Ethyl trichloroacetate supplier

Name
Ethyl trichloroacetate
EINECS 208-212-7
CAS No. 515-84-4
Article Data50
CAS DataBase
Density 1.447 g/cm³
Solubility Immiscible with water
Melting Point 237 °C
Formula C₄H₅Cl₃O₂
Boiling Point 167.8 °C at 760 mmHg
Molecular Weight 191.441
Flash Point 65 °C
Transport Information
Appearance clear colorless liquid
Safety 26-37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms NSC 8829;Aceticacid, trichloro-, ethyl ester (6CI,8CI,9CI);
PSA 26.30000
LogP 1.91970

Synthetic route

: 64-17-5
ethanol

: 76-03-9
trichloroacetic acid

: 515-84-4
Ethyl trichloroacetate

Conditions

Conditions	Yield
With sulfuric acid for 7h; Reflux;	85%
With sodium hydrogen sulfate for 2h; Esterification; Heating;	84.5%
With phosphorus pentoxide; copper(II) sulfate; sodium sulfate for 2h; Heating;	41%

: 866-23-9
diethyl (trichloromethyl)phosphonate

: 76-03-9
trichloroacetic acid

: 515-84-4
Ethyl trichloroacetate

Conditions

Conditions	Yield
at 120℃; for 24h;	77%

: 75-07-0
acetaldehyde

: 1-ethoxyethyl trichloroethanoate

: 122-52-1
triethyl phosphite

A: 515-84-4
Ethyl trichloroacetate

B: 69054-05-3
diethyl 1-(1-ethoxyethyl)ethylphosphonate

Conditions

Conditions	Yield
	A n/a B 76%

...Expand

: 127-18-4
1,1,2,2-tetrachloroethylene

: 64-17-5
ethanol

: 141-78-6
ethyl acetate

A: 354-56-3
freon-111

B: 515-84-4
Ethyl trichloroacetate

Conditions

Conditions	Yield
With chlorine monofluoride 1.) Freon 113; 2.) 20 - 25 deg C, 30 min.; Yield given. Multistep reaction;	A 68% B n/a

...Expand

: 116-16-5
1,1,1,3,3,3-hexachloro-propan-2-one

: 64-17-5
ethanol

: 515-84-4
Ethyl trichloroacetate

Conditions

Conditions	Yield
With N,N-dimethyl-formamide at 55℃; for 9h; Product distribution; other times, other temperatures;	98 % Chromat.
With aluminum ethoxide
With N,N-dimethyl-formamide at 55℃; for 9h;	98 % Chromat.

: 100191-69-3
trichloro-acetic acid-(1-ethoxy-4,4,4-trichloro-3-oxo-but-1-enyl ester)

: 64-17-5
ethanol

A: 515-84-4
Ethyl trichloroacetate

B: 3702-98-5
ethyl 4,4,4-trichloroacetoacetate

...Expand

: 64-17-5
ethanol

: 97925-35-4
chlorocarbonic acid pentachloroethyl ester

A: 515-84-4
Ethyl trichloroacetate

B: 541-41-3
chloroformic acid ethyl ester

...Expand

: 64-17-5
ethanol

: 65785-42-4
trichloro-acetic acid pentachloroethyl ester

: 515-84-4
Ethyl trichloroacetate

: 75-07-0
acetaldehyde

: 75-87-6
chloral

: 515-84-4
Ethyl trichloroacetate

Conditions

Conditions	Yield
With diethyl ether; aluminum ethoxide
With diethyl ether; magnesium methanolate
With aluminium triisopentylate

: 64-19-7
acetic acid

: 515-84-4
Ethyl trichloroacetate

Conditions

Conditions	Yield
With chlorine; phosphorus trichloride im UV-Licht; Behandeln des Reaktionsprodukts mit Aethanol;

: 555-75-9
aluminum ethoxide

: 75-87-6
chloral

: 515-84-4
Ethyl trichloroacetate

Conditions

Conditions	Yield
With benzene

: 555-75-9
aluminum ethoxide

: 75-87-6
chloral

: 71-43-2
benzene

A: 515-84-4
Ethyl trichloroacetate

B: 13686-37-8
2,2,2-trichloroethyl trichloroacetate

...Expand

: 122-51-0
orthoformic acid triethyl ester

: 76-02-8
Trichloroacetyl chloride

: 515-84-4
Ethyl trichloroacetate

Conditions

Conditions	Yield
at 95 - 160℃;

