Fluorescein chloride supplier

Name
FLUORESCEIN CHLORIDE
EINECS 211-147-7
CAS No. 630-88-6
Article Data9
CAS DataBase
Density 1.56 g/cm³
Solubility
Melting Point 253-255 °C(lit.)
Formula C20H10 Cl2 O3
Boiling Point 539.8ºC at 760 mmHg
Molecular Weight 369.204
Flash Point 214.3ºC
Transport Information
Appearance white to light yellow crystalline powder.
Safety 37/39-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Fluoran,3',6'-dichloro- (7CI,8CI); 3,6-Dichlorofluorescein; 3',6'-Dichlorofluoran;Fluorescein dichloride; NSC 231613
PSA 35.53000
LogP 5.56140

Synthetic route

: 2321-07-5
fluorescein

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
With sulfolane; thionyl chloride In N,N-dimethyl-formamide at 60 - 80℃; for 2.5h; Temperature;	90.5%
With phosphorus pentachloride at 100℃;
With thionyl chloride
With phosphorus pentachloride In chlorobenzene at 140℃; for 6h;
With phosphorus pentachloride In chlorobenzene at 140℃; for 6h;

: 108-43-0
3-monochlorophenol

: 76135-38-1
2-(4'-chloro-2'-hydroxybenzoyl)benzoic acid

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
With zinc(II) chloride at 155 - 160℃; for 12h;	76%

: 85-44-9
phthalic anhydride

: 108-43-0
3-monochlorophenol

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
With ferric hydrogen sulphate at 160℃; for 13h; neat (no solvent);	70%
With zinc(II) chloride at 185 - 190℃;

: 85-44-9
phthalic anhydride

activated aluminium: activated aluminium

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 195 - 200 °C 2: phosphorus pentachloride / 100 °C View Scheme

: 2513-33-9
2-(2,4-dihydroxybenzoyl)benzoic acid

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: beim Erhitzen ueber den Schmelzpunkt 2: phosphorus pentachloride / 100 °C View Scheme
Multi-step reaction with 2 steps 2: phosphorus pentachloride / 100 °C View Scheme

: 108-46-3
recorcinol

phenoldiazonium chloride-(4): phenoldiazonium chloride-(4)

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 195 - 200 °C 2: phosphorus pentachloride / 100 °C View Scheme
Multi-step reaction with 2 steps 2: phosphorus pentachloride / 100 °C View Scheme

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 87021-19-0
3,6-dichloro-9-(carboxyphenyl)xanthen

Conditions

Conditions	Yield
With acetic acid; zinc(II) chloride for 10h; Heating;	97%

: 1126-78-9
N-(n-butyl)aniline

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 915038-78-7
3'-N-butylanilino-6'-chlorofluoran

Conditions

Conditions	Yield
Stage #1: N-(n-butyl)aniline; 3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one; aluminum (III) chloride In sulfolane at 60 - 80℃; for 1.08333h; Stage #2: With hydrogenchloride; water In sulfolane at 0℃;	96%

: 578-54-1
ortho-ethylaniline

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 3,6-(o-ethylaniline)fluorescein

Conditions

Conditions	Yield
With aluminum (III) chloride In N,N-dimethyl-formamide at 100 - 150℃; for 10.5h; Temperature; Reagent/catalyst;	86.2%

: 279-40-3
7-aza-bicyclo[2.2.1]heptane

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 1225568-28-4
C32H30N2O3

Conditions

Conditions	Yield
With zinc(II) oxide; zinc(II) chloride at 190℃; for 12h; high pressure reactor;	40%

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 4-(2-aminoethyl)benzenesulfonic acid

: C36H30N2O9S2*H(1+)

Conditions

Conditions	Yield
With zinc(II) chloride In sulfolane at 200℃; for 4h;	40%

: 109-01-3
1-methyl-piperazine

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 1-(9-(2-carboxyphenyl)-6-(4-methylpiperazine-1-yl)-3H-xanthene-3-ylidene)-4-methylpiperazine-1-ium chloride

Conditions

Conditions	Yield
With zinc(II) chloride In 1,2-dichloro-benzene at 180℃; for 1h; Inert atmosphere;	14%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 915038-76-5
3'-chloro-6'-(1,2,3,4-tetrahydroquinolin-1-yl)fluoran

Conditions

Conditions	Yield
aluminum (III) chloride In sulfolane at 150℃; for 18h;	5.4%

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 10347-08-7
3',6'-dichloro-spiro[isoindole-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
With ammonia

: 64-17-5
ethanol

: 127-09-3
sodium acetate

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

hydrochloride of diethylamine: hydrochloride of diethylamine

3.6-bis-diethylamino-fluorane: 3.6-bis-diethylamino-fluorane

Conditions

Conditions	Yield
at 200 - 220℃; im Autoklaven;

