Dimethyl disulfide supplier

Name
Dimethyl disulfide
EINECS 210-871-0
CAS No. 624-92-0
Article Data190
CAS DataBase
Density 1.052 g/cm³
Solubility <0.1 g/100 mL at 20 °C in water
Melting Point -85 °C
Formula C₂H₆S₂
Boiling Point 109.7 °C at 760 mmHg
Molecular Weight 94.2016
Flash Point 24.4 °C
Transport Information UN 2381 3/PG 2
Appearance colourless to yellow liquid
Safety 26-61-45-38-36/37/39-28A-16-60
Risk Codes 11-20/22-36-51/53-36/37/38-26-22
Molecular Structure
Hazard Symbols Xn,F, T+, N
Synonyms FEMA No. 3536;Disulfide,dimethyl;Methyl disulfide (8CI);Disulfide, dimethyl;Methyldisulfide;(Methyldithio)methane;Methyldithiomethane;Dimethyl disulphide;2,3-Dithiabutane;Sulfa-Hitech;
PSA 50.60000
LogP 1.62740

Synthetic route

: 124-63-0
methanesulfonyl chloride

: 624-92-0
Dimethyldisulphide

Conditions

Conditions	Yield
With trimethylsilyl iodide In 1,2-dichloro-ethane for 16h; Heating;	100%
With sulfuric acid; sulfur dioxide; potassium iodide In water at 80℃; for 1h;	92.9%
With tungsten(VI) chloride; sodium iodide In acetonitrile for 12h; Ambient temperature;	90%

: 28925-45-3
S-methyl O-benzyl dithiocarbonate

A: 624-92-0
Dimethyldisulphide

B: 100-44-7
benzyl chloride

Conditions

Conditions	Yield
With copper(l) chloride; copper dichloride In acetonitrile for 96h; Ambient temperature;	A 100% B 60%

: 9-methylsulfinyl-10-(methylthio)anthracene

A: 624-92-0
Dimethyldisulphide

B: 84-65-1
9,10-phenanthrenequinone

Conditions

Conditions	Yield
Stage #1: 9-methylsulfinyl-10-(methylthio)anthracene With air; sulfuric acid In dichloromethane at 20℃; for 0.0833333h; Rearrangement; Stage #2: With water; sodium hydrogencarbonate Hydrolysis;	A n/a B 100%

: 74-93-1
methylthiol

: 624-92-0
Dimethyldisulphide

Conditions

Conditions	Yield
Stage #1: methylthiol With sodium hydroxide at 51℃; Stage #2: With oxygen at 55℃; under 4500.45 Torr; Temperature; Pressure; Reagent/catalyst;	97.6%
With Cu,Na-X zeolite; oxygen at 189.9℃; Product distribution; Mechanism; other catalysts; other temp.;
With air at 170 - 270℃;

: 33696-21-8
N,N-dimethylmethane sulfenamide

: 74-88-4
methyl iodide

A: 624-92-0
Dimethyldisulphide

B: 75-58-1
tertamethylammonium iodide

Conditions

Conditions	Yield
In chloroform Product distribution; Ambient temperature; var. amino thioethers, var. electrophiles;	A 96% B 96%

...Expand

: 629-45-8
dibutyl disulfide

: 1680-29-1
S-methyl decanethioate

A: 624-92-0
Dimethyldisulphide

B: S-butyl decanethioate

Conditions

Conditions	Yield
[RhCl(PPh3)] In 1,2-dichloro-benzene at 150℃; for 1.5h;	A n/a B 95%

...Expand

: 67-56-1
methanol

: 74-93-1
methylthiol

A: 75-15-0
carbon disulfide

B: 624-92-0
Dimethyldisulphide

C: 3658-80-8
dimethyltrisulfane

Conditions

Conditions	Yield
Stage #1: methanol; methylthiol With hydrogen sulfide; aluminum oxide with 14percent by weight of potassium tungstate at 400℃; Stage #2: With sulfur; N-cyclohexyl-cyclohexanamine	A n/a B 94.9% C n/a

