Product Name

  • Name

    Diethyl disulfide

  • EINECS 203-805-7
  • CAS No. 110-81-6
  • Article Data257
  • CAS DataBase
  • Density 0.99
  • Solubility SULFIDES and SULFATES.
  • Risk Codes R10;R36/37/38   
  • Molecular Structure Molecular Structure of 110-81-6 (Diethyl disulfide)
  • Hazard Symbols
  • Synonyms Ethyldisulfide (8CI); 3,4-Dithiahexane; Diethyl disulfide; Ethyl disulphide;Ethyldithioethane; NSC 8839
  • PSA 50.60000
  • LogP 2.40760

Synthetic route

ethyl bromide
74-96-4

ethyl bromide

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With lithium sulfide; sulfur; cetyl trimethyl ammonium bromide In chloroform; water for 1h; Ambient temperature;94%
With water; oxygen; sodium carbonate; thiourea at 35 - 40℃; for 5h; Green chemistry;87%
With sodium carbonate; sulfur; thiourea In water at 40℃; for 3h; Green chemistry;84%
ethanethiol
75-08-1

ethanethiol

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In chloroform at 20℃;100%
With air; iron(III) chloride; sodium iodide In acetonitrile for 0.116667h; Ambient temperature;98%
With oxygen; SiO2-Cl In dichloromethane at 0℃; for 0.166667h;98%
ethyl bromide
74-96-4

ethyl bromide

thiourea
17356-08-0

thiourea

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With sodium carbonate In water; acetonitrile at 80℃; for 3h; Sealed tube;89%
diethyl sulfate
64-67-5

diethyl sulfate

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With sodium disulfide; tetrabutylammomium bromide at 60 - 70℃; for 3h; Reagent/catalyst;95.3%
ethyl iodide
75-03-6

ethyl iodide

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With sodium sulfide; sulfur In chloroform; water at 25℃; for 2h;95%
With (C6H5CH2N(Et)3)6Mo7S24 In chloroform at 20℃; for 6h;92%
With diethyl ether; sodium disulfide
With carbon disulfide; potassium hydroxide In dimethyl sulfoxide for 2h;0.6 g
3,4-dichloro-5-ethylsulfanyl-2(5H)-furanone
34695-11-9

3,4-dichloro-5-ethylsulfanyl-2(5H)-furanone

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

4-chloro-5-ethoxy-2(5H)-furanone
32978-39-5

4-chloro-5-ethoxy-2(5H)-furanone

Conditions
ConditionsYield
With N,N,N,N-tetraethylammonium tetrafluoroborate; acetic acid In acetonitrile at 21.84℃; for 4.66667h; Electrolysis; Irradiation;
sodium thioethylate
811-51-8

sodium thioethylate

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With bromonitromethane In methanol85%
With water; iodine
With sulfur
With sulfuryl dichloride; water
With iodine
n-propanesulfonyl chloride
10147-36-1

n-propanesulfonyl chloride

ethanethiol
75-08-1

ethanethiol

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

propane-1-thiosulfonic acid S-ethyl ester
2043-79-0

propane-1-thiosulfonic acid S-ethyl ester

Conditions
ConditionsYield
With triethylamine In diethyl ether at 20℃; for 0.333333h; Sonication;A 34 %Chromat.
B 13 %Chromat.
ethyl ester of p-toluenesulfonic acid
80-40-0

ethyl ester of p-toluenesulfonic acid

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With sodium carbonate; sulfur; thiourea In water at 70℃; for 4h; Green chemistry;87%
With water; sodium disulfide at 110℃;
2-[bis(ethylsulfanyl)methyl]-1-(2-ethylthioethyl)-5-phenylpyrrole
934478-83-8

