Isonicotinic acid supplier

Name
Isonicotinic acid
EINECS 200-228-2
CAS No. 55-22-1
Article Data238
CAS DataBase
Density 1.293 g/cm³
Solubility 5.2 g/L (20 °C) inwater
Melting Point ≥300 °C(lit.)
Formula C₆H₅NO₂
Boiling Point 395.997 °C at 760 mmHg
Molecular Weight 123.111
Flash Point 193.3 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 4-Pyridinecarboxylic acid;p-Pyridinecarboxylic acid;INA;1,4-Dihydroisonicotinic acid;gamma-Picolinic acid;4-carboxypyridine;4-Picolinic acid;pyridine-4-carboxylate;pyridine-4-carboxylic acid;gamma-Pyridinecarboxylic acid;
PSA 50.19000
LogP 0.77980

Synthetic route

: 872-85-5
pyridine-4-carbaldehyde

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With formic acid; dihydrogen peroxide at 0 - 4℃; for 12h; other aromatic aldehydes;	100%
With sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide In water; acetonitrile at 10℃; for 1h;	100%
With formic acid; dihydrogen peroxide at 0 - 4℃; for 12h;	100%

: 108-89-4
picoline

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With sulfuric acid; ozone; acetic acid; manganese(II) acetate at 16℃; for 1h;	97%
Stage #1: picoline With β‐cyclodextrin In water at 60℃; for 0.5h; Stage #2: With sulfuric acid; dihydrogen peroxide; boric acid In water at 40℃; for 6h;	94.7%
With potassium hydroxide; oxygen; 18-crown-6 ether In 1,2-dimethoxyethane at 25℃; for 96h;	80%

: 586-95-8
pyridine-4-methanol

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy In aq. buffer at 20℃; for 13h; pH=9.8 - 10.1; Catalytic behavior; Electrolysis;	97%
With oxygen at 120℃; for 12h; Green chemistry;	92%
With Langlois reagent In acetonitrile at 25℃; for 12h; Irradiation; Sealed tube;	90%

: 81660-73-3
isonicotinate tert-butyl ester

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With water; iodine In acetonitrile for 4h; Heating;	92%
at 324.9℃; Rate constant; Thermodynamic data; Kinetics; gas-phase pyrolysis; other temperatures between 549-602 K; ΔH(excit.), ΔS(excit.);

: 872-85-5
pyridine-4-carbaldehyde

A: 586-95-8
pyridine-4-methanol

B: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 25℃; for 4h; Cannizzaro Reaction;	A n/a B 91%
With aluminum oxide; water; sodium hydroxide at 100℃; for 0.0333333h; Cannizzaro Reaction; Microwave irradiation;	A 47% B 47%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In chloroform at 0℃; for 2h;	A 45 % Chromat. B 41%
With N,N,N',N'-tetramethylguanidine In water at 20℃; for 5h; Cannizzaro reaction;	A 40% B 35%

: 1453-82-3
isonicotinamide

A: 55-22-1
pyridine-4-carboxylic acid

B: 54-85-3
isoniazid

Conditions

Conditions	Yield
With hydrazine dihydrochloride In aq. phosphate buffer at 30℃; for 1h; pH=7; Kinetics; Concentration; Time; Temperature; Enzymatic reaction;	A n/a B 90.4%

: 13602-12-5
Isonicotinic acid N-oxide

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol at 30℃; for 0.25h;	90%
With Dimethylphenylsilane In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;	79%
With ammonium formate; nickel In methanol at 50℃; for 3h;	74%

: 638203-02-8
3-methylbut-2-enyl isonicotinate

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With sodium iodide; zirconium(IV) chloride In acetonitrile for 1.5h; Heating;	90%

: 110-86-1
pyridine

: 124-38-9
carbon dioxide

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With [NiII(Me4-(NO2Bzo)2[14]tetraeneN4)]; tetrabutylammonium perchlorate In acetonitrile at 20℃; Electrochemical reaction; Inert atmosphere;	90%
With C28H20N2O2; tetrabutylammonium perchlorate In acetonitrile at 20℃; Mechanism; Electrolysis;	75%

