Conditions | Yield |
---|---|
With 1,1′-(pyridine-2,6-diylbis(methylene))bis(3-butylimidazolium) dibromide; carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); potassium tert-butylate; hydrogen In 1,4-dioxane at 130℃; under 37503.8 Torr; for 12h; Catalytic behavior; Reagent/catalyst; Temperature; Pressure; Autoclave; | A 39% B 100% |
With hydrogen In 1,4-dioxane at 250℃; under 30003 Torr; for 4h; Temperature; Solvent; Reagent/catalyst; Flow reactor; | A 93% B 99% |
With C24H38Cl2N3PRu; hydrogen; sodium methylate In tetrahydrofuran at 25℃; under 38002.6 Torr; for 16h; Autoclave; | A 99 %Chromat. B 95% |
[1,3]-dioxolan-2-one
methanol
A
ethylene glycol
B
carbonic acid dimethyl ester
Conditions | Yield |
---|---|
anion exchanging resin at 80.4 - 98℃; for 6h; Product distribution / selectivity; | A 99% B 99.7% |
potassium hydroxide In water at 98℃; under 838.584 Torr; for 500 - 6000h; Product distribution / selectivity; Heating / reflux; | A n/a B 99.88% |
potassium hydroxide at 98 - 130℃; under 784.578 - 838.584 Torr; for 500 - 6000h; Product distribution / selectivity; Heating / reflux; | A n/a B 99.99% |
[1,3]-dioxolan-2-one
methanol
A
ethylene glycol
B
carbonic acid dimethyl ester
C
diethylene glycol
Conditions | Yield |
---|---|
potassium hydroxide at 63.8 - 98℃; for 6.7h; Product distribution / selectivity; | A 99.1% B 99.8% C n/a |
sodium hydroxide at 49.8 - 56.2℃; under 342.034 Torr; Product distribution / selectivity; Industry scale; | A 91.3% B 91.3% C n/a |
potassium hydroxide at 47 - 56℃; under 228.023 - 342.034 Torr; Product distribution / selectivity; Industry scale; | A 90.5% B 90.5% C n/a |
at 55.9 - 56℃; under 342.034 Torr; Product distribution / selectivity; Industry scale; | A 38.9% B 38.9% C n/a |
Conditions | Yield |
---|---|
With hydrogenchloride; [RuCl2(CO)2(Ph2P-3-C6H4COOH)2] In methanol; water at 75℃; for 0.333333h; | A 99.1% B n/a C n/a |
Conditions | Yield |
---|---|
With C19H21N2(1+)*CHO2(1-); water at 110℃; under 15001.5 Torr; for 0.5h; Reagent/catalyst; Temperature; Autoclave; Inert atmosphere; | 99% |
With water at 98℃; under 9000.9 Torr; Reagent/catalyst; | 95% |
With water at 94℃; Kinetics; Concentration; Temperature; Autoclave; | 87.2% |
Conditions | Yield |
---|---|
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); potassium tert-butylate; hydrogen In tetrahydrofuran at 140℃; under 38002.6 Torr; for 0.5h; Time; Pressure; Autoclave; | 99% |
In water at 250℃; for 2h; Temperature; Sealed tube; Inert atmosphere; | 99% |
With potassium tert-butylate; hydrogen; C16H18BrCoINO2 In dibutyl ether at 160℃; under 45004.5 Torr; for 20h; Sealed tube; Autoclave; | 92% |
ethylene glycol
Conditions | Yield |
---|---|
With methanol; bromine for 0.5h; Heating; | 99% |
Conditions | Yield |
---|---|
With water under 76.0051 - 760.051 Torr; Reflux; | 99% |
With water; silica gel In neat (no solvent) at 150℃; under 1147.61 Torr; for 24h; Autoclave; | 10% |
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In water at 160℃; under 103430 Torr; for 4h; | 98.3% |
Conditions | Yield |
---|---|
With cerium(III) chloride; sodium iodide In acetonitrile for 2h; tosylate cleavage; Heating; | 98% |
Conditions | Yield |
---|---|
With hydrogen In methanol at 179.84℃; under 18751.9 Torr; | 98% |
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 100℃; under 38002.6 Torr; for 2h; Autoclave; | 97% |
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 100℃; under 37503.8 Torr; for 2h; | 97% |
A
disodium terephthalate
B
ethylene glycol
Conditions | Yield |
---|---|
With sodium hydroxide In octanol at 183℃; for 0.0833333h; Product distribution / selectivity; | A 98% B n/a |
