Flavone supplier | CasNO.525-82-6

Name
FLAVONE
EINECS 208-383-8
CAS No. 525-82-6
Article Data312
CAS DataBase
Density 1.24 g/cm³
Solubility Soluble in acetone (25 mg/ml), methanol, alcohol, and chloroform. Insoluble in water.
Melting Point 94-97 °C(lit.)
Formula C₁₅H₁₀O₂
Boiling Point 367.013 °C at 760 mmHg
Molecular Weight 222.243
Flash Point 171.058 °C
Transport Information
Appearance white crystalline powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Phenyl-4H-1-benzopyran-4-one;2-Phenyl-4H-chromen-4-one;2-Phenyl-g-benzopyrone;Chromocor;NSC 19028;
PSA 30.21000
LogP 3.46000

Synthetic route

: 1469-94-9
1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
copper dichloride In ethanol at 80℃; for 0.0833333h; microwave irradiation;	98%
With potassium hydrogensulfate at 120℃; for 2h; Temperature; Green chemistry;	98%
With gallium(III) triflate In nitromethane at 80℃; for 2h;	97%

: 533-58-4
2-Iodophenol

: 201230-82-2
carbon monoxide

: 536-74-3
phenylacetylene

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With C22H28Br2N4Pd; diethylamine In N,N-dimethyl-formamide at 80℃; under 3000.3 Torr; for 24h; Autoclave;	98%
With diethylamine In N,N-dimethyl-formamide at 100℃; under 10343.2 Torr; for 24h; Sonogashira Cross-Coupling; Autoclave;	96%
With (trihexyl)(tetradecyl)phosphonium bromide; triethylamine; palladium dichloride at 110℃; under 760.051 Torr; for 24h; Autoclave;	95%

...Expand

: 100-52-7
benzaldehyde

: 582-24-1
1-phenyl-2-hydroxyethanone

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium molybdate In hexan-1-ol at 70℃; for 3h;	98%

: 487-26-3
Flavanone

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With pyrrolidone hydrotribromide In dimethyl sulfoxide at 80℃; for 2h;	97%
With thallium(III) acetate In acetic acid for 3h; Heating;	96%
With thallium(III) acetate In acetic acid for 3h; Heating;	96%

: 888-12-0
(E)-2'-hydroxy-chalcone

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With indium(III) bromide; silica gel at 130 - 140℃; for 0.75h;	96%
With iodine In dimethyl sulfoxide for 1h; Reflux;	85%
With iodine In 2,2'-[1,2-ethanediylbis(oxy)]bisethanol at 150℃; for 4h; Product distribution; Further Variations:; Solvents; Temperatures; reaction times;	83%

: 16619-68-4
1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With dmap In N,N-dimethyl-formamide at 0 - 30℃; for 1.5h; Morita-Baylis-Hillman reaction; Inert atmosphere; regioselective reaction;	96%
With thallium(III) toluene-p-sulfonate In methanol at 65℃; for 6h; Reagent/catalyst; Solvent; Time; regioselective reaction;	91%
With lithium tert-butoxide In N,N-dimethyl-formamide at 20℃; for 0.166667h; Reagent/catalyst; Time; Temperature;	90%

: 81995-11-1
1-(2-hydroxyphenyl)-2-(triphenylphosphoranylidene)ethanone

: 98-88-4
benzoyl chloride

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With pyridine In toluene for 5h; Heating;	96%

: 1214-47-7
1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With Iodine monochloride; dimethyl sulfoxide at 50℃; for 0.5h; Temperature; Reagent/catalyst; Sonication; Green chemistry;	96%
With cerium (IV) sulfate tetrahydrate; silica gel In neat (no solvent) at 100℃; for 4h; Concentration; Time; Green chemistry;	94%
With copper(l) iodide; oxygen at 50℃; under 760.051 Torr; for 48h; oxa-Michael-oxidation; Ionic liquid;	92%

: 223511-19-1
1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-one

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With diethylamine In ethanol for 24h; Heating;	96%

: 16619-51-5
2'-allyloxychalcone

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With iodine In dimethyl sulfoxide at 120℃; for 0.5h; regioselective reaction;	96%
Multi-step reaction with 2 steps 1: acetic acid / 24 h / 20 °C 2: iodine / dimethyl sulfoxide / 0.5 h / 130 °C View Scheme

