Guaiazulene supplier | CasNO.489-84-9

Name
Guaiazulene
EINECS 207-701-2
CAS No. 489-84-9
Article Data93
CAS DataBase
Density 0.976
Solubility
Hazard Symbols
Synonyms Azulene,7-isopropyl-1,4-dimethyl- (8CI); 1,4-Dimethyl-7-(1-methylethyl)Azulene;1,4-Dimethyl-7-isopropylazulene; 3,8-Dimethyl-5-(2-propyl)azulene;7-Isopropyl-1,4-dimethylazulene; AZ 8; AZ 8 Beris; Azulen-Beris; Azulon;Azunol; Cuteazul; Eucazulen; Guaiazulene; Guaiazulene blue; Kessazulen; NSC4714; Purazulen; S-Guaiazulene; Silazulon; Uroazulen; Vaumigan; Vetivazulen
PSA 0.00000
LogP 4.53160

Synthetic route

: 1203707-11-2
1,1-bis{4-[2-(dimethylamino)ethoxy]phenyl}-2-(3-guaiazulenyl)ethylene

: 275-51-4
azulene

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 1314045-03-8
2-(azulen-1-yl)-1,1-bis{4-[2-(dimethylamino)ethoxy]phenyl}ethylene

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water; acetonitrile at 60℃; for 3h;	A 97% B 58%

...Expand

: 867380-19-6
1-chloro-7-isopropyl-4-methyl-azulene

: 13061-96-6
dihydroxy-methyl-borane

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

Conditions

Conditions	Yield
With palladium diacetate; potassium phosphate In toluene at 100℃; for 24h;	94%

: 275-51-4
azulene

: 741737-71-3
1,1-bis[4-(methoxy)phenyl]-2-(3-guaiazulenyl)ethylene

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 1314045-02-7
1,3-bis[2,2-bis(4-methoxyphenyl)ethenyl]azulene

C: 2-(azulen-1-yl)-1,1-bis(4-methoxyphenyl)ethylene

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water; acetonitrile at 60℃; for 3h;	A 93% B 19% C 34%

...Expand

: 1103995-55-6
1,1-bis[4-(dimethylamino)phenyl]-2-(3-guaiazulenyl)ethylene

: 275-51-4
azulene

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 1314044-93-3
2-(azulen-1-yl)-1,1-bis[4-(dimethylamino)phenyl]ethylene

C: 1314044-97-7
1,1-di(azulen-1-yl)-2,2-bis[4-(dimethylamino)phenyl]ethane

D: 1314044-96-6
1,3-bis{2,2-bis[4-(dimethylamino)phenyl]ethenyl}azulene

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water; acetonitrile at 60℃; for 3h;	A 91% B 46% C 13% D 19%

...Expand

: dimethyl 3-isopropyl-6,11-dimethyltricyclo<6.2.2.01,7>dodeca-2,4,6,9,11-pentaene-9,10-dicarboxylate

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 98525-07-6, 72898-39-6, 98525-12-3, 98525-13-4
dimethyl 1,6-dimethyl-9-(1-methylethyl)heptalene-4,5-dicarboxylate

Conditions

Conditions	Yield
In acetonitrile at 110℃; for 1h;	A 29% B 71%
In acetonitrile at 100℃; for 1h; in sealed tube;	A 29% B 71%

: 3-bromoguaiazulenium bromide

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 17509-79-4
2,2'-biguaiazulenyl

Conditions

Conditions	Yield
With methanol Title compound not separated from byproducts;	A 50% B 20%

: 64-17-5
ethanol

: 10487-58-8
bis(3,8-dimethyl-5-isopropyl-1-azulenyl) ketone

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 81920-91-4
ethyl 3,8-dimethyl-5-isopropylazulene-1-carboxylate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 0.166667h; Heating;
With toluene-4-sulfonic acid for 0.166667h; Mechanism; Heating; regioselectivity; other substrates;

...Expand

: 64-17-5
ethanol

: 150985-85-6
Azulen-1-yl-(5-isopropyl-3,8-dimethyl-azulen-1-yl)-methanone

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 1206-88-8
ethyl azulene-1-carboxylate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 6h; Heating;