...Expand

: 53475-19-7
2,3-dimethyl-3-methylsulfanyl-3H-indole

A: 91-55-4
2,3-dimethylindole

B: 624-92-0
Dimethyldisulphide

Conditions

Conditions	Yield
With mercaptoacetic acid In dichloromethane for 0.5h; Heating;	A 93% B n/a
With mercaptoacetic acid In dichloromethane for 0.5h; Mechanism; Heating;

: 69177-66-8
bis(2-methoxyethyl) disulfide

: 1680-29-1
S-methyl decanethioate

A: 1020261-42-0
S-(2-methoxy)ethyl decanethioate

B: 624-92-0
Dimethyldisulphide

Conditions

Conditions	Yield
[RhCl(PPh3)] In 1,2-dichloro-benzene at 150℃; for 1.5h;	A 93% B n/a

...Expand

: 1680-29-1
S-methyl decanethioate

: 67385-10-8
di-tert-butyl(disulfanediylbis(ethane-2,1-diyl))dicarbamate

A: 1020261-43-1
S-[2-(t-butoxycarbonyl)amino]ethyl decanethioate

B: 624-92-0
Dimethyldisulphide

Conditions

Conditions	Yield
[RhCl(PPh3)] In 1,2-dichloro-benzene at 150℃; for 1.5h;	A 92% B n/a

...Expand

: 12107-04-9
dicarbonyl(cyclopentadienyl)iron(II) chloride

: 10543-35-8
lithium methylsulfinyl carbanion

A: 38117-54-3
cyclopentadienyl iron(II) dicarbonyl dimer

B: 74-93-1
methylthiol

C: 624-92-0
Dimethyldisulphide

D: 6628-18-8
1,2-bis(methylthio)ethane

E: lithium chloride

Conditions

Conditions	Yield
In tetrahydrofuran mixing reactants in THF at -78°C, slow warming to room temp.; evapn. in vac., extn. with pentane, ether and finally acetone or CH2Cl2, concn., chromy. on Al2O3, purifn. by crystn., distn. or sublimation;	A 55% B n/a C 21% D 8% E 92%

...Expand

: 2-nitrobenzenediazonium o-benzenedisulfonamide

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 3058-47-7
methyl 2-nitrophenyl sulfide

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at -15℃; methylthiodeazoniation; dimerization;	A n/a B 91% C n/a

...Expand

: 2,4-dinitrobenzenediazonium o-benzenedisulfonimide

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 2363-23-7
methyl 2,4-dinitriophenyl sulfide

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at -15℃; methylthiodediazoniation; dimerization;	A n/a B 89% C n/a

...Expand

: 1271-19-8
bis(cyclopentadienyl)titanium dichloride

: 10543-35-8
lithium methylsulfinyl carbanion

A: Cp2Ti(SMe)2

B: 74-93-1
methylthiol

C: 624-92-0
Dimethyldisulphide

D: titanium(IV) oxide

E: lithium chloride

Conditions

Conditions	Yield
In tetrahydrofuran mixing reactants in THF at -78°C, slow warming to room temp.; evapn. in vac., extn. with pentane, ether and finally acetone or CH2Cl2, concn., chromy. on Al2O3, purifn. by crystn., distn. or sublimation;	A 31% B n/a C 9% D 43% E 89%

...Expand

: 2-methoxybenzenediazonium o-benzenedisulfonamide

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 2388-73-0
1-methoxy-2-(methylsulfanyl)benzene

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at 0 - 5℃; Dimerization; methylthiodediazoniation;	A n/a B 88% C n/a

...Expand

: 4-nitrobenzenediazonium o-benzenedisulfonimide

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 701-57-5
1-methylthio-4-nitro-benzene

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at -15℃; methylthiodeazoniation; dimerization;	A n/a B 88% C n/a

...Expand

: 1618-26-4
2,4-dithiapentane

: 65566-22-5
3<(t-Butyl) dimethyl silyloxy>-1-bromobutan

: 139929-52-5
((Z)-5-Bromo-pent-1-enyl)-trimethyl-silane

A: 624-92-0
Dimethyldisulphide

B: 79538-96-8
(Z)-9-(tert-Butyl-dimethyl-silanyloxy)-6,6-bis-methylsulfanyl-1-trimethylsilanyl-dec-1-ene