With sodium hydroxide In hexan-1-ol at 147℃; for 0.25h; Product distribution / selectivity; |
glycolaldehyde dimer
ethylene glycol
Conditions | Yield |
---|---|
With 5% active carbon-supported ruthenium; water; hydrogen at 60℃; under 22502.3 Torr; for 3h; Autoclave; | 98% |
With 5% active carbon-supported ruthenium; hydrogen In water at 80℃; under 67506.8 Torr; for 3h; Temperature; Pressure; Autoclave; | 98% |
Conditions | Yield |
---|---|
With tributylphosphine; carbon monoxide; hydrogen; acetylacetonatodicarbonylrhodium(l) In various solvent(s) at 80℃; under 73505.8 Torr; for 1h; Product distribution; other solvent (DMI); other reactn. time; other catalysts; | 97% |
With hydrogen; nickel In water at 40℃; under 37503.8 Torr; for 15h; | 90% |
durch Einw.gaerender Hefe; |
Conditions | Yield |
---|---|
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 100℃; under 38002.6 Torr; for 2h; Autoclave; | 97% |
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 100℃; under 37503.8 Torr; for 2h; | 97% |
With sodium tetrahydroborate In diethylene glycol dimethyl ether at 32 - 35℃; for 2h; | 89% |
Conditions | Yield |
---|---|
Stage #1: polyethylene terephthalate With sodium hydroxide In propan-1-ol at 89℃; for 0.25h; Stage #2: With hydrogenchloride In propan-1-ol; water Product distribution / selectivity; | A 96% B n/a |
Conditions | Yield |
---|---|
mercury Irradiation; | 95% |
In water for 200h; Solvent; Reagent/catalyst; Wavelength; Inert atmosphere; Irradiation; Green chemistry; | 55% |
With mercury Heating; Irradiation; | 97 % Chromat. |
Conditions | Yield |
---|---|
With sodium hydrogen sulfate; silica gel In dichloromethane; isopropyl alcohol at 20℃; for 2h; | 95% |
Conditions | Yield |
---|---|
In isopropyl alcohol at 180℃; under 3750.38 Torr; for 24h; Inert atmosphere; Autoclave; | A 94% B 6% |
With water; hydrogen; alumina, 27%; copper, 5%; copper oxide, 64%; lanthanum oxide, 5%; mixture of In methanol at 297℃; under 37503.8 Torr; Product distribution / selectivity; | A 86.2% B 8.8% |
With Ru-Cu/TMG-BEN at 230℃; under 60006 Torr; for 18h; Autoclave; | A 85% B n/a |
Conditions | Yield |
---|---|
With water; copper(II) oxide; zinc at 250℃; for 2.5h; Reagent/catalyst; Inert atmosphere; Autoclave; | 94% |
With [RuH(CO)(BPy-tPNN*)]; hydrogen In tetrahydrofuran at 110℃; under 7600.51 Torr; for 48h; Inert atmosphere; | 93 %Chromat. |
methanol
(2-hydroxyethyl) methyl carbonate
A
ethylene glycol
B
carbonic acid dimethyl ester
Conditions | Yield |
---|---|
With film supported Penicillium expansum at 60℃; for 48h; Reagent/catalyst; Concentration; Temperature; Time; Enzymatic reaction; | A 93% B 93% |
Conditions | Yield |
---|---|
With C24H38Cl2N3PRu; hydrogen; sodium methylate In tetrahydrofuran at 25℃; under 37503.8 Torr; for 16h; | 93% |
Conditions | Yield |
---|---|
With hydrogen In water at 119.84℃; under 7500.75 - 60006 Torr; for 2h; Catalytic behavior; Reagent/catalyst; Autoclave; Sealed tube; | 92% |
With ruthenium(IV) oxide; water at 150℃; under 478080 - 570018 Torr; Hydrogenation; | |
With water; pyrographite; ruthenium at 150℃; under 478080 - 570018 Torr; Hydrogenation; | |
With hydrogen; toluene-4-sulfonic acid; tris(2,4-pentanedionato)ruthenium(III); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In methanol at 200℃; under 12751.3 - 103510 Torr; for 3h; Product distribution / selectivity; | |
With hydrogen; toluene-4-sulfonic acid; tris(2,4-pentanedionato)ruthenium(III); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In ethylene glycol at 200℃; under 12751.3 - 103510 Torr; for 3h; Product distribution / selectivity; |
Dimethyl oxalate
