Glycylglycine supplier | CasNO.556-50-3

Name
Glycylglycine
EINECS 209-127-8
CAS No. 556-50-3
Article Data115
CAS DataBase
Density 1.337 g/cm³
Solubility Soluble in hot water
Melting Point 262-264 °C
Formula C₄H₈N₂O₃
Boiling Point 453.2 °C at 760 mmHg
Molecular Weight 132.119
Flash Point 227.9 °C
Transport Information
Appearance white powder
Safety 24/25-26
Risk Codes 36
Molecular Structure
Hazard Symbols Xi
Synonyms Diglycine;2-(Aminoacetamido)acetic acid;Glycine dipeptide;
PSA 92.42000
LogP -0.76290

Synthetic route

: 56-40-6
glycine

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With silica gel In toluene for 20h; Heating;	92.4%
With zeolite Na-BETA In water at 120℃; var. silicates and pH;
Multistep reaction;
With Sodium trimetaphosphate In aq. buffer at 37℃; under 225023 Torr; pH=10.7; Pressure; Temperature;

: 31972-52-8
Boc-Gly-Gly-OH

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane Large scale;	84.9%
With trifluoroacetic acid In dichloromethane at -5℃;

: 208645-74-3
Gly-Gly-MCA

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With ethylenediaminetetraacetic acid; dipeptydyl-peptidase DPP5; sodium phosphate; sodium chloride In water at 37℃; for 0.5h; pH=7.0; Catalytic behavior; Enzymatic reaction;

: tetrabutylphosphonium glycinate

: 5680-79-5
glycine ethyl ester hydrochloride

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
Stage #1: tetrabutylphosphonium glycinate; glycine ethyl ester hydrochloride at 60℃; for 3h; Inert atmosphere; Stage #2: With acetic acid In chloroform at 20℃; for 3h;	54%

: 627-74-7
glycylglycine ethyl ester

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With 15K(1+)H(1+)25H2O*O122P4W34Zr(16-); water; hydrogen chloride In water-d2 at 60℃; pH=5;

: 20238-94-2
glycylglycinamide

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With 15K(1+)H(1+)25H2O*O122P4W34Zr(16-); water; hydrogen chloride In water-d2 at 60℃; pH=5;

: 2566-19-0
CbzGlyGly

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With trifluoroacetic acid
With nitromethane; hydrogen bromide
With phosphonium iodide; acetic acid at 45 - 50℃; im Wasserstoff-Strom;

: 5893-07-2
N-tritylglycylglycine

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With acetic acid
With ethanol; palladium Hydrogenation;

N--glycine: N--glycine

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With ethanol; hydrazine hydrate

: 18409-49-9
N-carbamoyl-L-alanine

: 56-40-6
glycine

A: 56-41-7
L-alanin

B: 687-69-4
alanylglycine

C: 556-50-3
glycylglycine

D: 462-60-2
N-carbamoylglycine

Conditions

Conditions	Yield
In phosphate buffer at 80℃; for 1272h; pH=6.8;

...Expand

: 556-33-2
glycine-glycine-glycine

A: 556-50-3
glycylglycine

B: 56-40-6
glycine

Conditions

Conditions	Yield
With (Et2NH2)8[{α-PW11O39Zr-(μ-OH)(H2O)}2]*7H2O; water; 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid sodium salt In water-d2 at 50℃; for 24h; Reagent/catalyst;

: 7451-76-5
glycyl-glycyl-L-histidine

A: 556-50-3
glycylglycine

B: 71-00-1
L-histidine

Conditions

Conditions	Yield
With (Et2NH2)8[{α-PW11O39Zr-(μ-OH)(H2O)}2]*7H2O; water; 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid sodium salt In water-d2 at 60℃; Reagent/catalyst;

: 15474-96-1
chloroacetyldiglycine

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With lithium hydroxide; water; 1,2-diamino-benzene

: 3916-37-8
N-(N-benzyloxycarbonyl-glycyl)-glycine-(4-nitro-benzyl ester)

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With hydrogenchloride; methanol; palladium on activated charcoal Hydrogenation.R 4:THF;

: 39522-14-0
N-{N-[(2-nitro-phenoxy)-acetyl]-glycyl}-glycine

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With sodium hydrogencarbonate; platinum Hydrogenation.Erhitzen des Reaktionsprodukts mit H2O;

: 78641-72-2
[2-(3,5-Dinitro-4-oxo-4H-pyridin-1-yl)-acetylamino]-acetic acid

A: 556-50-3
glycylglycine

B: 78641-61-9
3,5-Dinitro-1-propyl-1H-pyridin-4-one

Conditions

Conditions	Yield
With propylamine	A 80% B n/a

: 106-57-0
Glycine anhydride

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With lithium hydroxide
With ammonia; water
With lithium hydroxide