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran	A n/a B 87%

...Expand

: 558-37-2
tert-butylethylene

: 13882-12-7
S-methyl methanethiosulfinate

: 407-25-0
trifluoroacetic anhydride

A: 2949-92-0
methanethiosulfonic acid S-methyl ester

B: 624-92-0
Dimethyldisulphide

C: 73682-79-8
methyl 3,3-dimethyl-1-trifluoroacetoxy-2-butyl sulfide

Conditions

Conditions	Yield
In tetrachloromethane 1) -20 deg C, 2) up to rt;	A 12% B 17% C 87%

...Expand

: 4-methoxybenzenediazonium o-benzenedisulfonimide

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 1879-16-9
1-methoxy-4-methylsulfanyl-benzene

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at 0 - 5℃; methylthiodediazoniation; dimerization;	A n/a B 87% C n/a

...Expand

: 4-toluenediazonium o-benzenedisulfonimide

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 623-13-2
4-methylphenyl methylsulfide

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at 0 - 5℃; Dimerization; methylthiodediazoniation;	A n/a B 86% C n/a

...Expand

: C6H4S2O4N(1-)*N2C6H5CH2(1+)

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 14092-00-3
methyl o-tolyl sulfide

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at 0 - 5℃; Dimerization; methylthiodediazoniation;	A n/a B 86% C n/a

...Expand

: 4-(chloro)benzenediazonium benzo[d][1,3,2]dithiazol-2-ide-1,1,3,3-tetraoxide

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 123-09-1
4-chlorophenyl methyl sulfide

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at 0 - 5℃; methylthiodediazoniation; dimerization;	A n/a B 86% C n/a

...Expand

: 4-hydroxybenzenediazonium o-benzenedisulfonimide

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 1073-72-9
4-hydroxythioanisole

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at 20 - 25℃; methylthiodediazoniation; dimerization;	A n/a B 86% C n/a

...Expand

: 3-methoxybenzenediazonium o-benzenedisulfonimide

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 2388-74-1
1-methoxy-3-methylsulfanyl-benzene

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at 0 - 5℃; Dimerization; methylthiodediazoniation;	A n/a B 85% C n/a

...Expand

: 4-Bromobenzenediazonium o-benzenedisulfonimide

: 5188-07-8
sodium thiomethoxide

A: 624-92-0
Dimethyldisulphide

B: 104-95-0
(4-bromophenyl)thioanisole

C: sodium o-benzenedisulfonimide

Conditions

Conditions	Yield
In methanol at 0 - 5℃; methylthiodeazoniation; dimerization;	A n/a B 85% C n/a

...Expand

: N-Boc-glutathione disulfide tetramethyl ester

: 2432-51-1
ethylthioacetic acid methyl ester

A: 1020261-44-2
N-[N-[N-{(1,1-dimethylethoxy)carbonyl}-L-γ-glutamyl]-3-(butyloylsulfuryl)-L-alanine] dimethyl ester

B: 624-92-0
Dimethyldisulphide

Conditions

Conditions	Yield
[RhCl(PPh3)] In 1,2-dichloro-benzene at 150℃; for 1.5h;	A 85% B n/a

...Expand

: 74-88-4
methyl iodide

A: 75-18-3
dimethylsulfide

B: 624-92-0
Dimethyldisulphide

Conditions

Conditions	Yield
With potassium hydroxide; sulfur; hydrazine hydrate In water at 50 - 70℃; for 0.5h;	A 6.1% B 84.3%
With sodium hydroxide; sulfur; hydrazine hydrate In water at 50 - 70℃; for 0.5h;	A 10% B 82%
With sodium hydroxide; hydrazine hydrate In water at 50 - 70℃; for 0.5h;	A 14.0 % Chromat. B 62.0 % Chromat.
With potassium hydroxide; hydrazine hydrate In water at 50 - 70℃; for 0.5h;	A 6.1 % Chromat. B 84.3 % Chromat.

