Conditions | Yield |
---|---|
With lithium sulfide; sulfur; cetyl trimethyl ammonium bromide In chloroform; water for 1h; Ambient temperature; | 94% |
With water; oxygen; sodium carbonate; thiourea at 35 - 40℃; for 5h; Green chemistry; | 87% |
With sodium carbonate; sulfur; thiourea In water at 40℃; for 3h; Green chemistry; | 84% |
Conditions | Yield |
---|---|
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In chloroform at 20℃; | 100% |
With air; iron(III) chloride; sodium iodide In acetonitrile for 0.116667h; Ambient temperature; | 98% |
With oxygen; SiO2-Cl In dichloromethane at 0℃; for 0.166667h; | 98% |
Conditions | Yield |
---|---|
With sodium carbonate In water; acetonitrile at 80℃; for 3h; Sealed tube; | 89% |
Conditions | Yield |
---|---|
With sodium disulfide; tetrabutylammomium bromide at 60 - 70℃; for 3h; Reagent/catalyst; | 95.3% |
Conditions | Yield |
---|---|
With sodium sulfide; sulfur In chloroform; water at 25℃; for 2h; | 95% |
With (C6H5CH2N(Et)3)6Mo7S24 In chloroform at 20℃; for 6h; | 92% |
With diethyl ether; sodium disulfide | |
With carbon disulfide; potassium hydroxide In dimethyl sulfoxide for 2h; | 0.6 g |
3,4-dichloro-5-ethylsulfanyl-2(5H)-furanone
A
Diethyl disulfide
B
4-chloro-5-ethoxy-2(5H)-furanone
Conditions | Yield |
---|---|
With N,N,N,N-tetraethylammonium tetrafluoroborate; acetic acid In acetonitrile at 21.84℃; for 4.66667h; Electrolysis; Irradiation; |
Conditions | Yield |
---|---|
With bromonitromethane In methanol | 85% |
With water; iodine | |
With sulfur | |
With sulfuryl dichloride; water | |
With iodine |
n-propanesulfonyl chloride
ethanethiol
A
Diethyl disulfide
B
propane-1-thiosulfonic acid S-ethyl ester
Conditions | Yield |
---|---|
With triethylamine In diethyl ether at 20℃; for 0.333333h; Sonication; | A 34 %Chromat. B 13 %Chromat. |
Conditions | Yield |
---|---|
With sodium carbonate; sulfur; thiourea In water at 70℃; for 4h; Green chemistry; | 87% |
With water; sodium disulfide at 110℃; |
2-[bis(ethylsulfanyl)methyl]-1-(2-ethylthioethyl)-5-phenylpyrrole
ethanethiol
B
Diethyl disulfide
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile) In benzene at 75℃; for 6h; | A 80% B n/a |
Conditions | Yield |
---|---|
With trimethylsilyl iodide In 1,2-dichloro-ethane for 16h; Heating; | 80% |
Conditions | Yield |
---|---|
With ammonia In water; isopropyl alcohol at 60℃; for 8h; sealed ampoule; | 56.2% |
triethylamine
A
Diethyl disulfide
B
2,4-N,N'-bis(diethylamido)-2,4-dithioxo-1,3,2λ5,4λ5-dithiadiphosphetane
Conditions | Yield |
---|---|
With tetraphosphorus decasulfide In benzene at 20℃; for 12h; | A 75% B 72% |
carbon disulfide
2-methyl-5-phenyl-1H-pyrrole
ethyl iodide
A
Diethyl disulfide
B
ethyl 2-methyl-5-phenylpyrrole-3-carbodithioate
Conditions | Yield |
---|---|
Stage #1: carbon disulfide; 2-methyl-5-phenyl-1H-pyrrole With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h; | A n/a B 61% |
carbon disulfide
ethyl iodide
2-(1,1-Dimethylethyl)-4-methyl-1H-pyrrole
A
Diethyl disulfide
Conditions | Yield |
---|---|
Stage #1: carbon disulfide; 2-(1,1-Dimethylethyl)-4-methyl-1H-pyrrole With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h; | A n/a B 62% |
2-methyl-1H-pyrrole
carbon disulfide
ethyl iodide
A
Diethyl disulfide
Conditions | Yield |
---|---|
Stage #1: 2-methyl-1H-pyrrole; carbon disulfide With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h; | A n/a B 46% |
2,3-dimethyl-1H-pyrrole
carbon disulfide
ethyl iodide
A
Diethyl disulfide
B