2-[bis(ethylsulfanyl)methyl]-1-(2-ethylthioethyl)-5-phenylpyrrole

ethanethiol
75-08-1

ethanethiol

A

1-(2-ethylthioethyl)-2-ethylthiomethyl-5-phenylpyrrole

1-(2-ethylthioethyl)-2-ethylthiomethyl-5-phenylpyrrole

B

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile) In benzene at 75℃; for 6h;A 80%
B n/a
Ethanesulfonyl chloride
594-44-5

Ethanesulfonyl chloride

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With trimethylsilyl iodide In 1,2-dichloro-ethane for 16h; Heating;80%
ethyl isothiocyanate
542-90-5

ethyl isothiocyanate

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With ammonia In water; isopropyl alcohol at 60℃; for 8h; sealed ampoule;56.2%
triethylamine
121-44-8

triethylamine

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

2,4-N,N'-bis(diethylamido)-2,4-dithioxo-1,3,2λ5,4λ5-dithiadiphosphetane
162889-84-1

2,4-N,N'-bis(diethylamido)-2,4-dithioxo-1,3,2λ5,4λ5-dithiadiphosphetane

Conditions
ConditionsYield
With tetraphosphorus decasulfide In benzene at 20℃; for 12h;A 75%
B 72%
carbon disulfide
75-15-0

carbon disulfide

2-methyl-5-phenyl-1H-pyrrole
3042-21-5

2-methyl-5-phenyl-1H-pyrrole

ethyl iodide
75-03-6

ethyl iodide

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

ethyl 2-methyl-5-phenylpyrrole-3-carbodithioate
306774-18-5

ethyl 2-methyl-5-phenylpyrrole-3-carbodithioate

Conditions
ConditionsYield
Stage #1: carbon disulfide; 2-methyl-5-phenyl-1H-pyrrole With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h;
Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h;
A n/a
B 61%
carbon disulfide
75-15-0

carbon disulfide

ethyl iodide
75-03-6

ethyl iodide

2-(1,1-Dimethylethyl)-4-methyl-1H-pyrrole
172907-63-0

2-(1,1-Dimethylethyl)-4-methyl-1H-pyrrole

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

ethyl 5-(tert-butyl)-3-methylpyrrole-2-carbodithioate

ethyl 5-(tert-butyl)-3-methylpyrrole-2-carbodithioate

Conditions
ConditionsYield
Stage #1: carbon disulfide; 2-(1,1-Dimethylethyl)-4-methyl-1H-pyrrole With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h;
Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h;
A n/a
B 62%
2-methyl-1H-pyrrole
636-41-9

2-methyl-1H-pyrrole

carbon disulfide
75-15-0

carbon disulfide

ethyl iodide
75-03-6

ethyl iodide

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

ethyl 5-methylpyrrole-2-carbodithioate

ethyl 5-methylpyrrole-2-carbodithioate

Conditions
ConditionsYield
Stage #1: 2-methyl-1H-pyrrole; carbon disulfide With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h;
Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h;
A n/a
B 46%
2,3-dimethyl-1H-pyrrole
600-28-2

2,3-dimethyl-1H-pyrrole

carbon disulfide
75-15-0

carbon disulfide

ethyl iodide
75-03-6

ethyl iodide

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

ethyl 4,5-dimethylpyrrole-2-carbodithioate
306774-22-1

ethyl 4,5-dimethylpyrrole-2-carbodithioate

Conditions
ConditionsYield
Stage #1: 2,3-dimethyl-1H-pyrrole; carbon disulfide With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h;
Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h;
A n/a
B 51%
2,4-dimethyl-1H-pyrrole
625-82-1