: 122-51-0
orthoformic acid triethyl ester

: 76-02-8
Trichloroacetyl chloride

A: 75-00-3
chloroethane

B: 515-84-4
Ethyl trichloroacetate

C: 109-94-4
formic acid ethyl ester

Conditions

Conditions	Yield
at 160℃; reagiert analog mit anderen Carbonsaeure- und Sulfonsaeurechloriden;
at 95 - 160℃;

...Expand

: 64-17-5
ethanol

: 76-02-8
Trichloroacetyl chloride

: 515-84-4
Ethyl trichloroacetate

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 95-92-1
oxalic acid diethyl ester

: 515-84-4
Ethyl trichloroacetate

: 75-07-0
acetaldehyde

: 75-87-6
chloral

magnesium aluminium ethylate: magnesium aluminium ethylate

A: 515-84-4
Ethyl trichloroacetate

B: 13686-37-8
2,2,2-trichloroethyl trichloroacetate

C: 141-78-6
ethyl acetate

D <2.2.2-trichloro-ethyl>-acetate: <2.2.2-trichloro-ethyl>-acetate

Conditions

Conditions	Yield
Prod.5,6,7:2.2.2-Trichlor-aethylalkohol, 3-Hydroxy-1-acetoxy-butan, 4.4.4-Trichlor-3-hydroxy-1-acetoxy-butan;

...Expand

: 64-17-5
ethanol

trichlorolactic acid tetrachloroethylidene ester: trichlorolactic acid tetrachloroethylidene ester

A: ethyl 3,3,3-trichloro-2-hydroxypropanoate

B: 515-84-4
Ethyl trichloroacetate

...Expand

: 6135-29-1
trichloromethyl trichloroacetate

alcohol (little): alcohol (little)

A: 515-84-4
Ethyl trichloroacetate

B: 541-41-3
chloroformic acid ethyl ester

...Expand

: 6135-29-1
trichloromethyl trichloroacetate

alcohol (many): alcohol (many)

A: 515-84-4
Ethyl trichloroacetate

B carbonic acid ester: carbonic acid ester

Conditions

Conditions	Yield
in Waerme;

...Expand

: 64-17-5
ethanol

trichlorolactic acid tetrachloroethylidene ester: trichlorolactic acid tetrachloroethylidene ester

A: 515-84-4
Ethyl trichloroacetate

B trichlorolactic acid ethyl ester: trichlorolactic acid ethyl ester

...Expand

: 100-52-7
benzaldehyde

: 1-ethoxyethyl trichloroethanoate

: 122-52-1
triethyl phosphite

A: 515-84-4
Ethyl trichloroacetate

B: ethyl 1-(1-ethoxyethyl)benzylphosphonate

...Expand

: 1-ethoxyethyl dichloroethanoate

: 122-52-1
triethyl phosphite

A: 515-84-4
Ethyl trichloroacetate

B: 23081-52-9
diethyl 1-ethoxyethylphosphonate

Conditions

Conditions	Yield
at 50 - 80℃; for 4.5h; Title compound not separated from byproducts;

...Expand

: 75-87-6
chloral

: 7440-66-6
zinc

A: 869769-11-9
ethyl 2,2,4,4,4-pentachloro-3-hydroxybutyrate

B: 515-84-4
Ethyl trichloroacetate

...Expand

: 515-84-4
Ethyl trichloroacetate

: (4aR,5R)-5,9-Bis-(tert-butyl-dimethyl-silanyloxy)-2,3,4,4a,5,8-hexahydro-1H-benzocycloheptene

: (1S,3S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-2,2-dichloro-tricyclo[6.4.0.01,3]dodec-5-ene

Conditions

Conditions	Yield
With sodium methylate	99%

: 515-84-4
Ethyl trichloroacetate

: 108-98-5
thiophenol

: 7605-25-6
ethyl phenylsulfenylacetate

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran 1.) r.t., 10 min, 2.) r.t., 10 min;	98%

: 515-84-4
Ethyl trichloroacetate

: 768-56-9
4-Phenyl-1-butene

: 1393712-30-5
C14H17Cl3O2

Conditions

Conditions	Yield
With silicon carbide In chlorobenzene at 200℃; for 1h; Microwave irradiation; regioselective reaction;	98%