: 491-37-2
2,3-dihydro-4H-1-benzopyran-4-one

: 98-80-6
phenylboronic acid

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With palladium(II) trifluoroacetate; 5-Nitro-1,10-phenanthroline; oxygen In dimethyl sulfoxide at 100℃; for 48h; Reagent/catalyst; Solvent;	96%

: 16619-68-4
1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one

A: 525-82-6
FLAVONE

B: 36685-41-3
(Z)-4'-methoxyaurone

Conditions

Conditions	Yield
With silver nitrate In methanol Ambient temperature;	A 5% B 95%

: 16619-68-4
1-(2-hydroxyphenyl)-3-phenylprop-2-yn-1-one

A: 525-82-6
FLAVONE

B: 37542-14-6
aurone

Conditions

Conditions	Yield
With silver nitrate In methanol Ambient temperature;	A 5% B 95%
With 2-pyridone sodium salt In tetrahydrofuran at 20℃; for 6h; Reagent/catalyst; Solvent; Temperature; Time; regioselective reaction;	A 3% B 93%
With tricyclohexylphosphine In ethanol at 30℃; for 2h;	A n/a B 55%

: 16619-67-3
1-(2-acetoxy-phenyl)-3-phenyl-2-propyn-1-one

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With piperazine In acetonitrile at 25℃; for 3h; Schlenk technique;	95%
With piperazine In acetonitrile at 20℃; for 6h; Schlenk technique;	95%
With 18-crown-6 ether; potassium methanolate In tetrahydrofuran at 20℃; for 0.25h; Reagent/catalyst; Time; Temperature; Solvent;	76%

: 13463-40-6
iron pentacarbonyl

: 533-58-4
2-Iodophenol

: 536-74-3
phenylacetylene

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With piperazine; palladium diacetate In acetonitrile at 50℃; for 12h; Schlenk technique;	95%

...Expand

: 93514-42-2, 6053-99-2
2-phenylchromene

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(ll) bromide In decane; toluene at 80℃; for 0.0833333h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;	94%
With thallium(III) nitrate In methanol Ambient temperature; overnight;	20%

: 491-38-3
1-benzopyran-4(4H)-one

: 98-80-6
phenylboronic acid

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
Stage #1: 1-benzopyran-4(4H)-one; phenylboronic acid With iron(III) trifluoromethanesulfonate; palladium diacetate; Trimethylacetic acid at 60℃; under air; Stage #2: With potassium nitrite; 2,3-dicyano-5,6-dichloro-p-benzoquinone	94%
Stage #1: 1-benzopyran-4(4H)-one With 1,10-Phenanthroline; oxygen; palladium diacetate In N,N-dimethyl-formamide for 0.0833333h; Heck type reaction; Stage #2: phenylboronic acid In N,N-dimethyl-formamide at 100℃; for 24h; Heck type reaction; regioselective reaction;	86%

: 491-37-2
2,3-dihydro-4H-1-benzopyran-4-one

: 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With palladium(II) trifluoroacetate; 5-Nitro-1,10-phenanthroline; oxygen In dimethyl sulfoxide at 100℃; for 48h;	93%
With palladium(II) trifluoroacetate; 5-Nitro-1,10-phenanthroline; oxygen In dimethyl sulfoxide at 100℃; Heck Reaction;	93%

: 36695-24-6
2'-benzyloxy-2-bromo-acetophenone

A: 525-82-6
FLAVONE

B: 4010-33-7
2-acetylphenyl benzoate

Conditions

Conditions	Yield
pyrex In benzene Irradiation;	A 4% B 92%

: 32865-61-5
2-iodophenyl acetate

: 201230-82-2
carbon monoxide

: 536-74-3
phenylacetylene

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine; thiourea; bis-triphenylphosphine-palladium(II) chloride; 1,3-bis-(diphenylphosphino)propane at 40℃; for 48h; Addition; cyclization;	92%

...Expand

: 98153-12-9
3-iodo-2-phenyl-4H-1-benzopyran-4-one

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With sodium formate; bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 90℃;	92%
With copper(l) iodide; potassium carbonate; isopropyl alcohol at 90℃; for 12h; Green chemistry; regioselective reaction;	92%

: 137527-18-5
4-oxo-2-phenyl-4H-chromen-6-yl 4-methylbenzenesulfonate

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With dimethylamine borane; potassium carbonate; triphenylphosphine; nickel In N,N-dimethyl-formamide at 120℃; for 12h;	92%

