Product Name

  • Name

    Flutriafol

  • EINECS
  • CAS No. 76674-21-0
  • Article Data7
  • CAS DataBase
  • Density 1.29 g/cm3
  • Solubility 130 mg l-1 (pH 7,20 °C)
  • Melting Point 130oC
  • Formula C16H13F2N3O
  • Boiling Point 506.5 °C at 760 mmHg
  • Molecular Weight 301.296
  • Flash Point 260.1 °C
  • Transport Information UN 1648 3/PG 2
  • Appearance solid
  • Safety 22-24/25-36-26
  • Risk Codes 22-36-20/21/22-11
  • Molecular Structure Molecular Structure of 76674-21-0 (Flutriafol)
  • Hazard Symbols HarmfulXn, FlammableF
  • Synonyms 1H-1,2,4-Triazole-1-ethanol, alpha-(2-fluorophenyl)-alpha-(4-fluorophenyl)-;Flutriafol [BSI:ISO];R 152450;(RS)-2,4-Difluoro-alpha-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol;Flutriafol Tech;alpha-(2-Fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol;1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)ethanol;Impact (pesticide);1H-1,2,4-Triazole-1-ethanol,R-(2-fluorophenyl)- R-(4-fluorophenyl)-;PP 450;
  • PSA 50.94000
  • LogP 2.49240

Synthetic route

1,2,4-Triazole
288-88-0

1,2,4-Triazole

1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide

1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide

flutriafol
76674-21-0

flutriafol

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide at 140℃; for 0.333333h; Temperature;93.5%
With dimethyl sulfoxide at 130 - 140℃; for 2h; Temperature; Green chemistry;186 g
2,4'-difluorobenzophenone
342-25-6

2,4'-difluorobenzophenone

flutriafol
76674-21-0

flutriafol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dimethyl sulfoxide / Heating; Green chemistry
1.2: 3 h / 30 - 40 °C / Green chemistry
2.1: dimethyl sulfoxide / 2 h / 130 - 140 °C / Green chemistry
View Scheme
flutriafol
76674-21-0

flutriafol

A

(S)-(+)-flutriafol
586965-70-0

(S)-(+)-flutriafol

B

(R)-flutriafol

(R)-flutriafol

Conditions
ConditionsYield
In methanol; water; acetonitrile at 20℃; Reagent/catalyst; Solvent; Resolution of racemate;

Flutriafol Chemical Properties

IUPAC Name: 1-(2-Fluorophenyl)-1-(4-fluorophenyl)-2-(1,2,4-triazol-1-yl)ethanol
Synonyms of Flutriafol (CAS NO.76674-21-0): (RS)-2,4'-Difluoro-alpha-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol ; Impact (pesticide) ; PP 450 ; R 152450 ; alpha-(2-Fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol ; 1H-1,2,4-Triazole-1-ethanol, alpha-(2-fluorophenyl)-alpha-(4-fluorophenyl)-
CAS NO: 76674-21-0
Classification Code: Agricultural Chemical ; Fungicide, bactericide, wood preservative
Molecular Formula of Flutriafol (CAS NO.76674-21-0): C16H13F2N3O
Molecular Weight: 301.2907
Molecular Structure:

Polar Surface Area: 39.94 Å2
Index of Refraction: 1.6
Molar Refractivity: 79.82 cm3
Molar Volume: 233.3 cm3
Surface Tension: 44.4 dyne/cm
Density of Flutriafol (CAS NO.76674-21-0): 1.29 g/cm3
Flash Point: 260.1 °C
Enthalpy of Vaporization: 81.75 kJ/mol
Boiling Point: 506.5 °C at 760 mmHg
Vapour Pressure: 4.43E-11 mmHg at 25°C
 

Flutriafol Uses

 Flutriafol (CAS NO.76674-21-0) is a major fungicide used in many world crops. It is used as the major active ingredient in the range of global seed treatments.

Flutriafol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 200mg/kg (200mg/kg)   Defense des Vegetaux. Vol. 38, Pg. 77, 1984.
mouse LD50 oral 179mg/kg (179mg/kg)   Defense des Vegetaux. Vol. 38, Pg. 77, 1984.
rabbit LD50 oral 200mg/kg (200mg/kg)   Defense des Vegetaux. Vol. 38, Pg. 77, 1984.
rabbit LD50 skin > 2gm/kg (2000mg/kg)   Pesticide Manual. Vol. 9, Pg. 427, 1991.
rat LD50 oral 1140mg/kg (1140mg/kg)   Pesticide Manual. Vol. 9, Pg. 427, 1991.
rat LD50 skin > 1gm/kg (1000mg/kg)   Pesticide Manual. Vol. 9, Pg. 427, 1991.

Flutriafol Consensus Reports

Reported in EPA TSCA Inventory.

Flutriafol Safety Profile

Hazard Codes: HarmfulXn,FlammableF
Risk Statements: 36-20/21/22-11 
R36: Irritating to eyes. 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed. 
R11: Highly flammable.
Safety Statements: 22-24/25-36-26 
S22: Do not breathe dust. 
S24/25: Avoid contact with skin and eyes. 
S36: Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 1648 3/PG 2
RTECS: XZ4825000
A poison by ingestion. Moderately toxic by skin contact. When heated to decomposition it emits toxic vapors of NOx and F−

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