: 624-92-0
Dimethyldisulphide

: 676-85-7
methylsulphinyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride; acetic acid at -20 - 20℃; for 2.5h;	100%
With sulfuryl dichloride; acetic acid at -20 - 35℃; for 6.3h;	97%
With sulfuryl dichloride; acetic acid at -20 - 35℃; for 6h;	97%

: 1003-91-4
N-methyl-2,4,5-tribromoimidazole

: 624-92-0
Dimethyldisulphide

: 145083-26-7
4,5-Dibromo-1-methyl-2-(methylthio)imidazole

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) r.t., 12 h;	100%
With n-butyllithium 1) THF, -78 deg C, 5 min; Yield given. Multistep reaction;

: 624-92-0
Dimethyldisulphide

: 67341-86-0
Ph2CCHHgBr

: 15096-10-3
methyl 2,2-diphenylethenyl sulfide

Conditions

Conditions	Yield
In benzene at 35 - 45℃; for 8h; Irradiation;	100%

: 624-92-0
Dimethyldisulphide

: 86051-74-3
1,2-dimethyl-5-trimethylstannylimidazole

: 86051-77-6
1,2-dimethyl-5-methylthioimidazole

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane 1.) -100 deg C, 1 h, 2.) room temperature, 1.5 h;	100%

: 624-92-0
Dimethyldisulphide

: 81356-73-2
4-bromo-1-ethoxymethyl-5-methylthio-2-phenylthioimidazole

: 81356-72-1
1-ethoxymethyl-4,5-bis(methylthio)-2-phenylthioimidazole

Conditions

Conditions	Yield
With n-butyllithium In diethyl ether; hexane 1.) -70 deg C, 1 h, 2.) room temperature;	100%
With n-butyllithium In diethyl ether at -70℃;	100%

: 624-92-0
Dimethyldisulphide

: 41879-78-1
naphtho<1,8-bc:4,5-b'c'>dithiophene

: 2,5-bis(methylthio)naphtho[1,8-bc:4,5-b'c']dithiophene

Conditions

Conditions	Yield
Stage #1: naphtho<1,8-bc:4,5-b'c'>dithiophene With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran; hexane at -30℃; for 1.5h; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at -30℃; for 1.5h;	100%
With n-butyllithium; N,N,N,N,-tetramethylethylenediamine 1.) THF, -30 deg C, 1.5 h, 2.) THF, -30 deg C, 1.5 h; Yield given. Multistep reaction;

: 624-92-0
Dimethyldisulphide

2,3-methano-2,4-didehydroadamantane: 2,3-methano-2,4-didehydroadamantane

Conditions

Conditions	Yield
In benzene-d6	100%

A

B: 100-44-7
benzyl chloride

Conditions

Conditions	Yield
With copper(l) chloride; copper dichloride In acetonitrile for 96h; Ambient temperature;	A 100% B 60%

: 624-92-0
Dimethyldisulphide

: 57680-64-5
8-Phenyl-tetrahydro-8λ5-[1,3,2]oxazaphospholo[2,3-b][1,3,2]oxazaphosphole

: 6a-Methylsulfanyl-6a-phenyl-tetrahydro-1,6-dioxa-3a-aza-6aλ5-phospha-pentalene

Conditions

Conditions	Yield
In benzene for 2h; Irradiation; var. time;	100%
In benzene at 20℃; Irradiation; relative rate constants, inhibition by α-methyl styrene;

: 36049-90-8
2-lithio-1,3-dithiane

: 624-92-0
Dimethyldisulphide

: 14758-37-3
2-(methylthio)-1,3-dithiane

Conditions

Conditions	Yield
In tetrahydrofuran at -78 - 20℃;	100%

: 624-92-0
Dimethyldisulphide

: 824-79-3
sodium 4-methylbenzenesulfinate

: 4973-66-4
methyl thiotosylate

Conditions

Conditions	Yield
With iodine In dichloromethane at 20℃; for 1h;	100%
With iodine at 30℃; for 2h;	90%
With copper(l) iodide; 1,10-Phenanthroline; ammonium tetrafluoroborate In N,N-dimethyl acetamide; water at 30℃; for 36h;	79%

: 624-92-0
Dimethyldisulphide

: 560095-49-0
(1-phenyl-2-propen-1-yl)pentamethyl phosphoric triamide

: 560095-81-0
(3-methylsulfanyl-1-phenyl-1-propen-1-yl)pentamethyl phosphoric triamide