methanol
A
glycolic acid methyl ester
B
ethylene glycol
Conditions | Yield |
---|---|
With hydrogen at 199.84℃; under 22502.3 Torr; Reagent/catalyst; | A 90.6% B n/a |
oxirane
[1,3]-dioxolan-2-one
aniline
A
N-phenyl-2-oxazolidinone
B
ethylene glycol
Conditions | Yield |
---|---|
With 1-n-butyl-3-methylimidazolim bromide; 3-butyl-1-methylimidazolium acetate at 140℃; for 9h; | A 90% B 90% |
Conditions | Yield |
---|---|
Stage #1: alpha-D-glucopyranose In water Pyrolysis; Stage #2: With 5% active carbon-supported ruthenium; hydrogen at 80℃; under 67506.8 Torr; for 6h; Pressure; Autoclave; | 88.8% |
With 1% Ru/SiO2; hydrogen In water at 195℃; under 22502.3 - 63756.4 Torr; Inert atmosphere; |
methanol
methylbutane
A
3,3,4,4-Tetramethylhexan
B
2,3-dimethylbutanol
C
2,2-Dimethyl-1-butanol
D
ethylene glycol
Conditions | Yield |
---|---|
With mercury for 17h; Product distribution; Mechanism; Heating; Irradiation; other alkanes; selectivity of cross-dimerization, relative reactivities in cross-dimerizations; | A n/a B 11% C 88% D n/a |
With mercury for 17h; Heating; Irradiation; | A n/a B 11% C 88% D n/a |
Conditions | Yield |
---|---|
With C32H32Cl2N2P2Ru; hydrogen; sodium methylate In para-xylene; toluene at 5 - 100℃; under 37503.8 Torr; for 4h; Reagent/catalyst; Glovebox; | A 86% B 13% |
With hydrogen In methanol at 219.84℃; under 18751.9 Torr; Autoclave; | A 76% B n/a |
With hydrogen In methanol at 219.84℃; under 18751.9 Torr; Autoclave; | A 31% B n/a |
Conditions | Yield |
---|---|
With potassium carbonate In methanol at 169.84℃; for 1h; Temperature; Reagent/catalyst; Autoclave; | A n/a B 86% |
With polystyrene resin bound methylimidazole hydroxyl ionic liquid catalyst In methanol at 80℃; for 8h; Catalytic behavior; Temperature; Ionic liquid; | |
With 2,6-di(isopropyl)pyridine In methanol at 90℃; under 760.051 Torr; for 10h; Temperature; Reagent/catalyst; Solvent; Inert atmosphere; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 3h; Heating; | 100% |
With sodium hydrogen sulfate; silica gel for 0.1h; Etherification; Acetalization; microwave irradiation; | 84% |
With toluene-4-sulfonic acid at 120℃; for 0.5h; | 59% |
Conditions | Yield |
---|---|
With zeolite HSZ-360 In toluene for 3h; Heating; | 100% |
With [Al(H2O)6][MS]3 In cyclohexane for 0.833333h; Reagent/catalyst; Dean-Stark; Reflux; | 100% |
With AgOTf and (3-(3,5-bis(diphenylphosphino)phenyl)-pyridine) In toluene for 12h; Reflux; | 99% |
Conditions | Yield |
---|---|
With H-Y zeolite at 60℃; for 2h; | 100% |
With sodium hydroxide for 0.0194444h; microwave irradiation; | 99% |
With SiO2-supported Co(II) Salen complex catalyst at 50℃; for 0.833333h; | 99% |
para-bromoacetophenone
ethylene glycol
2-(4-bromophenyl)-2-methyl-1,3-dioxolane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 39h; Heating; | 100% |
With p-toluenesulfonic acid monohydrate In benzene for 50h; Inert atmosphere; Reflux; Dean-Stark; | 100% |
With toluene-4-sulfonic acid In toluene at 160℃; for 16h; Dean-Stark; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene at 143℃; for 2h; Dean-Stark; | 100% |
With cyclohexane at 105℃; for 1h; Dean-Stark; | 100% |
With p-toluenesulfonic acid monohydrate In toluene for 4h; Reflux; | 100% |
Conditions | Yield |
---|---|
aluminum oxide In tetrachloromethane for 24h; Heating; other catalyst: SiO2; | 100% |
With monoaluminum phosphate In acetonitrile for 1.7h; Heating; | 100% |
With monoaluminum phosphate In acetonitrile for 1.7h; Product distribution; Heating; reaction rate; other aldehydes, other heterogeneous catalysts system, var. reaction time, solvent and amount of reagents; | 100% |
