Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

4-(3-Pyridinyl)-2-aminopyrimidine Manufacturer/High quality/Best price/In stock

Cas:66521-66-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermediate Transpo

Manufacturer high quality 4-(3-Pyridinyl)-2-aminopyrimidine Cas 66521-66-2 with good price

Cas:66521-66-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:intermediate Transportation:A

66521-66-24-(3-Pyridinyl)-2-aminopyrimidine

Cas:66521-66-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality Oled CAS 66521-66-2 2-Pyrimidinamine,4-(3-pyridinyl)-

Cas:66521-66-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-(Pyridin-3-yl)pyrimidin-2-amine

Cas:66521-66-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 66521-66-2 with competitive price

Cas:66521-66-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Pyrimidinamine,4-(3-pyridinyl)- 66521-66-2

Cas:66521-66-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

4-(3-Pyridinyl)-2-aminopyrimidine

Cas:66521-66-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

4-(3-Pyridinyl)-2-aminopyrimidine CAS:66521-66-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

4-(3-Pyridinyl)-2-aminopyrimidine CAS:66521-66-2

Cas:66521-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Pyrimidinamine,4-(3-pyridinyl)-

Cas:66521-66-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:66521-66-2

Cas:66521-66-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4-(3-Pyridinyl)-2-aminopyrimidine

Cas:66521-66-2

Min.Order:1 Kilogram

FOB Price: $15.0 / 25.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-(3-Piridinyl)-2-Pirimidine Amine

Cas:66521-66-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

4-(Pyridin-3-yl)pyrimidin-2-amine

Cas:66521-66-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-(Pyridin-3-yl)pyrimidin-2-amine

Cas:66521-66-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-(3-Pyridinyl)-2-aminopyrimidine

Cas:66521-66-2

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Pyrimidinamine,4-(3-pyridinyl)-

Cas:66521-66-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-(3-Piridinyl)-2-Pirimidine Amine

Cas:66521-66-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Light yellow solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Intermediate in the preparation of Nilotinib

4-(3-Pyridinyl)-2-aminopyrimidine

Cas:66521-66-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 4-(Pyridin-3-yl)Pyrimidin-2-Amine CAS No.:66521-66-2 Molecule Formula:C9H8N4 Molecule Weight:172.19 Purity: 98.0% Package: 25kg/drum Description:Light yellow to yellow crystalline powder Manufacture Standards:Enterprise Standard

Best Quality 4-(Pyridin-3-yl)Pyrimidin-2-Amine with good supplier

Cas:66521-66-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

(3-PYRIDINYL) -2-PYRIMIDINE AMINE; 4- (3-PYRIDINYL) -2-PYRIMIDINYLAMINE; 4- (PYRIDINYL) -YL) PYRIMIDIN-2-AMINE; 4- (3-Pyridyl) -2-pyrimidineamine; 4- CAS No: 66521-66-2 Molecular Formula: C9H8N4 Molecular Weight: 172.18700 Accurate Mass: 172.

4-(3-Pyridinyl)-2-aminopyrimidine, 98%

Cas:66521-66-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best Offer4-(3-Pyridinyl)-2-aminopyrimidine

Cas:66521-66-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

4-(3-Pyridinyl)-2-aminopyrimidine

Cas:66521-66-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

4-(3-Pyridinyl)-2-aminopyrimidine Basic information Product Name: 4-(3-Pyridinyl)-2-aminopyrimidine Synonyms: BUTTPARK 41\09-83;4-(3-PYRIDINYL)-2-PYRIMIDINAMINE;4-(3-PYRIDINYL)-2-PYRIMIDINE AMINE;4-(3-PYRIDINYL)-2-PYRIMIDINYLAMINE;4-(PYRIDIN-3

4-(3-Pyridinyl)-2-aminopyrimidine

Cas:66521-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-(Pyridin-3-yl)pyrimidin-2-amine

Cas:66521-66-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-(Pyridin-3-yl)pyrimidin-2-amine

Cas:66521-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4-(Pyridin-3-yl)pyrimidin-2-amine

Cas:66521-66-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

2-Pyrimidinamine,4-(3-pyridinyl)-

Cas:66521-66-2

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-(Pyridin-3-yl)pyrimidin-2-amine

Cas:66521-66-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-(3-Pyridinyl)-2-aminopyrimidine