ethyl 4,5-dimethylpyrrole-2-carbodithioate
Conditions | Yield |
---|---|
Stage #1: 2,3-dimethyl-1H-pyrrole; carbon disulfide With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h; | A n/a B 51% |
2,4-dimethyl-1H-pyrrole
carbon disulfide
ethyl iodide
A
Diethyl disulfide
Conditions | Yield |
---|---|
Stage #1: 2,4-dimethyl-1H-pyrrole; carbon disulfide With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h; | A n/a B 48% |
Conditions | Yield |
---|---|
Stage #1: carbon disulfide; 5-Methyl-2-(2-thienyl)pyrrole With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h; | A n/a B 46% |
2,3,5-trimethylpyrrole
carbon disulfide
ethyl iodide
A
Diethyl disulfide
Conditions | Yield |
---|---|
Stage #1: 2,3,5-trimethylpyrrole; carbon disulfide With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h; | A n/a B 43% |
2-methyl-4,5,6,7-tetrahydro-1H-indole
carbon disulfide
ethyl iodide
A
Diethyl disulfide
B
ethyl 2-methyl-4,5,6,7-tetrahydroindole-3-carbodithioate
Conditions | Yield |
---|---|
Stage #1: 2-methyl-4,5,6,7-tetrahydro-1H-indole; carbon disulfide With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h; | A n/a B 36% |
carbon disulfide
2-(2-furyl)-5-methyl-1H-pyrrole
ethyl iodide
A
Diethyl disulfide
Conditions | Yield |
---|---|
Stage #1: carbon disulfide; 2-(2-furyl)-5-methyl-1H-pyrrole With potassium hydroxide In dimethyl sulfoxide at 20℃; for 3h; Stage #2: ethyl iodide In dimethyl sulfoxide at 20℃; for 2h; | A n/a B 44% |
S-ethyl thioformate
dimethyl cis-but-2-ene-1,4-dioate
A
Diethyl disulfide
B
dimethyl 2-(ethylthio)succinate
Conditions | Yield |
---|---|
di-tert-butyl peroxide at 140℃; argon atmosphere; | A n/a B 90% |
Diethyl disulfide
Ti(η5-C5H5)2(SC2H5)2
A
Diethyl disulfide
B
bis(cyclopentadienyl)titanium dichloride
C
cyclopentadienyl titanium(IV) trichloride
Conditions | Yield |
---|---|
With tetrachloromethane In tetrachloromethane Irradiation (UV/VIS); (N2 or Ar); complex soln. irradiated (λ>530 nm) at room temp. with stirring for 10 min; not isolated, detected by NMR; |
Conditions | Yield |
---|---|
With ferric nitrate for 3h; Ambient temperature; | 87% |
ethanethiol
A
Diethyl disulfide
B
ethyl methyl disulfide
C
methane
D
ethane
Conditions | Yield |
---|---|
With Dimethyldisulphide; O(3P) at 25℃; Yield given. Yields of byproduct given; |
Conditions | Yield |
---|---|
With black phosphorus; sodium hydroxide In acetone at 40℃; for 15h; Inert atmosphere; Green chemistry; | 87% |
With phosphorus at 160℃; | |
With dihydrogen phosphide sodium In diethyl ether | |
With phosphorus; potassium hydroxide In dimethyl sulfoxide; toluene at 80℃; for 0.0833333h; Inert atmosphere; Schlenk technique; | 90 %Spectr. |
Diethyl disulfide
2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine
6-chloro-2-ethylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine
Conditions | Yield |
---|---|
Stage #1: Diethyl disulfide; 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine In acetonitrile at 65℃; Sonication; Stage #2: With isopentyl nitrite In acetonitrile for 0.666667h; | 66% |
With isopentyl nitrite In acetonitrile at 65℃; for 0.5h; Sonication; | 65% |
With isopentyl nitrite In acetonitrile at 60℃; for 20h; | 64% |
Diethyl disulfide
ethyl ethanethiosulfinate
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane | 100% |
With dihydrogen peroxide; L-proline In water; acetonitrile at 20 - 25℃; for 48h; Inert atmosphere; | 90% |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃; for 5h; | 56% |
Conditions | Yield |
---|---|