...Expand

: 142-04-1
aniline hydrochloride

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

3.6-dianilino-fluorane: 3.6-dianilino-fluorane

Conditions

Conditions	Yield
at 220℃;

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

: 62-53-3
aniline

3.6-dianilino-fluorane: 3.6-dianilino-fluorane

Conditions

Conditions	Yield
at 210 - 220℃;
at 210 - 220℃;

...Expand

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

phosphorus pentasulfide: phosphorus pentasulfide

3.6-dichloro-dithiofluorane: 3.6-dichloro-dithiofluorane

Conditions

Conditions	Yield
at 185℃;

: 10034-85-2
hydrogen iodide

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

3.6-dichloro-hydrofluoranoic acid: 3.6-dichloro-hydrofluoranoic acid

Conditions

Conditions	Yield
at 150℃; im Rohr;

: 7732-18-5
water

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

aqueous-alcoholic NaOH-solution: aqueous-alcoholic NaOH-solution

zinc dust: zinc dust

3.6-dichloro-hydrofluoranoic acid: 3.6-dichloro-hydrofluoranoic acid

...Expand

: 64-17-5
ethanol

: 3111-52-2
potassium thiophenolate

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

3.6-dithio-fluorescein-diphenyl ether: 3.6-dithio-fluorescein-diphenyl ether

...Expand

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

alcoholic potassium hydrosulfide: alcoholic potassium hydrosulfide

3.6-dithio-fluorescein: 3.6-dithio-fluorescein

: 7664-41-7
ammonia

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 10347-08-7
3',6'-dichloro-spiro[isoindole-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
at 190 - 200℃;

: ammonium chloride

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

lime/chalk/: lime/chalk/

: 10347-08-7
3',6'-dichloro-spiro[isoindole-1,9'-xanthen]-3-one

Conditions

Conditions	Yield
at 240 - 260℃;

...Expand

: 142-04-1
aniline hydrochloride

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 108-95-2
phenol

6-chloro-3-anilino-fluorane: 6-chloro-3-anilino-fluorane

...Expand

: 557-66-4
ethanamine hydrochloride

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

zinc oxide: zinc oxide

6-chloro-3-ethylamino-fluorane: 6-chloro-3-ethylamino-fluorane

Conditions

Conditions	Yield
at 160 - 170℃;

...Expand

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

sodium hydroxide: sodium hydroxide

A: 2513-33-9
2-(2,4-dihydroxybenzoyl)benzoic acid

B: 65-85-0
benzoic acid

C: 108-46-3
recorcinol

D 2.4.2'.4'-tetraoxy-benzophenone: 2.4.2'.4'-tetraoxy-benzophenone

Conditions

Conditions	Yield
at 230 - 240℃; Beim Schmelzen;

...Expand

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

lime milk: lime milk

: 2321-07-5
fluorescein

Conditions

Conditions	Yield
at 230℃; unter Druck;

: 64-17-5
ethanol

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Na2S2: Na2S2

compound C20H10O3S2: compound C20H10O3S2

...Expand

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Fast Acid Violet A 2 R: Fast Acid Violet A 2 R

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

Fast Acid Violet B: Fast Acid Violet B

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

oic acid rosamine A: oic acid rosamine A

: 630-88-6
3',6'-dichloro-spiro[phthalan-1,9'-xanthen]-3-one

rhodamine B: rhodamine B

Fluorescein chloride Chemical Properties

Molecular Structure:

Molecular Formula: C₂₀H₁₀Cl₂O₃
Molecular Weight: 369.1976
IUPAC Name: 3',6'-Dichlorospiro[2-benzofuran-3,9'-xanthene]-1-one
Synonyms of Fluorescein chloride (CAS NO.630-88-6): 3',6'-Dichlorofluoran ; EINECS 211-147-7 ; Fluorescein dichloride ; NSC 231613 ; 3',6'-Dichlorospiro(phthalide-3,9'-xanthene) ; Fluoran, 3',6'-dichloro- (8CI) ; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dichloro-
CAS NO: 630-88-6
Melting point: 253-255 °C
Index of Refraction: 1.736
Molar Refractivity: 94.59 cm³
Molar Volume: 235.4 cm³
Surface Tension: 71 dyne/cm
Density: 1.56 g/cm³
Flash Point: 214.3 °C
Enthalpy of Vaporization: 81.73 kJ/mol
Boiling Point: 539.8 °C at 760 mmHg
Vapour Pressure of Fluorescein chloride (CAS NO.630-88-6): 1.01E-11 mmHg at 25°C

Fluorescein chloride Safety Profile

Hazard Codes of Fluorescein chloride (CAS NO.630-88-6): Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 37/39-26
S37/39: Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3

Product Name

FLUORESCEIN CHLORIDE

Synthetic route

Fluorescein chloride Chemical Properties

Fluorescein chloride Safety Profile

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