Glycidyl butyrate supplier | CasNO.2461-40-7

Name
Glycidyl butyrate
EINECS
CAS No. 2461-40-7
Article Data12
CAS DataBase
Density 1.069 g/cm³
Solubility
Melting Point
Formula C₇H₁₂O₃
Boiling Point 196.258 °C at 760 mmHg
Molecular Weight 144.17
Flash Point 85 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Butanoicacid, oxiranylmethyl ester (9CI);Butyric acid, 2,3-epoxypropyl ester(6CI,7CI,8CI);(?à)-Glycidylbutyrate;2-Oxiranylmethyl butyrate;Glycidyl butanoate;Glycidyl butyrate;Glydicyl butyrate;NSC 83144;
PSA 38.83000
LogP 0.72850

Synthetic route

: 156-54-7
sodium butyrate

: 106-89-8
epichlorohydrin

: 2461-40-7
(+/-)-glycidyl butyrate

Conditions

Conditions	Yield
at 60℃; for 8h;	95%
With 15-crown-5 In acetonitrile for 14h; Ambient temperature;	92%
With tetrabutylammomium bromide In toluene for 5h; Solvent; Reflux;	90%
With 1,4-dioxane at 200℃;
With tetrabutylammomium bromide at 100℃; Kinetics; Temperature;

: 589-39-9
potassium n-butyrate

: 106-89-8
epichlorohydrin

: 2461-40-7
(+/-)-glycidyl butyrate

Conditions

Conditions	Yield
With tetrabutylammomium bromide In toluene for 5h; Solvent; Reflux;	70%

: 556-52-5
oxiranyl-methanol

: 141-75-3
butyryl chloride

: 2461-40-7
(+/-)-glycidyl butyrate

Conditions

Conditions	Yield
With triethylamine In toluene at 0℃; for 0.833333h;
Stage #1: oxiranyl-methanol With trimethylamine In dichloromethane for 0.5h; Cooling with ice; Stage #2: butyryl chloride In dichloromethane at 20℃; for 3h;

: 105-54-4
butanoic acid ethyl ester

: 107-18-6
allyl alcohol

A: 2461-40-7
(+/-)-glycidyl butyrate

B: 2051-78-7
allyl butyrate

C: 556-52-5
oxiranyl-methanol

Conditions

Conditions	Yield
With Novozym 435; dihydrogen peroxide 1.) 15 min, 2.) 40 deg C, 16 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 107-18-6
allyl alcohol

A: 2461-40-7
(+/-)-glycidyl butyrate

B: 2051-78-7
allyl butyrate

C: 556-52-5
oxiranyl-methanol

Conditions

Conditions	Yield
With Novozym 435; C3H7COOC2H5; dihydrogen peroxide 1.) 15 min, 2.) 40 deg C, 16 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 2461-40-7
(+/-)-glycidyl butyrate

: 31027-31-3
4-isopropylphenylisocyanate

: 121373-21-5
<3-(4-isopropylphenyl)-2-oxo-5-oxazolidinyl>methyl butyrate

Conditions

Conditions	Yield
With Tributylphosphine oxide; lithium bromide In xylene for 2h; Heating;	100%

: 2461-40-7
(+/-)-glycidyl butyrate

: 615-37-2
ortho-methylphenyl iodide

: 140-88-5
ethyl acrylate

: (E)-3-(2-(3-ethoxy-3-oxoprop-1-en-1-yl)-3-methylphenyl)-2-hydroxypropyl butyrate

Conditions

Conditions	Yield
With potassium (1S,4S)-bicyclo[2.2.1]hept-5-ene-2-carboxylate; palladium diacetate; XPhos In 1-methyl-pyrrolidin-2-one at 60℃; for 12h; Glovebox; Inert atmosphere; Sealed tube;	97%