2,4-dimethyl-1H-pyrrole

carbon disulfide
75-15-0

carbon disulfide

ethyl iodide
75-03-6

ethyl iodide

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

ethyl 3,5-dimethylpyrrole-2-carbodithioate

ethyl 3,5-dimethylpyrrole-2-carbodithioate

Conditions
ConditionsYield
Stage #1: 2,4-dimethyl-1H-pyrrole; carbon disulfide With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h;
Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h;
A n/a
B 48%
carbon disulfide
75-15-0

carbon disulfide

ethyl iodide
75-03-6

ethyl iodide

2-methyl-5-(2-thienyl)pyrrole

2-methyl-5-(2-thienyl)pyrrole

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

ethyl 2-methyl-5-(2-thienyl)pyrrole-3-carbodithioate

ethyl 2-methyl-5-(2-thienyl)pyrrole-3-carbodithioate

Conditions
ConditionsYield
Stage #1: carbon disulfide; 5-Methyl-2-(2-thienyl)pyrrole With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h;
Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h;
A n/a
B 46%
2,3,5-trimethylpyrrole
2199-41-9

2,3,5-trimethylpyrrole

carbon disulfide
75-15-0

carbon disulfide

ethyl iodide
75-03-6

ethyl iodide

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

ethyl 2,4,5-trimethylpyrrole-3-carbodithioate

ethyl 2,4,5-trimethylpyrrole-3-carbodithioate

Conditions
ConditionsYield
Stage #1: 2,3,5-trimethylpyrrole; carbon disulfide With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h;
Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h;
A n/a
B 43%
2-methyl-4,5,6,7-tetrahydro-1H-indole
90642-57-2

2-methyl-4,5,6,7-tetrahydro-1H-indole

carbon disulfide
75-15-0

carbon disulfide

ethyl iodide
75-03-6

ethyl iodide

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

ethyl 2-methyl-4,5,6,7-tetrahydroindole-3-carbodithioate
306774-17-4

ethyl 2-methyl-4,5,6,7-tetrahydroindole-3-carbodithioate

Conditions
ConditionsYield
Stage #1: 2-methyl-4,5,6,7-tetrahydro-1H-indole; carbon disulfide With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h;
Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h;
A n/a
B 36%
carbon disulfide
75-15-0

carbon disulfide

2-(2-furyl)-5-methyl-1H-pyrrole
107467-74-3

2-(2-furyl)-5-methyl-1H-pyrrole

ethyl iodide
75-03-6

ethyl iodide

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

ethyl 2-methyl-5-(2-furyl)pyrrole-3-carbodithioate

ethyl 2-methyl-5-(2-furyl)pyrrole-3-carbodithioate

Conditions
ConditionsYield
Stage #1: carbon disulfide; 2-(2-furyl)-5-methyl-1H-pyrrole With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h;
Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h;
A n/a
B 44%
S-ethyl thioformate
21071-39-6

S-ethyl thioformate

dimethyl cis-but-2-ene-1,4-dioate
624-48-6

dimethyl cis-but-2-ene-1,4-dioate

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

dimethyl 2-(ethylthio)succinate
94884-10-3

dimethyl 2-(ethylthio)succinate

Conditions
ConditionsYield
di-tert-butyl peroxide at 140℃; argon atmosphere;A n/a
B 90%
bis--disulfide

bis--disulfide

Diethyl disulfide
110-81-6

Diethyl disulfide

Ti(η5-C5H5)2(SC2H5)2
1291-79-8

Ti(η5-C5H5)2(SC2H5)2

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

bis(cyclopentadienyl)titanium dichloride
1271-19-8

bis(cyclopentadienyl)titanium dichloride

C

cyclopentadienyl titanium(IV) trichloride
1270-98-0

cyclopentadienyl titanium(IV) trichloride

Conditions
ConditionsYield
With tetrachloromethane In tetrachloromethane Irradiation (UV/VIS); (N2 or Ar); complex soln. irradiated (λ>530 nm) at room temp. with stirring for 10 min; not isolated, detected by NMR;
ethyl thioacetate
625-60-5

ethyl thioacetate

Diethyl disulfide
110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With ferric nitrate for 3h; Ambient temperature;87%
ethanethiol
75-08-1

ethanethiol

A

Diethyl disulfide
110-81-6

Diethyl disulfide

B

ethyl methyl disulfide
20333-39-5

ethyl methyl disulfide

C

methane
34557-54-5

methane

D

ethane
74-84-0

ethane

Conditions
ConditionsYield
With Dimethyldisulphide; O(3P) at 25℃; Yield given. Yields of byproduct given;
Diethyl disulfide
110-81-6