: 103-72-0
phenyl isothiocyanate

: 121574-49-0
Ac-Ala-DAPA-Gly-Gly-OH

A: 556-50-3
glycylglycine

B: (S)-2-Acetylamino-N-((S)-6-oxo-2-phenylamino-5,6-dihydro-4H-[1,3]thiazin-5-yl)-propionamide

Conditions

Conditions	Yield
With N-ethylmorpholine;; acetic acid In ethanol at 37℃; for 2.5h; Product distribution; other reagents, other times, other temp.;

...Expand

: 1419234-19-7
H2N-GGSEFG-COOH

: H2N-Y-ALPETGG-COOH

A: 556-50-3
glycylglycine

B: 1419234-20-0
H2N-YALPETGGSEFG-COOH

Conditions

Conditions	Yield
With sortase A; sodium chloride; calcium chloride In aq. buffer at 37℃; pH=7.5; Enzymatic reaction;

...Expand

: 56-40-6
glycine

A: 106-57-0
Glycine anhydride

B: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With silica gel In toluene for 20h; Heating;	A 44.3% B 10.7%
With silica gel In toluene for 20h; Product distribution; Heating; glycine adsorbed on silica gel;
In water at 200℃; under 187515 Torr; pH=6.1; Kinetics; Equilibrium constant; Further Variations:; Temperatures;
With 2Zn(2+)2H2OC8MoN8(4-) at 120℃; for 840h; Reagent/catalyst; Temperature;	A 20.3 %Chromat. B 19.23 %Chromat.

: 56-40-6
glycine

A: 107-97-1
sarcosine

B: 5473-12-1
N-methylglycine methylester

C: 556-50-3
glycylglycine

D: 142-73-4
iminodiacetic acid

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrogen at 180℃; under 300.03 Torr; for 0.166667h;

...Expand

: 53090-33-8
N-chloroglycylglycine

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With sulfite(2-) In various solvent(s) at 25℃; pH=8.59; Kinetics; Dehalogenation; UV-irradiation;

: 27440-15-9
N-(N-carboxy-glycyl)-glycine

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With borax; sodium dihydrogenphosphate at 26℃; Equilibrium constant;

: 2-<1-(2,5-dimethylpyrrolyl)>acetylglycine

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With potassium hydroxide; hydroxylamine hydrochloride In methanol; water for 24h; Heating; Yield given;

: 56-40-6
glycine

A: 106-57-0
Glycine anhydride

B: 556-33-2
glycine-glycine-glycine

C: 637-84-3
tetraglycine

D: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With hydrogen In water at 200℃; under 187515 Torr; for 0.0333333h; Product distribution; Further Variations:; Temperatures; Reagents;

...Expand

: (CO)3Mn((C5H3)(CH(CH3)N(CH3)2)(CHNCH2CONCuCH2COO))

A: (R(c),R,S(f))-2(α-(N,N-dimethylamino)ethyl)formylcymantrene

B: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With hydrogenchloride; sodium carbonate In water acid hydrolysis by addn. of 3N HCl, then neutralized by Na2CO3, extd. with CCl4;

: (CO)3Mn((C5H3)(CH(CH3)N(CH3)2)(CHNCH2CONCuCH2COO))

: (R,S(c),R,S(f))-2(α-(N,N-dimethylamino)ethyl)formylcymantrene

B: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With hydrogenchloride; sodium carbonate In water acid hydrolysis by addn. of 3N HCl, then neutralized by Na2CO3, extd. with CCl4;

: 6319-96-6
N-(chloroacetyl)glycine

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With ammonia; water

: 19525-53-2
Cbz-Gly-Gly-OBn

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid

: 100135-84-0
N-(N-benzylsulfanylcarbonyl-glycyl)-glycine

: 556-50-3
glycylglycine

Conditions

Conditions	Yield
With 1,4-dioxane; Perbenzoic acid; water
With Perbenzoic acid; water; benzene
With Perbenzoic acid; water; acetic acid

: 556-50-3
glycylglycine

: 106-57-0
Glycine anhydride

Conditions

Conditions	Yield
With 14C2H7N14H(1+)2H2O2O(2-)2Zr(4+)*O122P4W34(18-) In dimethyl sulfoxide at 70℃; for 24h; Solvent; Reagent/catalyst;	100%
With silica gel In gas at 180 - 200℃; under 0.08 Torr;	46%
With hydrogenchloride at 150 - 160℃; im Rohr;

