Diethyleneglycolmonohexylether supplier

Name
2-(2-HEXYLOXYETHOXY)ETHANOL
EINECS 203-988-3
CAS No. 112-59-4
Article Data6
CAS DataBase
Density 0.933 g/cm³
Solubility Soluble in water.
Melting Point ?40 ºC(lit.)
Formula C10H22 O3
Boiling Point 260 ºC at 760 mmHg
Molecular Weight 190.283
Flash Point 140 ºC
Transport Information
Appearance
Safety Moderately toxic by skin contact route. Mildly toxic by ingestion. An eye and severe skin irritant. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO₂, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also GLYCOL ETHERS.
Risk Codes 21-41
Molecular Structure
Hazard Symbols Xn
Synonyms 2-[2-(Hexyloxy)ethoxy]ethanol;3,6-Dioxa-1-dodecanol; DEGHE; Diethylene glycol hexyl ether; Diethylene glycolmonohexyl ether; HEDG; Hexyl Carbitol; Kyowanol HX 20; NSC 403666; Ucar FilmerEHC; n-Hexoxyethoxyethanol
PSA 38.69000
LogP 1.59220

Synthetic route

: 111-25-1
1-bromo-hexane

: 111-46-6
diethylene glycol

: 112-59-4
diethylene glycol monohexyl ether

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane at 100 - 105℃;	68%
With sodium hydride

: 75-21-8
oxirane

: 112-25-4
2-hexyloxyethanol

: 112-59-4
diethylene glycol monohexyl ether

Conditions

Conditions	Yield
With borontrifluoride acetic acid

: 75-21-8
oxirane

: 111-27-3
hexan-1-ol

: 112-59-4
diethylene glycol monohexyl ether

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate at 50℃;

: 111-25-1
1-bromo-hexane

sodium diethylene glycolate: sodium diethylene glycolate

: 112-59-4
diethylene glycol monohexyl ether

Conditions

Conditions	Yield
With diethylene glycol at 200℃;

: 112-59-4
diethylene glycol monohexyl ether

: 98-59-9
p-toluenesulfonyl chloride

: 187748-60-3
2-(2'-n-hexyloxyethoxy)ethyl p-toluenesulfonate

Conditions

Conditions	Yield
Stage #1: diethylene glycol monohexyl ether; p-toluenesulfonyl chloride With dmap In dichloromethane at 20℃; for 0.166667h; Stage #2: With triethylamine In dichloromethane at 20℃; for 3.25h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;	92%
With pyridine In dichloromethane at 20℃; for 3h;	71%
With dmap; triethylamine In dichloromethane for 3h;

: 1871-57-4
2-chloromethyl-3-chloroprop-1-ene

: 112-59-4
diethylene glycol monohexyl ether

: C24H48O6

Conditions

Conditions	Yield
Stage #1: diethylene glycol monohexyl ether With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.333333h; Inert atmosphere; Stage #2: 2-chloromethyl-3-chloroprop-1-ene In tetrahydrofuran; mineral oil at 65℃; for 5.5h; Inert atmosphere;	88%

: 112-59-4
diethylene glycol monohexyl ether

: 615-42-9
1,2-Diiodobenzene

: 1,2-bis-(2-(2-(hexyloxy)ethoxy)ethoxy)benzene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 72h; Inert atmosphere;	85%
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 72h; Inert atmosphere;	85%

: 112-59-4
diethylene glycol monohexyl ether

: 72510-64-6
1-[2-(2-chloroethoxy)ethoxy]hexane

Conditions

Conditions	Yield
With pyridine; thionyl chloride In toluene at -5 - 100℃; for 2h;	84%
With pyridine; thionyl chloride

: 112-59-4
diethylene glycol monohexyl ether

: 626-00-6
1,3-Diiodobenzene

: 1,3-bis(2-(2-hexylethoxy)ethoxy)benzene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene for 20h; Reflux; Inert atmosphere;	82%

: 591-50-4
iodobenzene

: 112-59-4
diethylene glycol monohexyl ether

: 928346-61-6
(2-(2-(hexyloxy)ethoxy)ethoxy)benzene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 24h; Inert atmosphere;	77%
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 24h; Inert atmosphere;	77%