: 515-84-4
Ethyl trichloroacetate

: 19202-54-1
(Z)-1-methoxy-1,2-diphenylethene

: 133616-56-5
1,1-Dichloro-r-2-methoxy-2,3-c-diphenylcyclopropane

Conditions

Conditions	Yield
With sodium methylate In diethyl ether 1.) -15 deg C, 90 min, 2.) 4 deg C, overnight;	95%

: 515-84-4
Ethyl trichloroacetate

: 142-62-1
hexanoic acid

: 123-66-0
Ethyl hexanoate

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate at 90 - 150℃; for 2h;	95%

: 515-84-4
Ethyl trichloroacetate

: 2043-61-0
cyclohexanecarbaldehyde

: 1012043-68-3
ethyl (Z)-2-chloro-3-cyclohexylacrylate

Conditions

Conditions	Yield
With manganese for 5h; Inert atmosphere; Heating; stereoselective reaction;	95%
With Rieke-manganese In tetrahydrofuran for 5h; Inert atmosphere; Reflux; optical yield given as %de; stereoselective reaction;	95%
With manganese In tetrahydrofuran for 5h; Reflux; Inert atmosphere; stereoselective reaction;	95%

: 515-84-4
Ethyl trichloroacetate

: 498-66-8
norbornene

: C11H15Cl3O2

Conditions

Conditions	Yield
ruthenium(II) bis(triphenylphosphine) dichloride In 1,4-dioxane at 75℃; for 24h; Kharasch reaction;	94%

: 515-84-4
Ethyl trichloroacetate

: 144018-29-1
endo-10'-<(triisopropylsilyl)oxy>-anti-spiro2,5>undec-3'-ene>

: 144018-30-4
4',exo-5'-dichloro-endo-11'-<(triisopropylsilyl)oxy>-anti-spiro2,6>dodec-3'-ene>

Conditions

Conditions	Yield
With sodium methylate In hexane 1) 0 deg C to room temperature, 2) room temperature, 8 h;	93%

: 515-84-4
Ethyl trichloroacetate

: 121-44-8
triethylamine

: 5411-58-5
ethyl N,N-diethyloxamate

Conditions

Conditions	Yield
With heptamethyl Coβ-perchlorato-cob(II)yrinate; tetrabutylammonium perchlorate In acetonitrile at 20℃; for 3h; Electrolysis;	93%

: 515-84-4
Ethyl trichloroacetate

: 590-86-3
isovaleraldehyde

: 1012043-67-2
ethyl (Z)-2-chloro-5-methylhex-2-enoate

Conditions

Conditions	Yield
With manganese In tetrahydrofuran for 5h; Inert atmosphere; Heating; stereoselective reaction;	92%
With Rieke-manganese In tetrahydrofuran for 5h; Inert atmosphere; Reflux; optical yield given as %de; stereoselective reaction;	92%
With manganese In tetrahydrofuran for 5h; Reflux; Inert atmosphere; stereoselective reaction;	92%

: 515-84-4
Ethyl trichloroacetate

: 179234-15-2, 179466-22-9
(E)-(1aS,7aR,1'aR,7'aS)-3,6,3',6'-Tetramethoxy-1a,2,7,7a,1'a,2',7',7'a-octahydro-[1,1']bi[cyclopropa[b]naphthalenylidene]

: C27H28Cl2O4

Conditions

Conditions	Yield
With sodium methylate In benzene at 0 - 18℃; for 16h;	91%

: 515-84-4
Ethyl trichloroacetate

: 931-57-7
1-methoxy-cyclohex-1-ene

: (1α,6α)-7,7-dichloro-1-methoxy<4.1.0>heptane

Conditions

Conditions	Yield
With sodium methylate In pentane 0 deg C to 18 deg C, 16 h;	90%

: 515-84-4
Ethyl trichloroacetate

: 96-49-1
[1,3]-dioxolan-2-one

Conditions

Conditions	Yield
In potassium carbonate; ethylene glycol	90%
With dmap In ethylene glycol

: 497-25-6
dimethylenecyclourethane

: 515-84-4
Ethyl trichloroacetate

: 3206-30-2
3-Carboethoxy-2-Oxazolidinone

Conditions

Conditions	Yield
With dmap	89%

: 622-97-9
1-ethenyl-4-methylbenzene

: 515-84-4
Ethyl trichloroacetate

: 57196-89-1
2,2,4-trichloro-4-phenyl-butyric acid ethyl ester

Conditions

Conditions	Yield
With PS-PEG-PPh2-CP*RuCl2 In water at 60℃; for 9h; Kharasch reaction; Inert atmosphere;	89%

