Ethyl succinyl chloride supplier

Name
Ethyl Succinyl Chloride
EINECS 238-855-9
CAS No. 14794-31-1
Article Data24
CAS DataBase
Density 1.179 g/cm³
Solubility 59.01g/L at 25℃
Melting Point
Formula C₆H₉ClO₃
Boiling Point 207.8 °C at 760 mmHg
Molecular Weight 164.589
Flash Point 84.4 °C
Transport Information UN 3265 8/PG 2
Appearance clear colourless to yellow liquid
Safety 26-27-36/37/39-45-24/25
Risk Codes 34-36/37-14
Molecular Structure
Hazard Symbols C
Synonyms Propionicacid, 3-(chloroformyl)-, ethyl ester (6CI,7CI,8CI);3-(Ethoxycarbonyl)propanoylchloride;3-Chlorocarbonylpropionic acid ethyl ester;4-Ethoxy-4-oxobutanoic acid chloride;Ethyl 3-chlorocarbonylpropionate;Ethyl 4-chloro-4-oxobutyrate;b-Ethoxycarbonylpropionyl chloride;
PSA 43.37000
LogP 1.09510

Synthetic route

: 1070-34-4
butanedioic acid, monoethyl ester

: 14794-31-1
ethyl 3-(chloroformyl)propionate

Conditions

Conditions	Yield
With thionyl chloride In dichloromethane Heating;	100%
With thionyl chloride for 1.5h; Heating;	97%
With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 38℃; for 5h; Inert atmosphere;	95%

: 108-30-5
succinic acid anhydride

: 64-17-5
ethanol

: 14794-31-1
ethyl 3-(chloroformyl)propionate

Conditions

Conditions	Yield
Stage #1: succinic acid anhydride; ethanol for 2h; Reflux; Stage #2: With thionyl chloride for 2h; Reflux;	82%
With thionyl chloride Yield given. Multistep reaction;

: 2459-05-4
(E)-4-ethoxy-4-oxobut-2-enoic acid

: 14794-31-1
ethyl 3-(chloroformyl)propionate

Conditions

Conditions	Yield
With thionyl chloride for 5h; Heating;	68%

sodium salt of succinic acid monoethyl ester: sodium salt of succinic acid monoethyl ester

: 14794-31-1
ethyl 3-(chloroformyl)propionate

Conditions

Conditions	Yield
With trichlorophosphate

: 123-25-1
succinic acid diethyl ester

: 14794-31-1
ethyl 3-(chloroformyl)propionate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 60 percent / KOH / ethanol / 16 h / 0 °C 2: 97 percent / SOCl2 / 1.5 h / Heating View Scheme

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 4192-77-2
ethyl cinnamate

: diethyl 4-oxo-3-phenylheptane-1,7-dioate

Conditions

Conditions	Yield
With magnesium In N,N-dimethyl-formamide at 20℃; for 15h;	100%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 69408-81-7
amonafide

: ethyl 4-N-[{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl}amino]-4-oxobutanoate

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 1h;	100%
In acetonitrile at 20℃; for 1h;	100%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 1402049-46-0
2,6-di-tert-butyl-4-{4-[3,5-di-tert-butyl-4-(4-hydroxybutoxy)phenylsulfanyl]piperidin-4-ylsulfanyl}phenol

: 1402049-48-2
4-[4-[3,5-di-tert-butyl-4-(4-hydroxybutoxy)phenylsulfanyl]-4-(3,5-di-tert-butyl-4-hydroxyphenyl-sulfanyl)piperidin-1-yl]-4-oxobutyric acid ethyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 0.25h;	100%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 18107-18-1
diazomethyl-trimethyl-silane

: 14594-25-3
ethyl 5-bromo-4-oxopentanoate

Conditions

Conditions	Yield
Stage #1: ethyl 3-(chloroformyl)propionate; diazomethyl-trimethyl-silane In diethyl ether; acetonitrile at 20℃; for 1h; Stage #2: With hydrogen bromide In diethyl ether; acetic acid; acetonitrile at -20 - 20℃; for 16.33h;	99%
Stage #1: ethyl 3-(chloroformyl)propionate; diazomethyl-trimethyl-silane In hexane; acetonitrile for 2h; Stage #2: With hydrogen bromide; acetic acid In hexane; acetonitrile for 1h;	64%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 77317-55-6
methyl 2-amino-5-iodobenzoate

: 884196-07-0
2-(3-ethoxycarbonyl-propionylamino)-5-iodo-benzoic acid methyl ester

Conditions

Conditions	Yield
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	99%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 101403-24-1
(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride

