• Name

  Demiditraz

• EINECS
• CAS No. 944263-65-4
• Article Data2
• CAS DataBase
• Density 1.053 g/cm³
• Solubility
• Melting Point
• Formula C₁₃H₁₆N₂
• Boiling Point 407.3 °C at 760 mmHg
• Molecular Weight 200.283
• Flash Point 212.2 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 2-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole;Demiditraz;PF 3814927;
• PSA 28.68000
• LogP 3.17830

Synthetic route

944263-08-5

demiditraz racemate

944263-65-4

2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

Conditions

Conditions	Yield
In ethanol Purification / work up;

944263-65-4

2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

74-88-4

methyl iodide

2-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1-methyl-1H-imidazole

Conditions

Conditions	Yield
With caesium carbonate In acetone at 20℃; for 4h;

75-44-5

phosgene

944263-65-4

2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

C14H15ClN2O

Conditions

Conditions	Yield
With pyridine In dichloromethane; toluene at 0℃; for 0.333333h;

944263-65-4

2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

503-38-8

trichloromethyl chloroformate

C15H15Cl3N2O2

Conditions

Conditions	Yield
With pyridine In acetonitrile at 0 - 20℃; for 0.166667 - 0.5h; Product distribution / selectivity;

944263-65-4

2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

501-53-1

benzyl chloroformate

Benzyl 2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3h;

944263-65-4

2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

460-37-7

1,1,1-trifluoro-3-iodopropane

2-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1-(3,3,3-trifluoropropyl)-1H-imidazole

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 100℃; for 0.75h; Microwave irradiation;

944263-65-4

2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

543-27-1

isobutyl chloroformate

Isobutyl 2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 18h;

944263-65-4

2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

1700-31-8

3-benzyloxybenzyl bromide

1-[3-(Benzyloxy)benzyl]-2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

Conditions

Conditions	Yield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 20℃; for 48h;

944263-65-4

2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

18997-19-8

Chloromethyl pivalate

{2-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazol-1-yl}methyl pivalate

Conditions

Conditions	Yield
With caesium carbonate In acetone at 20℃; for 18h;

1-(4-(bromomethyl)phenyl)-1H-1,2,4-triazole

944263-65-4

2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

1-[4-({2-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazol-1-yl}methyl)phenyl]-1H-1,2,4-triazole

Conditions

Conditions	Yield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 20℃; for 18h;

Demiditraz Specification