Ethyl 4-bromobutyrate supplier

Name
Ethyl 4-bromobutyrate
EINECS 221-005-6
CAS No. 2969-81-5
Article Data36
CAS DataBase
Density 1.352 g/cm³
Solubility immiscible with water
Melting Point 98-100 °C
Formula C₆H₁₁BrO₂
Boiling Point 198.3 °C at 760 mmHg
Molecular Weight 195.056
Flash Point 90.6 °C
Transport Information UN 2929
Appearance clear colorless to yellow liquid
Safety 26-36-37/39
Risk Codes 36/37/38-22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms Butyricacid, 4-bromo-, ethyl ester (6CI,7CI,8CI);1-Bromo-3-(carboethoxy)propane;3-(Ethoxycarbonyl)propylbromide;4-Bromobutanoic acid ethyl ester;4-Bromobutyric acid ethyl ester;Ethyl 4-bromobutanoate;Ethyl g-bromobutyrate;Butanoic acid, 4-bromo-, ethyl ester;g-Bromobutyric acid ethyl ester;
PSA 26.30000
LogP 1.72460

Synthetic route

: 64-17-5
ethanol

: 2623-87-2
bromobutyric acid

: 2969-81-5
4-bromoethylbutanoate

Conditions

Conditions	Yield
Stage #1: bromobutyric acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 5h; Stage #2: ethanol In dichloromethane at 20℃; for 15h;	84%
With tetrachloromethane; 5-sulfosalicylic Acid unter Entfernen des entstehenden Wassers;
With sulfuric acid
With sulfuric acid
With acetyl chloride at 20℃; for 4h;

: 96-48-0
4-butanolide

: 64-17-5
ethanol

: 2969-81-5
4-bromoethylbutanoate

Conditions

Conditions	Yield
With hydrogen bromide	79%
With hydrogen bromide
With hydrogen bromide In benzene
(i) aq. HBr, (ii) SOCl2, (iii) /BRN= 1718733/; Multistep reaction;
With hydrogen bromide

: 1191-95-3
cyclobutanone

: 1801-77-0
oxovanadium(V) ethoxydichloride

: 2969-81-5
4-bromoethylbutanoate

Conditions

Conditions	Yield
With Bromotrichloromethane In diethyl ether for 13h; Ambient temperature;	60%

: 64-17-5
ethanol

: 927-58-2
4-bromobutyroyl chloride

: 2969-81-5
4-bromoethylbutanoate

: 64-17-5
ethanol

: 56489-06-6
4-bromobutyryl bromide

: 2969-81-5
4-bromoethylbutanoate

: 1617-18-1
ethyl 3-butenoate

: 2969-81-5
4-bromoethylbutanoate

Conditions

Conditions	Yield
With hydrogen bromide

: 64-17-5
ethanol

: 5332-06-9
4-bromobutanenitrile

: 2969-81-5
4-bromoethylbutanoate

Conditions

Conditions	Yield
With sulfuric acid

: 36847-51-5
ethyl 2,4-dibromobutyrate

A: 2969-81-5
4-bromoethylbutanoate

B: 4606-07-9
ethyl cyclopropylcarboxylate

C: 105-54-4
butanoic acid ethyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; Product distribution; Mechanism; electrolysis; I*, napp; various conc. of the ester; in the presence and in the absence of 3,4-xylenol;

...Expand

: 1617-18-1
ethyl 3-butenoate

: 10035-10-6, 12258-64-9
hydrogen bromide

: 2969-81-5
4-bromoethylbutanoate

: 2623-87-2
bromobutyric acid

: 2969-81-5
4-bromoethylbutanoate

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane; ethanol; dichloromethane	3 g (85.5%)