: 1403822-87-6
(S)-ethyl 4-((5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)-4-oxobutanoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3h;	99%

: 59484-42-3
4-hydroxy-2,5-diphenyl-1,3-thiazole

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 131786-91-9
2,5-diphenyl-4-<(ethyloxysuccinyl)oxy>thiazole

Conditions

Conditions	Yield
With dmap In dichloromethane at 23℃; for 2h;	97%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 22608-12-4, 24939-16-0, 33171-05-0
bisdemethoxycurcumin

: 4,4'-((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(1,4-phenylene) diethyl disuccinate

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃; for 2h; Inert atmosphere;	97%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 86302-43-4
(tert-Butoxycarbonylmethylene)triphenylphosphorane

: 123475-42-3
t-butyl 5-ethoxycarbonyl-3-oxo-2-(triphenylphosphoranylidine)-pentanoate

Conditions

Conditions	Yield
In benzene	96%
In benzene at 8 - 20℃; for 1.5h;	87%
In benzene 1.) 8 deg C, 5 min, 2.) r.t., 1.5 h;	87%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 20323-74-4
2-carboethoxy-4,5-dimethoxyaniline

: 380396-37-2
4,5-dimethoxy-2-[(4-ethoxy-1,4-dioxobutyl)amino]benzoic acid ethyl ester

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 20℃; for 2h;	96%
With pyridine In toluene at 20℃; for 4h;	70%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 22608-11-3, 24939-17-1, 33171-16-3
demethoxycurcumin

: 4-((1E,6E)-7-(4-(4-ethoxy-4-oxobutanoyloxy)-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl)phenyl ethyl succinate

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃; for 2h; Inert atmosphere;	96%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: C13H10BrNO

: C19H18BrNO4

Conditions

Conditions	Yield
In dichloromethane at 60℃; for 1h;	96%
With sodium hydroxide In dichloromethane at 60℃; for 1h;	96%

: 123-75-1
pyrrolidine

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: C10H17NO3

Conditions

Conditions	Yield
Stage #1: pyrrolidine With triethylamine In dichloromethane at 0℃; for 0.25h; Inert atmosphere; Stage #2: ethyl 3-(chloroformyl)propionate In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;	96%
With triethylamine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;	96%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 14691-88-4
4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl

A: 554-68-7
triethylamine hydrochloride

B: 82032-23-3
C15H27N2O4

Conditions

Conditions	Yield
With triethylamine In benzene 1.) 0 degC, 2.) R.T. 12 h;	A n/a B 95%

...Expand

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 458-37-7
curcumin

: 4,4'-((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene) diethyl disuccinate

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃; for 2h; Inert atmosphere;	95%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 38841-98-4
n-octylmagnesium chloride

: 59941-35-4
4-Oxododecansaeure-ethylester

Conditions

Conditions	Yield
With copper(l) iodide In tetrahydrofuran at 0 - 20℃;	95%
With copper(l) iodide In tetrahydrofuran at 0 - 20℃; for 3h; Inert atmosphere;

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 518-82-1
1,6,8-trihydroxy-3-methyl-9,10-anthraquinone

: 1,8-dihydroxy-6-methyl-9,10-anthraquinone-3-oxy ethyl succinate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 3h;	94.7%

: 61-54-1
tryptamine

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 1157-57-9
ethyl 4-{[2-(1H-Indol-3-yl)ethyl]amino}-4-oxobutanoate

Conditions

Conditions	Yield
Stage #1: ethyl 3-(chloroformyl)propionate With triethylamine In dichloromethane at 20℃; Stage #2: tryptamine In methanol; chloroform at 20℃;	94%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 146953-11-9
1,1-dimethylethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate

: 146953-12-0
ethyl -4-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-4-oxobutanoate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 2h; Ambient temperature;	93%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 14630-40-1
Bis(trimethylsilyl)ethyne

: 178760-79-7
4-Oxo-6-trimethylsilanyl-hex-5-ynoic acid ethyl ester

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane 1) 0 deg C, 15 min, 2) rt, 3 h;	93%
With aluminium trichloride In dichloromethane at 0 - 20℃; for 4h; Acylation;

: 52199-35-6
tetrakis-5,10,15,20-(o-aminophenyl)porphyrin

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: α-5,10,15,20-tetrakis{2-[3-(ethoxycarbonyl)propionylamido]phenyl}porphyrin

Conditions

Conditions	Yield
Acylation;	93%
With triethylamine In tetrahydrofuran at 0℃;	93%

: 188290-36-0
thiophene

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 59086-25-8
ethyl 4-oxo-4-(thiophen-2-yl)butanoate