Conditions

Conditions	Yield
Stage #1: (1-phenyl-2-propen-1-yl)pentamethyl phosphoric triamide With n-butyllithium In tetrahydrofuran; hexane at -50℃; for 0.166667h; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at -50 - 20℃;	100%

: 624-92-0
Dimethyldisulphide

: 108-20-3
di-isopropyl ether

: sodium hydrogensulfite

: 101-79-1
4-amino-4'-chlorodiphenyl ether

: 4-chloro-4'-thiomethyldiphenylether

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water	100%

...Expand

: 624-92-0
Dimethyldisulphide

: 1,1'-bis[N-[(2S)-2-(methoxymethyl)tetrahydro-1H-1-pyrrolyl]-N-(E)-[phenylmethylideneamino]]ferrocene

: [1,1'-bis[N-[(2S)-2-(methoxymethyl)tetrahydro-1H-1-pyrrolyl]-N-[(E)phenylmethylideneamino]]]-[(Sp)-2-methylsulfanyl]ferrocene

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane Fe-complex in THF was cooled to -78°C, nBuLi in hexane was added,stirred for 9 h at -78°C under Ar, ligand was added dropwise, wa rmed to room temp. overnight, cooled to 0°C, quenched with aq. NH4Cl; washed with brine, dried over MgSO4, concd. under reduced pressure, column chromy. on silica gel with pentane-Et2O; elem. anal.;	100%

: 624-92-0
Dimethyldisulphide

: tricarbonyl((3a,7a-trans)-octahydro-3-(t-butyl)-2-(η(6)-phenyl)benzoxazole)chromium(0)

: tricarbony(l(3a,7a-trans)-octahydro-3-(t-butyl)-2-(η(6)-2'-methylthiophenyl)benzoxazole)chromium(0)

Conditions

Conditions	Yield
With BuLi In tetrahydrofuran N2-atmosphere, absence of light; addn. of slight excess of BuLi (in hexanes) to Cr-complex soln. (in THF) at -78°C, stirring (-78°C, 2.5 h), addn. of excess Me2S2, stirring (-78°C, 3.5 h), warming to room temp. over 45 min; evapn. (reduced pressure), dissoln. in Et2O, filtration (Celite), evapn., recrystn. (hexanes/Et2O); elem. anal.;	100%

: 624-92-0
Dimethyldisulphide

: 852950-12-0
(4-bromo-2,6-dimethylphenoxy)triisopropylsilane

: 852950-13-1
2,6-dimethyl-4-methylsulfanylphenoxytriisopropylsilane

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;	100%
Stage #1: (4-bromo-2,6-dimethylphenoxy)triisopropylsilane With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at -78 - 20℃; for 1h;	100%

: 3141-27-3
2,5-dibromothiophen

: 624-92-0
Dimethyldisulphide

: 86369-96-2
2-bromo-5-(methylthio)thiophene

Conditions

Conditions	Yield
Stage #1: 2,5-dibromothiophen With n-butyllithium In hexanes; diethyl ether at -78 - -65℃; Stage #2: Dimethyldisulphide In hexanes; diethyl ether at 0 - 20℃;	100%
Stage #1: 2,5-dibromothiophen With n-butyllithium In diethyl ether; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: Dimethyldisulphide In diethyl ether; hexane at 20℃; for 8h; Inert atmosphere;	98%
Stage #1: 2,5-dibromothiophen With n-butyllithium In tetrahydrofuran; hexane at -78 - -30℃; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at -78 - 0℃;
With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 12h; Inert atmosphere;

: 624-92-0
Dimethyldisulphide

: 42298-28-2
2-methoxyanthracene

: 1309600-92-7
3-methylthio-2-methoxyanthracene

Conditions

Conditions	Yield
Stage #1: 2-methoxyanthracene With n-butyllithium In tetrahydrofuran; hexane at 0 - 20℃; for 1h; Inert atmosphere; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at 0 - 20℃; for 7h; Inert atmosphere;	100%