4-oxopimelate
ethylene glycol
ethyl 3-<2-<2-(ethoxycarbonyl)ethyl><1,3>dioxolan-2-yl>propionate
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In toluene for 2h; Reflux; | 100% |
With pyridinium p-toluenesulfonate In toluene for 15h; Inert atmosphere; Reflux; | 99% |
With pyridinium p-toluenesulfonate In toluene for 22h; Reflux; Dean-Stark; | 90% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 24h; Reflux; | 100% |
With toluene-4-sulfonic acid In toluene Reflux; Dean-Stark; | 47% |
With sulfuric acid; sodium sulfate |
bromo-5-pentanone-2
ethylene glycol
ethylene-cetal de la bromo-5 pentanone-2
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid; orthoformic acid triethyl ester at 20℃; for 25h; | 100% |
With toluene-4-sulfonic acid; orthoformic acid triethyl ester | 98% |
With toluene-4-sulfonic acid In benzene for 5h; Heating; | 96% |
(E)-3-phenylacrylic acid
ethylene glycol
2-hydroxyethyl 3-(phenyl)-2-propenoate
Conditions | Yield |
---|---|
With sulfuric acid In toluene Heating; | 100% |
at 210℃; |
dehydroepiandrosterone
ethylene glycol
3β-hydroxy-17,17-ethylenedioxo-5-androstene
Conditions | Yield |
---|---|
With camphor-10-sulfonic acid In toluene at 111℃; | 100% |
With toluene-4-sulfonic acid In benzene for 4.5h; Heating; | 99% |
With camphor-10-sulfonic acid In cyclohexane for 20h; Reflux; | 99% |
isopregnanolone
ethylene glycol
(3β,5α)-3-hydroxypregnan-20-one 1,2-ethanediyl acetal
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid; trimethyl orthoformate In dichloromethane at 20℃; | 100% |
With toluene-4-sulfonic acid; trimethyl orthoformate In dichloromethane at 20℃; | 95% |
With toluene-4-sulfonic acid In toluene for 12h; Reflux; Dean-Stark; | 74% |
With toluene-4-sulfonic acid; benzene |
Conditions | Yield |
---|---|
zirconium(IV) oxide at 180℃; for 2h; in autoclave; | 100% |
With 1-(3-sulfonic acid)propylimidazole bisulfate ([Ps-im]HSO4) supported silica In cyclohexane at 150℃; under 760.051 Torr; for 5h; Pressure; Temperature; Time; | 99.61% |
With sulfonated charcoal In benzene for 5h; Heating; | 95% |
Conditions | Yield |
---|---|
distannoxane 1a In benzene for 0.5h; Mechanism; Product distribution; Heating; other distannoxane catalysts, other aldehydes, other alcohol, other solvents, other reaction times; | 100% |
With 9.0 wt% H4[SiW12O40] on SiO2 In neat (no solvent) at 60℃; for 6h; Reagent/catalyst; chemoselective reaction; | 99% |
With Kaolinitic clay In benzene for 2h; Heating; | 90% |
ethylene glycol
4-bromo-benzaldehyde
p-bromobenzaldehyde 1,3-dioxolane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene at 100 - 110℃; for 5h; | 100% |
With toluene-4-sulfonic acid In toluene at 110℃; for 12h; | 100% |
With toluene-4-sulfonic acid In toluene Reflux; | 98% |
Conditions | Yield |
---|---|
With dichloro(2-chlorovinyl)arsine | 100% |
With arsenic trichloride In tetrachloromethane at 15 - 20℃; for 1h; | 57% |
With pyridine; diethyl ether; arsenic trichloride |
ethylene glycol
1,2-bis(1,3,2-dioxaarsolan-2-yloxy)ethane
Conditions | Yield |
---|---|
With arsenous acid triisobutyl ester | 100% |
With arsenic trichloride at 40 - 70℃; | 66% |
With arsenic(III) trioxide at 140℃; |
Conditions | Yield |
---|---|
With triphenylphosphine; ruthenium trichloride at 120℃; for 2h; | 100% |
5-bromo-2-thiophencarboxaldehyde
ethylene glycol
2-(5-bromothiophen-2-yl)-1,3-dioxolane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 2h; Heating; | 100% |
With toluene-4-sulfonic acid In toluene for 0.15h; Reflux; Dean-Stark; | 98% |
With toluene-4-sulfonic acid In toluene for 15h; Reflux; Dean-Stark; | 98% |
2-(4-bromo-3-oxobutyl)isoindoline-1,3-dione