: 54751-01-8
4-(bromomethyl)pyridine

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With 5,10,15,20-tetra(4-nitrophenyl) porphyrinato iron chloride; [bis(acetoxy)iodo]benzene; water In methanol at 50℃; for 12h;	87%

: 1570-45-2
isonicotinic acid ethylester

: 141-78-6
ethyl acetate

A: 55-22-1
pyridine-4-carboxylic acid

B: 26377-17-3
ethyl 3-oxo-3-(4-pyridyl)propanoate

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 10 - 20℃; for 2.5h; Reagent/catalyst; Solvent;	A n/a B 86%

...Expand

: 108-89-4
picoline

A: 872-85-5
pyridine-4-carbaldehyde

B: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With water; oxygen; CrV0.95P0.05O4 at 324.84℃;	A 8.9% B 84.3%
With tert.-butylhydroperoxide; selenium(IV) oxide In 1,4-dioxane for 24h;	A 34% B 11%
With selenium(IV) oxide In 1,4-dioxane for 24h;	A 2% B 19%

: 54-85-3
isoniazid

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With water; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In chloroform at 20℃; for 1h;	75%
With cetyl-trimethylammonium dichromate; acetic acid In chloroform at 50℃; for 3h; Kinetics; Mechanism; Reagent/catalyst; Temperature; Solvent;	64%
With triiodide(1-); water; sodium chloride In hydrogenchloride at 24.9℃; Rate constant;

: 100-48-1
pyridine-4-carbonitrile

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With ((1,2-bis(diisopropylphosphino)ethane)NiH)2; water at 180℃; for 72h;	74%
With phosphate buffer at 30℃; for 72h; rhodococcus rhodocrous AJ270, pH 7.0;	50%
With potassium phosphate buffer at 30℃; for 72h; Rhodococcus sp. AJ270 cells;	50.1%

: 71653-47-9
4-methoxybenzyl isonicotinate

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With zirconium(IV) chloride In acetonitrile at 20℃; for 1.5h;	67%

: 2,2,2-trichloroethyl isonicotinate

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With indium; ammonium chloride In tetrahydrofuran for 12h; Heating;	62%

: 536-75-4
4-Ethylpyridine

A: 55-22-1
pyridine-4-carboxylic acid

B: 71708-14-0
oxo-pyridin-4-yl-acetic acid

Conditions

Conditions	Yield
With potassium hydroxide; potassium permanganate at 45℃; for 1.5h;	A 61.9% B 5.2%

: 100-43-6
4-vinylpyridine

: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 4-vinylpyridine With ozone In water; acetonitrile at 0℃; Inert atmosphere; Stage #2: With sodium chlorite In water; acetonitrile at 15 - 20℃; under 760.051 Torr; Inert atmosphere; Stage #3: With sodium hydrogen sulfate In water; acetonitrile at 35℃; for 0.166667h; Inert atmosphere;	59%
With sodium periodate; 2C16H13N2O10Ru2(1-)*Ca(2+) In water at 45℃; for 16h; Green chemistry;	57%
With nitric acid

: 54-85-3
isoniazid

: 2564-83-2, 45842-10-2
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

A: 55-22-1
pyridine-4-carboxylic acid

B: 1020092-80-1
2,2,6,6-tetramethylpiperidino isonicotinate

Conditions

Conditions	Yield
With water; periodic acid In acetonitrile at 0 - 20℃; Product distribution; Further Variations:; Reagents; nitrogen bubbling;	A n/a B 58%