...Expand

: 64-17-5
ethanol

: 150985-81-2
(5-Isopropyl-3,8-dimethyl-azulen-1-yl)-(4,6,8-trimethyl-azulen-1-yl)-methanone

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 81920-91-4
ethyl 3,8-dimethyl-5-isopropylazulene-1-carboxylate

C: 4,6,8-Trimethyl-azulene-1-carboxylic acid ethyl ester

D: 275-51-4
azulene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 0.166667h; Heating;

...Expand

: 64-17-5
ethanol

: 150985-82-3
1-[3-(5-Isopropyl-3,8-dimethyl-azulene-1-carbonyl)-4,6,8-trimethyl-azulen-1-yl]-ethanone

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 834-97-9
1-acetyl-4,6,8-trimethylazulene

C: 81920-91-4
ethyl 3,8-dimethyl-5-isopropylazulene-1-carboxylate

D: 3-Acetyl-4,6,8-trimethyl-azulene-1-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 1h; Heating;

...Expand

: 64-17-5
ethanol

: 150985-83-4
2,2,2-Trifluoro-1-[3-(5-isopropyl-3,8-dimethyl-azulene-1-carbonyl)-4,6,8-trimethyl-azulen-1-yl]-ethanone

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 81920-91-4
ethyl 3,8-dimethyl-5-isopropylazulene-1-carboxylate

C: 841-83-8
1-trifluoroacetyl-4,6,8-trimethylazulene

D: 4,6,8-Trimethyl-3-(2,2,2-trifluoro-acetyl)-azulene-1-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 2.5h; Heating; Further byproducts given;

...Expand

: 105369-35-5
guaia-1(5),6-diene

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

Conditions

Conditions	Yield
palladium on activated charcoal In xylene for 36h; Heating;

: 90052-61-2
3-bromo-7-isopropyl-1,4-dimethylazulene

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 17509-79-4
2,2'-biguaiazulenyl

C: 90052-62-3, 123287-97-8
7-(2-bromo-1-methylethyl)-1,4-dimethylazulene

D: 123279-26-5
7-<(Z)-2-bromo-1-methylethenyl>-1,4-dimethylazulene

E: 123257-39-6
7-<(E)-2-bromo-1-methylethenyl>-1,4-dimethylazulene

F: 123257-26-1
7-(1-bromomethyl-2-bromoethyl)-1,4-dimethylazulene

Conditions

Conditions	Yield
In benzene for 0.333333h; Product distribution; Ambient temperature; different solvent and reaction times;

...Expand

: 17066-71-6, 54999-07-4, 63568-74-1
ergolide

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

Conditions

Conditions	Yield
With selenium at 300 - 350℃; for 0.833333h;

: 111873-85-9, 119439-50-8
6-(3-guaiazulenyl)-1(6H)-guaiazulenone

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 111873-87-1
5-isopropylidene-3,8-dimethyl-1(5H)-azulenone

C: 111873-84-8, 119479-40-2
1-(3-guaiazulenyl)-6a-isopropyl-2,5-dimethyl-1,1a,3,6a-tetrahydrocyclopropainden-3-one

Conditions

Conditions	Yield
In octane at 80℃;

...Expand

: 144126-95-4
5-Isopropenyl-3,8-dimethyl-1,2,3,4,5,6,7,8-octahydro-azulen-1-ol

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid 1) benzene, reflux, 2 h, 2) decaline, reflux, 2 h; Yield given. Multistep reaction;

: alismol

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

Conditions

Conditions	Yield
palladium on activated charcoal at 320 - 330℃; for 0.0833333h; Heating;

: 151621-28-2
5-(1-guaiazulenyl)-5,6-dihydro-9-isopropyl-1-methyl-4-nitrocyclopentaheptalene

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 9-isopropyl-1-methyl-4-nitroaceheptylene

Conditions

Conditions	Yield
With phosphoric acid

: alismoxide

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

Conditions

Conditions	Yield
palladium on activated charcoal at 320 - 330℃; for 0.0833333h; Heating;

: 1-ethylideneguaiazulenium perchlorate

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

Conditions

Conditions	Yield
With 4,6,8-trimethylazulene In acetic acid for 2h; from boiling point to r.t.; Yield given;

