Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1) supplier

Name
2'-AMINOACETOPHENONE HYDROCHLORIDE
EINECS 246-930-2
CAS No. 25384-14-9
Article Data4
CAS DataBase
Density
Solubility
Melting Point 285-289 °C(lit.)
Formula C₈H₁₀ClNO
Boiling Point 251.8 °C at 760 mmHg
Molecular Weight 171.626
Flash Point 106.1 °C
Transport Information
Appearance
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Acetophenone,2'-amino-, hydrochloride (8CI);Ethanone, 1-(2-aminophenyl)-, hydrochloride(9CI);1-(2-Aminophenyl)ethanone hydrochloride;2'-Aminoacetophenonehydrochloride;o-Aminoacetophenone hydrochloride;
PSA 43.09000
LogP 2.85460

Synthetic route

: 577-59-3
2-acetylnitrobenzene

: 25384-14-9
2-aminoacetophenone hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride In ethanol; water at 30℃; Rate constant; Mechanism;

: 551-93-9
2-aminoacetophenone

: 25384-14-9
2-aminoacetophenone hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane; diethyl ether

: 25384-14-9
2-aminoacetophenone hydrochloride

: 4964-49-2
1-(2-aminophenyl)ethanone oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In ethanol for 264h; Ambient temperature;	94%

: 25415-67-2
ethyl isocaproate

: 25384-14-9
2-aminoacetophenone hydrochloride

: 342642-32-4
2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With sodium acetate In water at 100℃; for 18h;	93%

: 25384-14-9
2-aminoacetophenone hydrochloride

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 83876-53-3
3-methoxy-7-methyl-5,6-dihydrobenzacridine

Conditions

Conditions	Yield
at 140℃; for 0.166667h;	91%

: 108-94-1
cyclohexanone

: 25384-14-9
2-aminoacetophenone hydrochloride

: 6829-08-9
9-methyl-1,2,3,4-tetrahydroacridine

Conditions

Conditions	Yield
at 110℃; Friedlaender condensation;	89%
Stage #1: cyclohexanone; 2-aminoacetophenone hydrochloride at 90 - 110℃; Stage #2: With hydrogenchloride In ethanol; water Stage #3: With sodium hydroxide In ethanol; water pH=7;	89%
at 90 - 110℃;	89%
at 90 - 110℃;	89%

: 6836-19-7
7-Methoxy-1-tetralone

: 25384-14-9
2-aminoacetophenone hydrochloride

: 83876-52-2
2-methoxy-7-methyl-5,6-dihydrobenzacridine

Conditions

Conditions	Yield
at 140℃; for 0.166667h;	87%

: 33892-75-0
5-Methoxy-1-tetralone

: 25384-14-9
2-aminoacetophenone hydrochloride

: 83876-54-4
4-methoxy-7-methyl-5,6-dihydrobenzacridine

Conditions

Conditions	Yield
at 140℃; for 0.166667h;	84%

: 25384-14-9
2-aminoacetophenone hydrochloride

: 765-87-7
cyclohexane-1,2-dione

: 5298-71-5
6,7-dihydro-5,8-dimethyldibenzo<1,10>phenanthroline

Conditions

Conditions	Yield
In various solvent(s) for 48h; Heating;	79%

: 61362-78-5
8-bromo-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 1352285-82-5
1-bromo-2-methoxy-7-methyl-5,6-dihydrobenzo[c]acridine

Conditions

Conditions	Yield
at 140℃; for 7h; Friedlaender synthesis; Neat (no solvent);	35%

: 14869-39-7
2-ethoxyacetophenone

: 25384-14-9
2-aminoacetophenone hydrochloride

: 83463-84-7
3-ethoxy-4-methyl-2-phenylquinoline

Conditions

Conditions	Yield
at 150℃; for 1h;	34%

: 1120-73-6
2-methyl-2-cyclopenten-1-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 82757-44-6
1,4-dimethyl-3H-cyclopentaquinoline

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 19h; Heating;	21%

: 24424-99-5
di-tert-butyl dicarbonate

: 25384-14-9
2-aminoacetophenone hydrochloride

: 314773-77-8
tert-butyl (2-acetylphenyl)carbamate

Conditions

Conditions	Yield
With dmap In acetonitrile at 20℃; for 10h; Product distribution / selectivity;	21%
With potassium carbonate In water; ethyl acetate at 0 - 30℃; for 3.5h;

: 41374-14-5
1-benzenesulphonyl-2,2-bis-methylthio ethylene

: 25384-14-9
2-aminoacetophenone hydrochloride

: 4-Methyl-2-methylthio-3-(phenylsulfonyl)-chinolin

Conditions

Conditions	Yield
In acetic acid for 6h; Heating;	18.2%

: 860204-90-6
6-methoxy-3,4-dihydroquinoline-1(2H)-carbonitrile

: 25384-14-9
2-aminoacetophenone hydrochloride

: 2-(6-methoxy-3,4-dihydro-2H-[1]quinolyl)-4-methyl-quinazoline

Conditions

Conditions	Yield
With diphenylether

: 420-04-2
CYANAMID

: 25384-14-9
2-aminoacetophenone hydrochloride

: 6141-02-2
2-amino-4-methylquinazoline

: 25384-14-9
2-aminoacetophenone hydrochloride

: 127099-85-8, 780722-26-1
N-Cyanoguanidine

: 716-11-0
NSC 403387

: 37537-53-4
2-(4-bromo-phenyl)-4,5-dihydro-furo[2,3-c]acridine-6-carboxylic acid