ethylene glycol
2-[2-(2-Bromomethyl-[1,3]dioxolan-2-yl)-ethyl]-isoindole-1,3-dione
Conditions | Yield |
---|---|
With sulfuric acid In benzene for 5h; Heating; | 100% |
6-bromo-3,4-methylenedioxybenzaldehyde
ethylene glycol
5-bromo-6-(1,3-dioxolan-2-yl)benzo[d][1,3]dioxolane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene Heating; | 100% |
With toluene-4-sulfonic acid In benzene at 0 - 90℃; for 5h; Dean-Stark; | 98% |
Stage #1: 6-bromo-3,4-methylenedioxybenzaldehyde; ethylene glycol With toluene-4-sulfonic acid In toluene for 24h; Inert atmosphere; Reflux; Stage #2: With potassium carbonate In toluene for 0.5h; Inert atmosphere; | 96% |
Conditions | Yield |
---|---|
With dimethyltin dichloride; potassium carbonate In tetrahydrofuran for 12h; Ambient temperature; | 100% |
With dimethyltin dichloride; potassium carbonate In tetrahydrofuran at 20℃; Acylation; | 99% |
With pyridine In dichloromethane at 0 - 20℃; for 25h; Inert atmosphere; | 86% |
2-chloro-3-quinoline carboxaldehyde
ethylene glycol
2-chloro-3-[1,3-dioxolan-2-yl]-quinoline
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 4h; Heating; | 100% |
With molecular sieve; toluene-4-sulfonic acid In toluene Heating; | 92% |
With toluene-4-sulfonic acid In benzene at 120℃; for 4h; | 75% |
1-methoxycarbonyl-4-(3-oxo-1-butyl)indole
ethylene glycol
4-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethyl]-indole-1-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 1h; Heating; | 100% |
5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol
ethylene glycol
C20H25NO5
Conditions | Yield |
---|---|
methanesulfonic acid In tetrahydrofuran at 25℃; for 1h; | 100% |
With methanesulfonic acid In chloroform; 1-Propyl acetate at 5 - 10℃; for 0.666667h; |
Hexafluorobenzene
ethylene glycol
ethyleneglycol bispentafluorophenyl ether
Conditions | Yield |
---|---|
With sodium amide In ammonia at -40 - -33℃; for 6h; Product distribution; Mechanism; var. ratio of regents; var. substituted benzenes and nucleophilic reagents; | 100% |
With sodium amide 1.) liquid ammonia, 2.) from -40 to 33 deg C, 6 h; Yield given. Multistep reaction; |
2,2-dimethyl-4-pentenal
ethylene glycol
4,4-dimethyl-5,5-(ethylenedioxy)-1-pentene
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene Heating; | 100% |
toluene-4-sulfonic acid In benzene for 0.666667h; Heating; | 95% |
With toluene-4-sulfonic acid | 95% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene at 80℃; for 2h; | 100% |
aluminum oxide In tetrachloromethane for 24h; Heating; | 97% |
With toluene-4-sulfonic acid In water; benzene | 95% |
With toluene-4-sulfonic acid In benzene Heating; | 90% |
With toluene-4-sulfonic acid In water; benzene for 8h; Inert atmosphere; Reflux; | 90% |
(E)-Ethyl 3-methyl-4-oxo-2-pentenoate
ethylene glycol
(E)-ethyl 3-(2-methyl-1,3-dioxolan-2-yl)-but-2-enoate
Conditions | Yield |
---|---|
With pyridinium p-toluenesulfonate In benzene for 60h; Heating; | 100% |
With toluene-4-sulfonic acid; trimethyl orthoformate In dichloromethane at 20℃; for 12h; Inert atmosphere; |
(4-bromophenyl)(phenyl)methanone
ethylene glycol
2-(4-bromophenyl)-2-phenyl-1,3-dioxolane
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene for 48h; acetalisation; Heating; | 100% |
With toluene-4-sulfonic acid In benzene at 160℃; for 40h; Inert atmosphere; | 94% |
With toluene-4-sulfonic acid In benzene for 44h; Heating; | 92% |