: 111-25-1
1-bromo-hexane

: 111-46-6
diethylene glycol

: 112-59-4
diethylene glycol monohexyl ether

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane at 100 - 105℃;	68%
With sodium hydride

: 75-21-8
oxirane

: 112-25-4
2-hexyloxyethanol

: 112-59-4
diethylene glycol monohexyl ether

Conditions

Conditions	Yield
With borontrifluoride acetic acid

: 75-21-8
oxirane

: 111-27-3
hexan-1-ol

: 112-59-4
diethylene glycol monohexyl ether

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate at 50℃;

: 111-25-1
1-bromo-hexane

sodium diethylene glycolate: sodium diethylene glycolate

: 112-59-4
diethylene glycol monohexyl ether

Conditions

Conditions	Yield
With diethylene glycol at 200℃;

: 112-59-4
diethylene glycol monohexyl ether

: 98-59-9
p-toluenesulfonyl chloride

: 187748-60-3
2-(2'-n-hexyloxyethoxy)ethyl p-toluenesulfonate

Conditions

Conditions	Yield
Stage #1: diethylene glycol monohexyl ether; p-toluenesulfonyl chloride With dmap In dichloromethane at 20℃; for 0.166667h; Stage #2: With triethylamine In dichloromethane at 20℃; for 3.25h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;	92%
With pyridine In dichloromethane at 20℃; for 3h;	71%
With dmap; triethylamine In dichloromethane for 3h;

: 1871-57-4
2-chloromethyl-3-chloroprop-1-ene

: 112-59-4
diethylene glycol monohexyl ether

: C24H48O6

Conditions

Conditions	Yield
Stage #1: diethylene glycol monohexyl ether With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.333333h; Inert atmosphere; Stage #2: 2-chloromethyl-3-chloroprop-1-ene In tetrahydrofuran; mineral oil at 65℃; for 5.5h; Inert atmosphere;	88%

: 112-59-4
diethylene glycol monohexyl ether

: 615-42-9
1,2-Diiodobenzene

: 1,2-bis-(2-(2-(hexyloxy)ethoxy)ethoxy)benzene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 72h; Inert atmosphere;	85%
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 72h; Inert atmosphere;	85%

: 112-59-4
diethylene glycol monohexyl ether

: 72510-64-6
1-[2-(2-chloroethoxy)ethoxy]hexane

Conditions

Conditions	Yield
With pyridine; thionyl chloride In toluene at -5 - 100℃; for 2h;	84%
With pyridine; thionyl chloride

: 112-59-4
diethylene glycol monohexyl ether

: 626-00-6
1,3-Diiodobenzene

: 1,3-bis(2-(2-hexylethoxy)ethoxy)benzene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene for 20h; Reflux; Inert atmosphere;	82%

: 591-50-4
iodobenzene

: 112-59-4
diethylene glycol monohexyl ether

: 928346-61-6
(2-(2-(hexyloxy)ethoxy)ethoxy)benzene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 24h; Inert atmosphere;	77%
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 24h; Inert atmosphere;	77%

: 112-59-4
diethylene glycol monohexyl ether

: 309-88-6
hexafluoropropene-diethylamine adduct

A: N,N-diethyl 2,3,3,3-tetrafluoropropionamide

B: 1-[2-(2-Fluoro-ethoxy)-ethoxy]-hexane

C: 2,3,3,3-Tetrafluoro-propionic acid 2-(2-hexyloxy-ethoxy)-ethyl ester

Conditions

Conditions	Yield
In dichloromethane for 3h; Ambient temperature;	A n/a B 70% C 15%
In dichloromethane for 3h; Ambient temperature;	A n/a B 70% C 15%

...Expand

: 112-59-4
diethylene glycol monohexyl ether

: 2-methyl-2-octyldodecanoic acid

: C31H62O4

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 18h; Dean-Stark; Reflux;	70%

: 112-59-4
diethylene glycol monohexyl ether

: 90-14-2
1-Iodonaphthalene

: 1-(2-(2-(hexyloxy)ethoxy)ethoxy)naphthalene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 24h; Inert atmosphere;	67%