: 1025-86-1
3-bromo-2-phenyl-chromen-4-one

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; isopropyl alcohol at 90℃; for 12h; Catalytic behavior; Reagent/catalyst; Green chemistry; regioselective reaction;	92%

: 67139-31-5
trans-3-mesyloxyflavanone

A: 525-82-6
FLAVONE

B: 37542-14-6
aurone

Conditions

Conditions	Yield
With dibutylamine In dimethyl sulfoxide for 72h; Ambient temperature;	A 91.5% B 6.2%
With sodium acetate In dimethyl sulfoxide at 25℃; for 144h;	A 80.1% B 10.9%
With sodium acetate In dimethyl sulfoxide at 25℃; for 144h; Product distribution; other reaction temperatures, solvents, reaction time, reagents, catalists, other amount of catalists and use other 3-mesyloxy-flavanone;	A 80.1% B 10.9%
With potassium cyanate; 18-crown-6 ether In benzene for 21h; Heating;	A 31.3% B 48%
With isopropylamine In dimethyl sulfoxide for 72h; Ambient temperature;	A 57.5 % Spectr. B 32.9 % Spectr.

: 98153-26-5
1-(2-Hydroxy-4-methoxyphenyl)-3-phenylpropyn-1-one

A: 525-82-6
FLAVONE

B: 22395-22-8
7-methoxoyflavone

Conditions

Conditions	Yield
With silver nitrate In methanol Ambient temperature;	A 91% B n/a

: 108378-93-4
3-<(4-Methylphenyl)sulphinyl>-4H-1-benzopyran-4-one

: phenylmagnesium bromide

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With copper(I) bromide dimethylsulfide complex In tetrahydrofuran at -78 - 0℃; for 2.5h;	91%

: 36081-80-8
1-(2'-bromophenyl)-3-phenylpropane-1,3-dione

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 1h; Ullmann type reaction; under air;	91%
With tert-butylisonitrile; palladium diacetate; potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether In N,N-dimethyl-formamide at 120℃; for 2h; Reagent/catalyst; Solvent; chemoselective reaction;	86%

: 1657006-73-9
C18H16Br2O2

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With iodine In dimethyl sulfoxide at 130℃; for 0.5h;	91%

: 5465-04-3
4-thioflavone

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
With Clayfen for 0.025h; microwave irradiation;	90%
With tetraethylammonium perchlorate; ethidium Bromide In N,N-dimethyl-formamide cathodic reduction;
With air In ethanol at 20℃; Photolysis;

: 75630-53-4
2'-hydroxychalcone dichloride

: 525-82-6
FLAVONE

Conditions

Conditions	Yield
at 210 - 220℃; for 1.5h;	90%

: 525-82-6
FLAVONE

: 134051-30-2
1a,7a-Dihydro-1a-phenyl-7H-oxireno<1>benzopyran-7-one

Conditions

Conditions	Yield
With 3,3-dimethyldioxirane In dichloromethane; acetone at 0℃; for 36h;	100%
With 3,3-dimethyldioxirane In dichloromethane; acetone at 0℃; for 36h;	100%
With Oxone; 1,1,1-trifluoro-2-propanone; edetate disodium; sodium hydrogencarbonate In acetonitrile at 0 - 1℃; for 1.25h;	99%

: 525-82-6
FLAVONE

: 407-47-6
2,2,2-trifluoroethyl acrylate

: 2,2,2-trifluoroethyl (E)-3-(2-phenyl-4-oxo-4H-chromen-5-yl)acrylate

Conditions

Conditions	Yield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate In tert-Amyl alcohol at 20 - 100℃; for 12.33h; Schlenk technique; Sealed tube; regioselective reaction;	99%

: 525-82-6
FLAVONE

A: 487-26-3, 17002-31-2, 24271-98-5, 27439-12-9
(2S)-flavanone

B: 487-26-3, 17002-31-2, 24271-98-5, 27439-12-9
(R)-flavanone

Conditions

Conditions	Yield
Stage #1: FLAVONE With Dimethylphenylsilane; C50H52N2; bis(pentafluorophenyl)borohydride In toluene at 20℃; for 1h; Inert atmosphere; Glovebox; Stage #2: With trifluoroacetic acid In toluene at 20℃; for 0.166667h; Inert atmosphere; Glovebox; enantioselective reaction;	A n/a B 99%