: 124-13-0
Octanal

: 515-84-4
Ethyl trichloroacetate

: 1059581-48-4
ethyl (Z)-2-chlorodec-2-enoate

Conditions

Conditions	Yield
With Rieke-manganese In tetrahydrofuran for 5h; Inert atmosphere; Reflux; optical yield given as %de; stereoselective reaction;	89%
With manganese In tetrahydrofuran for 5h; Reflux; Inert atmosphere; stereoselective reaction;	89%

: 515-84-4
Ethyl trichloroacetate

: 1-((1,1-dimethylethyl)dimethylsilyloxy)-1,3-cyclohexadiene

: ethyl 2,2-dichloro-2-(4-oxocyclohex-2-en-1-yl)acetate

Conditions

Conditions	Yield
With N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper(II) bis(trifluoromethanesulfonate); sodium hydrogencarbonate In 1,2-dichloro-ethane at 80℃; for 18h; Inert atmosphere; Sealed tube; regioselective reaction;	89%

: 515-84-4
Ethyl trichloroacetate

: 68243-21-0
(3,4-dihydronaphthalen-1-yl)(phenyl)sulfane

: 126745-21-9
1,1-dichloro-1a,2,3,7b-tetrahydro-7b-(phenylthio)-1H-cyclopropanaphthalene

Conditions

Conditions	Yield
	88%

: 515-84-4
Ethyl trichloroacetate

: 124355-82-4
2,6,6-trimethyl-1-((trimethylsilyl)oxy)cycloheptene

: 124355-98-2
8,8-dichloro-3,3,7-trimethyl-1-((trimethylsilyl)oxy)bicyclo<5.1.0>octane

Conditions

Conditions	Yield
With sodium methylate In pentane 1) 0 deg C, 6h, 2) RT, 15h;	88%

: 515-84-4
Ethyl trichloroacetate

: 119294-45-0
N-(indolyl-3-imidoyl)guanidine

: 169788-30-1
2-amino-4-(indolyl-3)-6-trichloromethyl-sym-triazine

Conditions

Conditions	Yield
In ethanol Heating;	88%

: 515-84-4
Ethyl trichloroacetate

: 41795-26-0
benzoic acid hex-5-enyl ester

: 1393712-20-3
C17H21Cl3O4

Conditions

Conditions	Yield
With silicon carbide In chlorobenzene at 200℃; for 1h; Microwave irradiation; regioselective reaction;	88%

: 515-84-4
Ethyl trichloroacetate

: 14425-92-4
6β-methoxy-3α,5-cyclo-5α-androstan-17-one

: 81477-80-7
ethyl 6β-methoxy-20ξ-chloro-17(20)-i-pregnen-21-oate

Conditions

Conditions	Yield
With diethylaluminium chloride; zinc In tetrahydrofuran; hexane at 0℃; for 2h;	87%

: 112-45-8
10-Undecenal

: 515-84-4
Ethyl trichloroacetate

: 1059581-55-3
ethyl (Z)-2-chlorotrideca-2,12-dienoate

Conditions

Conditions	Yield
With Rieke-manganese In tetrahydrofuran for 5h; Inert atmosphere; Reflux; optical yield given as %de; stereoselective reaction;	87%
With manganese In tetrahydrofuran for 5h; Reflux; Inert atmosphere; stereoselective reaction;	87%

: 292638-84-7
styrene

: 515-84-4
Ethyl trichloroacetate

: 57196-89-1
2,2,4-trichloro-4-phenyl-butyric acid ethyl ester

Conditions

Conditions	Yield
With (η5-1-t-Bu-2-PhC≡C-(1,2-azaboronyl))RuCl(PPh3)2 In toluene at 85℃; for 5h; Schlenk technique; Inert atmosphere; Glovebox;	85%
With 2,2'-azobis(isobutyronitrile); Cp*Ru(PPh3)2Cl In (2)H8-toluene at 60℃; for 1.5h; Inert atmosphere;	61%
ruthenium(II) bis(triphenylphosphine) dichloride In benzene at 75℃; for 24h; Kharasch reaction;	60%

: 515-84-4
Ethyl trichloroacetate

: 536-74-3
phenylacetylene

: 66725-82-4
1,1,1-trichloro-4-phenyl-3-butyn-2-one

Conditions

Conditions	Yield
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: Ethyl trichloroacetate With boron trifluoride diethyl etherate In tetrahydrofuran; hexane at 20℃; for 2h; Further stages.;	85%
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 3h; Inert atmosphere; Stage #2: Ethyl trichloroacetate With boron trifluoride diethyl etherate In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere;	83%
(i) nBuLi, (ii) /BRN= 1761567/; Multistep reaction;