Cas:66521-66-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

guanidine nitrate
506-93-4

guanidine nitrate

(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
In butan-1-ol for 12h; Reflux;93%
With sodium hydroxide In butan-1-ol for 20h; Reflux; Inert atmosphere;76%
With sodium hydroxide In butan-1-ol for 24h; Reflux;4.49 g
guanidine hydrochloride
50-01-1

guanidine hydrochloride

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
With sodium hydroxide In tert-butyl alcohol at 85℃;90%
With potassium carbonate In propan-1-ol Reflux; Inert atmosphere;87%
With sodium hydroxide In butan-1-ol Reflux;85%
2-chloro-4-(pyridin-3-yl)pyrimidine
483324-01-2

2-chloro-4-(pyridin-3-yl)pyrimidine

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
With ammonium hydroxide In water at 80℃; for 16h; Sealed tube;87%
guanidine nitrate
506-93-4

guanidine nitrate

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
With sodium hydroxide In butan-1-ol for 12h; Inert atmosphere; Schlenk technique; Reflux;85.5%
With sodium hydroxide In butan-1-ol for 16h; Reflux;85%
With sodium hydroxide In butan-1-ol for 16h; Reflux;67%
With sodium hydroxide In butan-1-ol for 12h; Reflux;
With sodium hydroxide In butan-1-ol at 90℃; for 0.333333h; Microwave irradiation;1.18 g
2-amino-4-chloropyrimidine
3993-78-0

2-amino-4-chloropyrimidine

3-pyridylboronic acid
1692-25-7

3-pyridylboronic acid

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 100℃; for 6h; Inert atmosphere;81%
With 1-(2,6-diisopropylphenyl)-3-(2-oxo-2-(2,4,6-tri-tert-butylphenylamino)ethyl)-1H-imidazol-3-ium bromide; palladium diacetate; sodium hydroxide In water; dimethyl sulfoxide at 100℃; for 10h; Suzuki Coupling;72%
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
With guanidine hydrochloride; sodium hydroxide In isopropyl alcohol for 12h; Reflux;75%
With guanidine hydrochloride; sodium hydroxide In isopropyl alcohol for 18h; Inert atmosphere; Reflux;65%
With guanidine hydrochloride; sodium ethanolate In ethanol for 8h; Heating;
Multi-step reaction with 2 steps
1.1: nitric acid / ethanol / 0 °C
1.2: Reflux
1.3: Reflux
2.1: PYRIMIDINE; hydrazine hydrate / methanol / 0.25 h / 50 - 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: nitric acid / ethanol / 0 °C
1.2: Reflux
1.3: Reflux
2.1: PYRIMIDINE; hydrazine hydrate / methanol / 0.25 h / 50 - 60 °C
View Scheme
guanidine hydrochloride
50-01-1

guanidine hydrochloride

(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 6h; Heating;73%
With sodium hydroxide In butan-1-ol at 85℃; for 12h; Solvent;72%
With sodium hydroxide In butan-1-ol for 12h; Reflux;5.162 g
(Z)-3-chloro-3-(pyridin-3-yl)acrylaldehyde
1392279-39-8

(Z)-3-chloro-3-(pyridin-3-yl)acrylaldehyde

guanidine hydrochloride
50-01-1

guanidine hydrochloride

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
With potassium carbonate In methanol at 20℃; Reflux;71%
N-[4-(pyridin-3-yl)pyrimidin-2-yl]cyanamide
1144477-16-6

N-[4-(pyridin-3-yl)pyrimidin-2-yl]cyanamide

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
Stage #1: N-[4-(pyridin-3-yl)pyrimidin-2-yl]cyanamide With PYRIMIDINE; hydrazine hydrate In methanol at 50 - 60℃; for 0.25h;
Stage #2: In water
70%
CYANAMID
420-04-2

CYANAMID

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

2-nitro-aniline
88-74-4

2-nitro-aniline

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
Stage #1: 2-nitro-aniline With nitric acid In ethanol at 0℃;
Stage #2: CYANAMID In water pH=Ca. 3; Reflux;
Stage #3: 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one In isopropyl alcohol Reflux;
70%
diguanidine carbonate
593-85-1

diguanidine carbonate

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
With sodium hydroxide In butan-1-ol at 120℃; for 2h;66%
In iso-butanol for 24h; Heating / reflux;
guanidine nitrate

guanidine nitrate

(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one
55314-16-4, 75415-01-9, 123367-26-0