...Expand

: 108-89-4
picoline

: 2196-95-4, 17213-48-8
2,2'-diphenyl-[3,3']biindolylidene 1,1'-dioxide

A: 110-86-1
pyridine

B: 872-85-5
pyridine-4-carbaldehyde

C: 55-22-1
pyridine-4-carboxylic acid

D: 2415-33-0
2,2'-diphenyl-1H,1'H-3,3'-biindole

Conditions

Conditions	Yield
at 140℃; for 14h; Further byproducts given;	A 31% B 13% C 10% D 55%

...Expand

: 108-89-4
picoline

: 2196-95-4, 17213-48-8
2,2'-diphenyl-[3,3']biindolylidene 1,1'-dioxide

A: 110-86-1
pyridine

B: 872-85-5
pyridine-4-carbaldehyde

C: 55-22-1
pyridine-4-carboxylic acid

D: 50-00-0
formaldehyd

E: 2415-33-0
2,2'-diphenyl-1H,1'H-3,3'-biindole

Conditions

Conditions	Yield
at 140℃; for 14h; Product distribution;	A 31% B 13% C 10% D n/a E 55%

...Expand

: 2196-95-4, 17213-48-8
2,2'-diphenyl-[3,3']biindolylidene 1,1'-dioxide

A: 110-86-1
pyridine

B: 872-85-5
pyridine-4-carbaldehyde

C: 55-22-1
pyridine-4-carboxylic acid

D: 2415-33-0
2,2'-diphenyl-1H,1'H-3,3'-biindole

Conditions

Conditions	Yield
With picoline at 140℃; for 14h; Further byproducts given;	A 31% B 13% C 10% D 55%

...Expand

: 108-89-4
picoline

A: 110-86-1
pyridine

B: 872-85-5
pyridine-4-carbaldehyde

C: 586-95-8
pyridine-4-methanol

D: 55-22-1
pyridine-4-carboxylic acid

Conditions

Conditions	Yield
With oxygen; CrV0.95P0.05O4 at 325℃; Product distribution; Further Variations:; Temperatures; Reagents; atmospheric pressure;	A n/a B 38.5% C n/a D 42.1%

...Expand

: 67-56-1
methanol

: 54-85-3
isoniazid

A: 55-22-1
pyridine-4-carboxylic acid

B: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene at 10℃; for 6h;	A n/a B 40%

...Expand

: 55-22-1
pyridine-4-carboxylic acid

: 14254-57-0
4-(chlorocarbonyl)pyridine

Conditions

Conditions	Yield
With thionyl chloride for 2h; Reflux;	100%
With thionyl chloride In neat (no solvent) at 20℃; for 48h; Inert atmosphere;	100%
With thionyl chloride at 80℃; for 2h;	83%

: 55-22-1
pyridine-4-carboxylic acid

: 142-71-2
copper diacetate

: copper(II) isonicotinate

Conditions

Conditions	Yield
for 0.166667 - 6h; Product distribution / selectivity; Neat (no solvent); Mechanochemistry;	100%

: 55-22-1
pyridine-4-carboxylic acid

: 3-[4-(3-amino-phenylsulfanyl)-2,3-bis-trifluoromethyl-phenyl]-1-morpholin-4-yl-propenone

: C27H21F6N3O3S

Conditions

Conditions	Yield
Stage #1: pyridine-4-carboxylic acid With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 20℃; Stage #2: 3-[4-(3-amino-phenylsulfanyl)-2,3-bis-trifluoromethyl-phenyl]-1-morpholin-4-yl-propenone In DMF (N,N-dimethyl-formamide)	100%

: 55-22-1
pyridine-4-carboxylic acid

: 1-(piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

: 1191908-84-5
1-(1-isonicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;	100%

: 55-22-1
pyridine-4-carboxylic acid

: 1-(3,4-dichlorophenyl)-4-[2-(tetrahydro-2H-pyran-2-yloxy)-ethyl]-4,5-dihydro-1H-pyrazol-3-amine

: N-{1-(3,4-dichlorophenyl)-4-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-4,5-dihydro-1H-pyrazol-3-yl}-4-pyridinecarboxamide