Diethyl disulfide

triethyl trithiophosphite
688-62-0

triethyl trithiophosphite

Conditions
ConditionsYield
With black phosphorus; sodium hydroxide In acetone at 40℃; for 15h; Inert atmosphere; Green chemistry;87%
With phosphorus at 160℃;
With dihydrogen phosphide sodium In diethyl ether
With phosphorus; potassium hydroxide In dimethyl sulfoxide; toluene at 80℃; for 0.0833333h; Inert atmosphere; Schlenk technique;90 %Spectr.
Diethyl disulfide
110-81-6

Diethyl disulfide

2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine
16321-99-6

2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine

6-chloro-2-ethylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine
221552-84-7

6-chloro-2-ethylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

Conditions
ConditionsYield
Stage #1: Diethyl disulfide; 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine In acetonitrile at 65℃; Sonication;
Stage #2: With isopentyl nitrite In acetonitrile for 0.666667h;
66%
With isopentyl nitrite In acetonitrile at 65℃; for 0.5h; Sonication;65%
With isopentyl nitrite In acetonitrile at 60℃; for 20h;64%
Diethyl disulfide
110-81-6

Diethyl disulfide

ethyl ethanethiosulfinate
18542-39-7

ethyl ethanethiosulfinate

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane100%
With dihydrogen peroxide; L-proline In water; acetonitrile at 20 - 25℃; for 48h; Inert atmosphere;90%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃; for 5h;56%
Diethyl disulfide
110-81-6

Diethyl disulfide

Ethanesulfonyl chloride
594-44-5

Ethanesulfonyl chloride

Conditions
ConditionsYield
With chloro-trimethyl-silane; potassium nitrate In dichloromethane at 50℃; for 6h;90%
With hydrogenchloride; N-chloro-succinimide In water; acetonitrile at 20℃; for 0.5h;80%
With hydrogenchloride; N-chloro-succinimide In acetonitrile at 10℃;53.1%
Diethyl disulfide
110-81-6

Diethyl disulfide

6-phenylimidazo[2,1-b]thiazole
7008-63-1

6-phenylimidazo[2,1-b]thiazole

5-(ethylthio)-6-phenylimidazo[2,1-b]thiazole

5-(ethylthio)-6-phenylimidazo[2,1-b]thiazole

Conditions
ConditionsYield
With dihydrogen peroxide; iodine In ethanol at 60℃; for 18h; Green chemistry;90%
Diethyl disulfide
110-81-6

Diethyl disulfide

2-chloro-4-(3,4-dichlorophenyl)thiazole
26847-04-1

2-chloro-4-(3,4-dichlorophenyl)thiazole

2-chloro-4-(3,4-dichlorophenyl)-5-(ethylthio)thiazole

2-chloro-4-(3,4-dichlorophenyl)-5-(ethylthio)thiazole

Conditions
ConditionsYield
Stage #1: 2-chloro-4-(3,4-dichlorophenyl)thiazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h;
Stage #2: Diethyl disulfide for 0.166667h;
98%
Stage #1: 2-chloro-4-(3,4-dichlorophenyl)thiazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h;
Stage #2: Diethyl disulfide In tetrahydrofuran; hexane for 0.166667h;
98%
Diethyl disulfide
110-81-6

Diethyl disulfide

Ethanesulfenyl chloride
1496-75-9

Ethanesulfenyl chloride

Conditions
ConditionsYield
With chlorine at -17℃;
With chlorine In dichloromethane
With chlorine
Diethyl disulfide
110-81-6