(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
With sodium hydroxide In butan-1-ol at 120℃; for 4h; Reflux;60%
methyl-3-pyridylketone
350-03-8

methyl-3-pyridylketone

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2,2-dimethoxy-propane / 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 °C / Reflux
2: sodium hydroxide / butan-1-ol / 4 h / 120 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; 5,5-dimethyl-1,3-cyclohexadiene / 16 h / Reflux
2: sodium hydroxide / butan-1-ol / 24 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 °C / Inert atmosphere; Schlenk technique
2: sodium hydroxide / butan-1-ol / 12 h / Inert atmosphere; Schlenk technique; Reflux
View Scheme
3-Bromopyridine
626-55-1

3-Bromopyridine

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / hexane; diethyl ether / 1 h / -78 °C / Inert atmosphere
1.2: 1.67 h / -30 - 0 °C
1.3: 0.25 h / 0 - 20 °C
2.1: ammonium hydroxide / water / 16 h / 80 °C / Sealed tube
View Scheme
methyl 3-bromo-4-methylbenzoate
104901-43-1

methyl 3-bromo-4-methylbenzoate

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
917392-54-2

methyl 4-methyl-3 -[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate

Conditions
ConditionsYield
With C43H63ClNO2PPd; caesium carbonate In 1,4-dioxane at 120℃; for 1.5h; Inert atmosphere;95%
With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate In 1,4-dioxane at 120℃; for 1.5h; Inert atmosphere;81%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

(-)-dimethyl 2-((4-chlorophenyl)((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

(-)-dimethyl 2-((4-chlorophenyl)((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

Conditions
ConditionsYield
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;95%
4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

5-chloro-4-(pyridin-3-yl)pyrimidin-2-amine

5-chloro-4-(pyridin-3-yl)pyrimidin-2-amine

Conditions
ConditionsYield
With 1-chloro-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one In N,N-dimethyl-formamide at 20℃; for 12h; regioselective reaction;94%
diisopropyl malonate
13195-64-7

diisopropyl malonate

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

(-)-di-isopropyl 2-((4-chlorophenyl)((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

(-)-di-isopropyl 2-((4-chlorophenyl)((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

Conditions
ConditionsYield
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;94%
furfural
98-01-1

furfural

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

diethyl malonate
105-53-3

diethyl malonate

(+)-diethyl 2-(furan-2-yl((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)-malonate

(+)-diethyl 2-(furan-2-yl((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)-malonate

Conditions
ConditionsYield
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;94%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

diethyl malonate
105-53-3

diethyl malonate

(+)-diethyl 2-((4-chlorophenyl)((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

(+)-diethyl 2-((4-chlorophenyl)((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

Conditions
ConditionsYield
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;93%
furfural
98-01-1

furfural

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

diethyl malonate
105-53-3

diethyl malonate

(-)-diethyl 2-(furan-2-yl((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)-malonate

(-)-diethyl 2-(furan-2-yl((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)-malonate

Conditions
ConditionsYield
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;93%
benzaldehyde
100-52-7

benzaldehyde

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

(-)-dimethyl 2-(phenyl((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

(-)-dimethyl 2-(phenyl((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

Conditions
ConditionsYield
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;93%
3-acetyl-4-methyl-2-oxo-2H-benzopyran-7-yltrifluoromethanesulfonate

3-acetyl-4-methyl-2-oxo-2H-benzopyran-7-yltrifluoromethanesulfonate

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

3-acetyl-4-methyl-7-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}-2H-benzopyran-2-one

3-acetyl-4-methyl-7-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}-2H-benzopyran-2-one

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 100℃; Buchwald-Hartwig Coupling; Inert atmosphere;93%
N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide
581076-59-7

N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

imatinib
152459-95-5

imatinib

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 5h; Temperature;92%
Stage #1: N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)-methyl)benzamide; 4-pyridin-3-ylpyrimidin-2-ylamine In ethanol at 60℃; for 3h; Inert atmosphere;
Stage #2: With sodium hydroxide In water pH=8.7; Reagent/catalyst;
91%
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene for 5.16667h; Inert atmosphere; Reflux; Sonication;72%
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

diethyl malonate
105-53-3

diethyl malonate

(-)-diethyl 2-((4-chlorophenyl)((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