: dimethyl 3-isopropyl-6,11-dimethyltricyclo<6.2.2.01,7>dodeca-2,4,6,9,11-pentaene-9,10-dicarboxylate

A: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

B: 98525-07-6, 72898-39-6, 98525-12-3, 98525-13-4
dimethyl 1,6-dimethyl-9-(1-methylethyl)heptalene-4,5-dicarboxylate

C: 145948-89-6
dimethyl (Z)-1-(5-isopropyl-3,8-dimethylazulen-1-yl)ethene-1,2-dicarboxylate

Conditions

Conditions	Yield
In decane at 60 - 80℃; Kinetics; Thermodynamic data; Mechanism; var. solv. and temp;

...Expand

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 4482-01-3
o-benzenedisulfonimide

: 123-11-5
4-methoxy-benzaldehyde

: (3-guaiazulenyl)(4-methoxyphenyl)methylium o-benzenedisulfonimide

Conditions

Conditions	Yield
In acetonitrile at 20 - 25℃; for 2h;	99%

...Expand

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 4124-31-6
trichloroacetic acid anhydride

: 846-33-3
3-trichloroacetylguaiazulene

Conditions

Conditions	Yield
In dichloromethane	98%
In dichloromethane	76%
In dichloromethane
In dichloromethane at 20℃; for 2h;

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 643-79-8
o-phthalic dicarboxaldehyde

: 1,2-phenylenebis(3-guaiazulenylmethylium) bis(hexafluorophosphate)

Conditions

Conditions	Yield
In diethyl ether; acetonitrile at 25℃;	98%
With hexafluorophosphoric acid In water; acetic acid at 25℃; for 2h;	88%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 131543-46-9
Glyoxal

: α,α'-bis(3-guaiazulenylmethylium) bis(tetrafluoroborate)

Conditions

Conditions	Yield
With tetrafluoroboric acid; acetic acid In water at 25℃; for 1h;	98%
With tetrafluoroboric acid; acetic acid at 25℃; for 1h;	98%

: 98-03-3
thiophene-2-carbaldehyde

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: (3-guaiazulenyl)(2-thienyl)methylium hexafluorophosphate

Conditions

Conditions	Yield
With hexafluorophosphoric acid In methanol at 25℃; for 0.5h;	98%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: N-[(5-isopropyl-3,8-dimethylazulen-1-yl)methylene]-N-methylmethanaminium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 0℃; for 0.75h; Vilsmeier Reaction; Stage #2: 7-isopropyl-1,4-dimethyl-azulene at 0 - 40℃; Vilsmeier Reaction; Stage #3: With tetrafluoroboric acid In water	98%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 4464-76-0, 39090-28-3, 39090-30-7, 42565-21-9, 66768-20-5, 122798-27-0
1,2-bis(4-methoxyphenyl)-1,2-ethanediol

: 741737-71-3
1,1-bis[4-(methoxy)phenyl]-2-(3-guaiazulenyl)ethylene

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 60℃; for 3h;	97%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 123-08-0
4-hydroxy-benzaldehyde

: (3-guaiazulenyl)(4-hydroxyphenyl)methylium hexafluorophosphate

Conditions

Conditions	Yield
With hexafluorophosphoric acid In methanol; water at 25℃; for 2h;	97%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 123-11-5
4-methoxy-benzaldehyde

: (3-guaiazulenyl)(4-methoxyphenyl)methylium hexafluorophosphate

Conditions

Conditions	Yield
With hexafluorophosphoric acid In methanol; water at 25℃; for 2h;	97%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 3516-77-6
4'-methoxyazobenzene-4-carbaldehyde

: (3-guaiazulenyl)[4-(4-methoxyphenylazo)phenyl]methylium hexafluorophosphate

Conditions

Conditions	Yield
With hexafluorophosphoric acid In methanol; water at 25℃;	97%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 107321-41-5
(E)-4-((4-methoxyphenyl)diazenyl)benzaldehyde

: C29H29N2O(1+)*F6P(1-)

Conditions

Conditions	Yield
With hexafluorophosphoric acid In methanol at 25℃; for 2h;	97%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 1609117-40-9
4-[(E)-2-(3-guaiazulenyl)diazenyl]benzene-1-carbaldehyde