Conditions

Conditions	Yield
Stage #1: pyridine-4-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 0.0833333h; Stage #2: 1-(3,4-dichlorophenyl)-4-[2-(tetrahydro-2H-pyran-2-yloxy)-ethyl]-4,5-dihydro-1H-pyrazol-3-amine In dichloromethane at 40℃;	100%

: 55-22-1
pyridine-4-carboxylic acid

: C79H98N4O2Ru

: C83H97N5O3Ru

Conditions

Conditions	Yield
In tetrahydrofuran Inert atmosphere; Reflux;	100%

: 55-22-1
pyridine-4-carboxylic acid

: cadmium(II) nitrate tetrhydrate

: 64-17-5
ethanol

: 333-20-0
potassium thioacyanate

: Cd(2+)*CNS(1-)*C6H4NO2(1-)*2C2H6O

Conditions

Conditions	Yield
In water at 30℃; for 1h; Solvent; Time; Sonication; Green chemistry;	100%

...Expand

: 55-22-1
pyridine-4-carboxylic acid

: 39178-35-3
isonicotinoyl chloride hydrochloride

Conditions

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide at 20℃; Reflux;	99%
With thionyl chloride In 1,2-dichloro-ethane for 2h; Heating;	98.1%
With thionyl chloride In N,N-dimethyl-formamide at 20 - 40℃; for 0.5h;	98%

: 55-22-1
pyridine-4-carboxylic acid

: 62-53-3
aniline

: 3034-31-9
N-phenylisonicotinamide

Conditions

Conditions	Yield
Stage #1: pyridine-4-carboxylic acid With thionyl chloride for 2h; Reflux; Stage #2: aniline With potassium carbonate In tetrahydrofuran at 20℃; for 24h;	99%
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h;	90%
Stage #1: pyridine-4-carboxylic acid With 1,1'-carbonyldiimidazole at 50℃; for 0.5h; Stage #2: aniline at 50℃; for 20h;	70%
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 100℃;	17%
With cyanuric chloride - DMF; triethylamine 1) heating, 2h, 2) heating, 3h; Yield given. Multistep reaction;

: 55-22-1
pyridine-4-carboxylic acid

: trans-4,4'-benzophenonebis[(triflate)bis(triphenylphosphine)]diplatinum(II)

: trans-4,4'-benzophenonebis[(nicotinic acid)bis(triphenylphosphine)]diplatinum(II) bis(triflate)

Conditions

Conditions	Yield
In dichloromethane (N2); addn. of ligand and CH2Cl2 to platinum complex, stirring at room temp. for 6 h; evapn.; elem. anal.;	99%

: 55-22-1
pyridine-4-carboxylic acid

: meso-5,10,15,20-tetrakis(3,5-di-tert-butylphenyl)porphyrinato ruthenium(II) carbonyl

: 1449131-63-8, 358974-35-3
(5,10,15,20-tetrakis(3,5-di-tert-butylphenyl)porphyrinato)ruthenium(II) carbonyl(pyridine carboxylic acid)

Conditions

Conditions	Yield
In dichloromethane Sonication; to Ru complex in CH2Cl2 added ligand, sonicated and heated to 40°C for a few min; filtered(Celite), evapd.;	99%

: 55-22-1
pyridine-4-carboxylic acid

: 869641-37-2
2,12-bis[trans-Pt(PEt3)2NO3]-[7-(3,5-di-tert-butylphenyl)-5,6,8,9-tetrahydro-dibenzo[c,h]acridine]

: cyclo-bis[(2,12-bis(trans-Pt(PEt3)2)-7-(3,5-di-tert-butylphenyl)-5,6,8,9-tetrahydrodibenzo[c,h]acridine)(isonicotinic acid)2](NO3)4

Conditions

Conditions	Yield
In water; acetone (N2); a flask charged with Pt complex and ligand, a mixt. of acetone andH2O added, heated at 50-55°C; recrystd. (CH2Cl2/hexane); elem. anal.;	99%