(-)-diethyl 2-((4-chlorophenyl)((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

Conditions
ConditionsYield
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;92%
hexanal
66-25-1

hexanal

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

diethyl malonate
105-53-3

diethyl malonate

(-)-diethyl 2-(1-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)hexyl)malonate

(-)-diethyl 2-(1-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)hexyl)malonate

Conditions
ConditionsYield
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;91%
benzaldehyde
100-52-7

benzaldehyde

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

(+)-dimethyl 2-(phenyl((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

(+)-dimethyl 2-(phenyl((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

Conditions
ConditionsYield
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;91%
2-bromo-4-nitrotoluene
7745-93-9

2-bromo-4-nitrotoluene

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine
152460-09-8

N-(5-nitro-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine

Conditions
ConditionsYield
With copper(I) iodide; sodium hydroxide In water at 60℃; for 9h;90%
With copper(l) iodide; potassium carbonate In 1,4-dioxane at 20 - 120℃; Sealed tube; Inert atmosphere;83.7%
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 120℃; for 20h; Inert atmosphere; Sealed tube;83.7%
diisopropyl malonate
13195-64-7

diisopropyl malonate

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

(+)-di-isopropyl 2-((4-chlorophenyl)((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

(+)-di-isopropyl 2-((4-chlorophenyl)((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

Conditions
ConditionsYield
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;90%
diisopropyl malonate
13195-64-7

diisopropyl malonate

hexanal
66-25-1

hexanal

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

(-)-di-isopropyl 2-(1-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)hexyl)malonate

(-)-di-isopropyl 2-(1-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)hexyl)malonate

Conditions
ConditionsYield
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;90%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

diethyl malonate
105-53-3

diethyl malonate

(+)-diethyl ((4-methoxyphenyl)-2-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-methyl)malonate

(+)-diethyl ((4-methoxyphenyl)-2-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-methyl)malonate

Conditions
ConditionsYield
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;90%
4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

(+)-dimethyl (cyclohexyl-2-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

(+)-dimethyl (cyclohexyl-2-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

Conditions
ConditionsYield
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;90%
3-iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
926922-18-1

3-iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

nilotinib
641571-10-0

nilotinib

Conditions
ConditionsYield
With caesium carbonate; tris(dibenzylideneacetone)dipalladium (0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane; tert-butyl alcohol at 100℃; for 7h;89%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane; tert-butyl alcohol at 100℃; for 7h;89%
diisopropyl malonate
13195-64-7

diisopropyl malonate

hexanal
66-25-1

hexanal

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

(+)-di-isopropyl 2-(1-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)hexyl)malonate

(+)-di-isopropyl 2-(1-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)hexyl)malonate

Conditions
ConditionsYield
With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;88%
4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

(-)-dimethyl 2-(((4-(pyridin-3-yl)pyrimidin-2-yl)amino)(p-tolyl)methyl)-malonate

(-)-dimethyl 2-(((4-(pyridin-3-yl)pyrimidin-2-yl)amino)(p-tolyl)methyl)-malonate

Conditions
ConditionsYield
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;88%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

N-(3-bromo-4-methylphenyl)-4-(chloromethyl)benzamide
1072105-05-5

N-(3-bromo-4-methylphenyl)-4-(chloromethyl)benzamide

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

imatinib
152459-95-5

imatinib

Conditions
ConditionsYield
With copper(l) iodide; sodium acetate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 100℃; for 4h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;86%
4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

(-)-dimethyl (cyclohexyl-2-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

(-)-dimethyl (cyclohexyl-2-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)malonate

Conditions
ConditionsYield
With quinine In neat liquid at 50℃; for 48h; Mannich Aminomethylation; enantioselective reaction;86%
bromochlorobenzene
106-39-8

bromochlorobenzene

4-pyridin-3-ylpyrimidin-2-ylamine
66521-66-2

4-pyridin-3-ylpyrimidin-2-ylamine

N-(4-chlorophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

N-(4-chlorophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

Conditions
ConditionsYield
With copper(l) iodide; N,N'-dibenzylethanediamide; potassium tert-butylate In tert-butyl alcohol at 100℃; for 24h; Molecular sieve; Schlenk technique; Inert atmosphere;86%
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View