...Expand

: 2461-40-7
(+/-)-glycidyl butyrate

: 615-37-2
ortho-methylphenyl iodide

: 140-88-5
ethyl acrylate

: C19H26O5

Conditions

Conditions	Yield
With palladium diacetate; potassium bicyclo[2.2.1]hept-2-ene-5-carboxylate; XPhos In 1-methyl-pyrrolidin-2-one at 60℃; for 12h;	97%

...Expand

: 2461-40-7
(+/-)-glycidyl butyrate

: 124-38-9
carbon dioxide

: (2-oxo-1,3-dioxolan-4-yl)methyl butyrate

Conditions

Conditions	Yield
With 18-crown-6 ether at 120℃; under 39003.9 Torr; for 16h; Autoclave;	93%

: 2461-40-7
(+/-)-glycidyl butyrate

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 142944-71-6
Butyric acid 3-cyano-2-hydroxy-propyl ester

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 3.5h; Heating;	91%

: 2461-40-7
(+/-)-glycidyl butyrate

: 5471-81-8
methyl 4-iodo-3-methylbenzoate

: methyl 7-methyl-2-(butyryloxymethyl)-2,3-dihydrobenzofuran-5-carboxylate

Conditions

Conditions	Yield
With palladium diacetate; XPhos In 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Inert atmosphere; Sealed tube;	91%
With palladium diacetate; potassium bicyclo[2.2.1]hept-2-ene-5-carboxylate; XPhos In 1-methyl-pyrrolidin-2-one at 80℃; for 24h;	91%

: 75-15-0
carbon disulfide

: 2461-40-7
(+/-)-glycidyl butyrate

: C8H12O3S2

Conditions

Conditions	Yield
Stage #1: (+/-)-glycidyl butyrate With {Eu[N(SiMe3)2](μ-O:κ2-C6H5C(O)NC6H3(iPr)2)(THF)}2 at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: carbon disulfide at 50℃; for 6h; Inert atmosphere;	91%

: 2461-40-7
(+/-)-glycidyl butyrate

: 615-37-2
ortho-methylphenyl iodide

: 89343-06-6
tris-iso-propylsilyl acetylene

: 2-hydroxy-3-(3-methyl-2-((triisopropylsilyl)ethynyl)phenyl)propyl butyrate

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; norborn-2-ene; potassium acetate; palladium diacetate; XPhos at 60℃; for 24h; Glovebox; Inert atmosphere; Sealed tube; regioselective reaction;	83%

...Expand

: 2461-40-7
(+/-)-glycidyl butyrate

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 4-butyryloxy-3-hydroxybutyric acid ethyl ester

Conditions

Conditions	Yield
With 1,1-dimethyl-3,3-diethylguanidinecarbonylcobalt at 80℃; under 45004.5 Torr; for 24h; Autoclave;	79%
With 1,1-dimethyl-3,3-diethylguanidinecarbonylcobalt at 80℃; under 45004.5 Torr; for 24h; Autoclave; Schlenk technique;	79%

...Expand

: 2461-40-7
(+/-)-glycidyl butyrate

: 787514-56-1
selenobutyric acid

: 1040413-68-0
C11H20O4Se

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; toluene at -30 - 20℃;	75%

: 2461-40-7
(+/-)-glycidyl butyrate

: 790703-40-1
(4-benzyloxy-3-fluorophenyl)carbamic acid benzyl ester

: 3-(4-benzyloxy-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one

Conditions

Conditions	Yield
Stage #1: (4-benzyloxy-3-fluorophenyl)carbamic acid benzyl ester With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Stage #2: (+/-)-glycidyl butyrate In tetrahydrofuran; hexane at -78 - 20℃;	65.5%

: 2461-40-7
(+/-)-glycidyl butyrate

: 125188-61-6
Butyric acid thiiranylmethyl ester

Conditions

Conditions	Yield
With thiourea	60%

: 2461-40-7
(+/-)-glycidyl butyrate

A: 5309-42-2
1-sn-monobutyroylglycerol

B: 60456-26-0
(R)-glycidyl butyrate

C: 126254-87-3
(S)-2,3-dihydroxypropyl butyrate

Conditions

Conditions	Yield
With [(S,S)-N,N’-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediaminato(2-)]cobalt(II); air; acetic acid In tetrahydrofuran at 0 - 20℃;	A n/a B 46% C n/a