Diethyl disulfide

1,2-(methylenedioxy)-4-bromobenzene
2635-13-4

1,2-(methylenedioxy)-4-bromobenzene

5-(ethylthio)-1,3-benzodioxole
5279-34-5

5-(ethylthio)-1,3-benzodioxole

Conditions
ConditionsYield
Stage #1: 1,2-(methylenedioxy)-4-bromobenzene With n-butyllithium In tetrahydrofuran; hexanes at -78℃; for 0.5h;
Stage #2: Diethyl disulfide In tetrahydrofuran; hexanes for 0.5h;
99%
Diethyl disulfide
110-81-6

Diethyl disulfide

benzyl chloride
100-44-7

benzyl chloride

benzyl(ethyl)sulfane
6263-62-3

benzyl(ethyl)sulfane

Conditions
ConditionsYield
With hydrogenchloride; zinc In water at 20℃; for 0.5h; Ionic liquid; Inert atmosphere;99%
Diethyl disulfide
110-81-6

Diethyl disulfide

C20H15NOS
1316303-52-2

C20H15NOS

3-(ethylthio)-2-(2-(ethylthio)phenyl)-4-phenylbenzo[c][1,2]thiazine 2-oxide

3-(ethylthio)-2-(2-(ethylthio)phenyl)-4-phenylbenzo[c][1,2]thiazine 2-oxide

Conditions
ConditionsYield
Stage #1: C20H15NOS With n-butyllithium In tetrahydrofuran; acetone at -78℃; for 0.5h; Inert atmosphere;
Stage #2: Diethyl disulfide In tetrahydrofuran; acetone Inert atmosphere;
94%
Diethyl disulfide
110-81-6

Diethyl disulfide

C11H15ClO2

C11H15ClO2

C13H20O2S

C13H20O2S

Conditions
ConditionsYield
With nickel dibromide; zinc In toluene at 110℃; for 20h; Time;90.2%
Diethyl disulfide
110-81-6

Diethyl disulfide

C11H15BrO2

C11H15BrO2

C13H20O2S

C13H20O2S

Conditions
ConditionsYield
With nickel dibromide; zinc In toluene at 80℃; for 10h;93.4%
Diethyl disulfide
110-81-6

Diethyl disulfide

4-propylaniline
2696-84-6

4-propylaniline

C11H15NS

C11H15NS

Conditions
ConditionsYield
With iodine In tetrahydrofuran at 100℃; for 8h;87%
Diethyl disulfide
110-81-6

Diethyl disulfide

1-bromo-2-(methoxymethoxy)benzene
68314-54-5

1-bromo-2-(methoxymethoxy)benzene

1-(ethylsulfanyl)-2-(methoxymethoxy)benzene

1-(ethylsulfanyl)-2-(methoxymethoxy)benzene

Conditions
ConditionsYield
Stage #1: 1-bromo-2-(methoxymethoxy)benzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere;
Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere;
99%
Diethyl disulfide
110-81-6

Diethyl disulfide

1-bromo-2-(methoxymethoxy)-3-methylbenzene

1-bromo-2-(methoxymethoxy)-3-methylbenzene

1-(ethylsulfanyl)-2-(methoxymethoxy)-3-methylbenzene

1-(ethylsulfanyl)-2-(methoxymethoxy)-3-methylbenzene

Conditions
ConditionsYield
Stage #1: 1-bromo-2-(methoxymethoxy)-3-methylbenzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere;
Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere;
97%
Diethyl disulfide
110-81-6

Diethyl disulfide

2-bromo-1-(methoxymethoxy)-4-methylbenzene
104750-60-9

2-bromo-1-(methoxymethoxy)-4-methylbenzene

2-(ethylsulfanyl)-1-(methoxymethoxy)-4-methylbenzene

2-(ethylsulfanyl)-1-(methoxymethoxy)-4-methylbenzene

Conditions
ConditionsYield
Stage #1: 2-bromo-1-(methoxymethoxy)-4-methylbenzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere;
Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere;
99%
Diethyl disulfide
110-81-6