With chloro-trimethyl-silane; potassium nitrate In dichloromethane at 50℃; for 6h; | 90% |
With hydrogenchloride; N-chloro-succinimide In water; acetonitrile at 20℃; for 0.5h; | 80% |
With hydrogenchloride; N-chloro-succinimide In acetonitrile at 10℃; | 53.1% |
Conditions | Yield |
---|---|
With dihydrogen peroxide; iodine In ethanol at 60℃; for 18h; Green chemistry; | 90% |
Diethyl disulfide
2-chloro-4-(3,4-dichlorophenyl)thiazole
Conditions | Yield |
---|---|
Stage #1: 2-chloro-4-(3,4-dichlorophenyl)thiazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h; Stage #2: Diethyl disulfide for 0.166667h; | 98% |
Stage #1: 2-chloro-4-(3,4-dichlorophenyl)thiazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h; Stage #2: Diethyl disulfide In tetrahydrofuran; hexane for 0.166667h; | 98% |
Conditions | Yield |
---|---|
With chlorine at -17℃; | |
With chlorine In dichloromethane | |
With chlorine |
Diethyl disulfide
1,2-(methylenedioxy)-4-bromobenzene
5-(ethylthio)-1,3-benzodioxole
Conditions | Yield |
---|---|
Stage #1: 1,2-(methylenedioxy)-4-bromobenzene With n-butyllithium In tetrahydrofuran; hexanes at -78℃; for 0.5h; Stage #2: Diethyl disulfide In tetrahydrofuran; hexanes for 0.5h; | 99% |
Conditions | Yield |
---|---|
With hydrogenchloride; zinc In water at 20℃; for 0.5h; Ionic liquid; Inert atmosphere; | 99% |
Diethyl disulfide
C20H15NOS
Conditions | Yield |
---|---|
Stage #1: C20H15NOS With n-butyllithium In tetrahydrofuran; acetone at -78℃; for 0.5h; Inert atmosphere; Stage #2: Diethyl disulfide In tetrahydrofuran; acetone Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
With nickel dibromide; zinc In toluene at 110℃; for 20h; Time; | 90.2% |
Conditions | Yield |
---|---|
With nickel dibromide; zinc In toluene at 80℃; for 10h; | 93.4% |
Conditions | Yield |
---|---|
With iodine In tetrahydrofuran at 100℃; for 8h; | 87% |
Diethyl disulfide
1-bromo-2-(methoxymethoxy)benzene
Conditions | Yield |
---|---|
Stage #1: 1-bromo-2-(methoxymethoxy)benzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere; Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere; | 99% |
Diethyl disulfide
Conditions | Yield |
---|---|
Stage #1: 1-bromo-2-(methoxymethoxy)-3-methylbenzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere; Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere; | 97% |
Diethyl disulfide
2-bromo-1-(methoxymethoxy)-4-methylbenzene
Conditions | Yield |
---|---|
Stage #1: 2-bromo-1-(methoxymethoxy)-4-methylbenzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere; Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere; | 99% |
Diethyl disulfide
1-bromo-4-fluoro-2-(methoxymethoxy)benzene
Conditions | Yield |
---|---|
Stage #1: 1-bromo-4-fluoro-2-(methoxymethoxy)benzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere; Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere; | 98% |
Diethyl disulfide
2-bromo-4-fluoro-1-(methoxymethoxy)benzene
Conditions | Yield |
---|---|
Stage #1: 2-bromo-4-fluoro-1-(methoxymethoxy)benzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere; Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere; | 99% |
Diethyl disulfide
2-bromo-4-methoxy-1-(methoxymethoxy)-benzene
Conditions | Yield |
---|---|
Stage #1: 2-bromo-4-methoxy-1-(methoxymethoxy)-benzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 1h; Inert atmosphere; Stage #2: Diethyl disulfide In diethyl ether; pentane at 20℃; for 1h; Inert atmosphere; | 92% |
Conditions | Yield |
---|---|
With chlorine; acetic acid | |