: 624-92-0
Dimethyldisulphide

: 59115-43-4
2-methoxy-6-phenylnaphthalene

: 1310197-78-4
2-methoxy-3-methylthio-6-phenylnaphthalene

Conditions

Conditions	Yield
Stage #1: 2-methoxy-6-phenylnaphthalene With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Inert atmosphere; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at -78 - 20℃; for 20h; Inert atmosphere;	100%

: 624-92-0
Dimethyldisulphide

: 6-n-decyl-2-methoxynaphthalene

: 1310197-76-2
6-n-decyl-3-methylthio-2-methoxynaphthalene

Conditions

Conditions	Yield
Stage #1: 6-n-decyl-2-methoxynaphthalene With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Inert atmosphere; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at -78 - 20℃; for 20h; Inert atmosphere;	100%
Stage #1: 6-n-decyl-2-methoxynaphthalene With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 1h; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at -78 - 20℃; for 18h;	100%

: 97877-74-2
bis(acetonitrile)(5,10,15,20-tetramesitylporphyrinato)ruthenium(II)

: 624-92-0
Dimethyldisulphide

: 1357363-89-3
Ru(meso-tetrakis(2,4,6-trimethylphenyl)porphyrin)(MeSSMe)2

Conditions

Conditions	Yield
In benzene at 20℃; for 24h;	100%
In benzene-d6 identified by NMR;

: 624-92-0
Dimethyldisulphide

: 36319-03-6
2,6-dimethoxyanthracene

: 1397972-18-7
2,6-dimethoxy-3,7-bis(methylthio)anthracene

Conditions

Conditions	Yield
Stage #1: 2,6-dimethoxyanthracene With n-butyllithium In tetrahydrofuran; hexane at 0 - 20℃; for 1h; Inert atmosphere; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at 0 - 20℃; for 9h; Inert atmosphere;	100%

: 624-92-0
Dimethyldisulphide

: 34246-96-3
1-methoxypyrene

: 1527009-83-1
1-methoxy-2-methylthiopyrene

Conditions

Conditions	Yield
Stage #1: 1-methoxypyrene With n-butyllithium Inert atmosphere; Schlenk technique; Stage #2: Dimethyldisulphide Inert atmosphere; Schlenk technique;	100%

: 624-92-0
Dimethyldisulphide

: 2-(4-(methoxymethoxy)phenyl)-5,5-dimethyl-1,3-dioxane

: 2-(4-(methoxymethoxy)-3-(methylthio)phenyl)-5,5-dimethyl-1,3-dioxane

Conditions

Conditions	Yield
Stage #1: 2-(4-(methoxymethoxy)phenyl)-5,5-dimethyl-1,3-dioxane With n-butyllithium In tetrahydrofuran at -78 - 20℃; for 0.333333h; Stage #2: Dimethyldisulphide In tetrahydrofuran at -78 - 20℃; for 3h;	100%

: 624-92-0
Dimethyldisulphide

: 1,3-dibromo-5-methoxy-2-((4-methoxyphenyl)ethynyl)benzene

: (3-bromo-5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)sulfane

Conditions

Conditions	Yield
Stage #1: 1,3-dibromo-5-methoxy-2-((4-methoxyphenyl)ethynyl)benzene With n-butyllithium In tetrahydrofuran at -78℃; for 1.5h; Inert atmosphere; Stage #2: Dimethyldisulphide In tetrahydrofuran at -78 - 20℃; for 3h; Inert atmosphere;	100%

: 624-92-0
Dimethyldisulphide

: 78592-82-2
4-(tert-butyldimethylsilyloxy)-1-butyne

: 125657-48-9
tert-Butyl-dimethyl-(4-methylsulfanyl-but-3-ynyloxy)-silane

Conditions

Conditions	Yield
Stage #1: 4-(tert-butyldimethylsilyloxy)-1-butyne With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h; Inert atmosphere; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at 20℃; for 3h; Inert atmosphere;	100%

: 624-92-0
Dimethyldisulphide

: 153495-48-8
but-3-ynyloxy-triisopropyl-silane

: triisopropyl((4-(methylthio)but-3-yn-1-yl)oxy)silane

Conditions

Conditions	Yield
Stage #1: but-3-ynyloxy-triisopropyl-silane With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 1h; Inert atmosphere; Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at 20℃; for 3h; Inert atmosphere;	100%