Diethyl disulfide

1-bromo-4-fluoro-2-(methoxymethoxy)benzene
162269-78-5

1-bromo-4-fluoro-2-(methoxymethoxy)benzene

1-(ethylsulfanyl)-4-fluoro-2-(methoxymethoxy)benzene

1-(ethylsulfanyl)-4-fluoro-2-(methoxymethoxy)benzene

Conditions
ConditionsYield
Stage #1: 1-bromo-4-fluoro-2-(methoxymethoxy)benzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere;
Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere;
98%
Diethyl disulfide
110-81-6

Diethyl disulfide

2-bromo-4-fluoro-1-(methoxymethoxy)benzene
474711-11-0

2-bromo-4-fluoro-1-(methoxymethoxy)benzene

2-(ethylsulfanyl)-4-fluoro-1-(methoxymethoxy)benzene

2-(ethylsulfanyl)-4-fluoro-1-(methoxymethoxy)benzene

Conditions
ConditionsYield
Stage #1: 2-bromo-4-fluoro-1-(methoxymethoxy)benzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere;
Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere;
99%
Diethyl disulfide
110-81-6

Diethyl disulfide

2-bromo-4-methoxy-1-(methoxymethoxy)-benzene
195314-47-7

2-bromo-4-methoxy-1-(methoxymethoxy)-benzene

2-(ethylsulfanyl)-4-methoxy-1-(methoxymethoxy)benzene

2-(ethylsulfanyl)-4-methoxy-1-(methoxymethoxy)benzene

Conditions
ConditionsYield
Stage #1: 2-bromo-4-methoxy-1-(methoxymethoxy)-benzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere;
Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere;
92%
Diethyl disulfide
110-81-6

Diethyl disulfide

ethanesulfinyl chloride
1718-44-1

ethanesulfinyl chloride

Conditions
ConditionsYield
With chlorine; acetic acid
With chlorine; acetic acid at -15 - -10℃;
With sulfuryl dichloride In acetic acid at -20 - 20℃; for 3h; Inert atmosphere;
With sulfuryl dichloride; acetic acid at -20 - 20℃; for 3h; Inert atmosphere;
With sulfuryl dichloride; acetic acid at -40 - 35℃; for 4h; Inert atmosphere;
Diethyl disulfide
110-81-6

Diethyl disulfide

C20H32O4

C20H32O4

C22H36O3S

C22H36O3S

Conditions
ConditionsYield
With tributylphosphine In dichloromethane at 20℃; for 4.5h;58%
With tributylphosphine In dichloromethane at 20℃; for 4.5h;58%
Diethyl disulfide
110-81-6

Diethyl disulfide

(+)-4(Z)-(4R,5S)-4-hydroxy-4-(5-hydroxy-3-methylpent-3-en-1-ynyl)-3,3,5-trimethylcyclohexanone
130694-71-2

(+)-4(Z)-(4R,5S)-4-hydroxy-4-(5-hydroxy-3-methylpent-3-en-1-ynyl)-3,3,5-trimethylcyclohexanone

(4R,5S)-(3'Z)-4-(5'-(ethylthio)-3'-methylpent-3'-en-1'-ynyl)-4-hydroxy-3,3,5-trimethylcyclohexanone
1159072-21-5

(4R,5S)-(3'Z)-4-(5'-(ethylthio)-3'-methylpent-3'-en-1'-ynyl)-4-hydroxy-3,3,5-trimethylcyclohexanone

Conditions
ConditionsYield
With tributylphosphine In dichloromethane at 20℃; for 6h;63%
With tributylphosphine In dichloromethane at 20℃; for 6h;63%
Diethyl disulfide
110-81-6