Ethylene glycol, also known as ethylene glycol, is clear, colorless, syrupy, liquid with sweet taste. It is used as an antifreeze in cooling and heating systems. In organic synthesis, it is used as a protecting group for carbonyl groups. Ethylene glycol is miscible with water, ethanol, acetone, acetic acid, glycerol, pyridine, but difficultly soluble in chloroform, ether, benzene, carbon disulfide, and insoluble in hydrocarbons, chlorinated hydrocarbons, oils, rubber, natural resin. It also can dissolve table salt, zinc chloride, potassium carbonate, potassium chloride, potassium iodide, potassium hydroxide and other inorganic compounds.
Physical properties about Ethylene glycol are: (1)ACD/LogP: -1.688; (2)# of Rule of 5 Violations:0; (3)ACD/LogD (pH 5.5): -1.69; (4)ACD/LogD (pH 7.4): -1.69; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 2.87; (8)ACD/KOC (pH 7.4): 2.87; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.422; (13)Molar Refractivity: 14.384 cm3; (14)Molar Volume: 56.561 cm3; (15)Polarizability: 5.702 10-24cm3; (16)Surface Tension: 43.4129981994629 dyne/cm; (17)Density: 1.097 g/cm3; (18)Flash Point: 108.171 °C; (19)Enthalpy of Vaporization: 50.468 kJ/mol; (20)Boiling Point: 197.539 °C at 760 mmHg ; (21)Vapour Pressure: 0.096000000834465 mmHg at 25°C
Preparation of Ethylene glycol: In industrial, Ethylene glycol can be produced by chlorohydrin method, oxirane hydration and direct ethylene hydration.
1. Chlorohydrin method: Use chlorohydrin as raw material which hydrolyzes in the alkaline medium at 100 °C. It can generate oxirane first, and then hydrolyze to produce Ethylene glycol at pressure of 1.01 MPa.
2. Oxirane hydration: This method has catalytic hydration and direct hydration. The hydration process can be carried out both at atmospheric pressure and under pressure. Ordinary pressure uses a small amount of inorganic acid as catalyst and reacts at 50 ~ 70 °C. The molar ratio of oxirane and water of pressurized hydration is higher in the 1:6 or more, in order to reduce the side effect of generating ether. The reaction temperature is 150 °C and pressure is 147kPa. Ethylene glycol can be obtained by hydration. Now, there is gas-phase catalytic hydration, which uses silver oxide as catalyst, alumina as carrier, and reacts at 150 ~ 240 °C to produce 1,2-ethanediol.
3. Direct ethylene hydration: First, the single-acetate or diacetate can be produced by oxidation from ethylene in the presence of catalyst (such as antimony oxide TeO2, palladium catalyst) in acetic acid solution. Then, Ethylene glycol is obtained by further hydrolysis.
Uses of Ethylene glycol: Ethylene glycol is mainly used to make PET melt, which accounted for 86% of total consumption in 2009, and antifreeze, at around 7% of total consumption. It also has many niche applications due to its cheaply price. Ethylene glycol is used for the manufacture of resins, plasticizers, synthetic fibers, cosmetics, explosives and engine antifreeze. What's more, it is used as raw material for polyester fiber terylene. Ethylene glycol can often be instead of glycerin used as water mixture and solvent in the leather and pharmaceutical industries, respectively. Although the dissolving capacity of Ethylene glycol is strong, it can not be widely used as a solvent. Because it can be easy to be metabolized to produce toxic oxalic acid. Besides, Ethylene glycol is used as a medium for convective heat transfer in, for example, automobiles and liquid cooled computers. It is also commonly used in chilled water air conditioning systems that place either the chiller or air handlers outside, or systems that must cool below the freezing temperature of water. In addition, minor uses of Ethylene glycol include analysis reagents, liquid chromatography eluent, non-aqueous media of electrochemical analysis, and degreaser in electronic industry.