: 474711-11-0
2-bromo-4-fluoro-1-(methoxymethoxy)benzene

: 624-92-0
Dimethyldisulphide

: 4-fluoro-1-(methoxymethoxy)-2-(methylsulfanyl)benzene

Conditions

Conditions	Yield
Stage #1: 2-bromo-4-fluoro-1-(methoxymethoxy)benzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere; Stage #2: Dimethyldisulphide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere;	100%

Dimethyl disulfide Specification

The IUPAC name of Dimethyl disulfide is (methyldisulfanyl)methane. With the CAS registry number 624-92-0, it is also named as Methyl disulfide. The product's category is Sulfide Flavor. Besides, it is colourless to yellow liquid with a very unpleasant smell, which should be stored in sealed containers in a cool, dry place away from oxidizing agents and reducing agents. It is stable, but incompatible with strong bases, strong oxidizing agents, strong reducing agents. In addition, its molecular formula is C₂H₆S₂ and molecular weight is 94.19.

The other characteristics of this product can be summarized as: (1)EINECS: 210-871-0; (2)ACD/LogP: 1.77; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 1.77; (5)ACD/LogD (pH 7.4): 1.77; (6)ACD/BCF (pH 5.5): 13.04; (7)ACD/BCF (pH 7.4): 13.04; (8)ACD/KOC (pH 5.5): 218.72; (9)ACD/KOC (pH 7.4): 218.72; (10)#H bond acceptors: 0; (11)#H bond donors: 0; (12)#Freely Rotating Bonds: 1; (13)Index of Refraction: 1.522; (14)Molar Refractivity: 27.3 cm³; (15)Molar Volume: 89.4 cm³; (16)Surface Tension: 32.1 dyne/cm; (17)Density: 1.052 g/cm³; (18)Flash Point: 24.4 °C; (19)Melting Point: -85 °C; (20)Water Solubility: <0.1 g/100 mL at 20 °C; (21)Enthalpy of Vaporization: 33.78 kJ/mol; (22)Boiling Point: 109.7 °C at 760 mmHg; (23)Vapour Pressure: 28.7 mmHg at 25 °C.

Preparation of Dimethyl disulfide: this chemical can be prepared by the reaction of Dimethyl sulfate with Disodium disulfide.
Na₂S+S→Na₂S₂
Na₂S₂+(CH₃)₂SO₄→CH₃SSCH₃+Na₂SO₄

Uses of Dimethyl disulfide: this chemical is used as an intermediate of solvent and pesticide. It is also used as additive of fuel and lubricant. Additionally, it can be used as cooking inhibitor in ethylene furnace and refining equipment. The product can be used in the preparation of food flavors. Similarly, it can react with Diethyldisulfane to get Ethyl-methyl-disulfane.

This reaction needs NO, air and CD₃CN at temperature of 20 °C for 1 hour. The yield is 49 %.

When you are using this chemical, please be cautious about it as the following: it is highly Flammable. Please keep away from sources of ignition. It is also harmful and very toxic by inhalation and if swallowed. And it is irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Moreover, you should wear suitable protective clothing, gloves and eye/face protection. After contact with skin, wash immediately with plenty of soap-suds. And in case of insufficient ventilation, wear suitable respiratory equipment. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible). Additionally, it is toxic to aquatic organisms that may cause long-term adverse effects in the aquatic environment. Please avoid release to the environment. Refer to special instructions safety data sheet. This material and its container must be disposed of as hazardous waste.

People can use the following data to convert to the molecule structure.
(1)SMILES: S(SC)C
(2)InChI: InChI=1/C2H6S2/c1-3-4-2/h1-2H3
(3)InChIKey: WQOXQRCZOLPYPM-UHFFFAOYAV

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mammal (species unspecified)	LD50	unreported	138mg/kg (138mg/kg)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(6), Pg. 46, 1972.
mouse	LC50	inhalation	12300ug/m³/2H (12.3mg/m³)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(6), Pg. 46, 1972.
rat	LC50	inhalation	15850ug/m³/2H (15.85mg/m³)	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(6), Pg. 46, 1972.

Product Name

Dimethyl disulfide

Synthetic route

Dimethyl disulfide Specification

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