: 556-50-3
glycylglycine

: 996-50-9
N,N-diethyl-1,1,1-trimethylsilanamine

: 39553-15-6
N,O-bis(trimethylsilyl)glycyl-glycine

Conditions

Conditions	Yield
In acetonitrile for 2h;	100%

: 556-50-3
glycylglycine

: 104-15-4
toluene-4-sulfonic acid

: 107-18-6
allyl alcohol

: 1188307-54-1
PTSA*H-Gly-Gly-OAll

Conditions

Conditions	Yield
In toluene Reflux; Inert atmosphere;	100%

...Expand

: 556-50-3
glycylglycine

: 769922-77-2
(S)-benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

: 37700-64-4
(5S)-5-benzyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile at 20℃;	98%

: sodium tetrachloropalladate(II)

: 556-50-3
glycylglycine

: 89954-58-5
Dichlorobis(diglycinato)palladium(II)

Conditions

Conditions	Yield
In water stirring for etwa 13h; filtration, washing twofold with water, drying in vac., elem.anal.;	98%

: 556-50-3
glycylglycine

: N,3-diphenyl-N-((trifluoromethyl)sulfonyl)propiolamide

A: 456-64-4
phenyl trifluoromethanesulfonamide

B: (3-phenylpropioloyl)glycylglycine

Conditions

Conditions	Yield
In methanol; water at 20℃; for 5h; Green chemistry; chemoselective reaction;	A n/a B 97%

...Expand

: 556-50-3
glycylglycine

: C52H39N5O7

: C52H42N6O7

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 40℃;	93%

: 120-72-9
indole

: 50-00-0
formaldehyd

: 556-50-3
glycylglycine

: N,N-bis[(1H-indol-3-yl)methyl]glycylglycine

Conditions

Conditions	Yield
Stage #1: formaldehyd; glycylglycine In water at 55℃; Mannich Aminomethylation; Stage #2: indole In ethanol; water at 55℃; for 0.5h; Mannich Aminomethylation;	93%

...Expand

: 556-50-3
glycylglycine

: 98-88-4
benzoyl chloride

: 1145-32-0
N-(N'-benzoyl-2-aminoethanoyl)-2-aminoethanoic acid

Conditions

Conditions	Yield
With dodecyltrimethylammonium bromide; sodium carbonate In tetrahydrofuran Heating;	92%

: 1809-19-4
dibutyl hydrogen phosphite

: 556-50-3
glycylglycine

: 136884-29-2
N-(O,O-dibutylphosphoryl)-glycyl-glycine

Conditions

Conditions	Yield
With triethylamine In tetrachloromethane; ethanol; water 1) -3 - 0 deg C, 7-8 h, 2) r.t., 5-6 h;	92%

: 556-50-3
glycylglycine

: 138202-17-2
N2-tetrabromophthaloyl-L-aspartic anhydride

: 138202-30-9
{2-[(S)-2,5-Dioxo-3-(4,5,6,7-tetrabromo-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrrolidin-1-yl]-acetylamino}-acetic acid

Conditions

Conditions	Yield
In acetic acid 1.) 20 deg C, 30 min, 2.) 120 deg C;	92%

: 556-50-3
glycylglycine

: 80681-01-2
[2-Oxo-2-(2-thioxo-thiazolidin-3-yl)-ethyl]-carbamic acid benzyl ester

: 2566-20-3
[2-(2-Benzyloxycarbonylamino-acetylamino)-acetylamino]-acetic acid

Conditions

Conditions	Yield
Ambient temperature;	90%

: 556-50-3
glycylglycine

: 256235-92-4
N-succinimidyl 3-[3,3-dimethylspiro[2,3-dihydro-1H-indole-2,3'-(3'H-naphtho[2,1-b][1,4]oxazine)]-1-yl]-propionate

: 256235-93-5
3-[3,3-dimethylspiro[2,3-dihydro-1H-indole-2,3'-(3'H-naphtho[2,1-b][1,4]oxazine)]-1-yl]propionylglycylglycine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 20℃; for 6h;	90%

: 556-50-3
glycylglycine

: 1131147-59-5
7-(1H-benzo[d][1,2,3]triazole-1-carbonyl)-5-ethyl-[1,3]dioxolo[4,5-g]quinolin-8(5H)-one

: 1131147-69-7
2-[2-(5-ethyl-8-oxo-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxamido)acetamido]-3-acetic acid

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile at 20℃; for 3h;	90%

: 556-50-3
glycylglycine

: 1131148-55-4
1-[(9-fluorenylmethyloxycarbonyl)]benzotriazole

: 35665-38-4
2-[2-{({(9H-fluoren-9-yl)methoxy}carbonyl)amino}acetamido]acetic acid