...Expand

: 2461-40-7
(+/-)-glycidyl butyrate

A: 5309-42-2
1-sn-monobutyroylglycerol

B: 126254-87-3
(S)-2,3-dihydroxypropyl butyrate

C: 65031-96-1
(S)-glycidyl butyrate

Conditions

Conditions	Yield
With (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); air; acetic acid In tetrahydrofuran at 0 - 20℃;	A n/a B n/a C 46%
With water; chiral ((substituted salen)Co)2-InCl3 at 20℃; for 3h;	A n/a B n/a C 45%
With water; (R,R)-[Co(salen)]2*GaCl3 at 20℃; for 4h;	A n/a B n/a C 43%
With water; chiral salen-based cobalt(II) complex at 20℃; for 4h;	A n/a B n/a C 40%

...Expand

: 2461-40-7
(+/-)-glycidyl butyrate

A: 5309-42-2
1-sn-monobutyroylglycerol

B: 65031-96-1
(S)-glycidyl butyrate

Conditions

Conditions	Yield
With (1R,2R)-(-)-N,N'-bis(3,5-di-tert-butylsalicydene)-1,2-cyclohexanediaminocobalt(II); air; acetic acid In tetrahydrofuran at 0 - 20℃; for 16h;	A n/a B 46%
With 5CF3O3S(1-)2Co(3+)Y(3+)*2C36H52N2O2(2-); water In neat (no solvent) at 20℃; for 4h; Overall yield = 44 %; enantioselective reaction;	A n/a B n/a

: 2461-40-7
(+/-)-glycidyl butyrate

A: 60456-26-0
(R)-glycidyl butyrate

B: 126254-87-3
(S)-2,3-dihydroxypropyl butyrate

Conditions

Conditions	Yield
With [(S,S)-N,N’-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediaminato(2-)]cobalt(II); air; acetic acid In tetrahydrofuran at 0 - 20℃;	A 46% B n/a

: 2461-40-7
(+/-)-glycidyl butyrate

: 2150-89-2
(3-chlorophenyl) carbamic acid ethyl ester

: 42902-30-7
3-(3-chlorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran at -78 - 20℃;	46%

: 2461-40-7
(+/-)-glycidyl butyrate

: 615-37-2
ortho-methylphenyl iodide

: C14H18O3

Conditions

Conditions	Yield
With [methanesulfonato(2-dicyclohexylphosphino-2',6'-di-isopropoxy-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II)]; C11H16O2; sodium acetate In N,N-dimethyl-formamide at 120℃; for 24h; Inert atmosphere; Glovebox;	46%

: 2461-40-7
(+/-)-glycidyl butyrate

A: 60456-26-0
(R)-glycidyl butyrate

B: 57044-25-4
(R)-oxiranemethanol

Conditions

Conditions	Yield
With sodium phosphate buffer; 25 kDa lipase-like enzyme immobilized on DEAE-Sepharose In 1,4-dioxane; water at 25℃; for 10h; pH=7.00;	A n/a B 45%
With thermomyces lanuginosa In 1,4-dioxane; aq. phosphate buffer at 30℃; for 2h; pH=7; Temperature; Resolution of racemate; Enzymatic reaction;	A n/a B n/a

: 2461-40-7
(+/-)-glycidyl butyrate

A: 890051-54-4
butyric acid-3-chloro-(S)-2-hydroxy-propyl ester

B: 890051-57-7
butyric acid-3-chloro-(R)-2-hydroxy-propyl ester

C: 60456-26-0
(R)-glycidyl butyrate

D: 65031-96-1
(S)-glycidyl butyrate

Conditions

Conditions	Yield
With hydrogenchloride; (R,R)-[Co(salen)]2*GaCl3 In diethyl ether at 0 - 4℃; for 4h;	A 45% B n/a C n/a D 43%