Diethyl disulfide

2-(3-thiomethylphenyl)-[1,3]dioxolane

2-(3-thiomethylphenyl)-[1,3]dioxolane

2-(3-thioethyl-phenyl)-[1,3]dioxolane

2-(3-thioethyl-phenyl)-[1,3]dioxolane

Conditions
ConditionsYield
Stage #1: 2-(3-thiomethylphenyl)-[1,3]dioxolane With n-butyllithium In tetrahydrofuran; hexane for 0.166667h;
Stage #2: Diethyl disulfide In tetrahydrofuran; hexane at -78℃; for 1h;
78%
Diethyl disulfide
110-81-6

Diethyl disulfide

epoxiconazole

epoxiconazole

trans-1-[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiranylmethyl]-5-ethylsulfanyl-1H-[1,2,4]triazole

trans-1-[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiranylmethyl]-5-ethylsulfanyl-1H-[1,2,4]triazole

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 4h;81%

Ethyl disulfide Chemical Properties

Product Name: Diethyldisulfide (CAS NO.110-81-6)


Molecular Formula: C5H16NNaO3S2
Molecular Weight: 225.31g/mol
Mol File: 110-81-6.mol
Einecs: 205-710-6
Appearance: Clear colorless to light yellow liquid
Melting Point: 95-98.5 °C(lit.)
Boiling point: 154 °C at 760 mmHg
Storage Temperature: -20°C
Flash Point: 40 °C
Density: 0.993 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.506(lit.)
Surface Tension: 32.5 dyne/cm
Enthalpy of Vaporization: 37.58 kJ/mol
Vapour Pressure: 4.17 mmHg at 25°C
XLogP3-AA: 1.6
Product Categories: Sulfide Flavor

Ethyl disulfide Production

 Diethyldisulfide (CAS NO.110-81-6) is the preparation method is the first release within the reactor sodium sulfide solution, according to sodium sulfide: sulfur = 1:1 (molar ratio) is expected to vote put sulfur powder, jacket temperature, in the stirring, when the temperature reached 80 ~ 95 °C when the Serve warm 1h disulfide disodium salt (Na2S2) solution, and then pumped into the alkylation reactor in disulfide disodium salt solution, start stirring until the reaction vessel to a vacuum (2 ~ 3.3) × 104Pa off valves start the chlorine into the ethane, the reaction temperature was controlled at 75 ~ 90 °C, pressure control (1.17 ~ 1.18) × 105Pa, feed ratio (mole ratio) disulfide disodium salt: ethyl = 1:2, Tung finished chloroethane, the will be expected to cool to below 50 °C will be expected to put it aside for the oil pumped to the water separator layer, the upper reservoir shall be finished.

Ethyl disulfide Toxicity Data With Reference

1.    

skn-rbt 500 mg/24H MLD

    28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,171.
2.    

eye-rbt 100 mg/24H MOD

    28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,171.
3.    

orl-rat LD50:2030 mg/kg

    28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,171.

Ethyl disulfide Consensus Reports

Reported in EPA TSCA Inventory.

Ethyl disulfide Safety Profile

Safety Information of Diethyldisulfide (CAS NO.110-81-6):
Hazard Codes: Xn,Xi
Risk Statements: 22-38-41-36/37/38-10 
10:  Flammable
22:  Harmful if swallowed
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
41:  Risk of serious damage to eyes
Safety Statements: 26-39-37/39-16-36
16:  Keep away from sources of ignition - No smoking
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing  
37:  Wear suitable gloves  
39:  Wear eye/face protection

Ethyl disulfide Specification

 Diethyldisulfide ,its CAS NO. is 110-81-6,the synonyms is (C2h5s)2 ; 1-(Ethyldisulfanyl)ethane ; Diethyldisulfid ; Disulfide,diethyl ; Dlethyldisulfide ; Ethyldisulfanyl-ethane ; Ethyldisulphide ; Ethyldithioethan .

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