: {4-[(E)-2-(3-guaiazulenyl)diazenyl]phenyl}(3-guaiazulenyl)methylium hexafluorophosphate

Conditions

Conditions	Yield
With hexafluorophosphoric acid In methanol; water at 20℃; for 2h;	97%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 161126-12-1
3-Bromoazulene-1,5-quinone

: 5'-Isopropyl-3',8'-dimethyl-[1,1']biazulenyl-3,7-dione

Conditions

Conditions	Yield
In methanol Ambient temperature;	96%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 100-52-7
benzaldehyde

: (3-guaiazulenyl)phenylmethylium hexafluorophosphate

Conditions

Conditions	Yield
With hexafluorophosphoric acid In methanol; water at 25℃; for 1.5h;	96%
With hexafluorophosphoric acid In methanol at 25℃; for 1.5h;	96%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 104-55-2
3-phenyl-propenal

: (2E)-1-(3-guaiazulenyl)-3-phenyl-2-propen-1-ylium hexafluorophosphate

Conditions

Conditions	Yield
With hexafluorophosphoric acid In diethyl ether; water; acetonitrile at 25℃; for 1h;	96%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 135-02-4
ortho-anisaldehyde

: (3-guaiazulenyl)(2-methoxyphenyl)methylium tetrafluoroborate

Conditions

Conditions	Yield
With tetrafluoroboric acid In methanol; water at 25℃; for 2h;	96%

: 556-18-3
4-aminobenzaldehyde

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 1609117-40-9
4-[(E)-2-(3-guaiazulenyl)diazenyl]benzene-1-carbaldehyde

Conditions

Conditions	Yield
Stage #1: 4-aminobenzaldehyde With hydrogenchloride; sodium nitrite In water at 0 - 20℃; for 0.25h; Stage #2: 7-isopropyl-1,4-dimethyl-azulene In ethanol; water at 20℃; for 2h;	96%

: 884866-01-7
1-(4-methylbenzensulfonyl)-4-phenyl-1H-1,2,3-triazole

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: (Z)-N-(2-(5-isopropyl-3,8-dimethylazulen-1-yl)-2-phenylvinyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With dirhodium tetraacetate In 1,2-dichloro-ethane at 60℃; for 2h; diastereoselective reaction;	96%
With rhodium (II) octanoate dimer In 1,2-dichloro-ethane at 60℃; for 3h;	96%

: 1-(4-methylbenzenesulfonyl)-4-(4-methylphenyl)-1,2,3-triazole

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: (Z)-N-(2-(5-isopropyl-3,8-dimethylazulen-1-yl)-2-p-tolylvinyl)-4-methylbenzenesulfonamide

Conditions

Conditions	Yield
With dirhodium tetraacetate In 1,2-dichloro-ethane at 60℃; for 3h; diastereoselective reaction;	96%
With rhodium (II) octanoate dimer In 1,2-dichloro-ethane at 60℃; for 3h;	96%

: 50-00-0
formaldehyd

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 55544-35-9
3,3-methylenebis(guaiazulene)

Conditions

Conditions	Yield
With acetic acid at 25℃; for 1h;	95%
With ethanol; sodium hydrogencarbonate

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 3331-47-3
5-isopropyl-3,8-dimethylazulene-1-carbaldehyde

Conditions

Conditions	Yield
Stage #1: 7-isopropyl-1,4-dimethyl-azulene; N,N-dimethyl-formamide With trichlorophosphate at 0℃; for 1h; Vilsmeier formylation; Stage #2: With potassium hydroxide; water	95%
Stage #1: 7-isopropyl-1,4-dimethyl-azulene; N,N-dimethyl-formamide With trichlorophosphate at 0℃; for 1h; Stage #2: With water; potassium hydroxide	94%
With trichlorophosphate In benzene for 0.666667h;	92%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 90052-61-2
3-bromo-7-isopropyl-1,4-dimethylazulene

Conditions

Conditions	Yield
With N-Bromosuccinimide; hexamethylenetetramine In hexane	95%
Multi-step reaction with 2 steps 1: Br2 / hexane / -20 °C 2: 100 percent / alkali View Scheme