: 112-59-4
diethylene glycol monohexyl ether

: (5,10,15,20-tetraphenylporphinato)dichlorophosphorus(V) chloride

: di(3,6-dioxadodecyloxo)tetraphenylporphyrinatophosphorus(V) chloride

Conditions

Conditions	Yield
With pyridine In acetonitrile for 24h; Reflux;	66%
With pyridine In acetonitrile for 24h; Reflux;

: 112-59-4
diethylene glycol monohexyl ether

: 624-31-7
4-tolyl iodide

: 1-(2-(2-(hexyloxy)ethoxy)ethoxy)-4-methylbenzene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 24h; Inert atmosphere;	63%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 112-59-4
diethylene glycol monohexyl ether

: 928346-63-8
C13H21Cl2N3O3

Conditions

Conditions	Yield
With potassium carbonate In ethyl acetate at 20 - 50℃; for 20h; Product distribution / selectivity;	60%

: 112-59-4
diethylene glycol monohexyl ether

: 31599-61-8
3,4-dimethyliodobenzene

: 4-(2-(2-(hexyloxy)ethoxy)ethoxy)-1,2-dimethylbenzene

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 24h; Inert atmosphere;	60%

: 62446-93-9
1,2,3,4-tetra-O-acetyl-D-xylopyranose

: 112-59-4
diethylene glycol monohexyl ether

: triacetylhexyl bis(oxyethyl)-α-D-xyloside

Conditions

Conditions	Yield
With tin(IV) chloride In dichloromethane at 0℃; for 24h; Molecular sieve;	54%
With tin(IV) chloride Helferich Method; stereoselective reaction;

: 112-59-4
diethylene glycol monohexyl ether

: 118-75-2
chloranil

A: 2,3,5-trichloro-[6-(2-(2-hexyloxy)ethoxy)ethoxy]cyclohexa-2,5-diene-1,4-dione

B: C26H42Cl2O8

C: C26H42Cl2O8

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	A 38% B 4% C 17%

...Expand

: 117-80-6
2,3-Dichloro-1,4-naphthoquinone

: 112-59-4
diethylene glycol monohexyl ether

: 2-(2-(2-(hexyloxy)ethoxy)ethoxy)-3-chloro-1,4-naphthoquinone

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 12h;	25%

: 112-59-4
diethylene glycol monohexyl ether

: C64H86O43

: C72H104O44

Conditions

Conditions	Yield
With tin(IV) chloride In dichloromethane at 45℃; for 5h; glycosidation;	22%

: 75-21-8
oxirane

: 112-59-4
diethylene glycol monohexyl ether

: 25961-89-1
2-[2-(2-hexyloxy-ethoxy)-ethoxy]-ethanol

Conditions

Conditions	Yield
With borontrifluoride acetic acid

: 112-59-4
diethylene glycol monohexyl ether

: 39619-69-7
Tetraethylene glycol monohexyl ether

Conditions

Conditions	Yield
With pyridine; p-toluenesulfonyl chloride Erhitzen des Reaktionsprodukts mit Natrium-diaethylenglykolat in Diaethylenglykol auf 130grad;
Multi-step reaction with 2 steps 1: pyridine; thionyl chloride 2: diethylene glycol View Scheme

: 112-59-4
diethylene glycol monohexyl ether

: 107-13-1
acrylonitrile

: 102236-85-1
3-[2-(2-hexyloxy-ethoxy)-ethoxy]-propionitrile

Conditions

Conditions	Yield
With potassium hydroxide

: 112-59-4
diethylene glycol monohexyl ether

: 40843-25-2
diclofop

: 65634-01-7
2-[4-(2,4-Dichloro-phenoxy)-phenoxy]-propionic acid 2-(2-hexyloxy-ethoxy)-ethyl ester

Conditions

Conditions	Yield
(i) SOCl2, toluene, (ii) /BRN= 1743959/, Et3N; Multistep reaction;

