Hydralazine hydrochloride supplier

Name
Hydralazine hydrochloride
EINECS 206-151-0
CAS No. 304-20-1
Article Data6
CAS DataBase
Density 1.2961 (rough estimate)
Solubility Soluble in water. Slightly soluble in diethyl ether and alcohol.
Melting Point 273 °C
Formula C₈H₉ClN₄
Boiling Point 491.9 °C at 760 mmHg
Molecular Weight 196.639
Flash Point 251.3 °C
Transport Information UN 2811 6.1/PG 3
Appearance white crystalline solid
Safety 26-36/37/39-45
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 1(2H)-Phthalazinone,hydrazone, monohydrochloride (9CI);Phthalazine, 1-hydrazino-,monohydrochloride (8CI);(Phthalazin-1-yl)hydrazine hydrochloride;1-Hydrazinophthalazine hydrochloride;1-Hydrazinophthalazine monohydrochloride;Apresoline hydrochloride;Apulon;Hydralazine chloride;Hydralazine monohydrochloride;Lopres;Hydralazine hcl;
PSA 63.10000
LogP 1.72400

Synthetic route

: 119-39-1
phthalazone

: 304-20-1
hydralazine hydrochloride

Conditions

Conditions	Yield
Stage #1: phthalazone With trichlorophosphate at 75℃; for 0.5h; Stage #2: With hydrazine hydrate In ethanol; water at 60 - 70℃; for 2h; Stage #3: With hydrogenchloride In ethanol; water pH=3;	65%

: 1044569-46-1
1-hydrazinophthalazine

: 304-20-1
hydralazine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 70 - 80℃; Product distribution / selectivity;	80%
With hydrogenchloride In water at 70 - 80℃; Product distribution / selectivity;	80%
With hydrogenchloride In water at 70 - 80℃; for 0.25h; Product distribution / selectivity;	65%
With hydrogenchloride Product distribution / selectivity;

: 19820-56-5
2-formylphenyl tosylate

: 304-20-1
hydralazine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium carbonate; palladium(II) trifluoroacetate; 1,3-bis-(diphenylphosphino)propane; magnesium sulfate; t-butoxycarbonylhydrazine / acetonitrile / 21 h / 140 °C / 7500.75 Torr / Autoclave 2.1: trichlorophosphate / 0.5 h / 75 °C 2.2: 2 h / 60 - 70 °C 2.3: pH 3 View Scheme

: 90-02-8
salicylaldehyde

: 304-20-1
hydralazine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium carbonate / acetonitrile; water / 2 h / 20 °C 2.1: potassium carbonate; palladium(II) trifluoroacetate; 1,3-bis-(diphenylphosphino)propane; magnesium sulfate; t-butoxycarbonylhydrazine / acetonitrile / 21 h / 140 °C / 7500.75 Torr / Autoclave 3.1: trichlorophosphate / 0.5 h / 75 °C 3.2: 2 h / 60 - 70 °C 3.3: pH 3 View Scheme

: 19064-69-8
phthalazin-1-ylamine

: 304-20-1
hydralazine hydrochloride

Conditions

Conditions	Yield
Stage #1: phthalazin-1-ylamine With hydrogenchloride; sodium nitrite at -5℃; Stage #2: With tin(ll) chloride; sodium sulfite

Hydralazine hydrochloride Consensus Reports

IARC Cancer Review: Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 24 , 1980,p. 85.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory.

Hydralazine hydrochloride Specification

This chemical is called Hydralazine hydrochloride, and its IUPAC name is phthalazin-1-ylhydrazine hydrochloride. With the molecular formula of C₈H₉ClN₄, its classification codes are Antihypertensive; Drug / Therapeutic Agent; Mutation data; Reproductive Effect; Tumor data. The CAS registry number of this chemical is 304-20-1. Additionally, its product categories are Chemical Amines; Amines; Aromatics; Heterocycles; Inhibitors; Monoamine Oxidase. It's a direct-acting vasodilator that is used as an antihypertensive agent.

Other characteristics of the Hydralazine hydrochloride can be summarised as followings: (1)ACD/LogP: 1.00; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.54; (4)ACD/LogD (pH 7.4): 0.99; (5)ACD/BCF (pH 5.5): 1.17; (6)ACD/BCF (pH 7.4): 3.31; (7)ACD/KOC (pH 5.5): 28.69; (8)ACD/KOC (pH 7.4): 81.4; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 32.26 Å²; (13)Flash Point: 251.3 °C; (14)Enthalpy of Vaporization: 75.87 kJ/mol; (15)Boiling Point: 491.9 °C at 760 mmHg; (16)Vapour Pressure: 8.05E-10 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: Cl.n2nc(c1ccccc1c2)NN
2.InChI: InChI=1/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H
3.InChIKey: ZUXNZUWOTSUBMN-UHFFFAOYAU

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	83mg/kg (83mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 368, 1951.
mouse	LD50	intravenous	71mg/kg (71mg/kg)		Drugs in Japan Vol. -, Pg. 1006, 1995.
mouse	LD50	oral	188mg/kg (188mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 97, 1969.
mouse	LD50	subcutaneous	73mg/kg (73mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Sapporo Igaku Zasshi. Sapporo Medical Journal. Vol. 6, Pg. 362, 1954.
rat	LD50	intravenous	34mg/kg (34mg/kg)		Drugs in Japan Vol. 6, Pg. 619, 1982.
rat	LD50	oral	280mg/kg (280mg/kg)		Drugs in Japan Vol. -, Pg. 1006, 1995.

Product Name

Hydralazine hydrochloride

Synthetic route

Hydralazine hydrochloride Consensus Reports

Hydralazine hydrochloride Specification

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