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 122-03-2
(4-isopropylbenzaldehyde)

: 1-isopropyl-4-(3-guaiazulenylmethylium)benzene hexafluorophosphate

Conditions

Conditions	Yield
With hexafluorophosphoric acid In acetic acid at 25℃; for 2h;	95%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 39208-00-9
4-<<4'-(N,N-dimethylamino)phenyl-1'>azo>benzaldehyde

: {4-[4-(dimethylamino)phenylazo]phenyl}(3-guaiazulenyl)methylium hexafluorophosphate

Conditions

Conditions	Yield
With hexafluorophosphoric acid In methanol; water at 25℃;	95%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 1198330-30-1
3,3,3-trifluoro-2-hydroxy-2-(5-isopropyl-3,8-dimethylazulen-1-yl)propionic acid methyl ester

Conditions

Conditions	Yield
In hexane at 0℃; for 0.25h;	95%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 39208-00-9
(E)-4-((4-(dimethylamino)phenyl)diazenyl)benzaldehyde

: C30H32N3(1+)*F6P(1-)

Conditions

Conditions	Yield
With hexafluorophosphoric acid In methanol at 25℃; for 2h;	95%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 1316302-31-4
ethyl 2-benzoyl-4-(4-methoxyphenyl)-4-oxobut-2-enoate

: 1447465-53-3
ethyl 3-(guaiazulen-1-yl)-5-(4-methoxyphenyl)-2-phenylfuran-3-carboxylate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane for 5h; Reflux;	95%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 119-58-4
4,4'-bis(dimethylamino)benzhydrol

: 1562305-68-3
bis(4-dimethylaminophenyl)(3-guaiazulenyl)methane

Conditions

Conditions	Yield
With o-benzenedisulfonimide In neat (no solvent) at 30℃; for 5.5h; Friedel-Crafts Alkylation;	95%

: 489-84-9
7-isopropyl-1,4-dimethyl-azulene

: 407-25-0
trifluoroacetic anhydride

: 846-34-4
2,2,2-trifluoro-1-(5-isopropyl-3,8-dimethylazulen-1-yl)ethanone

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 2.3h;	94%
In dichloromethane

Guaiazulene Chemical Properties

Chemical Name: Guaiazulene
IUPAC NAME: 1,4-Dimethyl-7-propan-2-ylazulene
CAS No.: 489-84-9
EINECS: 207-701-2
RTECS: CO4790000
Molecular Formula: C₁₅H₁₈
Molecular Weight: 198.3 g/mol
Melting Point: 27-29 °C(lit.)
Density: 0.961 g/cm³
Flash Point: 142.3 °C
Boiling Point: 305.4 °C at 760 mmHg
Following is the structure of Guaiazulene (489-84-9):

Product Categories about Guaiazulene (489-84-9) are Azulenes ; Biochemistry ; Terpenes ; Terpenes (Others) ; Tropolones & Azulenes
The chemical synonymous of Guaiazulene (489-84-9) are 1,4-Dimethyl-7-(1-methylethyl)-azulen ; 1,4-Dimethyl-7-(1-methylethyl)azulene ; 1,4-Dimethyl-7-(1-methylethyl)-azulene ; 1,4-Dimethyl-7-isopropyl-azulen ; 3,8-Dimethyl-5-(2-propyl)azulene ; AZ-8 ; AZ-8 beris ; Azulen-Beris

Guaiazulene Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	525mg/kg (525mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 362, 1958.
mouse	LD50	oral	1220mg/kg (1220mg/kg)	BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 54, Pg. 362, 1958.
rat	LD50	oral	1550mg/kg (1550mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 615, 1969.

Guaiazulene Consensus Reports

Reported in EPA TSCA Inventory.

Guaiazulene Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
Xn: Harmful
Risk Statements about Guaiazulene (489-84-9):
R22 Harmful if swallowed.
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements about Guaiazulene (489-84-9):
S22 Do not breathe dust.
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
Attentions:
1. Storage: Keep container closed when not in use. Refrigerator (approx 4 °C). Store in a cool, dry area away from incompatible substances.
2. Handling: Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Do not breathe dust. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation

Product Name

Guaiazulene

Synthetic route

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