: 525-82-6
FLAVONE

: 56-53-1
diethylstilbestrol

: C18H20O2*2C15H10O2

Conditions

Conditions	Yield
In methanol at 20℃; Solvent;	98.72%

: 525-82-6
FLAVONE

: 13178-98-8
3-chloro-2-phenyl-chromen-4-one

Conditions

Conditions	Yield
With sulfuryl dichloride; Montmorillonite-K-10 clay In dichloromethane for 0.25h; Ambient temperature;	98%
With pyridine; chloro-trimethyl-silane; [bis(acetoxy)iodo]benzene In dichloromethane at 0℃; for 3.5h;	82%
With sulfuryl dichloride In tetrachloromethane	63%

: 525-82-6
FLAVONE

: 71840-34-1, 71840-35-2, 82908-23-4
(2R*,2’R*)-2,2’-diphenyl-[2,2’-bichromane]-4,4’-dione

Conditions

Conditions	Yield
With samarium diiodide In tetrahydrofuran; methanol at -40℃; for 24h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; stereoselective reaction;	98%

: 525-82-6
FLAVONE

: 71840-35-2
(2R*,2’S*)-2,2’-diphenyl-[2,2’-bichromane]-4,4’-dione

Conditions

Conditions	Yield
With samarium diiodide In tetrahydrofuran; methanol at 68℃; for 24h; Inert atmosphere; stereoselective reaction;	98%

: 525-82-6
FLAVONE

: 98153-13-0
3-Mercapto-2-phenyl-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With sulfur; lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.583333h;	97%

: 525-82-6
FLAVONE

: 487-25-2, 20107-47-5, 20107-48-6, 20902-95-8, 26049-32-1, 27439-08-3, 41886-75-3, 51196-78-2, 51196-83-9
2-phenyl-chroman-4-ol

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate; cobalt(II) 5,10,15,20-tetraphenylporphyrin; oxygen at 20℃; for 0.166667h; Kinetics; Reagent/catalyst; Time;	97%

: 525-82-6
FLAVONE

: 2-phenylchromanol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 20℃; for 3h; Inert atmosphere;	95%

: 941-55-9
4-toluenesulfonyl azide

: 525-82-6
FLAVONE

: 1607017-87-7
4-methyl-N-(4-oxo-2-phenyl-4H-chromen-5-yl)benzenesulfonamide

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium carbonate; acetic acid; silver(I) triflimide In 1,2-dichloro-ethane at 25℃; for 12h; Inert atmosphere;	95%

: 525-82-6
FLAVONE

: 19726-12-6
3-(2-hydroxyphenyl)-5-phenyl-pyrazole

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 90℃;	95%

: 930-88-1
N-methylmaleimide

: 525-82-6
FLAVONE

: 1-methyl-3-(4-oxo-2-phenyl-4H-chromen-5-yl)pyrrolidine-2,5-dione

Conditions

Conditions	Yield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; Trimethylacetic acid In 1,2-dichloro-ethane at 80℃; for 20h; Sealed tube;	94%

Flavone Chemical Properties

Synonyms :2-Phenyl-4H-1-benzopyran-4-one; 2-Phenylchromone
MF: C₁₅H₁₀O₂
MW: 222.24
EINECS: 208-383-8
2-PHENYLCHROMONE(525-82-6),its melting point is about 94-97 °C(lit.),boiling point is 185 °C / 1mmHg .
Following is the molecular structure of 2-PHENYLCHROMONE(525-82-6):

Flavone Toxicity Data With Reference

1.	dni-hmn:fbr 100 mg/L	BCPCA6 Biochemical Pharmacology. 33 (1984),3823.
2.	orl-mus LD50:2500 mg/kg	JHTCAO Journal of Heterocyclic Chemistry. 21 (1984),193.
3.	ipr-mus LD50:380 mg/kg	FRPSAX Farmaco, Edizione Scientifica. 13 (1958),561.
4.	scu-mus LD >400 mg/kg	ANTCAO Antibiotics and Chemotherapy. 3 (1953),603.

RTECS : DJ3100630

Flavone Consensus Reports

Reported in EPA TSCA Inventory.

Flavone Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating vapors.

Other safty informations about 2-PHENYLCHROMONE(525-82-6):
Hazard Codes: Xi (Irritant)
Risk Statements
R 36/37/38 (Irritating to eyes, respiratory system and skin )
Safety Statements :
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36 :Wear suitable protective clothing
WGK Germany : 2

Product Name

FLAVONE

Synthetic route

Flavone Chemical Properties

Flavone Toxicity Data With Reference

Flavone Consensus Reports

Flavone Safety Profile

Related Products

Hot Products