Product Name

  • Name

    Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride

  • EINECS 258-162-5
  • CAS No. 52763-21-0
  • Article Data5
  • CAS DataBase
  • Density 1.154 g/cm3
  • Solubility
  • Melting Point 162 °C (dec.)(lit.)
  • Formula C15H20ClNO3
  • Boiling Point 368.6 °C at 760 mmHg
  • Molecular Weight 297.782
  • Flash Point 176.7 °C
  • Transport Information
  • Appearance white to brown crystalline powder
  • Safety 26-36-37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 52763-21-0 (Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride)
  • Hazard Symbols IrritantXi
  • Synonyms 4-Piperidinecarboxylicacid, 3-oxo-1-(phenylmethyl)-, ethyl ester, hydrochloride (9CI);1-Benzyl-4-carbethoxy-3-oxopiperidine hydrochloride;Ethyl1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride;N-Benzyl-4-carbethoxy-3-piperidone hydrochloride;4-Piperidinecarboxylic acid, 3-oxo-1-(phenylmethyl)-, ethyl ester, hydrochloride (1:1);Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (1:1);
  • PSA 46.61000
  • LogP 2.38060

Synthetic route

4-[benzyl(ethoxycarbonylmethyl)amino]butyric acid ethyl ester
63876-32-4

4-[benzyl(ethoxycarbonylmethyl)amino]butyric acid ethyl ester

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

Conditions
ConditionsYield
Stage #1: 4-[benzyl(ethoxycarbonylmethyl)amino]butyric acid ethyl ester With sodium ethanolate In toluene at 20 - 85℃; for 3.5h; Large scale;
Stage #2: With hydrogenchloride In water; toluene Large scale;		94%
Stage #1: 4-[benzyl(ethoxycarbonylmethyl)amino]butyric acid ethyl ester With sodium methylate In ethyl acetate for 4h; Reflux; Large scale;
Stage #2: With water; sodium hydroxide pH=7 - 8; Large scale;
Stage #3: With hydrogenchloride pH=1 - 2; Reagent/catalyst; Solvent; Large scale;		8.6 kg
ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate
39514-19-7

ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 22℃; for 0.5h; Inert atmosphere; Large scale;76.8%
4-bromoethylbutanoate
2969-81-5

4-bromoethylbutanoate

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / 1,4-dioxane / 22 h / Reflux; Large scale
2.1: sodium ethanolate / toluene / 3.5 h / 20 - 85 °C / Large scale
2.2: Large scale
View Scheme
ethyl 2-(benzylamino)acetate
6436-90-4

ethyl 2-(benzylamino)acetate

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / 1,4-dioxane / 22 h / Reflux; Large scale
2.1: sodium ethanolate / toluene / 3.5 h / 20 - 85 °C / Large scale
2.2: Large scale
View Scheme
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

ethyl 3-oxopiperidine-4-carboxylate
70637-75-1

ethyl 3-oxopiperidine-4-carboxylate

Conditions
ConditionsYield
In methanol; palladium dihydroxide100%
With hydrogen; palladium dihydroxide In dichloromethane at 20℃; under 3750.3 Torr; for 24h;84%
debenzylation;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate
71233-25-5

ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; triethylamine In methanol for 4h; Autoclave;100%
With palladium 10% on activated carbon; hydrogen; sodium carbonate In ethanol at 50℃; under 28502.9 Torr; for 48h; Autoclave;100%
With triethylamine; palladium-carbon In diethyl ether; ethanol94%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate
206111-40-2

1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate

Conditions
ConditionsYield
With Pd(OH)2/C; hydrogen; triethylamine In ethanol for 20h;100%
formamidine acetic acid
3473-63-0

formamidine acetic acid

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one
69981-00-6

7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 2.5h; Inert atmosphere; Reflux; Large scale;100%
guanidine hydrogen carbonate
124-46-9, 20734-13-8, 100224-74-6, 593-85-1

guanidine hydrogen carbonate

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

2-amino-7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(4aH)-one
62458-92-8