: 515-84-4
Ethyl trichloroacetate

: C28H52O2Si2

: C23H37ClO2Si

Conditions

Conditions	Yield
With sodium methylate	85%

: 515-84-4
Ethyl trichloroacetate

: 19637-35-5
3-tetrahydropyran-2-yloxy-androst-5-en-17-one

: 81477-79-4
ethyl 20ξ-chloro-3β-(tetrahydropyranyloxy)-5,17(20)-pregnadien-21-oate

Conditions

Conditions	Yield
With diethylaluminium chloride; zinc In tetrahydrofuran; hexane at 0℃; for 2h;	85%

: 515-84-4
Ethyl trichloroacetate

: 74-86-2
acetylene

: 1,1,1-trichloro-but-3-yn-2-one

Conditions

Conditions	Yield
Stage #1: acetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: Ethyl trichloroacetate With boron trifluoride diethyl etherate In tetrahydrofuran; hexane at 20℃; for 2h; Further stages.;	85%

: 109-80-8
1.3-propanedithiol

: 515-84-4
Ethyl trichloroacetate

: 20462-00-4
ethyl 1,3-dithiane-2-carboxylate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h;	85%

Ethyl trichloroacetate Chemical Properties

The Molecular formula of Ethyl trichloroacetate(515-84-4):C₄H₅C_l3O₂
The Molecular Weight of Ethyl trichloroacetate(515-84-4):191.44
The Molecular Structure of Ethyl trichloroacetate(515-84-4) is:
Density: 1.447 g/cm³
melting point: 57 - 58 ^°C
Boiling point: 167.8 ^°C
Flash point:65 ^°C
Solubility in water:440 mg/l (Immiscible with alcohols, ethers and ketones)
Index of Refraction: 1.469
Molar Refractivity:36.86 cm³
Polarizability: 14.61 10^-24cm³
Surface Tension: 37.1 dyne/cm
Enthalpy of Vaporization: 40.42 kJ/mol
Vapour Pressure:1.67 mmHg at 25^°C
Appearance:Colourless liquid
IUPAC Name:ethyl 2,2,2-trichloroacetate
Synonyms:ETHYL TRICHLOROACETATE;TRICHLOROACETATE ETHYL ESTER;ethyltrichloracetate;TRICHLOROACETIC ACID ETHYL ESTER;Acetic acid, 2,2,2-trichloroethyl ester;Acetic acid, ester with trichloroethanol;ethanoicacid,trichloro-,ethylester;trichloro-aceticaciethylester

Ethyl trichloroacetate Uses

It's used in organic synthesis.And it's used as a spice in boiling point solvent and raw materials.Meantime,it's also used as pharmaceutical raw materials.

Ethyl trichloroacetate Production

It is made of trichloroacetic acid obtained by esterification of ethanol. The trichloroacetic acid, ethanol and sulfuric acid heated with reflux 6h. Pour in the water after cooling separate the ester layer, with 5-10% sodium carbonate solution and then water washing, add anhydrous calcium chloride drying overnight. After filtration or distillation was finished. Yield of 75%.

Ethyl trichloroacetate Toxicity Data With Reference

RTECS#: CAS# 515-84-4: None listed
LD50/LC50: RTECS: Not available.
Carcinogenicity: ETHYL TRICHLOROACETATE - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.

Ethyl trichloroacetate Safety Profile

Hazard Codes :Xn,Xi
Xn:Harmful
Xi:Irritant
Risk Statements :
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements:
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
RIDADR:2810
WGK Germany: 1

Ethyl trichloroacetate Specification

Chemical Stability: Ethyl trichloroacetate(515-84-4) is stable under normal temperatures and pressures.
Conditions to Avoid: Not available
Incompatibilities with Other Materials Strong oxidizing agents, strong bases.
Hazardous Decomposition Products Not available.
Hazardous Polymerization Has not been reported.

Product Name

Ethyl trichloroacetate

Synthetic route

Ethyl trichloroacetate Chemical Properties

Ethyl trichloroacetate Uses

Ethyl trichloroacetate Production

Ethyl trichloroacetate Toxicity Data With Reference

Ethyl trichloroacetate Safety Profile

Ethyl trichloroacetate Specification

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