Conditions

Conditions	Yield
With tin(IV) chloride In dichloromethane at 20℃; for 2h; Cooling;	93%
With tin(IV) chloride In dichloromethane at 20℃; Friedel-Crafts;	83%
With tin(IV) chloride In dichloromethane at 0 - 20℃; Friedel Crafts acylation;
With tin(IV) chloride at 20℃; Friedel-Crafts Acylation;

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: L-valylaminooctadecane

: N-(2-methyl-1-octadecylcarbamoyl-propyl)-succinamic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 12h;	93%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 5468-37-1
2-aminoacetophenone hydrochloride

: 133602-34-3
N-(3-Carbethoxypropanoyl)-ω-aminoacetophenone

Conditions

Conditions	Yield
In pyridine at 25℃; for 96h;	92%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 1'-(3-aza-spiro[5.5]undecane-9-carbonyl)-[4,4']bipiperidinyl-1-carboxylic acid benzyl ester

: 352348-32-4
1'-[3-(3-ethoxycarbonyl-propionyl)-3-aza-spiro[5.5]undecane-9-carbonyl]-[4,4']bipiperidinyl-1-carboxylic acid benzyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane	92%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: α-5,10,15-tris(2-aminophenyl)-α-20-[2-(acetylamido)phenyl]-porphyrin

: α-5,10,15-tris{2-[3-(ethoxycarbonyl)propionylamido]phenyl}-α-20-[2-(acetylamido)phenyl]-porphyrin

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃;	92%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 8-methoxy-2,3,4,4a,5,9b-hexahydro-1h-indeno[1,2-b]pyridine

: ethyl 4-(8-methoxy-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridin-1-yl)-4-oxobutanoate

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water at 0 - 20℃; for 2h;	92%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 38824-11-2
(2-aminophenyl)-(3-methoxyphenyl)methanone

: C20H21NO5

Conditions

Conditions	Yield
In dichloromethane at 60℃; for 1h;	92%
In dichloromethane at 60℃; for 1h;	92%

: 14794-31-1
ethyl 3-(chloroformyl)propionate

: 1885-32-1
2-amino-3-methylbenzamide

: 2-(1,4-dioxo-4-ethoxybutylamino)-3-methylbenzamide

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran for 16h;	92%
With pyridine In tetrahydrofuran for 16h;	92%

Ethyl succinyl chloride Chemical Properties

Molecular Structure of Butanoic acid, 4-chloro-4-oxo-, ethyl ester (CAS NO.14794-31-1):

IUPAC Name: ethyl 4-chloro-4-oxobutanoate
Empirical Formula: C₆H₉ClO₃
Molecular Weight: 164.5869
Sensitive: Moisture Sensitive
BRN: 1766126
EINECS: 238-855-9
H bond acceptors: 3
H bond donors: 0
Freely Rotating Bonds: 5
Polar Surface Area: 43.37Å²
Index of Refraction: 1.436
Molar Refractivity: 36.49 cm³
Molar Volume: 139.5 cm³
Surface Tension: 34.8 dyne/cm
Density: 1.179 g/cm³
Flash Point: 84.4 °C
Enthalpy of Vaporization: 44.41 kJ/mol
Boiling Point: 207.8 °C at 760 mmHg
Vapour Pressure: 0.22 mmHg at 25°C
InChI
InChI=1/C6H9ClO3/c1-2-10-6(9)4-3-5(7)8/h2-4H2,1H3
Smiles
O=C(OCC)CCC(Cl)=O

Ethyl succinyl chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 34-36/37-14
R34:Causes burns.
R36/37:Irritating to eyes and respiratory system.
R14 :Reacts violently with water.
Safety Statements: 26-27-36/37/39-45-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S24/25:Avoid contact with skin and eyes.
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
HazardClass: 8
PackingGroup: II

Ethyl succinyl chloride Specification

Butanoic acid, 4-chloro-4-oxo-, ethyl ester , with CAS number of 14794-31-1, can be called Ethyl 3-(chloroformyl)propionate ; 3-Carbethoxypropionyl chloride ; 3-Chlorocarbonylpropionic acid ethyl ester ; 4-Chloro-4-oxobutanoic acid ethylester ; 4-Ethoxy-4-oxobutanoic acid chloride ; Monoethylsuccinoyl chloride ; b-Ethoxycarbonylpropionyl chloride ; b-Carbethoxypropionyl chloride . It is a clear colourless to yellow liquid.

Product Name

Ethyl Succinyl Chloride

Synthetic route

Ethyl succinyl chloride Chemical Properties

Ethyl succinyl chloride Safety Profile

Ethyl succinyl chloride Specification

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