: 58258-01-8
4-diphenylmethoxypiperidine

A: 2969-81-5
4-bromoethylbutanoate

B: 125602-76-8
ethyl 4-(4-benzhydryloxypiperidino)butanoate

: 125603-02-3
4-<(4-chlorophenyl)phenylmethoxy>piperidine

A: ethyl 4-[4-[(4-chlorophenyl)-phenylmethoxy]-1-piperidyl]butanoate

B: 2969-81-5
4-bromoethylbutanoate

: 88535-96-0
4-piperidine

A: ethyl 4-[4-[bis(4-fluorophenyl)-methoxy]-1-piperidyl]butanoate

B: 2969-81-5
4-bromoethylbutanoate

: 125603-01-2
4-(phenyl-2-pyridylmethoxy)piperidine

A: 125602-78-0
ethyl 4-[4-(phenyl-2-pyridylmethoxy)-1-piperidyl]butanoate

B: 2969-81-5
4-bromoethylbutanoate

: 125603-04-5
4-[bis(4-methoxyphenyl)methoxy]piperidine

A: ethyl 4-[4-[bis(4-methoxyphenyl)-methoxy]-1-piperidyl]butanoate

B: 2969-81-5
4-bromoethylbutanoate

: 999-10-0
ethyl 4-hydroxybutanoate

: 2969-81-5
4-bromoethylbutanoate

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid at 50℃;

: 2969-81-5
4-bromoethylbutanoate

: 7425-53-8
ethyl 4-iodobutyrate

Conditions

Conditions	Yield
With sodium iodide In acetone at 22℃; for 19h; Inert atmosphere;	100%
With sodium iodide In acetone Heating;	98%
With sodium iodide In acetone at 60℃;	94%

: 3770-50-1
2-carbethoxyindole

: 2969-81-5
4-bromoethylbutanoate

: 131848-99-2
ethyl 1-(4-ethoxy-4-oxobutyl)-1H-indole-2-carboxylate

Conditions

Conditions	Yield
Stage #1: 2-carbethoxyindole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; Inert atmosphere; Stage #2: Ethyl 4-bromobutyrate In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	100%
Stage #1: 2-carbethoxyindole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Inert atmosphere; Stage #2: Ethyl 4-bromobutyrate In N,N-dimethyl-formamide; mineral oil at 20℃; for 30h; Inert atmosphere;	88%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 18h; Inert atmosphere;	87%
With sodium hydride 1.) DMF 2.) rt, 18 h; Yield given. Multistep reaction;

: 2969-81-5
4-bromoethylbutanoate

: 27522-87-8
N-cyclopentyl-3-chloro-4-hydroxybenzamide

: 109804-11-7
4-(2-Chloro-4-cyclopentylcarbamoyl-phenoxy)-butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	100%

: 2969-81-5
4-bromoethylbutanoate

: 109803-76-1
2-(1-hexyl)-5-hydroxyisoindole-1,3-dione

: 109804-00-4
4-(2-Hexyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yloxy)-butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	100%

: 2969-81-5
4-bromoethylbutanoate

: 109803-81-8
2-Butyl-5-chloro-6-hydroxy-isoindole-1,3-dione

: 109804-06-0
4-(2-Butyl-6-chloro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yloxy)-butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	100%

: 2969-81-5
4-bromoethylbutanoate

: 109803-57-8
N-methyl-N-cyclopentyl-2,3-dichloro-4-hydroxybenzamide

: 109804-13-9
4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	100%

: 2969-81-5
4-bromoethylbutanoate

: 2-Butyl-4-chloro-5-hydroxy-2,3-dihydro-isoindol-1-one

: 153144-11-7
4-(2-Butyl-4-chloro-1-oxo-2,3-dihydro-1H-isoindol-5-yloxy)-butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	100%

: 2969-81-5
4-bromoethylbutanoate

: 4-Chloro-2-cyclopentyl-5-hydroxy-2,3-dihydro-isoindol-1-one

: 153144-12-8
4-(4-Chloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-isoindol-5-yloxy)-butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	100%

: 2969-81-5
4-bromoethylbutanoate

: 603-35-0
triphenylphosphine

: 50479-11-3
(3-ethoxycarbonylpropyl)triphenylphosphonium bromide

Conditions

Conditions	Yield
at 120℃; for 16h; Inert atmosphere;	100%
at 120℃; for 16h; Inert atmosphere;	100%
at 120℃; for 16h; Inert atmosphere;	100%

: 2969-81-5
4-bromoethylbutanoate

: 123-08-0
4-hydroxy-benzaldehyde

: 92991-64-5
ethyl 4-(4-formylphenoxy)butyrate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	100%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;	100%

: 524-38-9
N-hydroxyphthalimide

: 2969-81-5
4-bromoethylbutanoate

: 27091-83-4
4-(1,3-dioxo-1,3-dihydroisoindole-2-yloxy)butyric acid ethyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20 - 80℃;	100%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20 - 80℃;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	91%
With sodium acetate 1.) DMSO, 60 deg C, 10 min, 2.) DMSO, reflux, 30 min; Multistep reaction;
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80℃;