: 112-59-4
diethylene glycol monohexyl ether

: 4-(4-chlorophenoxy)-α-phenoxy-propionic acid chloride

: 65634-00-6
2-[4-(4-Chloro-phenoxy)-phenoxy]-propionic acid 2-(2-hexyloxy-ethoxy)-ethyl ester

Conditions

Conditions	Yield
With triethylamine In toluene

: 112-59-4
diethylene glycol monohexyl ether

: 106-89-8
epichlorohydrin

: 120439-33-0
2-[2-(2-Hexyloxy-ethoxy)-ethoxymethyl]-oxirane

Conditions

Conditions	Yield
With sodium hydroxide at 70 - 90℃;

: 112-59-4
diethylene glycol monohexyl ether

: 7585-39-9
β‐cyclodextrin

: C42H70O35*C10H22O3

Conditions

Conditions	Yield
In water at 80℃; for 24h;

: 112-59-4
diethylene glycol monohexyl ether

: 920-46-7
Methacryloyl chloride

: 183317-57-9
C14H26O4

Conditions

Conditions	Yield
With triethylamine In benzene at 20℃;

: 112-59-4
diethylene glycol monohexyl ether

: 1,3-bis<2-(n-hexyloxyethoxy)ethoxy>propane-2-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 50percent aq. NaOH / 70 - 90 °C 2: 50percent aq. NaOH / 1 h / 70 - 80 °C View Scheme

Diethyleneglycolmonohexylether Chemical Properties

SYNONYMS Diethylene glycol hexyl ether; 2-((2-Hexyloxy)ethoxy)ethanol;
Diethylene glycol mono(n-hexyl) ether; Hexol carbitol; Diethylene glycol monohexyl ether; n-Hexoxyethoxyethanol; Diethyleneglycolmonohexylether; 2-((2-Hexyloxy)ethoxy)ethanol; 2-(2-(hexyloxy)ethoxy)ethanol;
EINECS NO.:203-988-3
FORMULA:CH₃(CH₂)₅OCH₂CH₂OH
MOL WT:146.23
PHYSICAL STATE:clear liquid
MELTING POINT:-40 °C
BOILING POINT:260 °C
SPECIFIC GRAVITY:0.93 - 0.94
FLASH POINT:141°C
REFRACTIVE INDEX:1.435
SOLUBILITY IN WATER:1.7 (g/100g)

Diethyleneglycolmonohexylether,it is sable under ordinary conditions.

Diethyleneglycolmonohexylether Toxicity Data With Reference

1.	skn-rbt 10 mg/24H open MLD	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 4 (1951),119.
2.	skn-rbt 500 mg/24H SEV	JPETAB Journal of Pharmacology and Experimental Therapeutics. 82 (1944),377.
3.	skn-rbt 500 mg open MLD	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/3 ,1971.
4.	eye-rbt 5 mg MOD	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 11/3 ,1971.
5.	orl-rat LD50:4920 mg/kg	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 4 (1951),119.
6.	skn-rbt LD50:1500 mg/kg	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 4 (1951),119.

Diethyleneglycolmonohexylether Consensus Reports

n-HEXYL CARBITOL is reported in PA TSCA Inventory. Glycol ether compounds are on the Community Right-To-Know List.

Diethyleneglycolmonohexylether Safety Profile

Moderately toxic by skin contact route. Mildly toxic by ingestion. An eye and severe skin irritant. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO₂, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also GLYCOL ETHERS.

Diethyleneglycolmonohexylether's Risk Statements:21:Harmful in contact with skin;41:Risk of serious damage to eyes
Diethyleneglycolmonohexylether's Safety Statements:26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;36/37:Wear suitable protective clothing and gloves;46:If swallowed, seek medical advice immediately and show this container or label;24/25:Avoid contact with skin and eyes
Hazard Codes:Xn
WGK Germany:1

Product Name

2-(2-HEXYLOXYETHOXY)ETHANOL

Synthetic route

Diethyleneglycolmonohexylether Chemical Properties

Diethyleneglycolmonohexylether Toxicity Data With Reference

Diethyleneglycolmonohexylether Consensus Reports

Diethyleneglycolmonohexylether Safety Profile

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