropan-2-aminium 4-methyl benzenesulfonate

racemic 1-(dodecyloxy)-1-oxo-3-phenylpropan-2-aminium 4-methyl benzenesulfonate

Conditions
ConditionsYield
In toluene Reflux;97%
Stage #1: 1-dodecyl alcohol; Phenylalanine In neat (no solvent) at 120℃; for 0.0833333h; Green chemistry;
Stage #2: toluene-4-sulfonic acid In neat (no solvent) at 130 - 135℃; Green chemistry;		82%
...Expand
N-benzyloxycarbonyl-3-aminopropionic acid succinimide ester
53733-97-4

N-benzyloxycarbonyl-3-aminopropionic acid succinimide ester

Phenylalanine
150-30-1

Phenylalanine

(±)-Cbz-βAla-Phe-OH
21612-32-8

(±)-Cbz-βAla-Phe-OH

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol; water; acetone at 20℃; for 5h;97%

DL-Phenylalanine History

In 1961,J. Heinrich Matthaei and Marshall W. Nirenberg discovered the genetic codon for phenylalanine was firstly . They pointed out that by using m-RNA to insert multiple uracil repeats into the bacterium E. coli, the bacterium produced a new protein consisting solely of repeated phenylalanine amino acids. This discovery caused the determination of the relationship between RNA and amino acids, which was fundamental to the understanding of the Genetic Code.

DL-Phenylalanine Consensus Reports

Dl-phenylalanine is reported in EPA TSCA Inventory.

DL-Phenylalanine Specification

The IUPAC name of DL-Phenylalanine is 2-amino-3-phenylpropanoic acid. With the CAS registry number 150-30-1, it is also named as Phenylalanine DL-form. The product's categories are Food & Feed Additives; Amino Acids Series; Amino Acids; Chiral; Organic Acids; Phenylalanine [Phe, F]; alpha-Amino Acids; Biochemistry; Amino Acids; Phenlalnine; Amino Acid; Food Additive; Pharmaceutical Intermediate. Besides, it is white crystalline powder, which should be sealed in a cool, dry place. It is stable, and incompatible with strong oxidizing agents. In addition, its molecular formula is C9H11NO2 and molecular weight is 165.19.

The other characteristics of this product can be summarized as: (1)EINECS: 205-756-7; (2)ACD/LogP: 0.24; (3)# of Rule of 5 Violations: 0; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.576; (12)Molar Refractivity: 45.493 cm3; (13)Molar Volume: 137.437 cm3; (14)Surface Tension: 53.597 dyne/cm; (15)Density: 1.202 g/cm3; (16)Flash Point: 139.771 °C; (17)Melting point: 266-267 °C; (18)Water solubility: 14.11 g/L (25 °C); (19)Enthalpy of Vaporization: 57.873 kJ/mol; (20)Boiling Point: 307.5 °C at 760 mmHg; (21)Vapour Pressure: 0 mmHg at 25 °C.

Preparation of DL-Phenylalanine: this chemical can be prepared by the reaction of Acetyl-L-phenylalanine with HCl. Furthermore, it is produced by acetylamino-benzyl-malonic acid diethyl ester.



This reaction needs H+, water by heating. The yield is 82 %.

Uses of DL-Phenylalanine: this chemical is used as a dietary supplement and as a nutritional supplement for its supposed analgesic and antidepressant activities. Additionally, it can react with acetic acid anhydride to get N-(1-benzyl-2-oxo-propyl)-acetamide.



This reaction needs pyridine by heating. The yield is 76 %.

When you are using this chemical, please be cautious about it as the following: it may cause burns. It is also irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing, gloves and eye/face protection to avoid contact with skin and eyes. Moreover, please take off immediately all contaminated clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: C1=CC=C(C=C1)CC(C(=O)O)N
(2)InChI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)
(3)InChIKey: COLNVLDHVKWLRT-UHFFFAOYSA-N

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