Hydralazine supplier | CasNO.86-54-4

Name
Hydralazine
EINECS 201-680-3
CAS No. 86-54-4
Density 1.2583 (rough estimate)
Solubility 4.8mg/L(22.5 oC)
Melting Point 172 ºC
Formula C8H8 N4
Boiling Point 276.07°C (rough estimate)
Molecular Weight 160.178
Flash Point
Transport Information
Appearance Yellow needles from methanol.
Safety Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, cardiomyopathy, changes in coronary arteries. Human teratogenic effects by an unspecified route: developmental abnormalities of the blood and lymphatic system. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1(2H)-Phthalazinone,hydrazone (9CI); Phthalazine, 1-hydrazino- (6CI,8CI); 1-Hydrazinophthalazine;1-Phthalazinylhydrazine; Apresolin; Apresoline; Apressin; Apressin(pharmaceutical); Aprezolin; Ba 5968; C 5968; Ciba 5968; Hidralazin;Hipoftalin; Hydralazin; Hydralazine; Hypophthalin; NSC 126699
PSA 63.83000
LogP 1.68870

Hydralazine Chemical Properties

IUPAC Name: Phthalazin-1-ylhydrazine
Product Name: Hydralazine
The MF of Hydralazine (CAS NO.86-54-4) is C₈H₈N₄.

The MW of Hydralazine (CAS NO.86-54-4) is 160.17592.
Synonyms of Hydralazine (CAS NO.86-54-4): 1(2H)-Phthalazinone, hydrazone, (1Z)- ; 1-Hydrazinophthalazine ; Phthalazin-1-yl-hydrazine ; [2H-Phthalazin-(1Z)-Ylidene]-Hydrazine Hydrochloride ; (2H)-Phthalazinone, hydrazone, monohydrochloride ; (2H)-Phthalazinone, hydrazone ; 1-Phthalazinylhydrazine
Product Categories: Amines;Aromatics;Heterocycles;Inhibitors
Apperance: Yiellow Solid
Index of Refraction: 1.777
EINECS: 201-680-3
Density: 1.373 g/ml
Flash Point: 251.3 °C
Boiling Point: 491.9 °C
Melting Point: 172 °C

Hydralazine Uses

Hydralazine (CAS NO.86-54-4) inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression.Used as Non-selective MAO-A/B inhibitor, semicarbazide-sensitive amine oxidase inhibitor and antihypertensive.

Hydralazine Production

Preparation Products: Hyaluronidase

Hydralazine Toxicity Data With Reference

1.	mma-sat 500 µg/plate	MUREAV Mutation Research. 66 (1979),247.
2.	slt-dmg-unr 200 mmol/L/6H	MUREAV Mutation Research. 120 (1983),233.
3.	orl-man TDLo:2086 mg/kg/2Y-I:SKN	BMJOAE British Medical Journal. 289 (1984),410.
4.	orl-wmn TDLo:730 mg/kg/2Y-I:SKN	BMJOAE British Medical Journal. 289 (1984),410.
5.	ims-man TDLo:89 µg/kg:CVS	EJPEDT European Journal of Pediatrics. 145 (1986),318.
6.	orl-rat LD50:90 mg/kg	PLRCAT Pharmacological Research Communications. 8 (1976),295.
7.	ipr-rat LD50:25 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 143 (1964),7.
8.	ivn-rat LD50:34 mg/kg	JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 40 (1951),559.
9.	orl-mus LD50:122 mg/kg	PLRCAT Pharmacological Research Communications. 8 (1976),295.
10.	ipr-mus LD50:100 mg/kg	JMCMAR Journal of Medicinal Chemistry. 22 (1979),671.
11.

Hydralazine Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 222.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 , 1980,p. 85.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

Hydralazine Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: allergic dermatitis, cardiomyopathy, changes in coronary arteries. Human teratogenic effects by an unspecified route: developmental abnormalities of the blood and lymphatic system. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Product Name

Hydralazine