: 2969-81-5
4-bromoethylbutanoate

: 19812-93-2
4-Cyano-4'-hydroxybiphenyl

: 191228-79-2
4-[4-(4-cyanophenyl)phenoxy]ethylbuterate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 85℃; for 20h;	100%
With caesium carbonate In tetrahydrofuran; dichloromethane at 20℃; for 16h;	55%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In butanone Heating;
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 18h; Alkylation;	3.30 g
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 3h; Williamson reaction;

: 2969-81-5
4-bromoethylbutanoate

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 174884-21-0
ethyl 4-(4-acetyl-2-methoxyphenoxy) butanoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 50℃; for 19h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20 - 50℃; for 19h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20 - 50℃; for 19h;	100%

: 2969-81-5
4-bromoethylbutanoate

: 29247-79-8
N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester

: 38314-47-5
ethyl 4-[N-(5-chloro-2-methoxycarbonylphenyl)-N-p-toluenesulfonylamino]butyrate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 4h; Alkylation;	100%
Stage #1: N-p-toluenesulfonyl-4-chloro-anthranilic acid methyl ester With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; deprotonation; Stage #2: Ethyl 4-bromobutyrate In N,N-dimethyl-formamide at 90℃; for 5h; Substitution; alkylation;	64%

: 2969-81-5
4-bromoethylbutanoate

: 247237-41-8
N-p-toluenesulfonyl-3-chloroanthranilic acid methyl ester

: 247237-44-1
methyl 3-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 4h; Alkylation;	100%

: 2969-81-5
4-bromoethylbutanoate

: 247237-42-9
methyl 6-chloro-2-(N-p-toluenesulfonyl)aminobenzoate

: 247237-45-2
methyl 6-chloro-2-[N-(3-ethoxycarbonyl)propyl-N-p-toluenesulfonyl]aminobenzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 4h; Alkylation;	100%

: 109-01-3
1-methyl-piperazine

: 2969-81-5
4-bromoethylbutanoate

: 487008-51-5
ethyl 4-(4-methylpiperazin-1-yl)butanoate

Conditions

Conditions	Yield
In ethyl acetate at 25 - 70℃; for 2h; Solvent; Temperature;	100%
In benzene for 0.5h; Alkylation; Heating;
With potassium carbonate In acetonitrile for 3h; Reflux;

: 2969-81-5
4-bromoethylbutanoate

: 22051-15-6
3-(4-methoxybenzoyl)indole

: 139155-86-5
ethyl 4-[3-(4-methoxybenzoyl)-1H-indol-1-yl]butyrate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 14h;	100%

: 2969-81-5
4-bromoethylbutanoate

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: (R)-2,2'-bis(3-carboxypropoxy)-1,1-binaphthyl diethyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetone for 48h; Heating;	100%
With potassium carbonate In acetone for 96h; Heating / reflux;	68%
With potassium carbonate In acetone for 24h; Reflux;

: 2969-81-5
4-bromoethylbutanoate

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 55716-88-6
N-[2-(3,4-dimethoxyphenyl)ethyl]-2-pyrrolidone

Conditions

Conditions	Yield
In 1,4-dioxane at 120℃; for 12h;	100%

: 2969-81-5
4-bromoethylbutanoate

: 51453-79-3
ethyl 4-azidobutyrate

Conditions

Conditions	Yield
With sodium azide In dimethyl sulfoxide at 45℃; for 24h;	100%
With sodium azide In water; acetone for 5h; Reflux;	100%
With sodium azide In methanol; water	98.6%

: 2969-81-5
4-bromoethylbutanoate

: 611-99-4
4,4'-Dihydroxybenzophenone

: 928663-94-9
4-{4-[4-(3-ethoxycarbonyl-propoxy)-benzoyl]-phenoxy}-butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 12h; Heating;	100%

: 2969-81-5
4-bromoethylbutanoate

: ethyl 4-(6-hexyl-2,2-dimethyl-3-oxoindan-5-yloxy)butyrate

Conditions

Conditions	Yield
Stage #1: 5-hexyl-6-hydroxy-2,2-dimethylindan-1-one With caesium carbonate In acetone at 56℃; for 0.5h; Stage #2: Ethyl 4-bromobutyrate In acetone for 7h; Heating / reflux;	100%