With chlorine; acetic acid at -15 - -10℃; | |
With sulfuryl dichloride In acetic acid at -20 - 20℃; for 3h; Inert atmosphere; | |
With sulfuryl dichloride; acetic acid at -20 - 20℃; for 3h; Inert atmosphere; | |
With sulfuryl dichloride; acetic acid at -40 - 35℃; for 4h; Inert atmosphere; |
Conditions | Yield |
---|---|
With tributylphosphine In dichloromethane at 20℃; for 4.5h; | 58% |
With tributylphosphine In dichloromethane at 20℃; for 4.5h; | 58% |
Diethyl disulfide
(+)-4(Z)-(4R,5S)-4-hydroxy-4-(5-hydroxy-3-methylpent-3-en-1-ynyl)-3,3,5-trimethylcyclohexanone
(4R,5S)-(3'Z)-4-(5'-(ethylthio)-3'-methylpent-3'-en-1'-ynyl)-4-hydroxy-3,3,5-trimethylcyclohexanone
Conditions | Yield |
---|---|
With tributylphosphine In dichloromethane at 20℃; for 6h; | 63% |
With tributylphosphine In dichloromethane at 20℃; for 6h; | 63% |
Diethyl disulfide
Conditions | Yield |
---|---|
Stage #1: 2-(3-thiomethylphenyl)-[1,3]dioxolane With n-butyllithium In tetrahydrofuran; hexane for 0.166667h; Stage #2: Diethyl disulfide In tetrahydrofuran; hexane at -78℃; for 1h; | 78% |
Diethyl disulfide
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 4h; | 81% |
Product Name: Diethyldisulfide (CAS NO.110-81-6)
Molecular Formula: C5H16NNaO3S2
Molecular Weight: 225.31g/mol
Mol File: 110-81-6.mol
Einecs: 205-710-6
Appearance: Clear colorless to light yellow liquid
Melting Point: 95-98.5 °C(lit.)
Boiling point: 154 °C at 760 mmHg
Storage Temperature: -20°C
Flash Point: 40 °C
Density: 0.993 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.506(lit.)
Surface Tension: 32.5 dyne/cm
Enthalpy of Vaporization: 37.58 kJ/mol
Vapour Pressure: 4.17 mmHg at 25°C
XLogP3-AA: 1.6
Product Categories: Sulfide Flavor
Diethyldisulfide (CAS NO.110-81-6) is the preparation method is the first release within the reactor sodium sulfide solution, according to sodium sulfide: sulfur = 1:1 (molar ratio) is expected to vote put sulfur powder, jacket temperature, in the stirring, when the temperature reached 80 ~ 95 °C when the Serve warm 1h disulfide disodium salt (Na2S2) solution, and then pumped into the alkylation reactor in disulfide disodium salt solution, start stirring until the reaction vessel to a vacuum (2 ~ 3.3) × 104Pa off valves start the chlorine into the ethane, the reaction temperature was controlled at 75 ~ 90 °C, pressure control (1.17 ~ 1.18) × 105Pa, feed ratio (mole ratio) disulfide disodium salt: ethyl = 1:2, Tung finished chloroethane, the will be expected to cool to below 50 °C will be expected to put it aside for the oil pumped to the water separator layer, the upper reservoir shall be finished.
1. | skn-rbt 500 mg/24H MLD | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,171. | ||
2. | eye-rbt 100 mg/24H MOD | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,171. | ||
3. | orl-rat LD50:2030 mg/kg | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,171. |
Reported in EPA TSCA Inventory.
Safety Information of Diethyldisulfide (CAS NO.110-81-6):
Hazard Codes: Xn,Xi
Risk Statements: 22-38-41-36/37/38-10
10: Flammable
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
41: Risk of serious damage to eyes
Safety Statements: 26-39-37/39-16-36
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
Diethyldisulfide ,its CAS NO. is 110-81-6,the synonyms is (C2h5s)2 ; 1-(Ethyldisulfanyl)ethane ; Diethyldisulfid ; Disulfide,diethyl ; Dlethyldisulfide ; Ethyldisulfanyl-ethane ; Ethyldisulphide ; Ethyldithioethan .
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