: 55-22-1
pyridine-4-carboxylic acid

: 16887-79-9
sodium pyridine-4-carboxylate

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃; for 0.5h;	99%
With sodium hydroxide
With sodium hydroxide
With sodium hydroxide In water

: 55-22-1
pyridine-4-carboxylic acid

: 6011-14-9
2-aminoacetonitrile hydrochloride

: 1184796-18-6
N-(cyanomethyl)isonicotinamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h;	99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h;

: 55-22-1
pyridine-4-carboxylic acid

: N-tert-butyl-N'-phenyl-S-phenylisothiourea

: 3034-31-9
N-phenylisonicotinamide

Conditions

Conditions	Yield
With iron(III)-acetylacetonate In iso-butanol at 98℃; for 48h; Microwave irradiation;	99%

: 55-22-1
pyridine-4-carboxylic acid

: 1450-14-2
1,1,1,2,2,2-hexamethyldisilane

: 25436-39-9
trimethylsilyl 4-pyridinecarboxylate

Conditions

Conditions	Yield
RT, then warmed slowly until violent gas evolution occured;	98%

: 55-22-1
pyridine-4-carboxylic acid

: 198419-20-4
(3R,4S)-3-Amino-4-hydroxy-azepane-1-carboxylic acid tert-butyl ester

: 602277-74-7
(3R,4S)-4-hydroxy-3-[(pyridine-4-carbonyl)amino]azepane-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 24h;	98%

: 55-22-1
pyridine-4-carboxylic acid

: 499-83-2
Pyridine-2,6-dicarboxylic acid

: palladium dichloride

: 236750-15-5
(NC5H4COOH)Pd(NC5H3(COO)2)

Conditions

Conditions	Yield
In nitric acid dissoln. Pd-compd. in aq. HNO3, addn. of ligands aq. soln.; ppt. washing, drying; elem. anal.;	98%

...Expand

: 55-22-1
pyridine-4-carboxylic acid

: 1120-71-4
1,3-propanesultone

: 1151655-30-9
3-(4-carboxypyridinium-1-yl)propane-1-sulfonate

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60℃; for 24h;	98%
at 140℃;	62%

: 55-22-1
pyridine-4-carboxylic acid

: 5984-56-5
piperidine-4-carboxylic acid hydrochloride

Conditions

Conditions	Yield
Stage #1: pyridine-4-carboxylic acid With hydrogen In water at 160℃; under 45004.5 Torr; for 24h; Autoclave; Stage #2: With hydrogenchloride chemoselective reaction;	98%

: 55-22-1
pyridine-4-carboxylic acid

: 64-17-5
ethanol

: 1570-45-2
isonicotinic acid ethylester

Conditions

Conditions	Yield
With pyrographite In toluene at 130℃; for 0.166667h; Claisen Condensation; Irradiation;	97.2%
With N-dodecanoyl-N-methyl-1-glucamine In water at 45℃; for 5h; Green chemistry;	90%
With sulfuric acid for 12h; Reflux;	90%

: 55-22-1
pyridine-4-carboxylic acid

: 64-17-5
ethanol

: 58827-14-8
isonicotinic acid ethyl ester; hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 30℃; for 6h; Reflux;	97.07%

: 55-22-1
pyridine-4-carboxylic acid

: 492-98-8
2,2'-biimidazole

: 7732-18-5
water

: 6018-89-9
nickel(II) acetate tetrahydrate

: [Ni(2,2'-biimidazole)2(OH2)2](isonicotinate)2*4H2O

Conditions

Conditions	Yield
In water 2,2'-biimidazole added to a soln. of metal acetate in hot water, a soln.of isonicotinic acid in hot water added; concn., controlled evapn. at room temp. for 2-3 wk; elem. anal.;	97%