2-amino-7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(4aH)-one

Conditions
ConditionsYield
With sodium ethanolate for 16h; Heating / reflux;99%
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

benzyl bromide
100-39-0

benzyl bromide

(SR)-1,4-dibenzyl-3-oxo-piperidine-4-carboxylic acid ethyl ester
312625-46-0

(SR)-1,4-dibenzyl-3-oxo-piperidine-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; Large scale;
Stage #2: benzyl bromide In tetrahydrofuran at 0 - 20℃; Large scale;		99%
With NaH; sodium hydrogencarbonate In water; N,N-dimethyl-formamide
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

ethyl 3-hydroxypiperidine-4-carboxylate
941571-79-5

ethyl 3-hydroxypiperidine-4-carboxylate

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; triethylamine In ethanol at 20℃; under 760.051 Torr; for 48h;99%
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 3.75 h / 0 - 20 °C
2: hydrogen; 10 wt% Pd(OH)2 on carbon / ethanol / 14 h / 20 °C
View Scheme
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

cyclopropylcarboxamidine hydrochloride
57297-29-7

cyclopropylcarboxamidine hydrochloride

7-benzyl-2-cyclopropyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

7-benzyl-2-cyclopropyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

Conditions
ConditionsYield
With sodium methylate In methanol at 25℃; for 20h; Inert atmosphere;99%
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate
39514-19-7

ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate

Conditions
ConditionsYield
With sodium hydrogencarbonate In diethyl ether; water for 1h;96%
With sodium ethanolate In ethanol
With sodium hydrogencarbonate In ethyl acetate for 2h;
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 0.5h;0.87 g
guanidine hydrochloride
50-01-1

guanidine hydrochloride

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

2-amino-7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(4aH)-one
62458-92-8

2-amino-7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(4aH)-one

Conditions
ConditionsYield
With sodium methylate In methanol at 100℃;96%
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

ethyl 3-oxopiperidine-4-carboxylate hydrochloride

ethyl 3-oxopiperidine-4-carboxylate hydrochloride

Conditions
ConditionsYield
With 5% Pd(II)/C(eggshell); hydrogen In ethanol at 20℃; under 3750.38 Torr; for 4h;95%
With hydrogenchloride; palladium 10% on activated carbon; hydrogen In ethanol at 40℃; for 8h;91.4%
With hydrogen; palladium 10% on activated carbon In ethanol at 50℃; for 4h;84%
acetamidine hydrochloride
124-42-5

acetamidine hydrochloride

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

7-benzyl-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one
62259-92-1

7-benzyl-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

Conditions
ConditionsYield
With sodium methylate In methanol at 25℃; for 20h; Inert atmosphere;95%
With sodium ethanolate In ethanol for 16h; Product distribution / selectivity; Heating / reflux;77%
With sodium ethanolate In ethanol; water; acetic acid17.1 g (95%)
Stage #1: acetamidine hydrochloride; ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride With sodium ethanolate In ethanol at 100℃; for 15h;
Stage #2: With hydrogenchloride In water pH=11; Product distribution / selectivity;
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl 1-benzyl-4-(2-ethoxy-2-oxoethyl)-3-oxopiperidine-4-carboxylate

ethyl 1-benzyl-4-(2-ethoxy-2-oxoethyl)-3-oxopiperidine-4-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride With potassium tert-butylate In tetrahydrofuran at 6 - 29℃; for 4h; Large scale;
Stage #2: ethyl bromoacetate In tetrahydrofuran at 10 - 20℃; for 29h; Large scale;		94%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate
98977-34-5

1-tert-butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate

Conditions
ConditionsYield
With hydrogen; triethylamine; palladium(II) hydroxide/carbon In ethanol under 3102.97 Torr; for 5h;93%
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

5-amino-3-methylthio-1,2,4-triazole
45534-08-5

5-amino-3-methylthio-1,2,4-triazole

A

8-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<3,4-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one
115549-85-4

8-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido<3,4-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one

B

6-benzyl-2-methylthio-5,6,7,8-tetrahydropyrido<4,3-e>-1,2,4-triazolo<1,5-a>pyrimidin-9(10H)-one

6-benzyl-2-methylthio-5,6,7,8-tetrahydropyrido<4,3-e>-1,2,4-triazolo<1,5-a>pyrimidin-9(10H)-one