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile at 20℃; for 2h;	90%

: 556-50-3
glycylglycine

: 114416-17-0
allyl 1H-benzo[d][1,2,3]triazole-1-carboxylate

: 343260-53-7
2-[2-{({allyloxy}carbonyl)amino}acetamido]acetic acid

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile at 20℃; for 2h;	90%

: 556-50-3
glycylglycine

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 35665-38-4
2-[2-{({(9H-fluoren-9-yl)methoxy}carbonyl)amino}acetamido]acetic acid

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane; water at 20℃; for 12h;	89%
With sodium carbonate In 1,4-dioxane; water at 20℃;	77%

: 556-50-3
glycylglycine

: 142-71-2
copper diacetate

: 118-93-4
o-hydroxyacetophenone

: potassium hydroxide

: K[Cu(N-2-hydroxyacetophenoneglycylglycine-3H)]*2.5H2O

Conditions

Conditions	Yield
In ethanol; water N compd. dissolved in aq. EtOH (1:2) containing KOH, cooled to room temp., soln. of aromatic compd. in abs. EtOH added slowly with stirring for 1.5 h, aq. soln. of Cu compd. added dropwise, pH adjusted with KOH to 9-10, stirred at 50°C for 8 h; filtered, concd., pptd. with acetone, recrystd. from water/acetone, dried in vac. over P2O5 at 35°C; elem. anal.;	89%

...Expand

: 556-50-3
glycylglycine

: 4-methyl-1,2,3-thiadiazol-5-ylcarbonylazide

: N-{[(4-methyl-1,2,3-thiadiazol-5-yl)carbamoyl]aminoacetyl}aminoacetic acid

Conditions

Conditions	Yield
In 1,4-dioxane for 3h; Reflux;	89%

: 556-50-3
glycylglycine

: 6780-38-7
N-phthaloylglycine chloride

: 93923-88-7
N-[N-(N,N-phthaloyl-glycyl)-glycyl]-glycine

Conditions

Conditions	Yield
Stage #1: glycylglycine With magnesium oxide In water at 25℃; for 4h; Stage #2: N-phthaloylglycine chloride In 1,4-dioxane; water at 25℃; for 2h;	87%
With 1,4-dioxane; sodium acetate; acetic acid
With water; sodium hydrogencarbonate; benzene

Glycylglycine Specification

The Glycylglycine, with the CAS registry number 556-50-3, is also known as [(Ammonioacetyl)amino]acetate. It belongs to the product categories of Biochemistry; Oligopeptides; Peptide Synthesis; Peptide. Its EINECS registry number is 209-127-8. This chemical's molecular formula is C₄H₈N₂O₃ and molecular weight is 132.12. Its IUPAC name is called 2-[(2-aminoacetyl)amino]acetic acid.

Physical properties of Glycylglycine: (1)ACD/LogP: -1.85; (2)ACD/LogD (pH 5.5): -4.34; (3)ACD/LogD (pH 7.4): -4.67; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 5; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 4; (11)Index of Refraction: 1.504; (12)Molar Refractivity: 29.3 cm³; (13)Molar Volume: 98.8 cm³; (14)Surface Tension: 60.1 dyne/cm; (15)Density: 1.337 g/cm³; (16)Flash Point: 227.9 °C; (17)Enthalpy of Vaporization: 78.1 kJ/mol; (18)Boiling Point: 453.2 °C at 760 mmHg; (19)Vapour Pressure: 1.78E-09 mmHg at 25°C.

Preparation: this chemical can be prepared by glycine and ethylenediamine. This reaction will need methanol.

Uses of Glycylglycine: it can be used to produce piperazine-2,5-dione at temperature of 150 - 160 °C. This reaction will need reagent diluted hydrochloric acid.

Glycylglycine is the dipeptide of glycine, making it the simplest peptide. Because of its low toxicity, it is useful as a buffer for biological systems with effective ranges between pH 2.5-3.8 and 7.5-8.9, however, it is only moderately stable for storage once dissolved. It is used in the synthesis of more complex peptides. The product is a biochemical reagents which is used for blood preservation and protein cytochrome C and injection of drug and stabilizer in biological research and medicine.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes. You must avoid contacting it with skin and eyes. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(C(=O)NCC(=O)O)N
(2)InChI: InChI=1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)
(3)InChIKey: YMAWOPBAYDPSLA-UHFFFAOYSA-N

Product Name

Glycylglycine

Synthetic route

Glycylglycine Specification

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