: 31121-11-6
3-hydroxy-N-phenylpropylamine

: 2969-81-5
4-bromoethylbutanoate

: 344436-54-0
ethyl 4-[(3-hydroxypropyl)phenylamino]butanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine at 100℃; for 1h;	100%
With N-ethyl-N,N-diisopropylamine

: 2969-81-5
4-bromoethylbutanoate

: 591-20-8
3-Bromophenol

: 157245-84-6
ethyl 4-(3-bromophenoxy)butanoate

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20 - 33℃; for 39h;	100%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 2.5h;	99%
With potassium carbonate; sodium iodide In acetone at 20 - 80℃;

: 2969-81-5
4-bromoethylbutanoate

: 1806-26-4
p-Octylphenol

: 1071001-73-4
4-(4-octylphenoxy)butyric acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetone for 18h; Reflux;	100%
With potassium carbonate In acetone Reflux;	71%
With potassium carbonate In acetone for 24h; Heating / reflux;	71%

: 2969-81-5
4-bromoethylbutanoate

: 873-62-1
m-cyanophenol

: 869299-47-8
ethyl 4-[(3-cyanophenyl)oxy]butanoate

Conditions

Conditions	Yield
Stage #1: m-cyanophenol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: Ethyl 4-bromobutyrate In N,N-dimethyl-formamide at 20℃; for 15h;	100%
Stage #1: m-cyanophenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Stage #2: Ethyl 4-bromobutyrate In N,N-dimethyl-formamide; mineral oil at 20℃; for 15h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;

: 2969-81-5
4-bromoethylbutanoate

: 90389-70-1
methyl (3-nitrobenzyl)amine hydrochloride

: 1093798-87-8
C14H20N2O4

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl acetamide at 70℃; for 16h;	100%

: 98-10-2
benzenesulfonamide

: 2969-81-5
4-bromoethylbutanoate

: 696660-74-9
ethyl 4-[phenylsulfonyl-(3-ethoxycarbonylpropyl)amino]butyrate

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 48h;	100%

: 2969-81-5
4-bromoethylbutanoate

: 1149587-11-0
4-bromo-5-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-3(2H)-one

: 1149587-20-1
ethyl 4-{5-bromo-6-oxo-4-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-1(6H)-yl}butanoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 2h;	100%

Ethyl 4-bromobutyrate Chemical Properties

IUPAC Name: Ethyl 4-bromobutanoate
Molecular Formula: C₆H₁₁BrO₂
Molecular Weight: 195.05 g/mol
SMILES: C(=O)(OCC)CCCBr
InChI: InChI=1/C6H11BrO2/c1-2-9-6(8)4-3-5-7/h2-5H2,1H3
EINECS: 221-005-6
Product Categories: Acids & Esters;Bromine Compounds; C6 to C7; Carbonyl Compounds; Esters
Water Solubility: immiscible
Index of Refraction: 1.457
Molar Refractivity: 39.35 cm³
Molar Volume: 144.2 cm³
Polarizability: 15.6×10^-24 cm³
Surface Tension: 33.7 dyne/cm
Density: 1.352 g/cm³
Flash Point: 90.6 °C
Enthalpy of Vaporization: 43.45 kJ/mol
Boiling Point: 198.3 °C at 760 mmHg
Vapour Pressure of Ethyl 4-bromobutyrate (CAS NO.2969-81-5): 0.362 mmHg at 25 °C

Ethyl 4-bromobutyrate Uses

Ethyl 4-bromobutyrate (CAS NO.2969-81-5) is used as an intermediate for the synthesis of pharmaceutucals and other organic chemicals.

Ethyl 4-bromobutyrate Safety Profile

Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 36/37/38-22
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
RIDADR: 2929
WGK Germany of Ethyl 4-bromobutyrate (CAS NO.2969-81-5): 3

Ethyl 4-bromobutyrate Specification

Ethyl 4-bromobutyrate (CAS NO.2969-81-5), its Synonyms are Butanoic acid, 4-bromo-, ethyl ester (9CI) ; 4-Bromobutanoic acid, ethyl ester ; Ethyl gamma-bromobutyrate . It is clear colorless to yellow liquid.

Product Name

Ethyl 4-bromobutyrate

Synthetic route

Ethyl 4-bromobutyrate Chemical Properties

Ethyl 4-bromobutyrate Uses

Ethyl 4-bromobutyrate Safety Profile

Ethyl 4-bromobutyrate Specification

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