Conditions
ConditionsYield
In acetic acid for 6.5h; Heating;A 91%
B 2%
...Expand
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

1,1-dimethylguanidine dihydrogensulfate
311-77-3

1,1-dimethylguanidine dihydrogensulfate

7-benzyl-2-(dimethylamino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

7-benzyl-2-(dimethylamino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

Conditions
ConditionsYield
With sodium methylate In methanol at 25℃; for 20h; Inert atmosphere;90%
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

thiourea
17356-08-0

thiourea

methyl iodide
74-88-4

methyl iodide

7-benzyl-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidin-4(4aH)-one
871107-81-2

7-benzyl-5,6,7,8-tetrahydro-2-(methylthio)pyrido[3,4-d]pyrimidin-4(4aH)-one

Conditions
ConditionsYield
Stage #1: ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride; thiourea With sodium methylate In methanol at 100℃;
Stage #2: methyl iodide In methanol at 20℃; for 1h;		88%
...Expand
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

allyl bromide
106-95-6

allyl bromide

ethyl 1-benzyl-3-oxo-4-(prop-2-en-1-yl)piperidine-4-carboxylate

ethyl 1-benzyl-3-oxo-4-(prop-2-en-1-yl)piperidine-4-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 1h; Inert atmosphere;
Stage #2: allyl bromide In tetrahydrofuran at 0 - 20℃; Inert atmosphere;		84%
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

urea
57-13-6

urea

7-benzyl-5,6,7,8-tetrahydropyridine[3,4-d]pyrimidine-2,4-diol
62459-02-3

7-benzyl-5,6,7,8-tetrahydropyridine[3,4-d]pyrimidine-2,4-diol

Conditions
ConditionsYield
With sodium In ethanol at 75℃; for 36h;83.2%
With ethanol; sodium at 75℃; for 36h;83.2%
With ethanol; sodium at 90℃; for 12h;62%
With ethanol; sodium at 80℃; for 20h;62%
With sodium methylate In methanol; ethanol for 4h; Reflux;
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

6-benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-ol
909187-64-0

6-benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-ol

Conditions
ConditionsYield
With hydrazine hydrate; triethylamine In ethanol at 80℃; for 1.5h;83%
With hydrazine at 20℃; for 48h;
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

5-amino-3-methylthio-1,2,4-triazole
45534-08-5

5-amino-3-methylthio-1,2,4-triazole

8-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido[3,4-d][1,2,4]triazolo[1,5-a]pyrimidin-5(10H)-one monohydrochloride

8-benzyl-2-methylthio-6,7,8,9-tetrahydropyrido[3,4-d][1,2,4]triazolo[1,5-a]pyrimidin-5(10H)-one monohydrochloride

Conditions
ConditionsYield
With acetic acid for 8h; Condensation; Heating;81%
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

urea
57-13-6

urea

7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione
62459-02-3

7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With sodium methylate In ethanol for 17h; Heating / reflux;80%
With sodium methylate In methanol for 18h; Reflux; Inert atmosphere;58.3%
With sodium methylate In methanol at 0℃; for 20h; Reflux; Inert atmosphere;
benzamidine monohydrochloride
1670-14-0

benzamidine monohydrochloride

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

C20H19N3O
62259-93-2

C20H19N3O

Conditions
ConditionsYield
With sodium methylate In methanol; ethanol at 0℃; Heating / reflux;80%
2-methylisothiourea sulphate
14527-26-5, 867-44-7

