Ecabet sodium supplier | CasNO.86408-72-2

Name
Ecabet sodium
EINECS 1312995-182-4
CAS No. 86408-72-2
Article Data2
CAS DataBase
Density 1.241 g/cm^3/sup>
Solubility
Melting Point >300°
Formula C₂₀H₂₈O₅S . Na
Boiling Point
Molecular Weight 402.487
Flash Point
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1-Phenanthrenecarboxylicacid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-,monosodium salt, (1R,4aS,10aR)- (9CI);Gastrom;TA 2711;
PSA 102.88000
LogP 4.88980

Ecabet sodium Specification

Ecabet sodium , with cas registry number of 86408-72-2, is classifed as Anti-infective agents and Gastrointestinal Agents. It is also called Ecabet sodium salt ; 12-Sulfodehydroabietic acid monosodium salt ; Sulfodehydroabietic acid monosodium salt ; 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, (1R-(1-alpha,4a-beta,10a-alpha))-, monosodium salt . Besides these names, it also has its own IUPAC name and systematic name which are Sodium (4bS,8R,8aR)-8-methoxycarbonyl-4b-methyl-2-propan-2-yl-6,7,8,8a,9,10-hexahydro-5H-phenanthrene-3-sulfonate and 12-Sulfoabieta-8(14),9(11),12-trien-18-oic acid . Ecabet sodium is soluble in water with solubility of 13.44 mg/L at 25 °C.

About its structure, its SMILES is O=S(=O)(O)c1c(cc2c(c1)[C@@]3([C@@H](CC2)[C@@](C(=O)O)(C)CCC3)C)C(C)C which is used to convert directly to the structure. There are also other information about its bonds which are H bond acceptors 5, H bond donors 2, and Freely Rotating Bonds 3.

In some reported patents, we can see the synthesis method about aqueous ecabet sodium solution. The reaction is in solution at a concentration of 1 w/v % or more of sulfodehydroabietic acid with the pH ranging from 7 to 8.5. And one pH buffer is selected from a salt of a polycarboxylic acid and a salt of a polyphoshoric acid, and an inorganic base.

In many studies, Ecabet sodium is found that it is a good anti-ulcer agent which has efficacy against Helicobacter pylori under acidic conditions. It has dual therapy with lansoprazole and amoxicillin. Some of its toxicity data has been studied showing in the table below:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	oral	> 2gm/kg (2000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 667, 1994.
rat	LD50	oral	> 2gm/kg (2000mg/kg)	United States Patent Document. Vol. #4529602,
rat	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 667, 1994.

There are some suppliers who can provide Ecabet sodium like Hangzhou Dayangchem Co., Ltd., nakoda Chemicals Ltd. and Taizhou Candorly Sea Biochemical & Health Products Co., Ltd..

Product Name

Ecabet sodium

Ecabet sodium Specification

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