...Expand

: 55-22-1
pyridine-4-carboxylic acid

: {Cu2(μ-bis(diphenylphosphino)methane)2(CH3CN)2}{BF4}2

: [(Cu2(bis(diphenylphosphino)methane)2(μ-4-pyridylcarboxylato))4][BF4]4

Conditions

Conditions	Yield
In dichloromethane under N2; suspn. of (Cu(dppm)MeCN))2(BF4)2 and 4-pyridinecarboxylic acidin CH2Cl2 was stirred at ambient temp. for 30 min, resulting soln. was stirred for 10 min; evapn. under vac., ppt was washed with Et2O, recrystn. from CH2Cl2/hexane; elem. anal.;	97%

: 55-22-1
pyridine-4-carboxylic acid

: 5970-45-6
zinc(II) acetate dihydrate

: pyridine-4-carboxylic acid zinc salt

Conditions

Conditions	Yield
In neat (no solvent) at 200℃; for 16h; Green chemistry;	97%
In neat (no solvent, solid phase) stoich., mixed, ground in agate mortar for 10 min, heated at 180°C for 2 h; XRD;	96%
With CH3OH In neat (no solvent, solid phase) stoich., mixed, ground in agate mortar for 10 min, immerced in CH3OH, dried at 40°C; XRD;

: 55-22-1
pyridine-4-carboxylic acid

: C7β-Hydroxyobacunone

: C32H35NO8

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;	97%

Isonicotinic acid Chemical Properties

Molecular Structure of Isonicotinic acid (CAS NO.55-22-1):

IUPAC Name: pyridine-4-carboxylic acid
Molecular formula: C₆H₅NO₂
Molecular Weight: 123.11
EINECS: 200-228-2
Melting point: ≥300 °C(lit.)
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 39.19Å²
Index of Refraction: 1.57
Molar Refractivity: 31.27 cm³
Molar Volume: 95.1 cm³
Surface Tension: 58.7 dyne/cm
Density: 1.293 g/cm³
Flash Point: 193.3 °C
Enthalpy of Vaporization: 68.15 kJ/mol
Boiling Point: 396 °C at 760 mmHg
Vapour Pressure: 5.56E-07 mmHg at 25°C
Water Solubility: 5.2 g/L (20°C)
Merck: 14,5187
BRN: 109599
InChI
InChI=1/C6H5NO2/c8-6(9)5-1-3-7-4-2-5/h1-4H,(H,8,9)
Smiles
c1(ccncc1)C(O)=O
Product Categories: Nitrogen cyclic compounds; Pyridine; API intermediates; API's

Isonicotinic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	436mg/kg (436mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Pharmaceutical Chemistry Journal Vol. 11, Pg. 481, 1977.
mouse	LD50	intravenous	5gm/kg (5000mg/kg)		Therapie. Vol. 23, Pg. 1343, 1968.
mouse	LD50	oral	3123mg/kg (3123mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Pharmaceutical Chemistry Journal Vol. 11, Pg. 481, 1977.
rat	LD50	oral	5gm/kg (5000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Pharmaceutical Chemistry Journal Vol. 11, Pg. 481, 1977.

Isonicotinic acid Consensus Reports

Reported in EPA TSCA Inventory.

Isonicotinic acid Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by intravenous route. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes: Irritant Xi
Risk Statements information:
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements information:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 2

Isonicotinic acid Specification

Isonicotinic acid , with CAS number of 55-22-1, can be called 4-Pyridinecarboxylic acid ; p-Pyridinecarboxylic acid ; 1,4-Dihydroisonicotinic acid ; gamma-Picolinic acid ; 4-Picolinic acid ; pyridine-4-carboxylate ; gamma-Pyridinecarboxylic acid . It is a white to light yellow crystal powder.

Product Name

Isonicotinic acid

Synthetic route

Isonicotinic acid Chemical Properties

Isonicotinic acid Toxicity Data With Reference

Isonicotinic acid Consensus Reports

Isonicotinic acid Safety Profile

Isonicotinic acid Specification

Related Products

Hot Products