DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:66521-66-2
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermediate Transpo
Cas:66521-66-2
Min.Order:1 Kilogram
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inquiryGood quality Good price Promptly delivery Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:intermediate Transportation:A
Cas:66521-66-2
Min.Order:1 Kilogram
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Type:Manufacturers
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:66521-66-2
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:66521-66-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:66521-66-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:66521-66-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Cas:66521-66-2
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiry4-(3-Pyridinyl)-2-aminopyrimidine CAS:66521-66-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality
Cas:66521-66-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:66521-66-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:66521-66-2
Min.Order:1 Kilogram
FOB Price: $15.0 / 25.0
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s
Cas:66521-66-2
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:66521-66-2
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:66521-66-2
Min.Order:0 Metric Ton
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Type:Other
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:66521-66-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:66521-66-2
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:Light yellow solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Intermediate in the preparation of Nilotinib
Cas:66521-66-2
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryProduct name: 4-(Pyridin-3-yl)Pyrimidin-2-Amine CAS No.:66521-66-2 Molecule Formula:C9H8N4 Molecule Weight:172.19 Purity: 98.0% Package: 25kg/drum Description:Light yellow to yellow crystalline powder Manufacture Standards:Enterprise Standard
Cas:66521-66-2
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiry(3-PYRIDINYL) -2-PYRIMIDINE AMINE; 4- (3-PYRIDINYL) -2-PYRIMIDINYLAMINE; 4- (PYRIDINYL) -YL) PYRIMIDIN-2-AMINE; 4- (3-Pyridyl) -2-pyrimidineamine; 4- CAS No: 66521-66-2 Molecular Formula: C9H8N4 Molecular Weight: 172.18700 Accurate Mass: 172.
Cas:66521-66-2
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:66521-66-2
Min.Order:0
Negotiable
Type:Trading Company
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:66521-66-2
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiry4-(3-Pyridinyl)-2-aminopyrimidine Basic information Product Name: 4-(3-Pyridinyl)-2-aminopyrimidine Synonyms: BUTTPARK 41\09-83;4-(3-PYRIDINYL)-2-PYRIMIDINAMINE;4-(3-PYRIDINYL)-2-PYRIMIDINE AMINE;4-(3-PYRIDINYL)-2-PYRIMIDINYLAMINE;4-(PYRIDIN-3
Cas:66521-66-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:66521-66-2
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:66521-66-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:66521-66-2
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Cas:66521-66-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryguanidine nitrate
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
In butan-1-ol for 12h; Reflux; | 93% |
With sodium hydroxide In butan-1-ol for 20h; Reflux; Inert atmosphere; | 76% |
With sodium hydroxide In butan-1-ol for 24h; Reflux; | 4.49 g |
guanidine hydrochloride
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With sodium hydroxide In tert-butyl alcohol at 85℃; | 90% |
With potassium carbonate In propan-1-ol Reflux; Inert atmosphere; | 87% |
With sodium hydroxide In butan-1-ol Reflux; | 85% |
2-chloro-4-(pyridin-3-yl)pyrimidine
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With ammonium hydroxide In water at 80℃; for 16h; Sealed tube; | 87% |
guanidine nitrate
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With sodium hydroxide In butan-1-ol for 12h; Inert atmosphere; Schlenk technique; Reflux; | 85.5% |
With sodium hydroxide In butan-1-ol for 16h; Reflux; | 85% |
With sodium hydroxide In butan-1-ol for 16h; Reflux; | 67% |
With sodium hydroxide In butan-1-ol for 12h; Reflux; | |
With sodium hydroxide In butan-1-ol at 90℃; for 0.333333h; Microwave irradiation; | 1.18 g |
2-amino-4-chloropyrimidine
3-pyridylboronic acid
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 100℃; for 6h; Inert atmosphere; | 81% |
With 1-(2,6-diisopropylphenyl)-3-(2-oxo-2-(2,4,6-tri-tert-butylphenylamino)ethyl)-1H-imidazol-3-ium bromide; palladium diacetate; sodium hydroxide In water; dimethyl sulfoxide at 100℃; for 10h; Suzuki Coupling; | 72% |
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With guanidine hydrochloride; sodium hydroxide In isopropyl alcohol for 12h; Reflux; | 75% |
With guanidine hydrochloride; sodium hydroxide In isopropyl alcohol for 18h; Inert atmosphere; Reflux; | 65% |
With guanidine hydrochloride; sodium ethanolate In ethanol for 8h; Heating; | |
Multi-step reaction with 2 steps 1.1: nitric acid / ethanol / 0 °C 1.2: Reflux 1.3: Reflux 2.1: PYRIMIDINE; hydrazine hydrate / methanol / 0.25 h / 50 - 60 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: nitric acid / ethanol / 0 °C 1.2: Reflux 1.3: Reflux 2.1: PYRIMIDINE; hydrazine hydrate / methanol / 0.25 h / 50 - 60 °C View Scheme |
guanidine hydrochloride
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With sodium ethanolate In ethanol for 6h; Heating; | 73% |
With sodium hydroxide In butan-1-ol at 85℃; for 12h; Solvent; | 72% |
With sodium hydroxide In butan-1-ol for 12h; Reflux; | 5.162 g |
(Z)-3-chloro-3-(pyridin-3-yl)acrylaldehyde
guanidine hydrochloride
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With potassium carbonate In methanol at 20℃; Reflux; | 71% |
N-[4-(pyridin-3-yl)pyrimidin-2-yl]cyanamide
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
Stage #1: N-[4-(pyridin-3-yl)pyrimidin-2-yl]cyanamide With PYRIMIDINE; hydrazine hydrate In methanol at 50 - 60℃; for 0.25h; Stage #2: In water | 70% |
CYANAMID
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
2-nitro-aniline