: 25384-14-9
2-aminoacetophenone hydrochloride

: 37537-57-8
2-(4-bromo-phenyl)-6-methyl-4,5-dihydro-furo[2,3-c]acridine

Conditions

Conditions	Yield
at 150℃;

: 22929-52-8
tetrahydrofuran-3-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 17592-98-2
9-methyl-2,3-dihydro-furo[3,2-b]quinoline

Conditions

Conditions	Yield
at 145℃;

: 1003-04-9
Tetrahydrothiophen-3-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 17517-72-5
9-methyl-2,3-dihydrothieno[3,2-b]quinoline

Conditions

Conditions	Yield
at 135℃;

: 19090-03-0
dihydro-2H-thiopyran-3(4H)-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 17517-54-3
10-methyl-3,4-dihydro-2H-thiopyrano[3,2-b]quinoline

: 50565-24-7
4,5-dihydro-5-methylthiophen-3(2H)-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 17517-52-1
2,9-dimethyl-2,3-dihydro-thieno[3,2-b]quinoline

Conditions

Conditions	Yield
at 135℃;

: 29943-42-8
Tetrahydro-4H-pyran-4-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 17517-74-7
10-methyl-3,4-dihydro-1H-pyrano[4,3-b]quinoline

Conditions

Conditions	Yield
at 120℃;

: 1072-72-6
Tetrahydrothiopyran-4-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 17517-56-5
10-methyl-3,4-dihydro-1H-thiopyrano[4,3-b]quinoline

Conditions

Conditions	Yield
at 140℃;

: 3051-27-2
1-(2-thienyl)-1,3-butanedione

: 25384-14-9
2-aminoacetophenone hydrochloride

: 14428-42-3
(2,4-dimethyl-quinolin-3-yl)-thiophen-2-yl-methanone

Conditions

Conditions	Yield
at 160℃;

: 6786-30-7
3,4-dihydro-1-benzoxepin-5(2H)-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 18835-88-6
8-methyl-6,7-dihydro-benzo[2,3]oxepino[4,5-b]quinoline

Conditions

Conditions	Yield
at 140℃;

: 39513-75-2
6-methyl-4-chromanone

: 25384-14-9
2-aminoacetophenone hydrochloride

: 51723-17-2
2,7-dimethyl-6H-chromeno[4,3-b]quinoline

Conditions

Conditions	Yield
In neat (no solvent) at 140℃; for 0.5h;

: 6948-34-1
6-methyl-thiochroman-4-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 51723-27-4
2,7-dimethyl-6H-thiochromeno[4,3-b]quinoline

Conditions

Conditions	Yield
In neat (no solvent) at 140℃; for 0.5h;

: 37674-72-9
6-chloro-chroman-4-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 51723-19-4
2-chloro-7-methyl-6H-chromeno[4,3-b]quinoline

Conditions

Conditions	Yield
In neat (no solvent) at 140℃; for 0.5h;

: 13735-12-1
6-chlorothiochroman-4-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 51723-29-6
2-chloro-7-methyl-6H-thiochromeno[4,3-b]quinoline

Conditions

Conditions	Yield
In neat (no solvent) at 140℃; for 0.5h;

: 491-37-2
2,3-dihydro-4H-1-benzopyran-4-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 1589-01-1
7-methyl-6H-chromeno[4,3-b]quinoline

Conditions

Conditions	Yield
In neat (no solvent) at 140℃; for 0.5h;

: 3528-17-4
2,3-dihydro-4H-[1]benzothiopyran-4-one

: 25384-14-9
2-aminoacetophenone hydrochloride

: 1541-60-2
7-methyl-6H-thiochromeno[4,3-b]quinoline

Conditions

Conditions	Yield
In neat (no solvent) at 140℃; for 0.5h;

Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1) Specification

This chemical is called Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1), and its systematic name is 1-(2-aminophenyl)ethanone hydrochloride (1:1). With CAS registry number of 25384-14-9, its product categories are Aromatic Acetophenones & Derivatives (substituted); C7 to C8; Carbonyl Compounds; Ketones. Additionally, its classification code is TSCA Flag P [A commenced PMN (Premanufacture Notice) substance]. It should be stored in the cool and dry place.

Other characteristics of the Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1) can be summarised as followings: (1)ACD/LogP: 1.62; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.62; (4)ACD/LogD (pH 7.4): 1.62; (5)ACD/BCF (pH 5.5): 10.02; (6)ACD/BCF (pH 7.4): 10.03; (7)ACD/KOC (pH 5.5): 181.14; (8)ACD/KOC (pH 7.4): 181.25; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 20.31 Å²; (13)Flash Point: 106.1 °C; (14)Enthalpy of Vaporization: 48.91 kJ/mol; (15)Boiling Point: 251.8 °C at 760 mmHg; (16)Vapour Pressure: 0.0201 mmHg at 25°C.

Uses of this chemical: The Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1) could react with 2-methyl-cyclopent-2-enone, and obtain the 3,9-dimethyl-1H-cyclopenta[b]quinoline. This reaction needs the reagent of concd. hydrochloric acid, and the solvent of aq. ethanol. The yield is 21 %. In addition, this reaction should be taken for 19 hours with the heating.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: O=C(c1ccccc1N)C.Cl
2.InChI: InChI=1/C8H9NO.ClH/c1-6(10)7-4-2-3-5-8(7)9;/h2-5H,9H2,1H3;1H
3.InChIKey: APTPPYQXBFFQHZ-UHFFFAOYAJ

Product Name

2'-AMINOACETOPHENONE HYDROCHLORIDE

Synthetic route

Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1) Specification

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