2-methylisothiourea sulphate

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

7-benzyl-2-(methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol

7-benzyl-2-(methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol

Conditions
ConditionsYield
With sodium methylate In methanol at 20℃; for 12h;80%
formamidine acetic acid
3473-63-0

formamidine acetic acid

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one
62458-96-2

7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one

Conditions
ConditionsYield
With sodium methylate In methanol at 25℃; for 20h; Inert atmosphere;79%
Stage #1: formamidine acetic acid; ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride With sodium methylate In methanol at 25℃; for 20h;
Stage #2: With acetic acid In methanol; water at 0 - 25℃;		79%
With sodium methylate In methanol at 20℃; for 20h;70%
Stage #1: formamidine acetic acid; ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride With sodium methylate In methanol at 20℃; for 20h;
Stage #2: With acetic acid In methanol; water at 0 - 20℃; for 1h;		70%
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

trifluoroacetamidine
354-37-0, 133640-88-7, 133640-89-8

trifluoroacetamidine

7-benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol
647862-97-3

7-benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-ol

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 20 - 80℃; for 17.25h;78%
With ethanol; sodium at 20 - 80℃; for 17h; Inert atmosphere;78%
With sodium ethanolate In ethanol at 20℃; for 31.25h;
Stage #1: ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride; trifluoroacetamidine With sodium ethanolate at 20℃; for 1.25h;
Stage #2: for 30h; Heating / reflux;
With sodium ethanolate In ethanol for 31.25h; Heating / reflux;
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
911010-88-3

ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

Conditions
ConditionsYield
With ammonium acetate In ethanol at 20℃; for 1h;75%
With ammonium acetate In ethanol at 20℃; for 1h;
With ammonium acetate In ethanol at 20℃; for 3h;29.2 g
With ammonium acetate In ethanol at 20℃; for 3h;29.2 g
5-amino-3-morpholino-1H-1,2,4-triazole
51420-46-3

5-amino-3-morpholino-1H-1,2,4-triazole

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride
52763-21-0

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

A

8-benzyl-2-morpholino-6,7,8,9-tetrahydropyrido<3,4-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one
115549-86-5

8-benzyl-2-morpholino-6,7,8,9-tetrahydropyrido<3,4-d>-1,2,4-triazolo<1,5-a>pyrimidin-5(10H)-one

B

6-benzyl-2-morpholino-5,6,7,8-tetrahydropyrido<4,3-e>-1,2,4-triazolo<1,5-a>pyrimidin-9(10H)-one

6-benzyl-2-morpholino-5,6,7,8-tetrahydropyrido<4,3-e>-1,2,4-triazolo<1,5-a>pyrimidin-9(10H)-one

Conditions
ConditionsYield
In acetic acid for 7h; Heating;A 72%
B 3%
...Expand

Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride Specification

The Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride, with the CAS registry number 52763-21-0 and EINECS registry number 258-162-5, has the systematic name of ethyl 1-benzyl-3-oxo-piperidine-4-carboxylate hydrochloride. It is a kind of white to brown crystalline powder, and belongs to the following product categories: Piperidines, Piperidones, Piperazines. And the molecular formula of this chemical is C15H20ClNO3.

The physical properties of Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride are as followings: (1)H-Bond Donor: 1; (2)H-Bond Acceptor: 4; (3)Rotatable Bond Count: 5; (4)Tautomer Count: 5; (5)Exact Mass: 297.113171; (6)MonoIsotopic Mass: 297.113171; (7)Topological Polar Surface Area: 46.6; (8)Heavy Atom Count: 20; (9)Formal Charge: 0; (10)Complexity: 323; (11)Isotope Atom Count: 0; (12)Defined Atom StereoCenter Count: 0; (13)Undefined Atom StereoCenter Count: 1; (14)Defined Bond StereoCenter Count: 0; (15)Undefined Bond StereoCenter Count: 0; (16)Covalently-Bonded Unit Count: 2.

Uses of Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride: It can react with 5-methylamino-3-methylthio-1,2,4-triazole to produce 6-benzyl-10-methyl-2-methylthio-5,6,7,8-tetrahydropyrido[4,3-e]-1,2,4-triazolo[1,5-a]pyrimidin-9(10H)-one. This reaction will need reagent acetic acid. The reaction time is 6 hours with heating, and the yield is about 62%.   

You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: CCOC(=O)C1CCN(CC1=O)Cc2ccccc2.Cl
(2)InChI: InChI=1/C15H19NO3.ClH/c1-2-19-15(18)13-8-9-16(11-14(13)17)10-12-6-4-3-5-7-12;/h3-7,13H,2,8-11H2,1H3;1H
(3)InChIKey: UQOMEAWPKSISII-UHFFFAOYAM

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