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
Stage #1: 2-nitro-aniline With nitric acid In ethanol at 0℃; Stage #2: CYANAMID In water pH=Ca. 3; Reflux; Stage #3: 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one In isopropyl alcohol Reflux; | 70% |
diguanidine carbonate
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With sodium hydroxide In butan-1-ol at 120℃; for 2h; | 66% |
In iso-butanol for 24h; Heating / reflux; |
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With sodium hydroxide In butan-1-ol at 120℃; for 4h; Reflux; | 60% |
methyl-3-pyridylketone
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2,2-dimethoxy-propane / 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 °C / Reflux 2: sodium hydroxide / butan-1-ol / 4 h / 120 °C / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide; 5,5-dimethyl-1,3-cyclohexadiene / 16 h / Reflux 2: sodium hydroxide / butan-1-ol / 24 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 °C / Inert atmosphere; Schlenk technique 2: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Schlenk technique; Reflux View Scheme |
3-Bromopyridine
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium / hexane; diethyl ether / 1 h / -78 °C / Inert atmosphere 1.2: 1.67 h / -30 - 0 °C 1.3: 0.25 h / 0 - 20 °C 2.1: ammonium hydroxide / water / 16 h / 80 °C / Sealed tube View Scheme |
methyl 3-bromo-4-methylbenzoate
4-pyridin-3-ylpyrimidin-2-ylamine
methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
Conditions | Yield |
---|---|
With C43H63ClNO2PPd; caesium carbonate In 1,4-dioxane at 120℃; for 1.5h; Inert atmosphere; | 95% |
With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate In 1,4-dioxane at 120℃; for 1.5h; Inert atmosphere; | 81% |
4-chlorobenzaldehyde
4-pyridin-3-ylpyrimidin-2-ylamine
malonic acid dimethyl ester
Conditions | Yield |
---|---|
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 95% |
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With 1-chloro-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one In N,N-dimethyl-formamide at 20℃; for 12h; regioselective reaction; | 94% |
diisopropyl malonate
4-chlorobenzaldehyde
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 94% |
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 94% |
4-chlorobenzaldehyde
4-pyridin-3-ylpyrimidin-2-ylamine
diethyl malonate
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 93% |
Conditions | Yield |
---|---|
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 93% |
benzaldehyde
4-pyridin-3-ylpyrimidin-2-ylamine
malonic acid dimethyl ester
Conditions | Yield |
---|---|
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 93% |
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 100℃; Buchwald-Hartwig Coupling; Inert atmosphere; | 93% |
N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide
4-pyridin-3-ylpyrimidin-2-ylamine
imatinib
Conditions | Yield |
---|---|
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 5h; Temperature; | 92% |
Stage #1: N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide; 4-pyridin-3-ylpyrimidin-2-ylamine In ethanol at 60℃; for 3h; Inert atmosphere; Stage #2: With sodium hydroxide In water pH=8.7; Reagent/catalyst; | 91% |
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene for 5.16667h; Inert atmosphere; Reflux; Sonication; | 72% |
4-chlorobenzaldehyde
4-pyridin-3-ylpyrimidin-2-ylamine
diethyl malonate
Conditions | Yield |
---|---|
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 92% |
Conditions | Yield |
---|---|
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 91% |
benzaldehyde
4-pyridin-3-ylpyrimidin-2-ylamine
malonic acid dimethyl ester
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 91% |
2-bromo-4-nitrotoluene
4-pyridin-3-ylpyrimidin-2-ylamine
N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine
Conditions | Yield |
---|---|
With copper(I) iodide; sodium hydroxide In water at 60℃; for 9h; | 90% |
With copper(l) iodide; potassium carbonate In 1,4-dioxane at 20 - 120℃; Sealed tube; Inert atmosphere; | 83.7% |
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 120℃; for 20h; Inert atmosphere; Sealed tube; | 83.7% |
diisopropyl malonate
4-chlorobenzaldehyde
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 90% |
Conditions | Yield |
---|---|
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 90% |
4-methoxy-benzaldehyde
4-pyridin-3-ylpyrimidin-2-ylamine
diethyl malonate
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 90% |
4-pyridin-3-ylpyrimidin-2-ylamine
malonic acid dimethyl ester
cyclohexanecarbaldehyde
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 90% |
3-iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
4-pyridin-3-ylpyrimidin-2-ylamine
nilotinib
Conditions | Yield |
---|---|
With caesium carbonate; tris(dibenzylideneacetone)dipalladium (0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane; tert-butyl alcohol at 100℃; for 7h; | 89% |
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane; tert-butyl alcohol at 100℃; for 7h; | 89% |
Conditions | Yield |
---|---|
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 88% |
4-methyl-benzaldehyde
4-pyridin-3-ylpyrimidin-2-ylamine
malonic acid dimethyl ester
Conditions | Yield |
---|---|
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 88% |
1-methyl-piperazine
N-(3-bromo-4-methylphenyl)-4-(chloromethyl)benzamide
4-pyridin-3-ylpyrimidin-2-ylamine
imatinib
Conditions | Yield |
---|---|
With copper(l) iodide; sodium acetate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 100℃; for 4h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | 86% |
4-pyridin-3-ylpyrimidin-2-ylamine
malonic acid dimethyl ester
cyclohexanecarbaldehyde
Conditions | Yield |
---|---|
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction; | 86% |
bromochlorobenzene
4-pyridin-3-ylpyrimidin-2-ylamine
Conditions | Yield |
---|---|
With copper(l) iodide; N,N'-dibenzylethanediamide; potassium tert-butylate In tert-butyl alcohol at 100℃; for 24h; Molecular sieve; Schlenk technique; Inert atmosphere; | 86% |
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