When you are using this chemical, please be cautious about it as the following: Due to the sweet taste of 1,2-ethanediol, children and animals are more inclined to consume large quantities of it than of other poisons. It is harmful if swallowed and it is irritating to eyes. It and its toxic byproducts first affect the central nervous system, then the heart, and finally the kidneys. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)Smiles:C(CO)O;
(2)InChI:InChI=1/C2H6O2/c3-1-2-4/h3-4H,1-2H2;
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | oral | 1650mg/kg (1650mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978. |
cat | LDLo | subcutaneous | 2gm/kg (2000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS BLOOD: OTHER CHANGES | Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933. |
child | TDLo | oral | 5500mg/kg (5500mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Postgraduate Medical Journal. Vol. 52, Pg. 598, 1976. |
dog | LD50 | oral | 5500mg/kg (5500mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978. |
guinea pig | LD50 | oral | 6610mg/kg (6610mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. |
guinea pig | LD50 | unreported | 11150mg/kg (11150mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968. |
guinea pig | LDLo | subcutaneous | 5gm/kg (5000mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 51, Pg. 398, 1935. | |
human | LDLo | oral | 398mg/kg (398mg/kg) | BEHAVIORAL: HEADACHE GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: OTHER CHANGES | Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. Vol. 26(2), Pg. 48, 1983. |
human | LDLo | oral | 786mg/kg (786mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: COMA | European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 373, 1976. |
human | TCLo | inhalation | 10000mg/m3 (10000mg/m3) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933. |
man | LDLo | unreported | 1637mg/kg (1637mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
man | TDLo | oral | 1195mg/kg (1195mg/kg) | PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED | Annals of Emergency Medicine. Vol. 20, Pg. 208, 1991. |
man | TDLo | oral | 15gm/kg (15000mg/kg) | PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED | Annals of Emergency Medicine. Vol. 20, Pg. 208, 1991. |
man | TDLo | oral | 16gm/kg (16000mg/kg) | BEHAVIORAL: COMA KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED | Human & Experimental Toxicology. Vol. 9, Pg. 317, 1990. |
man | TDLo | oral | 24gm/kg (24000mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 445, 2000. |
mouse | LC | inhalation | > 200mg/m3/2H (200mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981. | |
mouse | LD50 | intraperitoneal | 5614mg/kg (5614mg/kg) | LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI BLOOD: CHANGES IN SPLEEN | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947. |
mouse | LD50 | intravenous | 3gm/kg (3000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939. | |
mouse | LD50 | oral | 5500mg/kg (5500mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(3), Pg. 31, 1967. | |
mouse | LD50 | unreported | 8050mg/kg (8050mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: EXCITEMENT | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968. |
mouse | LDLo | subcutaneous | 2700mg/kg (2700mg/kg) | British Journal of Industrial Medicine. Vol. 1, Pg. 207, 1944. | |
rabbit | LD50 | skin | 9530uL/kg (9.53mL/kg) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 731, 1969. | |
rabbit | LD50 | unreported | 5017mg/kg (5017mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968. |
rabbit | LDLo | intramuscular | 5500mg/kg (5500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA | Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931. |
rabbit | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 502, 1966. | |
rabbit | LDLo | intravenous | 5gm/kg (5000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931. |
rat | LC | inhalation | > 200mg/m3/4H (200mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981. | |
rat | LD50 | intraperitoneal | 5010mg/kg (5010mg/kg) | Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981. | |
rat | LD50 | intravenous | 3260mg/kg (3260mg/kg) | Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981. | |
rat | LD50 | oral | 4700mg/kg (4700mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(6), Pg. 28, 1982. | |
rat | LD50 | subcutaneous | 2800mg/kg (2800mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 49, 1974. | |
rat | LD50 | unreported | 13gm/kg (13000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: EXCITEMENT | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968. |
rat | LDLo | intramuscular | 3300mg/kg (3300mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931. |
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