...Expand

: 2461-40-7
(+/-)-glycidyl butyrate

: 65031-96-1
(S)-glycidyl butyrate

Conditions

Conditions	Yield
In tetrahydrofuran	44%

: 2461-40-7
(+/-)-glycidyl butyrate

A: 60456-26-0
(R)-glycidyl butyrate

B: 126254-87-3
(S)-2,3-dihydroxypropyl butyrate

C: 65031-96-1
(S)-glycidyl butyrate

Conditions

Conditions	Yield
With (acetao)(aqua)(S,S)-N,N′-bis(3,5-di-tert-butylsalicylidene-1,2-cyclohexanediamino)-cobalt(III); water In tetrahydrofuran at 0℃; for 12h; Jacobsen rearrangement; optical yield given as %ee;	A 40% B n/a C n/a

...Expand

: 2461-40-7
(+/-)-glycidyl butyrate

: 103-49-1
dibenzylamine

A: 3-(N,N-dibenzylamino)-2-hydroxypropyl butyrate

B: 3-(N,N-dibenzylamino)-1-hydroxypropan-2-yl butyrate

Conditions

Conditions	Yield
With ytterbium(III) triflate In tetrahydrofuran for 0.333333h; Heating; Yield given. Yields of byproduct given;

...Expand

: 2461-40-7
(+/-)-glycidyl butyrate

A: 78906-37-3
C7H9O3

B: 78906-48-6
C7H11O3

Conditions

Conditions	Yield
With tert-butoxyl radical In various solvent(s)

: 2461-40-7
(+/-)-glycidyl butyrate

: 6811-77-4
3-deazaadenine

: Butyric acid (R)-3-(4-amino-imidazo[4,5-c]pyridin-1-yl)-2-hydroxy-propyl ester

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 5h;

: 2461-40-7
(+/-)-glycidyl butyrate

A: Butyric acid 3-azido-2-hydroxy-propyl ester

B: Butyric acid 2-azido-3-hydroxy-propyl ester

Conditions

Conditions	Yield
With hydrogenchloride; trimethylsilylazide; lithium isopropoxide; ytterbium(III) triflate 1) THF, r.t., 17 h, 2) THF; Yield given. Multistep reaction. Yields of byproduct given;

Glycidyl butyrate Chemical Properties

Product Name: Glycidyl butyrate (2461-40-7)

Molecular Formula: C₇H₁₂O₃
Molecular Weight: 144.17g/mol
Mol File: 2461-40-7.mol
Boiling point: 196.3 °C at 760 mmHg
Flash Point: 85 °C
Density: 1.069 g/cm³
Product Categories: API intermediates
Synonyms of Glycidyl butyrate (2461-40-7): glycidyl butyrate ; (r)-2,3-epoxypropyl butyrate ; 2,3-epoxypropyl ester butyric acid .

Glycidyl butyrate Uses

Glycidyl butyrate (2461-40-7) is widely used in chiral drugs, pesticides, spices chiral synthesis.Ink. Resin. Acrylic paint. Adhesives. Latex. Plastic alloy. Photosensitive materials, organic synthesis, polymer synthesis of modified.

Glycidyl butyrate Specification

Glycidyl butyrate (2461-40-7) is a colorless and transparent liquid, insoluble in water, almost insoluble in all organic solvents, on the skin and mucous membrane irritant, almost non-toxic. Because of its carbon-carbon molecule that contains both the double bond, but also contains epoxy groups, both to free radical-type reaction, but also for ion-type reaction, therefore, has a very high response flexibility to separate the different reactions. widely used in medicine, photosensitive materials, organic synthesis and polymer-modified and other fields. derived products have excellent anti-UV, water-resistant heat-resistant characteristics, is an important fine chemical raw material.

Product Name

Glycidyl butyrate

Synthetic route

Glycidyl butyrate Chemical Properties

Glycidyl butyrate Uses

Glycidyl butyrate Specification

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